{"id":"https://openalex.org/W4285159792","doi":"https://doi.org/10.1093/infdis/jiac183","title":"Impact of Respiratory Syncytial Virus on Child, Caregiver, and Family Quality of Life in the United States: Systematic Literature Review and Analysis","display_name":"Impact of Respiratory Syncytial Virus on Child, Caregiver, and Family Quality of Life in the United States: Systematic Literature Review and Analysis","publication_year":2022,"publication_date":"2022-05-04","ids":{"openalex":"https://openalex.org/W4285159792","doi":"https://doi.org/10.1093/infdis/jiac183","pmid":"https://pubmed.ncbi.nlm.nih.gov/35968873","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9377042"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/jiac183","doi":"https://doi.org/10.1093/infdis/jiac183","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiac183","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/infdis/jiac183","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001395865","display_name":"Elizabeth L Glaser","orcid":"https://orcid.org/0000-0002-1918-057X","observed_orcids":["https://orcid.org/0000-0002-1918-057X"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth L Glaser","raw_affiliation_strings":["The Heller School for Social Policy and Management, Brandeis University , Waltham, Massachusetts , USA"],"raw_orcid":"https://orcid.org/0000-0002-1918-057X","affiliations":[{"raw_affiliation_string":"The Heller School for Social Policy and Management, Brandeis University , Waltham, Massachusetts , USA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059016824","display_name":"Dhwani Hariharan","orcid":"https://orcid.org/0000-0001-7329-7376","observed_orcids":["https://orcid.org/0000-0001-7329-7376"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhwani Hariharan","raw_affiliation_strings":["The Heller School for Social Policy and Management, Brandeis University , Waltham, Massachusetts , USA"],"raw_orcid":"https://orcid.org/0000-0001-7329-7376","affiliations":[{"raw_affiliation_string":"The Heller School for Social Policy and Management, Brandeis University , Waltham, Massachusetts , USA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080607571","display_name":"Diana Bowser M. P. H","orcid":"https://orcid.org/0000-0001-9582-7761","observed_orcids":["https://orcid.org/0000-0001-9582-7761"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana M Bowser","raw_affiliation_strings":["The Heller School for Social Policy and Management, Brandeis University , Waltham, Massachusetts , USA"],"raw_orcid":"https://orcid.org/0000-0001-9582-7761","affiliations":[{"raw_affiliation_string":"The Heller School for Social Policy and Management, Brandeis University , Waltham, Massachusetts , USA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028606086","display_name":"Ra\u00edssa M Gervasio","orcid":"https://orcid.org/0000-0002-1510-2734","observed_orcids":["https://orcid.org/0000-0002-1510-2734"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ra\u00edssa M Gervasio","raw_affiliation_strings":["The Heller School for Social Policy and Management, Brandeis University , Waltham, Massachusetts , USA"],"raw_orcid":"https://orcid.org/0000-0002-1510-2734","affiliations":[{"raw_affiliation_string":"The Heller School for Social Policy and Management, Brandeis University , Waltham, Massachusetts , USA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017125843","display_name":"Katharine R Rowlands","orcid":"https://orcid.org/0000-0002-3572-7221","observed_orcids":["https://orcid.org/0000-0002-3572-7221"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katharine R Rowlands","raw_affiliation_strings":["The Heller School for Social Policy and Management, Brandeis University , Waltham, Massachusetts , USA"],"raw_orcid":"https://orcid.org/0000-0002-3572-7221","affiliations":[{"raw_affiliation_string":"The Heller School for Social Policy and Management, Brandeis University , Waltham, Massachusetts , USA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lauren Buckley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Buckley","raw_affiliation_strings":["The Heller School for Social Policy and Management, Brandeis University , Waltham, Massachusetts , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Heller School for Social Policy and Management, Brandeis University , Waltham, Massachusetts , USA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046012456","display_name":"Christopher B. Nelson","orcid":"https://orcid.org/0000-0003-1046-7635","observed_orcids":["https://orcid.org/0000-0003-1046-7635"]},"institutions":[{"id":"https://openalex.org/I4210111804","display_name":"Sanofi (United States)","ror":"https://ror.org/027vj4x92","country_code":"US","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210111804"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher B Nelson","raw_affiliation_strings":["Sanofi , Swiftwater, Pennsylvania , USA"],"raw_orcid":"https://orcid.org/0000-0003-1046-7635","affiliations":[{"raw_affiliation_string":"Sanofi , Swiftwater, Pennsylvania , USA","institution_ids":["https://openalex.org/I4210111804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060678650","display_name":"Donald S. Shepard","orcid":"https://orcid.org/0000-0003-2187-0593","observed_orcids":["https://orcid.org/0000-0003-2187-0593"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald S Shepard","raw_affiliation_strings":["The Heller School for Social Policy and Management, Brandeis University , Waltham, Massachusetts , USA"],"raw_orcid":"https://orcid.org/0000-0003-2187-0593","affiliations":[{"raw_affiliation_string":"The Heller School for Social Policy and Management, Brandeis University , Waltham, Massachusetts , USA","institution_ids":["https://openalex.org/I6902469"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001395865"],"corresponding_institution_ids":["https://openalex.org/I6902469"],"apc_list":{"value":4320,"currency":"USD","value_usd":4320},"apc_paid":{"value":4320,"currency":"USD","value_usd":4320},"fwci":1.1518,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.77414861,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"226","issue":"Supplement_2","first_page":"S236","last_page":"S245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-syncytial-virus","display_name":"respiratory syncytial virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9810000061988831},{"id":"https://openalex.org/keywords/quality-adjusted-life-years","display_name":"quality-adjusted life years","score":0.7599999904632568},{"id":"https://openalex.org/keywords/caregivers","display_name":"caregivers","score":0.3930000066757202},{"id":"https://openalex.org/keywords/family-quality-of-life","display_name":"family quality of life","score":0.6100000143051147},{"id":"https://openalex.org/keywords/lower-respiratory-tract-infection","display_name":"lower respiratory tract infection","score":0.7509999871253967},{"id":"https://openalex.org/keywords/term-infants","display_name":"term infants","score":0.6230000257492065},{"id":"https://openalex.org/keywords/utility-loss","display_name":"utility loss","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5407862663269043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5245633125305176},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.45810815691947937},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.42024335265159607},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.36469605565071106},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3233984708786011},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.17208445072174072}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017028","descriptor_name":"Caregivers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018113","descriptor_name":"Respiratory Syncytial Virus, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018357","descriptor_name":"Respiratory Syncytial Virus Infections","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D018357","descriptor_name":"Respiratory Syncytial Virus Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/infdis/jiac183","doi":"https://doi.org/10.1093/infdis/jiac183","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiac183","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9377042","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9377042","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Infect Dis","raw_type":"Text"},{"id":"pmid:35968873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35968873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/infdis/jiac183","doi":"https://doi.org/10.1093/infdis/jiac183","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiac183","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1977614971","https://openalex.org/W1980812572","https://openalex.org/W1986189079","https://openalex.org/W2000182266","https://openalex.org/W2009110528","https://openalex.org/W2031140235","https://openalex.org/W2043864886","https://openalex.org/W2061489302","https://openalex.org/W2067409044","https://openalex.org/W2073483759","https://openalex.org/W2087379459","https://openalex.org/W2095917253","https://openalex.org/W2101114010","https://openalex.org/W2110951274","https://openalex.org/W2113998054","https://openalex.org/W2118705380","https://openalex.org/W2149976813","https://openalex.org/W2156098321","https://openalex.org/W2158543557","https://openalex.org/W2165679507","https://openalex.org/W2533155835","https://openalex.org/W2727509207","https://openalex.org/W2746698216","https://openalex.org/W2910906639","https://openalex.org/W2941295101","https://openalex.org/W2943343204","https://openalex.org/W2945080790","https://openalex.org/W2967094020","https://openalex.org/W2989899677","https://openalex.org/W2991792334","https://openalex.org/W2997708100","https://openalex.org/W3035132240","https://openalex.org/W3134043337","https://openalex.org/W3148962211","https://openalex.org/W4206563682"],"related_works":["https://openalex.org/W4205203716","https://openalex.org/W4386303872","https://openalex.org/W4380990207","https://openalex.org/W4414083602","https://openalex.org/W4386995706","https://openalex.org/W2980647784","https://openalex.org/W4328047899","https://openalex.org/W7166504681","https://openalex.org/W4378083681","https://openalex.org/W2804211399"],"abstract_inverted_index":{"BACKGROUND:":[0],"Respiratory":[1],"syncytial":[2],"virus":[3],"(RSV),":[4],"a":[5,30,60],"leading":[6],"cause":[7],"of":[8,18,21,44,107,146,161],"lower":[9],"respiratory":[10],"tract":[11],"infection":[12],"in":[13,34,40,163,182],"US":[14],"children,":[15,22],"reduces":[16],"quality":[17],"life":[19],"(QOL)":[20],"their":[23],"caregivers,":[24],"and":[25,37,58,72,84,153,171,189],"families.":[26],"METHODS:":[27],"We":[28],"conducted":[29],"systematic":[31,61],"literature":[32],"review":[33,71],"PubMed,":[35],"EconLit,":[36],"other":[38],"databases":[39],"the":[41,75,90,113,141,164],"United":[42,165],"States":[43,166],"articles":[45],"published":[46],"since":[47],"2000,":[48],"derived":[49],"utility":[50],"lost":[51,125],"per":[52,105,130],"RSV":[53,129,168,179],"episode":[54,106,132],"from":[55,89,133],"cohort":[56,79,92,114],"studies,":[57,80,83],"performed":[59],"analysis.":[62],"RESULTS:":[63],"From":[64,112],"2262":[65],"unique":[66],"citations,":[67],"35":[68],"received":[69],"full-text":[70],"7":[73],"met":[74],"inclusion":[76],"criteria":[77],"(2":[78],"4":[81],"modeling":[82],"1":[85],"synthesis).":[86],"Pooled":[87],"data":[88,158],"2":[91],"studies":[93,194],"(both":[94],"containing":[95],"only":[96,173],"hospitalized":[97,175,198],"premature":[98,174,199],"infants)":[99],"gave":[100],"quality-adjusted":[101],"life-year":[102],"(QALY)":[103],"losses":[104],"0.0173":[108],"at":[109,187],"day":[110],"38.":[111],"study":[115],"that":[116],"also":[117],"assessed":[118],"caregivers'":[119],"QOL,":[120],"we":[121],"calculated":[122],"net":[123],"QALYs":[124],"directly":[126],"attributable":[127],"to":[128,135],"nonfatal":[131],"onset":[134,139],"60":[136],"days":[137],"after":[138],"for":[140],"child,":[142],"caregiver,":[143],"child-and-caregiver":[144],"dyad":[145],"0.0169":[147],"(167%":[148],"over":[149],"prematurity":[150],"alone),":[151],"0.0031,":[152],"0.0200,":[154],"respectively.":[155],"CONCLUSION:":[156],"Published":[157],"on":[159],"QOL":[160,193],"children":[162,183],"with":[167],"are":[169,195],"scarce":[170],"consider":[172],"infants,":[176],"whereas":[177],"most":[178],"episodes":[180],"occur":[181],"who":[184],"were":[185,190],"born":[186],"term":[188],"otherwise":[191],"healthy.":[192],"needed":[196],"beyond":[197],"infants.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-14T00:00:00"}