{"id":"https://openalex.org/W4285385776","doi":"https://doi.org/10.1126/sciadv.abq2005","title":"Nanocapping-enabled charge reversal generates cell-enterable endosomal-escapable bacteriophages for intracellular pathogen inhibition","display_name":"Nanocapping-enabled charge reversal generates cell-enterable endosomal-escapable bacteriophages for intracellular pathogen inhibition","publication_year":2022,"publication_date":"2022-07-13","ids":{"openalex":"https://openalex.org/W4285385776","doi":"https://doi.org/10.1126/sciadv.abq2005","pmid":"https://pubmed.ncbi.nlm.nih.gov/35857522","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11581130"},"language":"en","primary_location":{"id":"doi:10.1126/sciadv.abq2005","doi":"https://doi.org/10.1126/sciadv.abq2005","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.abq2005","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1126/sciadv.abq2005","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102986177","display_name":"Lu Meng","orcid":"https://orcid.org/0000-0003-3297-6377","observed_orcids":["https://orcid.org/0000-0003-3297-6377","https://orcid.org/0000-0003-0822-671X","https://orcid.org/0000-0001-5178-1773"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Meng","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China","Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":"https://orcid.org/0000-0003-3297-6377","affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210110011","https://openalex.org/I4210138900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055886928","display_name":"Fengmin Yang","orcid":"https://orcid.org/0000-0003-1057-6495","observed_orcids":["https://orcid.org/0000-0003-1057-6495"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengmin Yang","raw_affiliation_strings":["Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":"https://orcid.org/0000-0003-1057-6495","affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210110011","https://openalex.org/I4210138900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079431213","display_name":"Yan Pang","orcid":"https://orcid.org/0000-0002-6722-9403","observed_orcids":["https://orcid.org/0000-0002-6722-9403"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Pang","raw_affiliation_strings":["Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Department of Ophthalmology, Shanghai Ninth People\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China"],"raw_orcid":"https://orcid.org/0000-0002-6722-9403","affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Department of Ophthalmology, Shanghai Ninth People\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089066582","display_name":"Zhenping Cao","orcid":"https://orcid.org/0000-0002-5190-9674","observed_orcids":["https://orcid.org/0000-0002-5190-9674"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenping Cao","raw_affiliation_strings":["Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210110011","https://openalex.org/I4210138900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056651698","display_name":"Feng Qi Wu","orcid":"https://orcid.org/0000-0003-4714-7707","observed_orcids":["https://orcid.org/0000-0003-4714-7707"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Wu","raw_affiliation_strings":["Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210110011","https://openalex.org/I4210138900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068278242","display_name":"Deyue Yan","orcid":"https://orcid.org/0000-0002-8681-0332","observed_orcids":["https://orcid.org/0000-0002-8681-0332","https://orcid.org/0000-0003-0969-227X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Deyue Yan","raw_affiliation_strings":["School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China","Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":"https://orcid.org/0000-0003-0969-227X","affiliations":[{"raw_affiliation_string":"School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210110011","https://openalex.org/I4210138900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081717764","display_name":"Jinyao Liu","orcid":"https://orcid.org/0000-0002-6044-2033","observed_orcids":["https://orcid.org/0000-0002-6044-2033","https://orcid.org/0000-0002-6844-7138"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jinyao Liu","raw_affiliation_strings":["Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":"https://orcid.org/0000-0002-6044-2033","affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210110011","https://openalex.org/I4210138900"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5068278242","https://openalex.org/A5079431213","https://openalex.org/A5081717764"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210097066","https://openalex.org/I4210110011","https://openalex.org/I4210138900"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":3.2672,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.94579496,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"8","issue":"28","first_page":"eabq2005","last_page":"eabq2005"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacteriophages","display_name":"bacteriophages","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cationic-polymers","display_name":"cationic