{"id":"https://openalex.org/W4285099082","doi":"https://doi.org/10.1053/j.jfas.2022.07.002","title":"Pain Reduction With AbobotulinumtoxinA for the Treatment of Hallux Valgus in Adult Participants: Results of a Randomized and Placebo-Controlled Phase 2 Trial","display_name":"Pain Reduction With AbobotulinumtoxinA for the Treatment of Hallux Valgus in Adult Participants: Results of a Randomized and Placebo-Controlled Phase 2 Trial","publication_year":2022,"publication_date":"2022-07-12","ids":{"openalex":"https://openalex.org/W4285099082","doi":"https://doi.org/10.1053/j.jfas.2022.07.002","pmid":"https://pubmed.ncbi.nlm.nih.gov/36335048"},"language":"en","primary_location":{"id":"doi:10.1053/j.jfas.2022.07.002","doi":"https://doi.org/10.1053/j.jfas.2022.07.002","is_oa":true,"landing_page_url":"https://doi.org/10.1053/j.jfas.2022.07.002","pdf_url":null,"source":{"id":"https://openalex.org/S194540436","display_name":"The Journal of Foot & Ankle Surgery","issn_l":"1067-2516","issn":["1067-2516","1542-2224"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Foot and Ankle Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1053/j.jfas.2022.07.002","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034035627","display_name":"David G. Armstrong","orcid":"https://orcid.org/0000-0003-1887-9175","observed_orcids":["https://orcid.org/0000-0003-1887-9175","https://orcid.org/0000-0001-5533-8648","https://orcid.org/0000-0003-3652-9662","https://orcid.org/0000-0002-5067-5108"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. Armstrong","raw_affiliation_strings":["Keck School of Medicine, University of Southern California, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Keck School of Medicine, University of Southern California, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003371346","display_name":"Lawrence A. DiDomenico","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lawrence A. DiDomenico","raw_affiliation_strings":["NOMS Ankle and Foot Care Centers, Youngstown, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NOMS Ankle and Foot Care Centers, Youngstown, OH","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028437080","display_name":"Babak Baravarian","orcid":"https://orcid.org/0000-0003-3504-6693","observed_orcids":["https://orcid.org/0000-0003-3504-6693"]},"institutions":[{"id":"https://openalex.org/I4210161738","display_name":"University Foot & Ankle Institute","ror":"https://ror.org/05afz7j54","country_code":"US","type":"other","lineage":["https://openalex.org/I4210161738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Babak Baravarian","raw_affiliation_strings":["University Foot and Ankle Institute, Los Angeles, CA"],"raw_orcid":"https://orcid.org/0000-0003-3504-6693","affiliations":[{"raw_affiliation_string":"University Foot and Ankle Institute, Los Angeles, CA","institution_ids":["https://openalex.org/I4210161738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003878548","display_name":"Selene G. Parekh","orcid":"https://orcid.org/0000-0002-1308-9038","observed_orcids":["https://orcid.org/0000-0002-1308-9038"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Selene G. Parekh","raw_affiliation_strings":["Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001836111","display_name":"Magali Volteau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183367347","display_name":"Ipsen (France)","ror":"https://ror.org/00d801g55","country_code":"FR","type":"company","lineage":["https://openalex.org/I183367347"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Magali Volteau","raw_affiliation_strings":["Ipsen, Les Ulis, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ipsen, Les Ulis, Paris, France","institution_ids":["https://openalex.org/I183367347"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007892806","display_name":"Robert Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143751","display_name":"Ipsen (United