{"id":"https://openalex.org/W4285290664","doi":"https://doi.org/10.20517/mrr.2022.01","title":"Modeling microbiota-associated human diseases: from minimal models to complex systems","display_name":"Modeling microbiota-associated human diseases: from minimal models to complex systems","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4285290664","doi":"https://doi.org/10.20517/mrr.2022.01","pmid":"https://pubmed.ncbi.nlm.nih.gov/38046357","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10688821"},"language":"en","primary_location":{"id":"doi:10.20517/mrr.2022.01","doi":"https://doi.org/10.20517/mrr.2022.01","is_oa":true,"landing_page_url":"https://doi.org/10.20517/mrr.2022.01","pdf_url":"https://oaepublish.com/mrr/article/download/4860","source":{"id":"https://openalex.org/S4220651643","display_name":"Microbiome Research Reports","issn_l":"2771-5965","issn":["2771-5965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiome Research Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://oaepublish.com/mrr/article/download/4860","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037122250","display_name":"Doriane Aguanno","orcid":"https://orcid.org/0000-0002-4154-3592","observed_orcids":["https://orcid.org/0000-0002-4154-3592"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Doriane Aguanno","raw_affiliation_strings":["Chair of Nutrition and Immunology, Technical University of Munich, Freising 85354, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Nutrition and Immunology, Technical University of Munich, Freising 85354, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082628752","display_name":"Amira Metwaly","orcid":"https://orcid.org/0000-0001-5740-0230","observed_orcids":["https://orcid.org/0000-0001-5740-0230"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Amira Metwaly","raw_affiliation_strings":["Chair of Nutrition and Immunology, Technical University of Munich, Freising 85354, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Nutrition and Immunology, Technical University of Munich, Freising 85354, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040726327","display_name":"Olivia I. Coleman","orcid":"https://orcid.org/0000-0002-4075-7820","observed_orcids":["https://orcid.org/0000-0002-4075-7820"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Olivia I. Coleman","raw_affiliation_strings":["Chair of Nutrition and Immunology, Technical University of Munich, Freising 85354, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Nutrition and Immunology, Technical University of Munich, Freising 85354, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027459947","display_name":"Dirk Haller","orcid":"https://orcid.org/0000-0002-6977-4085","observed_orcids":["https://orcid.org/0000-0002-6977-4085"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Dirk Haller","raw_affiliation_strings":["Chair of Nutrition and Immunology, Technical University of Munich, Freising 85354, Germany","ZIEL Institute for Food & Health, Technical University of Munich, Freising 85354, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Nutrition and Immunology, Technical University of Munich, Freising 85354, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"ZIEL Institute for Food & Health, Technical University of Munich, Freising 85354, Germany","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027459947"],"corresponding_institution_ids":["https://openalex.org/I62916508"],"apc_list":null,"apc_paid":null,"fwci":0.3529,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.32933129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"1","issue":"2","first_page":"17","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.906000018119812},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.7929999828338623},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6769999861717224},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.9559999704360962},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9240000247955322},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/in-vitro-fermentation","display_name":"in vitro fermentation","score":0.5540000200271606},{"id":"https://openalex.org/keywords/intestinal-organoids","display_name":"intestinal organoids","score":0.9539999961853027},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.8100000023841858},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.8103957176208496},{"id":"https://openalex.org/C91478284","wikidata":"https://www.wikidata.org/wiki/Q6623796","display_name":"Human