{"id":"https://openalex.org/W4285380596","doi":"https://doi.org/10.1016/j.exphem.2021.12.333","title":"3116 \u2013 SELECTIVE TARGETING OF SPLICING FACTOR MUTANT HEMATOPOIETIC STEM AND PROGENITOR CELLS VIA STAT3 INHIBITION","display_name":"3116 \u2013 SELECTIVE TARGETING OF SPLICING FACTOR MUTANT HEMATOPOIETIC STEM AND PROGENITOR CELLS VIA STAT3 INHIBITION","publication_year":2021,"publication_date":"2021-08-01","ids":{"openalex":"https://openalex.org/W4285380596","doi":"https://doi.org/10.1016/j.exphem.2021.12.333"},"language":"en","primary_location":{"id":"doi:10.1016/j.exphem.2021.12.333","doi":"https://doi.org/10.1016/j.exphem.2021.12.333","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exphem.2021.12.333","pdf_url":null,"source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.exphem.2021.12.333","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056389825","display_name":"Kathryn S. Potts","orcid":"https://orcid.org/0000-0002-3246-9597","observed_orcids":["https://orcid.org/0000-0002-3246-9597"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathryn Potts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051062602","display_name":"Rosannah C. Cameron","orcid":"https://orcid.org/0000-0003-4303-6364","observed_orcids":["https://orcid.org/0000-0003-4303-6364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosannah Cameron","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085789230","display_name":"Juan Martin Barajas","orcid":"https://orcid.org/0000-0002-0664-5243","observed_orcids":["https://orcid.org/0000-0002-0664-5243"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Barajas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052895144","display_name":"Ana I. Leal-Cervantes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Leal Cervantes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077002654","display_name":"LaShanale M. Wallace","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LaShanale Wallace","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Varun Gupta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Varun Gupta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017590661","display_name":"Noura Ghazale","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Noura Ghazale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017337262","display_name":"Srinivas Aluri","orcid":"https://orcid.org/0000-0003-4084-1747","observed_orcids":["https://orcid.org/0000-0003-4084-1747","https://orcid.org/0000-0002-9497-7212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srinivas Aluri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047829092","display_name":"Mia McKinstry","orcid":"https://orcid.org/0000-0002-6775-9914","observed_orcids":["https://orcid.org/0000-0002-6775-9914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mia McKinstry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028659798","display_name":"Xiaoying Bai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoying Bai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Gaurav Chaudhary","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gaurav Chaudhary","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040239548","display_name":"Aditi Shastri","orcid":"https://orcid.org/0000-0002-5366-8288","observed_orcids":["https://orcid.org/0000-0002-5366-8288"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aditi Shastri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039886481","display_name":"Amit Verma","orcid":"https://orcid.org/0000-0002-5408-1673","observed_orcids":["https://orcid.org/0000-0002-5408-1673"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amit Verma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088194956","display_name":"Esther A. Obeng","orcid":"https://orcid.org/0000-0002-8691-7439","observed_orcids":["https://orcid.org/0000-0002-8691-7439"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Esther Obeng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023082638","display_name":"Teresa Venezia Bowman","orcid":"https://orcid.org/0000-0002-6103-6862","observed_orcids":["https://orcid.org/0000-0002-6103-6862"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teresa Bowman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30743457,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"100","issue":null,"first_page":"S98","last_page":"S98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.4207000136375427,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.4207000136375427,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.15520000457763672,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.11129999905824661,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat3-inhibition","display_name":"STAT3 inhibition","score":0.8820000290870667},{"id":"https://openalex.org/keywords/splicing-factor-mutations","display_name":"splicing factor mutations","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/selective-targeting","display_name":"selective targeting","score":0.7900000214576721},{"id":"https://openalex.org/keywords/splicing-factors","display_name":"splicing factors","score":0.34700000286102295},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6544249057769775},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6092596650123596},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5446429252624512},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.5187328457832336},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.500133752822876},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4692874848842621},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4530957043170929},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40766453742980957},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3532004952430725},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33477145433425903},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1993507444858551},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15944671630859375},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.061749398708343506}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.exphem.2021.12.333","doi":"https://doi.org/10.1016/j.exphem.2021.12.333","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exphem.2021.12.333","pdf_url":null,"source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.exphem.2021.12.333","doi":"https://doi.org/10.1016/j.exphem.2021.12.333","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exphem.2021.12.333","pdf_url":null,"source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.6499999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3214164540","https://openalex.org/W2969712748","https://openalex.org/W4311310213","https://openalex.org/W3135308120","https://openalex.org/W4285380143","https://openalex.org/W2969382884","https://openalex.org/W7223258625","https://openalex.org/W4386631872","https://openalex.org/W4385983122","https://openalex.org/W7223360299"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-07-14T00:00:00"}