{"id":"https://openalex.org/W4285091192","doi":"https://doi.org/10.3390/ijms23147697","title":"Characterization of Endothelial Progenitor Cell: Past, Present, and Future","display_name":"Characterization of Endothelial Progenitor Cell: Past, Present, and Future","publication_year":2022,"publication_date":"2022-07-12","ids":{"openalex":"https://openalex.org/W4285091192","doi":"https://doi.org/10.3390/ijms23147697","pmid":"https://pubmed.ncbi.nlm.nih.gov/35887039","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9318195"},"language":"en","primary_location":{"id":"doi:10.3390/ijms23147697","doi":"https://doi.org/10.3390/ijms23147697","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23147697","pdf_url":"https://www.mdpi.com/1422-0067/23/14/7697/pdf?version=1657630940","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/14/7697/pdf?version=1657630940","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055780507","display_name":"Amankeldi A. Salybekov","orcid":"https://orcid.org/0000-0001-5490-9365","observed_orcids":["https://orcid.org/0000-0001-5490-9365"]},"institutions":[{"id":"https://openalex.org/I4210151342","display_name":"Shonan Kamakura General Hospital","ror":"https://ror.org/03xz3hj66","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210151342"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Amankeldi A. Salybekov","raw_affiliation_strings":["Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura 2478533, Japan","Qazaq Institute of Innovative Medicine, Nur-Sultan 010000, Kazakhstan","Shonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, Kamakura 2478533, Japan"],"raw_orcid":"https://orcid.org/0000-0001-5490-9365","affiliations":[{"raw_affiliation_string":"Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura 2478533, Japan","institution_ids":["https://openalex.org/I4210151342"]},{"raw_affiliation_string":"Qazaq Institute of Innovative Medicine, Nur-Sultan 010000, Kazakhstan","institution_ids":[]},{"raw_affiliation_string":"Shonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, Kamakura 2478533, Japan","institution_ids":["https://openalex.org/I4210151342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017068401","display_name":"Shuzo Kobayashi","orcid":"https://orcid.org/0000-0003-2373-814X","observed_orcids":["https://orcid.org/0000-0003-2373-814X"]},"institutions":[{"id":"https://openalex.org/I4210151342","display_name":"Shonan Kamakura General Hospital","ror":"https://ror.org/03xz3hj66","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210151342"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuzo Kobayashi","raw_affiliation_strings":["Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura 2478533, Japan","Shonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, Kamakura 2478533, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura 2478533, Japan","institution_ids":["https://openalex.org/I4210151342"]},{"raw_affiliation_string":"Shonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, Kamakura 2478533, Japan","institution_ids":["https://openalex.org/I4210151342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079342872","display_name":"Takayuki Asahara","orcid":"https://orcid.org/0000-0001-8272-2055","observed_orcids":["https://orcid.org/0000-0001-8272-2055","https://orcid.org/0000-0002-2354-9325"]},"institutions":[{"id":"https://openalex.org/I4210151342","display_name":"Shonan Kamakura General Hospital","ror":"https://ror.org/03xz3hj66","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210151342"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takayuki Asahara","raw_affiliation_strings":["Shonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, Kamakura 2478533, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, Kamakura 2478533, Japan","institution_ids":["https://openalex.org/I4210151342"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055780507","https://openalex.org/A5079342872"],"corresponding_institution_ids":["https://openalex.org/I4210151342"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":1.4968,"has_fulltext":true,"cited_by_count":71,"citation_normalized_percentile":{"value":0.84663798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"23","issue":"14","first_page":"7697","last_page":"7697"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.03370000049471855,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-progenitor-cells","display_name":"endothelial progenitor cells","score":1.0},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.5270000100135803},{"id":"https://openalex.org/keywords/revascularization","display_name":"revascularization","score":0.9039999842643738},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.783207893371582},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5703386068344116},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5483508706092834},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.5259806513786316},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.4936002492904663},{"id":"https://openalex.org/C2780152582","wikidata":"https://www.wikidata.org/wiki/Q1340830","display_name":"Endothelial progenitor cell","level":4,"score":0.4619256854057312},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.45476916432380676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45368918776512146},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.42409518361091614},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.41569364070892334},{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.4100254774093628},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3723389208316803},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3608558773994446},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34419649839401245},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3064303994178772},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17431500554084778},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13965165615081787},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044968","descriptor_name":"Regenerative Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066026","descriptor_name":"Endothelial