microbiome","level":3,"score":0.7639609575271606},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6709640026092529},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6565914154052734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6387771964073181},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5799878239631653},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46347153186798096},{"id":"https://openalex.org/C190944805","wikidata":"https://www.wikidata.org/wiki/Q3922751","display_name":"Human Microbiome Project","level":4,"score":0.437500536441803},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.42990192770957947},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3724595010280609},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36544764041900635},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2661972641944885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20665162801742554},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.092018723487854},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.20517/mrr.2022.01","doi":"https://doi.org/10.20517/mrr.2022.01","is_oa":true,"landing_page_url":"https://doi.org/10.20517/mrr.2022.01","pdf_url":"https://oaepublish.com/mrr/article/download/4860","source":{"id":"https://openalex.org/S4220651643","display_name":"Microbiome Research Reports","issn_l":"2771-5965","issn":["2771-5965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiome Research Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10688821","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10688821","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10688821/pdf/mrr-1-3-17.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiome Res Rep","raw_type":"Text"},{"id":"pmid:38046357","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38046357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiome research reports","raw_type":"Journal Article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1774603","doi":null,"is_oa":true,"landing_page_url":"https://mediatum.ub.tum.de/1774603","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:zenodo.org:10950092","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38046357","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbiome Res Rep, 1(3)(17), 22, (2024-04-09)","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:zenodo.org:8205313","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/8205313","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbiome Research Reports","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.5281/zenodo.10950091","doi":"https://doi.org/10.5281/zenodo.10950091","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.10950091","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReview"},{"id":"doi:10.5281/zenodo.10950092","doi":"https://doi.org/10.5281/zenodo.10950092","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.10950092","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReview"}],"best_oa_location":{"id":"doi:10.20517/mrr.2022.01","doi":"https://doi.org/10.20517/mrr.2022.01","is_oa":true,"landing_page_url":"https://doi.org/10.20517/mrr.2022.01","pdf_url":"https://oaepublish.com/mrr/article/download/4860","source":{"id":"https://openalex.org/S4220651643","display_name":"Microbiome Research Reports","issn_l":"2771-5965","issn":["2771-5965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiome Research Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2260345425","display_name":"International Human Microbiome Coordination and Support Action","funder_award_id":"964590","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G306507530","display_name":null,"funder_award_id":"SFB1371","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5144545689","display_name":null,"funder_award_id":"SFB 1371","funder_id":"https://openalex.org/F4320323383","funder_display_name":"Technische Universit\u00e4t M\u00fcnchen"},{"id":"https://openalex.org/G8235906861","display_name":"SFB 1371: Microbiome Signatures  Funktionelle Relevanz des Mikrobioms im