{"id":"https://openalex.org/W4285332201","doi":"https://doi.org/10.3390/ecsoc-25-11766","title":"Molecular Docking Study of Flavonoids to Block the Aryl Hydrocarbon Receptor","display_name":"Molecular Docking Study of Flavonoids to Block the Aryl Hydrocarbon Receptor","publication_year":2021,"publication_date":"2021-11-14","ids":{"openalex":"https://openalex.org/W4285332201","doi":"https://doi.org/10.3390/ecsoc-25-11766"},"language":"en","primary_location":{"id":"doi:10.3390/ecsoc-25-11766","doi":"https://doi.org/10.3390/ecsoc-25-11766","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ecsoc-25-11766","pdf_url":"https://www.mdpi.com/2673-4583/8/1/77/pdf?version=1655289624","source":{"id":"https://openalex.org/S4306523851","display_name":"International Electronic Conference on Synthetic Organic Chemistry (ECSOC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 25th International Electronic Conference on Synthetic Organic Chemistry","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.mdpi.com/2673-4583/8/1/77/pdf?version=1655289624","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017135081","display_name":"Oscar Guillermo Collado Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]},{"id":"https://openalex.org/I78807220","display_name":"University of Camag\u00fcey","ror":"https://ror.org/040qyzk67","country_code":"CU","type":"education","lineage":["https://openalex.org/I78807220"]}],"countries":["BE","CU"],"is_corresponding":true,"raw_author_name":"Oscar Collado Garc\u00eda","raw_affiliation_strings":["Department of Chemistry, Faculty of Applied Sciences, University of Camag\u00fcey, Camag\u00fcey 74650, Cuba","Laboratory of Medicinal Chemistry, University of Antwerp, BE-2610 Antwerp, Belgium","Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, BE-2610 Antwerp, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Applied Sciences, University of Camag\u00fcey, Camag\u00fcey 74650, Cuba","institution_ids":["https://openalex.org/I78807220"]},{"raw_affiliation_string":"Laboratory of Medicinal Chemistry, University of Antwerp, BE-2610 Antwerp, Belgium","institution_ids":["https://openalex.org/I149213910"]},{"raw_affiliation_string":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, BE-2610 Antwerp, Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048522237","display_name":"Hans L. De Winter","orcid":"https://orcid.org/0000-0002-4450-7677","observed_orcids":["https://orcid.org/0000-0002-4450-7677"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Hans De Winter","raw_affiliation_strings":["Laboratory of Medicinal Chemistry, University of Antwerp, BE-2610 Antwerp, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Medicinal Chemistry, University of Antwerp, BE-2610 Antwerp, Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paul Cos","orcid":"https://orcid.org/0000-0002-4450-7677","observed_orcids":["https://orcid.org/0000-0002-4450-7677"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Paul Cos","raw_affiliation_strings":["Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, BE-2610 Antwerp, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-4450-7677","affiliations":[{"raw_affiliation_string":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, BE-2610 Antwerp, Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064488322","display_name":"Mar\u00eda Jo\u00e3o Matos","orcid":"https://orcid.org/0000-0002-3470-8299","observed_orcids":["https://orcid.org/0000-0002-3470-8299"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]},{"id":"https://openalex.org/I4405256299","display_name":"Centro de Investiga\u00e7\u00e3o em Qu\u00edmica","ror":"https://ror.org/040at6s67","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4405256299"]}],"countries":["ES","PT"],"is_corresponding":false,"raw_author_name":"Maria Jo\u00e3o Matos","raw_affiliation_strings":["CIQUP/Department of Chemistry and Biochemistry, Faculdade de Ci\u00eancias, Universidade do Porto, 4169-007 Porto, Portugal","Department of Organic Chemistry, Faculty of Pharmacy, Universidade Santiago de Compostela, 15782 Santiago de Compostela, Spain"],"raw_orcid":"https://orcid.org/0000-0002-3470-8299","affiliations":[{"raw_affiliation_string":"CIQUP/Department of Chemistry and Biochemistry, Faculdade de Ci\u00eancias, Universidade do Porto, 4169-007 Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4405256299"]},{"raw_affiliation_string":"Department of Organic Chemistry, Faculty of Pharmacy, Universidade Santiago de Compostela, 15782 Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I200284239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070602119","display_name":"Eugenio Uriarte","orcid":"https://orcid.org/0000-0001-6218-2899","observed_orcids":["https://orcid.org/0000-0001-6218-2899"]},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eugenio Uriarte","raw_affiliation_strings":["Department of Organic Chemistry, Faculty of Pharmacy, Universidade Santiago de Compostela, 15782 Santiago de