States)","ror":"https://ror.org/03bzkqg41","country_code":"US","type":"company","lineage":["https://openalex.org/I183367347","https://openalex.org/I4210143751"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert Silva","raw_affiliation_strings":["Ipsen, Cambridge, MA. Electronic address: Robsilva2188@gmail.com","Ipsen, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ipsen, Cambridge, MA. Electronic address: Robsilva2188@gmail.com","institution_ids":["https://openalex.org/I4210143751"]},{"raw_affiliation_string":"Ipsen, Cambridge, MA","institution_ids":["https://openalex.org/I4210143751"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5007892806"],"corresponding_institution_ids":["https://openalex.org/I4210143751"],"apc_list":{"value":2840,"currency":"USD","value_usd":2840},"apc_paid":{"value":2840,"currency":"USD","value_usd":2840},"fwci":0.4159,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.57290963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"62","issue":"2","first_page":"244","last_page":"253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10455","display_name":"Foot and Ankle Surgery","score":0.08389999717473984,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11018","display_name":"Lower Extremity Biomechanics and Pathologies","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hallux-valgus","display_name":"hallux valgus","score":0.9549999833106995},{"id":"https://openalex.org/keywords/botulinum-toxin-type-a","display_name":"botulinum toxin type A","score":0.8619999885559082},{"id":"https://openalex.org/keywords/abobotulinumtoxina","display_name":"abobotulinumtoxinA","score":0.9670000076293945},{"id":"https://openalex.org/keywords/forefoot-pain","display_name":"forefoot pain","score":0.6899999976158142},{"id":"https://openalex.org/keywords/foot-deformity","display_name":"foot deformity","score":0.6259999871253967},{"id":"https://openalex.org/keywords/conservative-treatment","display_name":"conservative treatment","score":0.7429999709129333},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.7950000166893005},{"id":"https://openalex.org/keywords/acetylcholine-release-inhibition","display_name":"acetylcholine release inhibition","score":0.6610000133514404},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.6850000023841858},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.7250000238418579},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.7789999842643738},{"id":"https://openalex.org/keywords/walking-difficulty","display_name":"walking difficulty","score":0.4790000021457672},{"id":"https://openalex.org/keywords/foot-orthoses","display_name":"foot orthoses","score":0.35600000619888306}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8973755836486816},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.7757652997970581},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.6400694251060486},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5962839126586914},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5250972509384155},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4166260361671448},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3898584246635437},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06359541416168213},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071378","descriptor_name":"Bunion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006215","descriptor_name":"Hallux Valgus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019274","descriptor_name":"Botulinum Toxins, Type A","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1053/j.jfas.2022.07.002","doi":"https://doi.org/10.1053/j.jfas.2022.07.002","is_oa":true,"landing_page_url":"https://doi.org/10.1053/j.jfas.2022.07.002","pdf_url":null,"source":{"id":"https://openalex.org/S194540436","display_name":"The Journal of Foot & Ankle Surgery","issn_l":"1067-2516","issn":["1067-2516","1542-2224"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Foot and Ankle