Verdauungstrakt","funder_award_id":"395357507","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320323383","display_name":"Technische Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/02kkvpp62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285290664.pdf","grobid_xml":"https://content.openalex.org/works/W4285290664.grobid-xml"},"referenced_works_count":159,"referenced_works":["https://openalex.org/W39962999","https://openalex.org/W593945491","https://openalex.org/W1483496013","https://openalex.org/W1586609806","https://openalex.org/W1741548448","https://openalex.org/W1915524531","https://openalex.org/W1965157206","https://openalex.org/W1966921473","https://openalex.org/W1970777915","https://openalex.org/W1973187395","https://openalex.org/W1980475824","https://openalex.org/W1980914602","https://openalex.org/W1982595964","https://openalex.org/W1985774274","https://openalex.org/W1990606472","https://openalex.org/W1993399595","https://openalex.org/W1994366077","https://openalex.org/W1996955003","https://openalex.org/W1998240361","https://openalex.org/W2002513358","https://openalex.org/W2003525072","https://openalex.org/W2003808681","https://openalex.org/W2008549364","https://openalex.org/W2008631743","https://openalex.org/W2015567271","https://openalex.org/W2019931716","https://openalex.org/W2020621701","https://openalex.org/W2023430279","https://openalex.org/W2032022203","https://openalex.org/W2034082915","https://openalex.org/W2040643779","https://openalex.org/W2042074642","https://openalex.org/W2042521699","https://openalex.org/W2046753869","https://openalex.org/W2047208232","https://openalex.org/W2050944254","https://openalex.org/W2051082976","https://openalex.org/W2053039168","https://openalex.org/W2054112179","https://openalex.org/W2062333123","https://openalex.org/W2063577643","https://openalex.org/W2064099549","https://openalex.org/W2072965356","https://openalex.org/W2075313774","https://openalex.org/W2085284704","https://openalex.org/W2086248022","https://openalex.org/W2087292184","https://openalex.org/W2093500216","https://openalex.org/W2096290681","https://openalex.org/W2097478615","https://openalex.org/W2097875133","https://openalex.org/W2099662390","https://openalex.org/W2104249477","https://openalex.org/W2104890139","https://openalex.org/W2108260765","https://openalex.org/W2111317067","https://openalex.org/W2111916909","https://openalex.org/W2116231168","https://openalex.org/W2119914001","https://openalex.org/W2125784987","https://openalex.org/W2125826054","https://openalex.org/W2125932918","https://openalex.org/W2127568565","https://openalex.org/W2130725058","https://openalex.org/W2136552678","https://openalex.org/W2137076924","https://openalex.org/W2141125135","https://openalex.org/W2142864711","https://openalex.org/W2143777796","https://openalex.org/W2147637673","https://openalex.org/W2148103005","https://openalex.org/W2149573313","https://openalex.org/W2149848289","https://openalex.org/W2151241623","https://openalex.org/W2153456263","https://openalex.org/W2155882037","https://openalex.org/W2155997663","https://openalex.org/W2158626993","https://openalex.org/W2163826296","https://openalex.org/W2166363067","https://openalex.org/W2167062509","https://openalex.org/W2170925079","https://openalex.org/W2173894147","https://openalex.org/W2182578492","https://openalex.org/W2188930066","https://openalex.org/W2208085400","https://openalex.org/W2210259689","https://openalex.org/W2289494545","https://openalex.org/W2307660471","https://openalex.org/W2319483236","https://openalex.org/W2328023807","https://openalex.org/W2343758687","https://openalex.org/W2367851449","https://openalex.org/W2403475582","https://openalex.org/W2473006101","https://openalex.org/W2476079089","https://openalex.org/W2524820142","https://openalex.org/W2530535683","https://openalex.org/W2554281579","https://openalex.org/W2571062870","https://openalex.org/W2586959160","https://openalex.org/W2613175376","https://openalex.org/W2749700969","https://openalex.org/W2762689525","https://openalex.org/W2762883136","https://openalex.org/W2765195199","https://openalex.org/W2767512583","https://openalex.org/W2783611475","https://openalex.org/W2788735115","https://openalex.org/W2797413896","https://openalex.org/W2883832900","https://openalex.org/W2887509155","https://openalex.org/W2889517260","https://openalex.org/W2889646458","https://openalex.org/W2896740537","https://openalex.org/W2910577978","https://openalex.org/W2911391319","https://openalex.org/W2917423992","https://openalex.org/W2917520831","https://openalex.org/W2938158705","https://openalex.org/W2943733498","https://openalex.org/W2944190704","https://openalex.org/W2947189704","https://openalex.org/W2950045601","https://openalex.org/W2955323986","https://openalex.org/W2965604684","https://openalex.org/W2969376989","https://openalex.org/W2972869264","https://openalex.org/W2977850219","https://openalex.org/W2983830192","https://openalex.org/W2991550463","https://openalex.org/W2996301527","https://openalex.org/W2996612201","https://openalex.org/W2997486622","https://openalex.org/W3001098195","https://openalex.org/W3033475562","https://openalex.org/W3038764318","https://openalex.org/W3039530833","https://openalex.org/W3043617350","https://openalex.org/W3047172990","https://openalex.org/W3081717401","https://openalex.org/W3084060423","https://openalex.org/W3091836995","https://openalex.org/W3106671040","https://openalex.org/W3108788068","https://openalex.org/W3127384363","https://openalex.org/W3133337437","https://openalex.org/W3145572982","https://openalex.org/W3158847163","https://openalex.org/W3159974931","https://openalex.org/W3186293931","https://openalex.org/W3194087029","https://openalex.org/W3194813638","https://openalex.org/W3199205086","https://openalex.org/W3199798706","https://openalex.org/W3206854493","https://openalex.org/W3214269027","https://openalex.org/W4211240480","https://openalex.org/W4239017233"],"related_works":["https://openalex.org/W3128051916","https://openalex.org/W2902021250","https://openalex.org/W2024151129","https://openalex.org/W1809729829","https://openalex.org/W2736839127","https://openalex.org/W2124630529","https://openalex.org/W3002373988","https://openalex.org/W4411379763","https://openalex.org/W2148103005","https://openalex.org/W4401250762"],"abstract_inverted_index":{"Alterations":[0],"in":[1,54,80,102,129,152,203,233],"the":[2,12,38,45,61,90,95,119,125,153,160,172,176,196,208,234,244],"intestinal":[3,47,62,214],"microbiota":[4,63,92,109,210],"are":[5,33],"associated":[6,19,188],"with":[7,182],"various":[8],"human":[9,46,81,91,107,127,134,180,209,229],"diseases":[10,24,32],"of":[11,37,44,68,77,99,106,124,146,155,175,198,207,236,248],"digestive":[13],"system,":[14],"including":[15],"obesity":[16,185],"and":[17,26,41,93,97,121,157,186,192,211,246],"its":[18,187],"metabolic":[20,42,189],"diseases,":[21,52,82,181,190,239],"inflammatory":[22],"bowel":[23],"(IBD),":[25],"colorectal":[27],"cancer":[28],"(CRC).":[29],"All":[30],"three":[31,238],"characterized":[34],"by":[35],"modifications":[36],"richness,":[39],"composition,":[40],"functions":[43],"microbiota.":[48],"Despite":[49],"being":[50],"multi-factorial":[51],"studies":[53,147],"germ-free":[55],"animal":[56,111],"models":[57,83,112,136,232],"have":[58,148],"unarguably":[59],"identified":[60],"as":[64,202,216,218,240,242],"a":[65,114,130],"causal":[66,120],"driver":[67],"disease":[69],"pathogenesis.":[70],"However,":[71],"for":[72,117],"an":[73,143],"increased":[74],"mechanistic":[75],"understanding":[76],"microbial":[78],"signatures":[79],"require":[84],"detailed":[85],"refinement":[86],"to":[87,140,179],"closely":[88],"mimic":[89],"reflect":[94],"complexity":[96],"range":[98],"dysbiosis":[100],"observed":[101],"patients.":[103],"The":[104],"transplantation":[105],"fecal":[108],"into":[110],"represents":[113],"powerful":[115],"tool":[116],"studying":[118],"functional":[122,173],"role":[123],"dysbiotic":[126],"microbiome":[128],"pathological":[131],"context.":[132],"While":[133],"microbiota-associated":[135,230],"were":[137],"initially":[138],"employed":[139],"study":[141],"obesity,":[142],"increasing":[144],"number":[145],"applied":[149],"this":[150,164,249],"approach":[151],"context":[154,235],"IBD":[156],"CRC":[158],"over":[159],"past":[161],"decade.":[162],"In":[163],"review,":[165],"we":[166],"discuss":[167,195],"different":[168],"approaches":[169],"that":[170],"allow":[171],"validation":[174],"bacterial":[177],"contribution":[178],"emphasis":[183],"on":[184,228],"IBD,":[191],"CRC.":[193],"We":[194],"utility":[197],"simple":[199],"models,":[200],"such":[201],"vitro":[204],"fermentation":[205],"systems":[206],"ex":[212],"vivo":[213],"organoids,":[215],"well":[217,241],"more":[219],"complex":[220],"whole":[221],"organism":[222],"models.":[223],"Our":[224],"focus":[225],"here":[226],"lies":[227],"mouse":[231],"all":[237],"highlighting":[243],"advantages":[245],"limitations":[247],"approach.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-07-14T00:00:00"}