Compostela, Spain","Institute of Applied Chemical Sciences, Autonomous University of Chile, Santiago de Chile 7500912, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry, Faculty of Pharmacy, Universidade Santiago de Compostela, 15782 Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I200284239"]},{"raw_affiliation_string":"Institute of Applied Chemical Sciences, Autonomous University of Chile, Santiago de Chile 7500912, Chile","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037193275","display_name":"Gabriel Llaurad\u00f3 Maury","orcid":"https://orcid.org/0000-0001-5961-9375","observed_orcids":["https://orcid.org/0000-0001-5961-9375"]},"institutions":[{"id":"https://openalex.org/I199856841","display_name":"Universidad de Oriente","ror":"https://ror.org/03kqap970","country_code":"CU","type":"education","lineage":["https://openalex.org/I199856841"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Gabriel Llaurado Maury","raw_affiliation_strings":["Center for Industrial Biotechnology (CEBI), Universidad de Oriente, Santiago de Cuba 90500, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Industrial Biotechnology (CEBI), Universidad de Oriente, Santiago de Cuba 90500, Cuba","institution_ids":["https://openalex.org/I199856841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035019670","display_name":"Jorrit De Waele","orcid":"https://orcid.org/0000-0002-9999-6156","observed_orcids":["https://orcid.org/0000-0002-9999-6156"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jorrit De Waele","raw_affiliation_strings":["Center for Oncological Research (CORE), Integrated Personalized & Precision Oncology Network (IPPON), University of Antwerp, BE-2610 Antwerp, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Oncological Research (CORE), Integrated Personalized & Precision Oncology Network (IPPON), University of Antwerp, BE-2610 Antwerp, Belgium","institution_ids":["https://openalex.org/I149213910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113121804","display_name":"Glay Chinea Santiago","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130720","display_name":"Centro de Ingenier\u00eda Gen\u00e9tica y Biotecnolog\u00eda","ror":"https://ror.org/03qxwgf98","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210130720"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Glay Chinea Santiago","raw_affiliation_strings":["Bioinformatics Group, Center for Genetic Engineering and Biotechnology, Havana 10600, Cuba"],"raw_orcid":"https://orcid.org/0000-0002-9999-6156","affiliations":[{"raw_affiliation_string":"Bioinformatics Group, Center for Genetic Engineering and Biotechnology, Havana 10600, Cuba","institution_ids":["https://openalex.org/I4210130720"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110505263","display_name":"Enrique Molina","orcid":"https://orcid.org/0000-0001-7987-1893","observed_orcids":["https://orcid.org/0000-0001-7987-1893"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]},{"id":"https://openalex.org/I78807220","display_name":"University of Camag\u00fcey","ror":"https://ror.org/040qyzk67","country_code":"CU","type":"education","lineage":["https://openalex.org/I78807220"]}],"countries":["BE","CU"],"is_corresponding":false,"raw_author_name":"Enrique Molina","raw_affiliation_strings":["Department of Chemistry, Faculty of Applied Sciences, University of Camag\u00fcey, Camag\u00fcey 74650, Cuba","Laboratory of Medicinal Chemistry, University of Antwerp, BE-2610 Antwerp, Belgium","Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, BE-2610 Antwerp, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Applied Sciences, University of Camag\u00fcey, Camag\u00fcey 74650, Cuba","institution_ids":["https://openalex.org/I78807220"]},{"raw_affiliation_string":"Laboratory of Medicinal Chemistry, University of Antwerp, BE-2610 Antwerp, Belgium","institution_ids":["https://openalex.org/I149213910"]},{"raw_affiliation_string":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, BE-2610 Antwerp, Belgium","institution_ids":["https://openalex.org/I149213910"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5017135081"],"corresponding_institution_ids":["https://openalex.org/I149213910","https://openalex.org/I78807220"],"apc_list":null,"apc_paid":null,"fwci":0.9617,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.76060606,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"77","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.09160000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.06350000202655792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.8889999985694885},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.7860000133514404},{"id":"https://openalex.org/keywords/fisetin","display_name":"fisetin","score":0.7739999890327454},{"id":"https://openalex.org/keywords/luteolin","display_name":"luteolin","score":0.8899999856948853},{"id":"https://openalex.org/keywords/apigenin","display_name":"apigenin","score":0.9480000138282776},{"id":"https://openalex.org/keywords/galangin","display_name":"galangin","score":0.8399999737739563},{"id":"https://openalex.org/keywords/kaempferol","display_name":"kaempferol","score":0.8610000014305115},{"id":"https://openalex.org/keywords/flavones","display_name":"flavones","score":0.7400000095367432},{"id":"https://openalex.org/keywords/bhlh-domain","display_name":"bHLH