{"id":"https://openalex.org/W4285493333","doi":"https://doi.org/10.1136/bjo-2022-321415","title":"Safety and effectiveness of the fluocinolone acetonide intravitreal implant (ILUVIEN): 3-year results from the European IRISS registry study","display_name":"Safety and effectiveness of the fluocinolone acetonide intravitreal implant (ILUVIEN): 3-year results from the European IRISS registry study","publication_year":2022,"publication_date":"2022-07-15","ids":{"openalex":"https://openalex.org/W4285493333","doi":"https://doi.org/10.1136/bjo-2022-321415","pmid":"https://pubmed.ncbi.nlm.nih.gov/35840291","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10579189"},"language":"en","primary_location":{"id":"doi:10.1136/bjo-2022-321415","doi":"https://doi.org/10.1136/bjo-2022-321415","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bjo-2022-321415","pdf_url":"https://bjo.bmj.com/content/bjophthalmol/early/2022/07/15/bjo-2022-321415.full.pdf","source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://bjo.bmj.com/content/bjophthalmol/early/2022/07/15/bjo-2022-321415.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058642781","display_name":"Ramin Khoramnia","orcid":"https://orcid.org/0000-0002-6237-7773","observed_orcids":["https://orcid.org/0000-0002-6237-7773"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ramin Khoramnia","raw_affiliation_strings":["International Vision Correction Research Centre, Department of Ophthalmology, University Hospital Heidelberg, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6237-7773","affiliations":[{"raw_affiliation_string":"International Vision Correction Research Centre, Department of Ophthalmology, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018227698","display_name":"T\u00fcnde Pet\u0151","orcid":"https://orcid.org/0000-0001-6265-0381","observed_orcids":["https://orcid.org/0000-0001-6265-0381"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tunde Peto","raw_affiliation_strings":["Centre for Public Health, Blackwell's Queen's University, Belfast, UK"],"raw_orcid":"https://orcid.org/0000-0001-6265-0381","affiliations":[{"raw_affiliation_string":"Centre for Public Health, Blackwell's Queen's University, Belfast, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087717348","display_name":"Frank Koch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Koch","raw_affiliation_strings":["Department of Ophthalmology, Section of Vitreo-Retinal Surgery, Hospital of the Goethe University, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Section of Vitreo-Retinal Surgery, Hospital of the Goethe University, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100700098","display_name":"Simon R J Taylor","orcid":"https://orcid.org/0000-0002-1228-881X","observed_orcids":["https://orcid.org/0000-0002-1228-881X"]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon R Taylor","raw_affiliation_strings":["Department of Ophthalmology, University of Surrey, Guildford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Surrey, Guildford, UK","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101767222","display_name":"Jo\u00e3o Paulo Castro Sousa","orcid":"https://orcid.org/0000-0002-0025-1841","observed_orcids":["https://orcid.org/0000-0002-0025-1841"]},"institutions":[{"id":"https://openalex.org/I4403386522","display_name":"Centro Hospitalar Leiria EPE","ror":"https://ror.org/00ey4m741","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4403386522"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Paulo Castro de Sousa","raw_affiliation_strings":["Ophthalmology Department, Leiria Hospital Centre, Pousos, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, Leiria Hospital Centre, Pousos, Portugal","institution_ids":["https://openalex.org/I4403386522"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lauren Hill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lauren Hill","raw_affiliation_strings":["Consultant, Bozeman, Montana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant, Bozeman, Montana, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012964371","display_name":"Clare Bailey","orcid":"https://orcid.org/0000-0003-2141-4512","observed_orcids":["https://orcid.org/0000-0003-2141-4512"]},"institutions":[{"id":"https://openalex.org/I4210109786","display_name":"Bristol Eye Hospital","ror":"https://ror.org/01w151e64","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210109786","https://openalex.org/I4405276282"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Clare Bailey","raw_affiliation_strings":["Bristol Eye Hospital, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol Eye Hospital, Bristol, UK","institution_ids":["https://openalex.org/I4210109786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019521414","display_name":"Usha Chakravarthy","orcid":"https://orcid.org/0000-0002-2606-3734","observed_orcids":["https://orcid.org/0000-0002-2606-3734"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Usha