Surgery","raw_type":"journal-article"},{"id":"pmid:36335048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36335048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons","raw_type":"Randomized Controlled Trial"}],"best_oa_location":{"id":"doi:10.1053/j.jfas.2022.07.002","doi":"https://doi.org/10.1053/j.jfas.2022.07.002","is_oa":true,"landing_page_url":"https://doi.org/10.1053/j.jfas.2022.07.002","pdf_url":null,"source":{"id":"https://openalex.org/S194540436","display_name":"The Journal of Foot & Ankle Surgery","issn_l":"1067-2516","issn":["1067-2516","1542-2224"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Foot and Ankle Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W654566995","https://openalex.org/W1812574243","https://openalex.org/W1922281101","https://openalex.org/W1943094646","https://openalex.org/W1963565314","https://openalex.org/W1992382253","https://openalex.org/W1997109000","https://openalex.org/W1997768658","https://openalex.org/W2002265699","https://openalex.org/W2011599191","https://openalex.org/W2013458750","https://openalex.org/W2016178396","https://openalex.org/W2017766892","https://openalex.org/W2023978253","https://openalex.org/W2036840738","https://openalex.org/W2038597343","https://openalex.org/W2070858944","https://openalex.org/W2076933615","https://openalex.org/W2088449269","https://openalex.org/W2103219300","https://openalex.org/W2104282233","https://openalex.org/W2107153119","https://openalex.org/W2111149452","https://openalex.org/W2128008235","https://openalex.org/W2128198868","https://openalex.org/W2134850499","https://openalex.org/W2136987560","https://openalex.org/W2146490118","https://openalex.org/W2149440551","https://openalex.org/W2151082115","https://openalex.org/W2163703657","https://openalex.org/W2179819431","https://openalex.org/W2312593346","https://openalex.org/W2467357301","https://openalex.org/W2510867973","https://openalex.org/W2586327237","https://openalex.org/W2756112749","https://openalex.org/W2802892699","https://openalex.org/W2884200735","https://openalex.org/W2917615682","https://openalex.org/W2965226820","https://openalex.org/W2980280693","https://openalex.org/W2999222675","https://openalex.org/W3000907698","https://openalex.org/W3014054670","https://openalex.org/W3025951351","https://openalex.org/W3033299320","https://openalex.org/W3075838012","https://openalex.org/W3103529117","https://openalex.org/W4230462431","https://openalex.org/W4234814399","https://openalex.org/W4252221895","https://openalex.org/W6841980941"],"related_works":["https://openalex.org/W1963565314","https://openalex.org/W3099820724","https://openalex.org/W4320000500","https://openalex.org/W2036840738","https://openalex.org/W4386264475","https://openalex.org/W3124167733","https://openalex.org/W2898755322","https://openalex.org/W17298317","https://openalex.org/W2909094517","https://openalex.org/W2771746419"],"abstract_inverted_index":{"AbobotulinumtoxinA":[0],"(aboBoNT-A,":[1],"Dysport\u00ae":[2],"[Ipsen,":[3],"Paris,":[4],"France])":[5],"inhibits":[6],"acetylcholine":[7],"release":[8],"at":[9,69,112,140,212,250,328,375,434],"the":[10,144,164,186,229,278,322,343,378,385,388,435,489,526],"neuromuscular":[11],"junction":[12],"and":[13,39,51,81,163,201,215,297,315,453],"may":[14,345],"modulate":[15],"pain":[16,64,109,296,349,386,403,448,464,476,527],"signaling":[17],"in":[18,45,62,76,98,106,185,350,457,475,497],"hallux":[19],"valgus":[20,276],"(HV).":[21],"This":[22,325],"randomized":[23],"study":[24,326,355,413,491],"(NCT03569098)":[25],"included":[26,74,356,414],"a":[27,99,107,152,237,264,282,284,332,458,498],"double-blind":[28],"phase":[29],"(aboBoNT-A":[30],"300U,":[31],"500U":[32,121,160,178,188],"or":[33,125,340],"placebo":[34,126,132,162,180,218,243],"injections":[35,330,379,400,480],"into":[36,342],"forefoot":[37],"muscles)":[38],"an":[40,48,520],"open-label":[41],"aboBoNT-A":[42,116,138,159,177,187,399,479,495],"treatment":[43,245,267,427,450,466,522],"period":[44,102],"participants":[46,84,104,167