polymers","score":0.8859999775886536},{"id":"https://openalex.org/keywords/charge-reversal","display_name":"charge reversal","score":0.7900000214576721},{"id":"https://openalex.org/keywords/endosomal-escape","display_name":"endosomal escape","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cell-entry","display_name":"cell entry","score":0.800000011920929},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/intracellular-pathogens","display_name":"intracellular pathogens","score":0.8569999933242798},{"id":"https://openalex.org/keywords/antimicrobial-therapy","display_name":"antimicrobial therapy","score":0.5590000152587891},{"id":"https://openalex.org/keywords/intestinal-infection","display_name":"intestinal infection","score":0.6449999809265137},{"id":"https://openalex.org/keywords/pathogen-translocation","display_name":"pathogen translocation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/proton-sponge-effect","display_name":"proton sponge effect","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.7738108038902283},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7578171491622925},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.624938428401947},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5472700595855713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5224460959434509},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5151394605636597},{"id":"https://openalex.org/C153726182","wikidata":"https://www.wikidata.org/wiki/Q3720909","display_name":"Intracellular parasite","level":3,"score":0.5017035007476807},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.49254903197288513},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46280449628829956},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4548701345920563},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.43907949328422546},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.43545860052108765},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.2740315794944763},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14827272295951843},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1369086503982544},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11204296350479126}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001435","descriptor_name":"Bacteriophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003141","descriptor_name":"Communicable Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/sciadv.abq2005","doi":"https://doi.org/10.1126/sciadv.abq2005","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.abq2005","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11581130","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11581130/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11581130/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Adv","raw_type":"Text"},{"id":"pmid:35857522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35857522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1126/sciadv.abq2005","doi":"https://doi.org/10.1126/sciadv.abq2005","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.abq2005","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1729376853","display_name":null,"funder_award_id":"SHSMU-ZDCX20210900","funder_id":"https://openalex.org/F1831464670","funder_display_name":"Innovative Research Team of High-level Local University in Shanghai"},{"id":"https://openalex.org/G1821523136","display_name":"\u80c3\u5185\u53ef\u505c\u7559\u7ed9\u836f\u7cfb\u7edf\u7684\u6784\u5efa\u53ca\u5e94\u7528\u7814\u7a76","funder_award_id":"21875135","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G55459840","display_name":null,"funder_award_id":"SHSMU\u2010ZDCX20210700","funder_id":"https://openalex.org/F1831464670","funder_display_name":"Innovative Research Team of High-level Local University in Shanghai"},{"id":"https://openalex.org/G5806830816","display_name":null,"funder_award_id":"20191820","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6406554511","display_name":null,"funder_award_id":"32101218","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G647921135","display_name":null,"funder_award_id":"20DZ2270800","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7006083613","display_name":null,"funder_award_id":"20191820","funder_id":"https://openalex.org/F1831464670","funder_display_name":"Innovative Research Team of High-level Local University in Shanghai"},{"id":"https://openalex.org/G724604810","display_name":null,"funder_award_id":"SHSMU-ZDCX20210700","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8014115200","display_name":null,"funder_award_id":"ZDCX20210900","funder_id":"https://openalex.org/F1831464670","funder_display_name":"Innovative Research Team of High-level Local University in Shanghai"},{"id":"https://openalex.org/G948518591","display_name":null,"funder_award_id":"22105123","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F1831464670","display_name":"Innovative Research Team of High-level Local University in Shanghai","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285385776.pdf","grobid_xml":"https://content.openalex.org/works/W4285385776.