Chakravarthy","raw_affiliation_strings":["Queen's University Belfast, Belfast, UK u.chakravarthy@qub.ac.uk","Queen's University Belfast, Belfast BT7 1NN, UK"],"raw_orcid":"https://orcid.org/0000-0002-2606-3734","affiliations":[{"raw_affiliation_string":"Queen's University Belfast, Belfast, UK u.chakravarthy@qub.ac.uk","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"Queen's University Belfast, Belfast BT7 1NN, UK","institution_ids":["https://openalex.org/I126231945"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5019521414"],"corresponding_institution_ids":["https://openalex.org/I126231945"],"apc_list":null,"apc_paid":null,"fwci":2.6807,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.89954558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"107","issue":"10","first_page":"1502","last_page":"1508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.044199999421834946,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluocinolone-acetonide","display_name":"fluocinolone acetonide","score":0.9779999852180481},{"id":"https://openalex.org/keywords/intravitreal-implant","display_name":"intravitreal implant","score":0.9359999895095825},{"id":"https://openalex.org/keywords/iluvien","display_name":"ILUVIEN","score":0.9580000042915344},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.9010000228881836},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.6000000238418579},{"id":"https://openalex.org/keywords/visual-acuity","display_name":"visual acuity","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cataract-surgery","display_name":"cataract surgery","score":0.9710000157356262},{"id":"https://openalex.org/keywords/long-term-safety","display_name":"long-term safety","score":0.6320000290870667},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9628349542617798},{"id":"https://openalex.org/C2777463590","wikidata":"https://www.wikidata.org/wiki/Q924467","display_name":"Fluocinolone acetonide","level":2,"score":0.9011558890342712},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.665800929069519},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.6448390483856201},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.6170811653137207},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4859544038772583},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4635756313800812},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.43203648924827576},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.087586909532547}],"mesh":[{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004343","descriptor_name":"Drug Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005446","descriptor_name":"Fluocinolone Acetonide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007498","descriptor_name":"Iris","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058449","descriptor_name":"Intravitreal Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1136/bjo-2022-321415","doi":"https://doi.org/10.1136/bjo-2022-321415","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bjo-2022-321415","pdf_url":"https://bjo.bmj.com/content/bjophthalmol/early/2022/07/15/bjo-2022-321415.full.pdf","source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10579189","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10579189","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10579189/pdf/bjo-2022-321415.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Ophthalmol","raw_type":"Text"},{"id":"pmid:35840291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35840291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of ophthalmology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.qub.ac.uk/portal:openaire/d202bdeb-2e83-41f3-bbba-215b317be428","doi":null,"is_oa":true,"landing_page_url":"https://pureadmin.qub.ac.uk/ws/files/586746194/Safety_and_effectiveness.pdf","pdf_url":"https://pureadmin.qub.ac.uk/ws/files/586746194/Safety_and_effectiveness.pdf","source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Khoramnia, R, Peto, T, Koch, F, Taylor, S R, Castro de Sousa, J P, Hill, L, Bailey, C, Chakravarthy, U & ILUVIEN Registry Safety Study (IRISS) Investigators Group 2023, 'Safety and effectiveness of the fluocinolone acetonide intravitreal implant (ILUVIEN): 3-year results from the European IRISS registry study', British Journal of Ophthalmology, vol. 107, no. 10, pp. 1502-1508. https://doi.org/10.1136/bjo-2022-321415","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:open-archive.highwire.org:bjophthalmol:107/10/1502","doi":null,"is_oa":false,"landing_page_url":"http://bjo.bmj.com/cgi/content/short/107/10/1502","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:publikationen.ub.uni-frankfurt.de:75403","doi":null,"is_oa":true,"landing_page_url":"http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/75403","pdf_url":null,"source":{"id":"https://openalex.org/S4306400432","display_name":"Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114090438","host_organization_name":"Goethe University Frankfurt","host_organization_lineage":["https://openalex.org/I114090438"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/bjo-2022-321415","doi":"https://doi.org/10.1136/bjo-2022-321415","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bjo-2022-321415","pdf_url":"https://bjo.bmj.com/content/bjophthalmol/early/2022/07/15/bjo-2022-321415.full.pdf","source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320318194","display_name":"Alimera Sciences","ror":"https://ror.org/00endtw77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285493333.pdf","grobid_xml":"https://content.openalex.org/works/W4285493333.