{"id":"https://openalex.org/W4285289327","doi":"https://doi.org/10.21203/rs.3.rs-2067581/v1","title":"Comprehensive Transcriptome and Metabolome Profiling Reveals Key Regulating Signaling and Metabolic Pathways of Resistant Hypertension in Drug Users","display_name":"Comprehensive Transcriptome and Metabolome Profiling Reveals Key Regulating Signaling and Metabolic Pathways of Resistant Hypertension in Drug Users","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4285289327","doi":"https://doi.org/10.21203/rs.3.rs-2067581/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-2067581/v1","doi":"https://doi.org/10.21203/rs.3.rs-2067581/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2067581/v1","pdf_url":"https://www.researchsquare.com/article/rs-2067581/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-2067581/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009279111","display_name":"Ji-Qun Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094163","display_name":"Kunming Third People's Hospital","ror":"https://ror.org/00pv01967","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094163"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji-Qun Yang","raw_affiliation_strings":["Third People\u2019s Hospital of Kunming City/Drug Rehabilitation Hospital of Kunming City","The Third People\u2019s Hospital of Kunming City - Drug Rehabilitation Hospital of Kunming City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third People\u2019s Hospital of Kunming City/Drug Rehabilitation Hospital of Kunming City","institution_ids":["https://openalex.org/I4210094163"]},{"raw_affiliation_string":"The Third People\u2019s Hospital of Kunming City - Drug Rehabilitation Hospital of Kunming City","institution_ids":["https://openalex.org/I4210094163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101453836","display_name":"Jie Jia","orcid":"https://orcid.org/0000-0003-3238-1947","observed_orcids":["https://orcid.org/0000-0003-3238-1947"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]},{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Jia","raw_affiliation_strings":["First Affiliated Hospital of Kunming Medical University","Kunming Medical University - NHC Key Laboratory of Drug Addiction Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Kunming Medical University","institution_ids":["https://openalex.org/I4210120169"]},{"raw_affiliation_string":"Kunming Medical University - NHC Key Laboratory of Drug Addiction Medicine","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023144754","display_name":"Yu Ming Zhao","orcid":"https://orcid.org/0000-0002-9197-274X","observed_orcids":["https://orcid.org/0000-0002-9197-274X"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]},{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Zhao","raw_affiliation_strings":["First Affiliated Hospital of Kunming Medical University","Kunming Medical University - NHC Key Laboratory of Drug Addiction Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Kunming Medical University","institution_ids":["https://openalex.org/I4210120169"]},{"raw_affiliation_string":"Kunming Medical University - NHC Key Laboratory of Drug Addiction Medicine","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100398430","display_name":"Weijie Wang","orcid":"https://orcid.org/0000-0002-5717-1818","observed_orcids":["https://orcid.org/0000-0002-5717-1818"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]},{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei-Jie Wang","raw_affiliation_strings":["First Affiliated Hospital of Kunming Medical University","Kunming Medical University - NHC Key Laboratory of Drug Addiction Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Kunming Medical University","institution_ids":["https://openalex.org/I4210120169"]},{"raw_affiliation_string":"Kunming Medical University - NHC Key Laboratory of Drug Addiction Medicine","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100461271","display_name":"Tong Chen","orcid":"https://orcid.org/0000-0002-2456-7170","observed_orcids":["https://orcid.org/0000-0002-2456-7170","https://orcid.org/0000-0002-3065-5978","https://orcid.org/0009-0005-0371-0643"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]},{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tong Chen","raw_affiliation_strings":["First Affiliated Hospital of Kunming Medical University","Kunming Medical University - NHC Key Laboratory of Drug Addiction Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Kunming Medical University","institution_ids":["https://openalex.org/I4210120169"]},{"raw_affiliation_string":"Kunming Medical University - NHC Key Laboratory of Drug Addiction Medicine","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078450567","display_name":"Yingrong Du","orcid":"https://orcid.org/0000-0001-5872-865X","observed_orcids":["https://orcid.org/0000-0001-5872-865X"]},"institutions":[{"id":"https://openalex.org/I4210094163","display_name":"Kunming Third People's Hospital","ror":"https://ror.org/00pv01967","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094163"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying-Rong Du","raw_affiliation_strings":["Third People\u2019s Hospital of Kunming City/Drug Rehabilitation Hospital of Kunming City","The Third People\u2019s Hospital of Kunming City - Drug Rehabilitation Hospital of Kunming City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third People\u2019s Hospital of