{"id":"https://openalex.org/W4285165409","doi":"https://doi.org/10.20517/2394-5079.2022.04","title":"The pros and cons of biological effects of herbs and herb-derived compounds on liver tumorigenesis","display_name":"The pros and cons of biological effects of herbs and herb-derived compounds on liver tumorigenesis","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4285165409","doi":"https://doi.org/10.20517/2394-5079.2022.04"},"language":"en","primary_location":{"id":"doi:10.20517/2394-5079.2022.04","doi":"https://doi.org/10.20517/2394-5079.2022.04","is_oa":true,"landing_page_url":"https://doi.org/10.20517/2394-5079.2022.04","pdf_url":"https://hrjournal.net/article/download/4845","source":{"id":"https://openalex.org/S4210208932","display_name":"Hepatoma Research","issn_l":"2394-5079","issn":["2394-5079","2454-2520"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatoma Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://hrjournal.net/article/download/4845","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052464729","display_name":"Mohamad Khalil","orcid":"https://orcid.org/0000-0002-5943-9531","observed_orcids":["https://orcid.org/0000-0002-5943-9531"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mohamad Khalil","raw_affiliation_strings":["Clinica Medica \"Augusto Murri\", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari 70124, Italy","Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari 70126, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Medica \"Augusto Murri\", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari 70124, Italy","institution_ids":["https://openalex.org/I5561750"]},{"raw_affiliation_string":"Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari 70126, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103191302","display_name":"Maria Piera Calasso","orcid":"https://orcid.org/0000-0003-2500-8650","observed_orcids":["https://orcid.org/0000-0003-2500-8650"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Calasso","raw_affiliation_strings":["Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari 70126, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari 70126, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037788155","display_name":"Leonilde Bonfrate","orcid":"https://orcid.org/0000-0002-4955-7964","observed_orcids":["https://orcid.org/0000-0002-4955-7964"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Leonilde Bonfrate","raw_affiliation_strings":["Clinica Medica \"Augusto Murri\", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari 70124, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Medica \"Augusto Murri\", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari 70124, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083227959","display_name":"Agostino Di Ciaula","orcid":"https://orcid.org/0000-0002-5476-7376","observed_orcids":["https://orcid.org/0000-0002-5476-7376"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Agostino Di Ciaula","raw_affiliation_strings":["Clinica Medica \"Augusto Murri\", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari 70124, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Medica \"Augusto Murri\", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari 70124, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022100128","display_name":"Maria De Angelis","orcid":"https://orcid.org/0000-0002-2010-884X","observed_orcids":["https://orcid.org/0000-0002-2010-884X"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria De Angelis","raw_affiliation_strings":["Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari 70126, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari 70126, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019115247","display_name":"David Q.\u2010H. Wang","orcid":"https://orcid.org/0000-0002-5439-7651","observed_orcids":["https://orcid.org/0000-0002-5439-7651"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Q. H. Wang","raw_affiliation_strings":["Department of Medicine and Genetics, Division of Gastroenterology and Liver Diseases, Marion Bessin Liver Research Center,","Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, New York, NY 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Genetics, Division of Gastroenterology and Liver Diseases, Marion Bessin Liver Research Center,","institution_ids":[]},{"raw_affiliation_string":"Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, New York, NY 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088702595","display_name":"Piero Portincasa","orcid":"https://orcid.org/0000-0001-5359-1471","observed_orcids":["https://orcid.org/0000-0001-5359-1471"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piero Portincasa","raw_affiliation_strings":["Clinica Medica \"Augusto Murri\", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari 70124, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Medica \"Augusto Murri\", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari 70124, Italy","institution_ids":["https://openalex.org/I5561750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6454,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.57938466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"8","issue":null,"first_page":"23","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":0.37229999899864197,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":0.37229999899864197,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.17970000207424164,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.10459999740123749,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herbs","display_name":"herbs","score":0.6759999990463257},{"id":"https://openalex.org/keywords/herbal-products","display_name":"herbal products","score":0.6069999933242798},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.8610000014305115},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9909999966621399},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7705110311508179},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5954792499542236},{"id":"https://openalex.org/C2779824472","wikidata":"https://www.wikidata.org/wiki/Q207123","display_name":"Herb","level":3,"score":0.4287719428539276},{"id":"https://openalex.org/C2777363581","wikidata":"https://www.wikidata.org/wiki/Q15098235","display_name":"Harm","level":2,"score":0.42666497826576233},{"id":"https://openalex.org/C2991655182","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal herbs","level":2,"score":0.3889722526073456},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32701629400253296},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.20517/2394-5079.2022.04","doi":"https://doi.org/10.20517/2394-5079.2022.04","is_oa":true,"landing_page_url":"https://doi.org/10.20517/2394-5079.2022.04","pdf_url":"https://hrjournal.net/article/download/4845","source":{"id":"https://openalex.org/S4210208932","display_name":"Hepatoma Research","issn_l":"2394-5079","issn":["2394-5079","2454-2520"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatoma Research","raw_type":"journal-article"},{"id":"pmh:oai:ricerca.uniba.it:11586/409776","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11586/409776","pdf_url":"https://ricerca.uniba.it/bitstream/11586/409776/2/Khalil%20et%20al%202022_The%20pros%20and%20cons%20of%20biological%20effects%20of%20herbs.pdf","source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ricerca.uniba.it:11586/490380","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11586/490380","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.20517/2394-5079.2022.04","doi":"https://doi.org/10.20517/2394-5079.2022.04","is_oa":true,"landing_page_url":"https://doi.org/10.20517/2394-5079.2022.04","pdf_url":"https://hrjournal.net/article/download/4845","source":{"id":"https://openalex.org/S4210208932","display_name":"Hepatoma Research","issn_l":"2394-5079","issn":["2394-5079","2454-2520"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatoma Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G822825482","display_name":"Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease","funder_award_id":"722619","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G957256232","display_name":"mitoFOIE GRAS: Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease","funder_award_id":"734719","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285165409.pdf","grobid_xml":"https://content.openalex.org/works/W4285165409.grobid-xml"},"referenced_works_count":129,"referenced_works":["https://openalex.org/W85364195","https://openalex.org/W274993306","https://openalex.org/W389362000","https://openalex.org/W845074655","https://openalex.org/W1169841467","https://openalex.org/W1523250366","https://openalex.org/W1525535257","https://openalex.org/W1607413668","https://openalex.org/W1857938233","https://openalex.org/W1964926602","https://openalex.org/W1965414691","https://openalex.org/W1965850195","https://openalex.org/W1965888433","https://openalex.org/W1966252255","https://openalex.org/W1966789643","https://openalex.org/W1969630613","https://openalex.org/W1973210473","https://openalex.org/W1974522045","https://openalex.org/W1975476103","https://openalex.org/W1975943261","https://openalex.org/W1981117441","https://openalex.org/W1981293590","https://openalex.org/W1983389273","https://openalex.org/W1983895037","https://openalex.org/W1984130814","https://openalex.org/W1984268551","https://openalex.org/W1985239808","https://openalex.org/W1990604260","https://openalex.org/W1993599993","https://openalex.org/W2002318555","https://openalex.org/W2011456387","https://openalex.org/W2022969579","https://openalex.org/W2028521648","https://openalex.org/W2029090151","https://openalex.org/W2029709855","https://openalex.org/W2030268077","https://openalex.org/W2042852113","https://openalex.org/W2049470260","https://openalex.org/W2050036407","https://openalex.org/W2057671866","https://openalex.org/W2062483322","https://openalex.org/W2065501783","https://openalex.org/W2066341704","https://openalex.org/W2068467958","https://openalex.org/W2078142926","https://openalex.org/W2090227862","https://openalex.org/W2095847680","https://openalex.org/W2099215442","https://openalex.org/W2099984528","https://openalex