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W769576241","https://openalex.org/W1915008606","https://openalex.org/W1972102480","https://openalex.org/W1982901421","https://openalex.org/W2007155254","https://openalex.org/W2019546117","https://openalex.org/W2042362462","https://openalex.org/W2097612780","https://openalex.org/W2370729570","https://openalex.org/W2605619962","https://openalex.org/W2793401320","https://openalex.org/W2805868637","https://openalex.org/W2891244783","https://openalex.org/W2900925102","https://openalex.org/W2919593621","https://openalex.org/W2923945074","https://openalex.org/W2999430947","https://openalex.org/W3028268230","https://openalex.org/W3108978639","https://openalex.org/W3109050838","https://openalex.org/W3118856954","https://openalex.org/W3132158873","https://openalex.org/W3161495651","https://openalex.org/W3198024176","https://openalex.org/W3206019788","https://openalex.org/W4206553637"],"related_works":["https://openalex.org/W2891244783","https://openalex.org/W2905750139","https://openalex.org/W2738592239","https://openalex.org/W6939793279","https://openalex.org/W3028268230","https://openalex.org/W3161495651","https://openalex.org/W2751069120","https://openalex.org/W3038229589","https://openalex.org/W4311316804","https://openalex.org/W3186813043"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,37],"ILUVIEN":[2],"Registry":[3],"Safety":[4],"Study":[5],"was":[6,134],"a":[7,111,120,162,204,214],"multicentre,":[8],"open-label,":[9],"non-randomised,":[10],"observational,":[11],"phase":[12],"4":[13],"study":[14,38,219],"designed":[15],"to":[16,167,177],"assess":[17],"the":[18,23,58,72,75,199,221,227],"safety":[19],"and":[20,43,51,55,91,104,143],"effectiveness":[21],"of":[22,64,74,82,114,124,138,150,164,186,192,226],"fluocinolone":[24],"acetonide":[25],"(FAc)":[26],"implant":[27,229],"in":[28,31,34,87,136,184,230,238],"all":[29],"indications":[30],"real-world":[32],"practices":[33],"Europe.":[35],"METHODS:":[36],"included":[39,54],"data":[40,70],"collected":[41],"prospectively":[42],"retrospectively.":[44],"Patients":[45],"receiving":[46],"FAc":[47,121,228],"implants":[48],"between":[49],"2013":[50],"2017":[52],"were":[53,97,117,182],"monitored":[56],"until":[57],"last":[59],"patient":[60],"reached":[61],"\u22653":[62],"years":[63],"follow-up.":[65,157],"Mean":[66,158],"intraocular":[67],"pressure":[68],"(IOP)":[69],"over":[71],"course":[73],"study,":[76],"along":[77],"with":[78,110,119,173,203,213,232,234],"IOP":[79,132],"events,":[80],"use":[81,96],"IOP-lowering":[83],"therapy,":[84],"mean":[85],"change":[86],"visual":[88],"acuity":[89],"(VA)":[90],"information":[92],"on":[93],"supplemental":[94],"therapy":[95,242],"analysed":[98],"post-FAc":[99],"implantation.":[100],"RESULTS:":[101],"Six":[102],"hundred":[103],"ninety-five":[105],"eyes":[106,125,139,148,231],"from":[107,161],"556":[108],"patients,":[109],"mean\u00b1SD":[112],"follow-up":[113],"1150.5\u00b1357.36":[115],"days,":[116],"treated":[118],"implant.":[122],"96.7%":[123],"had":[126],"chronic":[127],"diabetic":[128],"macular":[129],"oedema":[130],"(cDMO).":[131],"lowering":[133],"achieved":[135],"34.5%":[137],"using":[140],"topical":[141],"agents":[142],"4.3%":[144],"by":[145,190],"surgery.":[146],"Seventy-three":[147],"(64.6%":[149],"113":[151],"phakic)":[152],"required":[153],"cataract":[154],"surgery":[155],"during":[156],"VA":[159,209],"increased":[160],"baseline":[163],"52.2":[165],"letters":[166,169],"57.1":[168],"at":[170],"month":[171,178],"36,":[172],"improvement":[174],"observed":[175],"up":[176],"48.":[179],"Supplementary":[180],"therapies":[181],"given":[183],"43.7%":[185],"eyes.":[187],"When":[188],"classified":[189],"length":[191],"cDMO":[193],"less":[194],"than":[195,198,211],"or":[196],"greater":[197,208],"median":[200],"duration":[201],"those":[202,212],"shorter":[205],"history":[206],"experienced":[207],"gains":[210],"longer":[215],"history.":[216],"CONCLUSION:":[217],"This":[218],"confirms":[220],"favourable,":[222],"long-term":[223],"benefit-to-risk":[224],"profile":[225],"cDMO,":[233],"an":[235],"additional":[236],"benefit":[237],"patients":[239],"when":[240],"this":[241],"is":[243],"administered":[244],"earlier.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-15T00:00:00"}