Kunming City/Drug Rehabilitation Hospital of Kunming City","institution_ids":["https://openalex.org/I4210094163"]},{"raw_affiliation_string":"The Third People\u2019s Hospital of Kunming City - Drug Rehabilitation Hospital of Kunming City","institution_ids":["https://openalex.org/I4210094163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024979722","display_name":"Gui-Fang Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094163","display_name":"Kunming Third People's Hospital","ror":"https://ror.org/00pv01967","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094163"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gui-Fang Hu","raw_affiliation_strings":["Third People\u2019s Hospital of Kunming City/Drug Rehabilitation Hospital of Kunming City","The Third People\u2019s Hospital of Kunming City - Drug Rehabilitation Hospital of Kunming City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third People\u2019s Hospital of Kunming City/Drug Rehabilitation Hospital of Kunming City","institution_ids":["https://openalex.org/I4210094163"]},{"raw_affiliation_string":"The Third People\u2019s Hospital of Kunming City - Drug Rehabilitation Hospital of Kunming City","institution_ids":["https://openalex.org/I4210094163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362092","display_name":"Jun Li","orcid":"https://orcid.org/0000-0003-3519-8638","observed_orcids":["https://orcid.org/0000-0003-3519-8638"]},"institutions":[{"id":"https://openalex.org/I4210094163","display_name":"Kunming Third People's Hospital","ror":"https://ror.org/00pv01967","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094163"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["Third People\u2019s Hospital of Kunming City/Drug Rehabilitation Hospital of Kunming City","The Third People\u2019s Hospital of Kunming City - Drug Rehabilitation Hospital of Kunming City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third People\u2019s Hospital of Kunming City/Drug Rehabilitation Hospital of Kunming City","institution_ids":["https://openalex.org/I4210094163"]},{"raw_affiliation_string":"The Third People\u2019s Hospital of Kunming City - Drug Rehabilitation Hospital of Kunming City","institution_ids":["https://openalex.org/I4210094163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054557639","display_name":"Mingchun Wang","orcid":"https://orcid.org/0000-0002-6470-2330","observed_orcids":["https://orcid.org/0000-0002-6470-2330","https://orcid.org/0009-0000-5008-3201"]},"institutions":[{"id":"https://openalex.org/I4210094163","display_name":"Kunming Third People's Hospital","ror":"https://ror.org/00pv01967","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094163"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming-Chun Wang","raw_affiliation_strings":["Third People\u2019s Hospital of Kunming City/Drug Rehabilitation Hospital of Kunming City","The Third People\u2019s Hospital of Kunming City - Drug Rehabilitation Hospital of Kunming City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third People\u2019s Hospital of Kunming City/Drug Rehabilitation Hospital of Kunming City","institution_ids":["https://openalex.org/I4210094163"]},{"raw_affiliation_string":"The Third People\u2019s Hospital of Kunming City - Drug Rehabilitation Hospital of Kunming City","institution_ids":["https://openalex.org/I4210094163"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022540352","display_name":"Yi\u2010Qun Kuang","orcid":"https://orcid.org/0000-0002-1452-4388","observed_orcids":["https://orcid.org/0000-0002-1452-4388"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]},{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Qun Kuang","raw_affiliation_strings":["First Affiliated Hospital of Kunming Medical University","Kunming Medical University - NHC Key Laboratory of Drug Addiction Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Kunming Medical University","institution_ids":["https://openalex.org/I4210120169"]},{"raw_affiliation_string":"Kunming Medical University - NHC Key Laboratory of Drug Addiction Medicine","institution_ids":["https://openalex.org/I26080491"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resistant-hypertension","display_name":"resistant hypertension","score":0.9160000085830688},{"id":"https://openalex.org/keywords/people-who-use-drugs","display_name":"drug users","score":0.7979999780654907},{"id":"https://openalex.org/keywords/drug-induced-hypertension","display_name":"drug-induced hypertension","score":0.6380000114440918},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8050000071525574},{"id":"https://openalex.org/keywords/metabolic-profiling","display_name":"metabolite profiling","score":0.7139999866485596},{"id":"https://openalex.org/keywords/toll-like-receptor-signaling","display_name":"Toll-like receptor signaling","score":0.9440000057220459},{"id":"https://openalex.org/keywords/interleukin-signaling","display_name":"interleukin signaling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/histidine-metabolism","display_name":"histidine metabolism","score":0.7630000114440918},{"id":"https://openalex.org/keywords/hippurate","display_name":"hippurate","score":0.7739999890327454},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gene-co-expression-network","display_name":"gene co-expression network","score":0.703000009059906},{"id":"https://openalex.org/keywords/peripheral-blood","display_name":"peripheral