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W42039641","https://openalex.org/W1650035715","https://openalex.org/W1943327251","https://openalex.org/W1974053222","https://openalex.org/W1980595924","https://openalex.org/W1989635094","https://openalex.org/W1991987688","https://openalex.org/W2034351145","https://openalex.org/W2046097911","https://openalex.org/W2047085996","https://openalex.org/W2081209254","https://openalex.org/W2094666828","https://openalex.org/W2095771450","https://openalex.org/W2137281497","https://openalex.org/W2158084007","https://openalex.org/W2172687959","https://openalex.org/W2312350879","https://openalex.org/W2433691210","https://openalex.org/W2537659534","https://openalex.org/W2612489315","https://openalex.org/W2612642053","https://openalex.org/W2617130732","https://openalex.org/W2753535100","https://openalex.org/W2766807003","https://openalex.org/W2787489447","https://openalex.org/W2793294724","https://openalex.org/W2802799708","https://openalex.org/W2806270978","https://openalex.org/W2883752853","https://openalex.org/W2885904114","https://openalex.org/W2886168820","https://openalex.org/W2895726097","https://openalex.org/W2901024871","https://openalex.org/W2904514550","https://openalex.org/W2907167357","https://openalex.org/W2910246763","https://openalex.org/W2911362701","https://openalex.org/W2915312833","https://openalex.org/W2932670353","https://openalex.org/W2960949354","https://openalex.org/W2969353230","https://openalex.org/W2972260587","https://openalex.org/W2977502951","https://openalex.org/W2988550413","https://openalex.org/W2999639869","https://openalex.org/W3003557640","https://openalex.org/W3012730150","https://openalex.org/W3036648058","https://openalex.org/W3037988741","https://openalex.org/W3044924119","https://openalex.org/W3086081693","https://openalex.org/W3092041420","https://openalex.org/W3132074470","https://openalex.org/W3133732787","https://openalex.org/W3152443067","https://openalex.org/W3159506811","https://openalex.org/W3181237670","https://openalex.org/W3185093397","https://openalex.org/W3204725434","https://openalex.org/W3217305585"],"related_works":["https://openalex.org/W6908632335","https://openalex.org/W2891478615","https://openalex.org/W4388440827","https://openalex.org/W7160058404","https://openalex.org/W3185417489","https://openalex.org/W4410924869","https://openalex.org/W3181237670","https://openalex.org/W3086410194","https://openalex.org/W112642727","https://openalex.org/W7155839747"],"abstract_inverted_index":{"Bacteriophages":[0],"(phages)":[1],"are":[2,88],"widely":[3],"explored":[4],"as":[5],"antimicrobials":[6],"for":[7,145],"treating":[8],"infectious":[9],"diseases":[10],"due":[11],"to":[12,17,28,52,90,100,122],"their":[13],"specificity":[14],"and":[15,19,41,79,95],"potency":[16],"infect":[18],"inhibit":[20,29],"host":[21],"bacteria.":[22],"However,":[23],"the":[24,47,75,84,118],"application":[25],"of":[26,49,83,108,113,120],"phages":[27,70,87,115],"intracellular":[30],"pathogens":[31,121],"has":[32],"been":[33],"greatly":[34],"restricted":[35],"by":[36,64],"inadequacy":[37],"in":[38,68],"cell":[39],"entry":[40],"endosomal":[42],"escape.":[43],"Here,":[44],"we":[45],"describe":[46],"use":[48],"cationic":[50],"polymers":[51],"selectively":[53],"cap":[54],"negatively":[55],"charged":[56,62],"phage":[57,139],"head":[58],"rather":[59],"than":[60],"positively":[61],"tail":[63],"electrostatic":[65],"interaction,":[66],"resulting":[67],"charge-reversed":[69],"with":[71],"uninfluenced":[72],"vitality.":[73],"Given":[74],"positive":[76],"surface":[77],"charge":[78],"proton":[80],"sponge":[81],"effect":[82],"nanocapping,":[85],"capped":[86,114],"able":[89],"enter":[91],"intestinal":[92,109],"epithelial":[93],"cells":[94],"subsequently":[96],"escape":[97],"from":[98],"endosomes":[99],"lyse":[101],"harbored":[102],"pathogens.":[103],"In":[104],"a":[105,126,142],"murine":[106],"model":[107],"infection,":[110],"oral":[111],"ingestion":[112],"significantly":[116],"reduces":[117],"translocation":[119],"major":[123],"organs,":[124],"showing":[125],"remarkable":[127],"inhibition":[128],"efficacy.":[129],"Our":[130],"work":[131],"proposes":[132],"that":[133],"simple":[134],"synthetic":[135],"nanocapping":[136],"can":[137],"manipulate":[138],"bioactivity,":[140],"offering":[141],"facile":[143],"platform":[144],"preparing":[146],"next-generation":[147],"antimicrobials.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2022-07-14T00:00:00"}