domain","score":0.7089999914169312},{"id":"https://openalex.org/keywords/pas-domain","display_name":"PAS domain","score":0.7620000243186951},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.6990000009536743},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C45815257","wikidata":"https://www.wikidata.org/wiki/Q109984923","display_name":"Aryl hydrocarbon receptor nuclear translocator","level":5,"score":0.8795599937438965},{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.8082269430160522},{"id":"https://openalex.org/C2776080593","wikidata":"https://www.wikidata.org/wiki/Q415011","display_name":"Luteolin","level":4,"score":0.6904531121253967},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6126102805137634},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5583006739616394},{"id":"https://openalex.org/C2777376040","wikidata":"https://www.wikidata.org/wiki/Q418384","display_name":"Fisetin","level":4,"score":0.4999368190765381},{"id":"https://openalex.org/C2777302768","wikidata":"https://www.wikidata.org/wiki/Q2456591","display_name":"Galangin","level":5,"score":0.4830684959888458},{"id":"https://openalex.org/C2777810353","wikidata":"https://www.wikidata.org/wiki/Q393336","display_name":"Kaempferol","level":4,"score":0.4607546925544739},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4499087929725647},{"id":"https://openalex.org/C2778609962","wikidata":"https://www.wikidata.org/wiki/Q424567","display_name":"Apigenin","level":4,"score":0.4160211980342865},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.41501832008361816},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3690052628517151},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3630148768424988},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3481080234050751},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21721020340919495},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.12393397092819214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11077812314033508},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07689216732978821},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/ecsoc-25-11766","doi":"https://doi.org/10.3390/ecsoc-25-11766","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ecsoc-25-11766","pdf_url":"https://www.mdpi.com/2673-4583/8/1/77/pdf?version=1655289624","source":{"id":"https://openalex.org/S4306523851","display_name":"International Electronic Conference on Synthetic Organic Chemistry (ECSOC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 25th International Electronic Conference on Synthetic Organic Chemistry","raw_type":"proceedings-article"},{"id":"pmh:oai:doaj.org/article:124f230765e44447a37e6b2af96c16e0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/124f230765e44447a37e6b2af96c16e0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chemistry Proceedings, Vol 8, Iss 1, p 77 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ecsoc-25-11766","doi":"https://doi.org/10.3390/ecsoc-25-11766","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ecsoc-25-11766","pdf_url":"https://www.mdpi.com/2673-4583/8/1/77/pdf?version=1655289624","source":{"id":"https://openalex.org/S4306523851","display_name":"International Electronic Conference on Synthetic Organic Chemistry (ECSOC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 25th International Electronic Conference on Synthetic Organic Chemistry","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1286990824","display_name":null,"funder_award_id":"UIDB/00081","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G1397544711","display_name":null,"funder_award_id":"CEECIND/02423/2018","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G2578531282","display_name":null,"funder_award_id":"LA/P/0056","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G3288321441","display_name":"Instituto de Ci\u00eancias Moleculares","funder_award_id":"LA/P/0056/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4806396020","display_name":"Desenvolvimento de inibidores bona fide do tipo covalente para elucidar a estrutura cristalina da NOX2","funder_award_id":"EXPL/BIA-BQM/0492/2021","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5454278309","display_name":null,"funder_award_id":"/2017","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5616482380","display_name":null,"funder_award_id":"CU2017TEA433A102","funder_id":"https://openalex.org/F4320323782","funder_display_name":"Vlaamse Interuniversitaire Raad"},{"id":"https://openalex.org/G6293371769","display_name":"Centro de Investiga\u00e7\u00e3o em Qu\u00edmica da Universidade do Porto","funder_award_id":"UIDB/00081/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G8492047954","display_name":"Desenvolvimento de novos antibi\u00f3ticos para aquacultura","funder_award_id":"PTDC/ASP-PES/28397/2017","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320323071","display_name":"Belgisch Ontwikkelingsagentschap","ror":"https://ror.org/0211vdk93"},{"id":"https://openalex.org/F4320323782","display_name":"Vlaamse Interuniversitaire Raad","ror":"https://ror.org/00q3h2974"},{"id":"https://openalex.org/F4320331563","display_name":"VLIRUOS","ror":null},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285332201.pdf","grobid_xml":"https://content.openalex.org/works/W4285332201.