.org/W2100338283","https://openalex.org/W2103339350","https://openalex.org/W2104612455","https://openalex.org/W2107267132","https://openalex.org/W2121350994","https://openalex.org/W2124720982","https://openalex.org/W2130505805","https://openalex.org/W2132182488","https://openalex.org/W2135421972","https://openalex.org/W2137052325","https://openalex.org/W2138245221","https://openalex.org/W2139025268","https://openalex.org/W2152517571","https://openalex.org/W2170839518","https://openalex.org/W2171462836","https://openalex.org/W2237552112","https://openalex.org/W2268088388","https://openalex.org/W2295337505","https://openalex.org/W2304969002","https://openalex.org/W2332035597","https://openalex.org/W2346165422","https://openalex.org/W2465774066","https://openalex.org/W2525477789","https://openalex.org/W2528762358","https://openalex.org/W2559259017","https://openalex.org/W2560449537","https://openalex.org/W2570434430","https://openalex.org/W2588446860","https://openalex.org/W2621666981","https://openalex.org/W2765449362","https://openalex.org/W2770138994","https://openalex.org/W2789132639","https://openalex.org/W2796190341","https://openalex.org/W2799860138","https://openalex.org/W2805006390","https://openalex.org/W2808314577","https://openalex.org/W2809911985","https://openalex.org/W2810415790","https://openalex.org/W2869734327","https://openalex.org/W2890881463","https://openalex.org/W2899906407","https://openalex.org/W2900362104","https://openalex.org/W2901383905","https://openalex.org/W2903717988","https://openalex.org/W2905124162","https://openalex.org/W2923914675","https://openalex.org/W2948408040","https://openalex.org/W2963671541","https://openalex.org/W2966483284","https://openalex.org/W2969325008","https://openalex.org/W2996186141","https://openalex.org/W3004510868","https://openalex.org/W3007210463","https://openalex.org/W3022329859","https://openalex.org/W3025424626","https://openalex.org/W3027938178","https://openalex.org/W3036080212","https://openalex.org/W3039436229","https://openalex.org/W3040033330","https://openalex.org/W3043116893","https://openalex.org/W3045233091","https://openalex.org/W3047759655","https://openalex.org/W3048297441","https://openalex.org/W3083034244","https://openalex.org/W3093455517","https://openalex.org/W3106857259","https://openalex.org/W3113184829","https://openalex.org/W3119175192","https://openalex.org/W3119855800","https://openalex.org/W3135909026","https://openalex.org/W3155381907","https://openalex.org/W3170959831","https://openalex.org/W4232447721","https://openalex.org/W4247878364","https://openalex.org/W4253787555","https://openalex.org/W4292437890","https://openalex.org/W4298036686","https://openalex.org/W4298842436","https://openalex.org/W6656274682","https://openalex.org/W6829544573"],"related_works":["https://openalex.org/W2136959587","https://openalex.org/W2113446710","https://openalex.org/W2338842742","https://openalex.org/W2091173889","https://openalex.org/W2053194360","https://openalex.org/W2255617533","https://openalex.org/W4211008610","https://openalex.org/W4396639118","https://openalex.org/W4386461290","https://openalex.org/W429108983"],"abstract_inverted_index":{"Consumption":[0],"of":[1,19,29,44,134,157],"natural":[2],"products":[3,114,136,146],"such":[4],"as":[5,25],"herbs,":[6],"spices,":[7],"plant-derived":[8],"compounds,":[9],"and":[10,31,47,52,79,88,112,140,155],"foods":[11],"is":[12,22,39,49,85,109],"on":[13],"the":[14,34,53,107,110,142,153],"rise":[15],"globally.":[16],"The":[17,42,81],"use":[18],"these":[20],"substances":[21],"widely":[23],"recognized":[24],"an":[26],"integral":[27],"part":[28],"culture":[30],"tradition,":[32],"with":[33],"philosophy":[35],"being":[36],"\u201cno":[37],"benefit":[38],"no":[40],"harm\u201d.":[41],"utility":[43],"medicinal":[45],"plants":[46,63],"extracts":[48],"under":[50],"scrutiny,":[51],"scientific":[54],"community":[55],"needs":[56],"to":[57,144],"clarify":[58],"many":[59],"conceptual":[60],"gaps.":[61],"Medicinal":[62],"are":[64],"rich":[65],"in":[66,138,152],"bioactive":[67],"phytochemicals":[68],"that":[69,92,98,147],"produce":[70],"chemopreventive":[71],"effects":[72,118],"at":[73],"different":[74],"levels,":[75],"including":[76],"cellular,":[77],"animal,":[78],"clinical.":[80],"ultimate":[82],"translational":[83],"value":[84],"often":[86],"missing,":[87],"some":[89],"studies":[90],"suggest":[91],"botanicals":[93],"may":[94,148],"contain":[95],"toxic":[96],"compounds":[97],"cause":[99],"acute":[100],"or":[101,119],"chronic":[102],"toxicity.":[103],"In":[104,126],"this":[105,127],"regard,":[106],"liver":[108,124,158],"center,":[111],"herbal":[113,135,145],"can":[115],"show":[116],"protective":[117],"induce":[120],"hepatotoxicity,":[121],"thereby":[122],"promoting":[123],"cancer.":[125],"review":[128],"article,":[129],"we":[130],"examine":[131],"a":[132],"range":[133],"implicated":[137],"hepatocarcinogenesis":[139],"extend":[141],"discussion":[143],"be":[149],"potentially":[150],"involved":[151],"prevention":[154],"treatment":[156],"carcinoma.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-07-14T00:00:00"}