],"with":[47,85,136,158,168,176,193,202,293,352,419,478,485,502,529],"HV":[49,53],"diagnosis":[50],"no":[52,473,486,503],"surgery.":[54],"The":[55,354,372,391,412],"primary":[56,145,230],"endpoint":[57,146,231],"was":[58,133,147,156,174,225,232,394,429,472],"change":[59,75],"from":[60,88,171],"baseline":[61,89,172,199,210],"numeric":[63],"rating":[65],"scale":[66],"(NPRS)":[67],"score":[68],"week":[70,141,150,251,460],"8.":[71],"Secondary":[72],"endpoints":[73,235],"NPRS":[77,90,173,195,203,211],"(other":[78],"time":[79],"points)":[80],"proportion":[82,165],"of":[83,96,166,246,307,331,335],"\u226520%":[86,169],"reduction":[87,170,474],"(responders).":[91],"Post-hoc":[92],"analyses":[93],"assessed":[94],"number":[95],"days":[97,192,456],"7-day":[100],"evaluation":[101,255],"that":[103,287,383,425,494],"spent":[105,190],"lower":[108,194,206],"state":[110],"than":[111,196,207,407,451,467],"baseline.":[113],"Participants":[114,184],"received":[115],"300U":[117],"(n":[118,122,127],"=":[119,123,128,182],"63),":[120],"60)":[124],"63).":[129],"Superiority":[130],"to":[131,258,347,361,423,514,523],"not":[134,366],"observed":[135,157],"either":[137],"dose":[139],"8,":[142],"thus":[143],"unmet.":[148],"At":[149],"12,":[151],"trend":[153],"toward":[154],"efficacy":[155],"versus":[161,179,217,242],"greater":[175],"(p":[181],".006).":[183],"group":[189],"more":[191],"their":[197,208,305,370],"lowest":[198],"score,":[200],"\u22652":[204],"points":[205],"mean":[209],"weeks":[213,406,483],"8":[214,405,482],"12":[216,438,507],"(all":[219],"p":[220],"<":[221],".05;":[222],"post-hoc).":[223],"AboBoNT-A":[224],"well":[226,377,441],"tolerated.":[227],"Although":[228],"unmet,":[233],"other":[234,490],"showed":[236],"nominal":[238],"advantage":[239],"for":[240,244,269,281,525],"aboBoNT":[241],"HV-related":[247],"pain,":[248],"particularly":[249],"12.":[252],"Further":[253,509],"clinical":[254],"is":[256,277,321,512],"needed":[257,513],"establish":[259,515],"whether":[260,395,516],"botulinum":[261,336,517],"toxins":[262,518],"represent":[263,519],"viable":[265],"non-operative":[266],"option":[268],"HV-associated":[270],"pain.":[271],"PLAIN":[272],"LANGUAGE":[273],"SUMMARY:":[274],"Hallux":[275],"medical":[279,510],"name":[280],"bunion,":[283],"foot":[285,344],"deformity":[286],"can":[288,299,303],"worsen":[289],"over":[290],"time.":[291],"Patients":[292],"bunions":[294],"experience":[295],"walking":[298],"become":[300],"difficult,":[301],"which":[302],"affect":[304],"quality":[306],"life.":[308],"Foot":[309],"support":[310],"aids":[311],"(e.g.,":[312],"braces,":[313],"splints":[314],"inserts)":[316],"are":[317],"available,":[318],"but":[319],"surgery":[320,368,524],"standard":[323],"treatment.":[324,411,487],"looked":[327,374,433],"how":[329,376,443,454],"specific":[333],"type":[334],"toxin,":[337],"called":[338],"abobotulinumtoxinA":[339],"\"aboBoNT-A\",":[341],"help":[346],"reduce":[348],"patients":[351,358,396,415,445,461],"bunions.":[353,530],"186":[357],"aged":[359],"18":[360],"75":[362],"years":[363],"who":[364,397,416],"had":[365,367,398,401,446],"on":[369],"bunion.":[371],"researchers":[373],"worked":[380],"using":[381],"scales":[382],"measure":[384],"levels":[387,477],"patient":[389],"experienced.":[390],"main":[392],"outcome":[393],"less":[402,447,463],"after":[404,437,449,465,481,506],"they":[408,468],"did":[409,469],"before":[410,452],"were":[417],"injected":[418],"saltwater":[420],"(no":[421],"treatment)":[422],"check":[424],"any":[426],"effect":[428],"real.":[430],"Researchers":[431],"also":[432],"results":[436],"weeks,":[439],"as":[440,442],"many":[444,455],"given":[459],"experienced":[462],"before.":[470],"There":[471],"compared":[484,501],"However,":[488],"outcomes":[492],"suggested":[493],"resulted":[496],"small":[499],"benefit":[500],"treatment,":[504],"especially":[505],"weeks.":[508],"research":[511],"alternative":[521],"associated":[528]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-14T00:00:00"}