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1506948354","https://openalex.org/W1529448601","https://openalex.org/W1604405121","https://openalex.org/W1968222807","https://openalex.org/W1974571230","https://openalex.org/W1996589301","https://openalex.org/W1999390565","https://openalex.org/W2029588268","https://openalex.org/W2037548392","https://openalex.org/W2118744236","https://openalex.org/W2129562311","https://openalex.org/W2150192011","https://openalex.org/W2151471568","https://openalex.org/W2151481630","https://openalex.org/W2154139219","https://openalex.org/W2227173042","https://openalex.org/W2292990827","https://openalex.org/W2437960705","https://openalex.org/W2585100782","https://openalex.org/W2586054114","https://openalex.org/W2599603428","https://openalex.org/W2614737589","https://openalex.org/W2623621210","https://openalex.org/W2756335070","https://openalex.org/W2789391988","https://openalex.org/W2803701672","https://openalex.org/W2909700857","https://openalex.org/W2980438605","https://openalex.org/W3023901842","https://openalex.org/W3049627973","https://openalex.org/W3049896770","https://openalex.org/W3096904551","https://openalex.org/W3116500958","https://openalex.org/W3152962648","https://openalex.org/W3165711900","https://openalex.org/W3180527094","https://openalex.org/W3199914957","https://openalex.org/W3205763954"],"related_works":["https://openalex.org/W4400981891","https://openalex.org/W2072056842","https://openalex.org/W2789391988","https://openalex.org/W4323651853","https://openalex.org/W4288926754","https://openalex.org/W2462543596","https://openalex.org/W3152962648","https://openalex.org/W2053851675","https://openalex.org/W2473229907","https://openalex.org/W2127213420"],"abstract_inverted_index":{"Anti-HIF":[0],"flavonoids":[1,56,130,143,156],"have":[2],"been":[3,61,73],"described":[4],"for":[5,75,87,101,129,174],"their":[6],"antitumor":[7],"activity":[8],"by":[9,63,70],"interfering":[10],"with":[11,57,77,146,158,163],"a":[12,35],"presumed":[13],"antioxidant":[14],"mechanism":[15],"through":[16],"direct":[17],"and":[18,40,49,93,112,127,138,162,169,196,198,212],"indirect":[19],"ways":[20],"of":[21,23,54,90,141,178],"overexpression":[22],"the":[24,58,78,88,103,107,110,142,147,154,166,176,179,201],"hypoxia":[25],"inducible":[26],"factor":[27],"(HIF-1\u03b1).":[28],"The":[29,52,66,117,171],"aryl":[30],"hydrocarbon":[31],"receptor":[32],"(AhR)":[33],"is":[34,41,187],"protein":[36],"homologous":[37],"to":[38,120,123,183,203],"HIF-1\u03b1":[39],"overexpressed":[42],"in":[43,189,208],"smoking":[44],"patients":[45,211],"suffering":[46],"from":[47],"lung":[48,213],"breast":[50],"cancer.":[51,214],"interaction":[53,97],"thirteen":[55],"AhR":[59],"has":[60,72,199],"evaluated":[62,144],"molecular":[64],"docking.":[65],"AhR:ARNT":[67,121,180],"model":[68],"obtained":[69],"SwissModel":[71],"used":[74],"docking":[76],"MOE":[79],"2019.01":[80],"program,":[81],"as":[82,84,193],"well":[83],"several":[85],"servers":[86],"determination":[89],"protein\u2013protein":[91],"interactions":[92],"alanine":[94],"mutations.":[95],"Different":[96],"sites":[98],"were":[99],"identified":[100],"blocking":[102,118,175],"AhR:":[104],"functional":[105],"ARNT,":[106],"interface":[108],"between":[109,125],"bHLH":[111],"PAS-A":[113],"domains,":[114],"being":[115],"important.":[116],"capacity":[119],"proved":[122,182],"be":[124,184],"50":[126],"60%":[128],"4\u2032,7-dihydroxy-flavone,":[131],"fisetin,":[132,185],"luteolin,":[133],"5-hydroxy-2-(4\u2032-hydroxy)-7-methoxy-flavonone,":[134],"flavone,":[135,161],"apigenin,":[136],"galangin":[137],"7-hydroxy-5-methoxy-flavonone.":[139],"None":[140],"interact":[145,157],"PAS-B":[148],"domain":[149],"(AhR":[150],"active":[151],"site).":[152],"All":[153],"studied":[155],"AhR,":[159],"except":[160,165],"ARNT":[164],"compounds":[167],"3,7-dihydroxy-flavone":[168],"kaempferol.":[170],"best":[172],"flavonoid":[173],"formation":[177],"heterodimer":[181],"which":[186],"found":[188],"food":[190],"sources":[191],"such":[192],"strawberries,":[194],"apples":[195],"grapes,":[197],"shown":[200],"ability":[202],"reduce":[204],"pro-cancer":[205],"inflammatory":[206],"markers":[207],"colorectal":[209],"cancer":[210]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-14T00:00:00"}