blood","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.8746625185012817},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7697776556015015},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.5939297080039978},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.545353353023529},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48294275999069214},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4666239023208618},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4384012520313263},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.4366598129272461},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42577311396598816},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.4210507571697235},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.42020106315612793},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3634251356124878},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3541627824306488},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24603307247161865},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24290964007377625},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21902430057525635},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16756156086921692},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11675602197647095},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21203/rs.3.rs-2067581/v1","doi":"https://doi.org/10.21203/rs.3.rs-2067581/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2067581/v1","pdf_url":"https://www.researchsquare.com/article/rs-2067581/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"doi:10.2139/ssrn.4150498","doi":"https://doi.org/10.2139/ssrn.4150498","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4150498","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-2067581/v1","doi":"https://doi.org/10.21203/rs.3.rs-2067581/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2067581/v1","pdf_url":"https://www.researchsquare.com/article/rs-2067581/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322268","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285289327.pdf","grobid_xml":"https://content.openalex.org/works/W4285289327.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1981149380","https://openalex.org/W1982576821","https://openalex.org/W2008614812","https://openalex.org/W2013036395","https://openalex.org/W2015920118","https://openalex.org/W2021050906","https://openalex.org/W2064858030","https://openalex.org/W2089630582","https://openalex.org/W2121497863","https://openalex.org/W2133402519","https://openalex.org/W2153626991","https://openalex.org/W2169848995","https://openalex.org/W2327220247","https://openalex.org/W2467227182","https://openalex.org/W2602400640","https://openalex.org/W2615547515","https://openalex.org/W2789863794","https://openalex.org/W2791547377","https://openalex.org/W2807338784","https://openalex.org/W2810785966","https://openalex.org/W2909928304","https://openalex.org/W2914086965","https://openalex.org/W2937033043","https://openalex.org/W2964507531","https://openalex.org/W2973333082","https://openalex.org/W3005411776","https://openalex.org/W3005889306","https://openalex.org/W3021993348","https://openalex.org/W3036107805","https://openalex.org/W3109715914","https://openalex.org/W3121882824","https://openalex.org/W4281754318"],"related_works":["https://openalex.org/W4281754318","https://openalex.org/W4303192447","https://openalex.org/W4283170137","https://openalex.org/W4207072695","https://openalex.org/W2761371314","https://openalex.org/W4403397800","https://openalex.org/W4405761538","https://openalex.org/W7172525843","https://openalex.org/W3199909620","https://openalex.org/W2887551220"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Hypertension":[2],"patients":[3,40,48],"with":[4,41,103],"drug":[5,21,42,50,150],"use":[6,43,51,151],"have":[7],"a":[8,96,109,135],"low":[9],"susceptibility":[10],"to":[11,112],"hypotensor.":[12],"The":[13,114],"pathogenesis":[14],"and":[15,32,45,61,77,91,120,142],"metabolic":[16],"characteristics":[17],"of":[18,34,70,89,116,138,145],"hypertension":[19,39,47],"in":[20,67,86,127,149],"users":[22],"remain":[23],"unknown.":[24],"Methods:":[25],"We":[26,94],"performed":[27],"high-throughput":[28],"sequencing":[29],"for":[30],"transcriptome":[31],"metabolome":[33],"peripheral":[35],"blood":[36],"from":[37],"30":[38,46],"(HBP-DU)":[44],"without":[49],"(HBP).":[52],"Results:":[53],"Differentially":[54,80],"expressed":[55],"genes":[56],"(DEGs)":[57],"between":[58],"the":[59,68,87,104,128,143],"HBP":[60],"HBP-DU":[62,105,129],"groups":[63],"were":[64,83],"mainly":[65],"involved":[66],"pathways":[69,88],"toll-like":[71,146],"receptor":[72,147],"(TLR)":[73],"cascades,":[74],"FCERI":[75],"signaling,":[76],"interleukin":[78],"signaling.":[79],"metabolites":[81],"(DMs)":[82],"significantly":[84,125],"enriched":[85],"alanine":[90],"histidine":[92],"metabolism.":[93],"identified":[95],"gene":[97],"cluster":[98],"(turquoise":[99],"module,":[100],"MEturquoise)":[101],"correlated":[102],"group,":[106],"which":[107],"has":[108],"similar":[110],"function":[111,137],"DEGs.":[113],"abundance":[115],"CD4+":[117],"T":[118,122],"cells":[119,123],"CD8+":[121],"was":[124],"decreased":[126],"group.":[130],"Conclusions:":[131],"These":[132],"results":[133],"indicated":[134],"potential":[136],"histidine,":[139],"immune":[140],"cells,":[141],"pathway":[144],"cascades":[148],"hypertension.":[152]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-14T00:00:00"}