Progenitor Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms23147697","doi":"https://doi.org/10.3390/ijms23147697","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23147697","pdf_url":"https://www.mdpi.com/1422-0067/23/14/7697/pdf?version=1657630940","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9318195","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9318195","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:35887039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35887039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms23147697","doi":"https://doi.org/10.3390/ijms23147697","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23147697","pdf_url":"https://www.mdpi.com/1422-0067/23/14/7697/pdf?version=1657630940","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2955686997","display_name":"Single-cell gene analysis of myocardial infarction regenerative microenvironment in diabetic and aged individuals","funder_award_id":"22K08224","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285091192.pdf","grobid_xml":"https://content.openalex.org/works/W4285091192.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1499075785","https://openalex.org/W1502896205","https://openalex.org/W1837519471","https://openalex.org/W1973035870","https://openalex.org/W1986991023","https://openalex.org/W1993175314","https://openalex.org/W1999341915","https://openalex.org/W1999579644","https://openalex.org/W2008018400","https://openalex.org/W2011849709","https://openalex.org/W2014441531","https://openalex.org/W2033170207","https://openalex.org/W2034916016","https://openalex.org/W2034924908","https://openalex.org/W2037639211","https://openalex.org/W2040727722","https://openalex.org/W2042116568","https://openalex.org/W2042720695","https://openalex.org/W2045360522","https://openalex.org/W2049466721","https://openalex.org/W2053704719","https://openalex.org/W2066877588","https://openalex.org/W2069905905","https://openalex.org/W2083632015","https://openalex.org/W2086261536","https://openalex.org/W2097937723","https://openalex.org/W2100727184","https://openalex.org/W2101840264","https://openalex.org/W2104042130","https://openalex.org/W2107922629","https://openalex.org/W2110419512","https://openalex.org/W2110918588","https://openalex.org/W2111004371","https://openalex.org/W2120049306","https://openalex.org/W2127209890","https://openalex.org/W2127872440","https://openalex.org/W2129752592","https://openalex.org/W2133346775","https://openalex.org/W2134723585","https://openalex.org/W2137310032","https://openalex.org/W2138756918","https://openalex.org/W2145524503","https://openalex.org/W2145639716","https://openalex.org/W2149162919","https://openalex.org/W2152251877","https://openalex.org/W2153592558","https://openalex.org/W2156849764","https://openalex.org/W2164598295","https://openalex.org/W2330714519","https://openalex.org/W2336351765","https://openalex.org/W2511380210","https://openalex.org/W2566992148","https://openalex.org/W2594052307","https://openalex.org/W2625219423","https://openalex.org/W2780891619","https://openalex.org/W2785971314","https://openalex.org/W2791849171","https://openalex.org/W2803061087","https://openalex.org/W2884926531","https://openalex.org/W2900059621","https://openalex.org/W2900756811","https://openalex.org/W2910971031","https://openalex.org/W2912237514","https://openalex.org/W2921377925","https://openalex.org/W2922793932","https://openalex.org/W2930116093","https://openalex.org/W2938046474","https://openalex.org/W2942236680","https://openalex.org/W2950486100","https://openalex.org/W2965119273","https://openalex.org/W2982231641","https://openalex.org/W3012485315","https://openalex.org/W3136356600","https://openalex.org/W3166361416","https://openalex.org/W3197344562","https://openalex.org/W3198395769","https://openalex.org/W3204079369","https://openalex.org/W3209679951"],"related_works":["https://openalex.org/W2302060297","https://openalex.org/W2901634147","https://openalex.org/W4235100187","https://openalex.org/W4414746406","https://openalex.org/W2065131580","https://openalex.org/W2147955341","https://openalex.org/W2011849709","https://openalex.org/W2052569119","https://openalex.org/W1979683616","https://openalex.org/W1781322782"],"abstract_inverted_index":{"Endothelial":[0],"progenitor":[1],"cells":[2,140,149],"(EPCs)":[3],"are":[4,61],"currently":[5],"being":[6,45],"studied":[7],"as":[8],"candidate":[9],"cell":[10],"sources":[11,102],"for":[12,24,56],"revascularization":[13],"strategies.":[14],"Despite":[15],"these":[16],"promising":[17],"results,":[18],"widespread":[19],"clinical":[20,25],"acceptance":[21],"of":[22,39,54,79,88,103,133,138,147],"EPCs":[23,40,55,89,134],"therapies":[26],"remains":[27],"hampered":[28],"by":[29],"several":[30],"challenges.":[31],"The":[32],"challenges":[33],"and":[34,41,52,75,77,106,110,127,141],"issues":[35],"surrounding":[36],"the":[37,42,49,72,86,95,99,131,136,145],"use":[38],"current":[43,126],"paradigm":[44],"developed":[46],"to":[47,84,98],"improve":[48],"harvest":[50],"efficiency":[51],"functionality":[53],"application":[57],"in":[58,90,144],"regenerative":[59],"medicine":[60],"discussed.":[62,117],"It":[63],"has":[64],"been":[65],"observed":[66],"that":[67],"controversies":[68],"have":[69],"emerged":[70],"regarding":[71,130],"isolation":[73],"techniques":[74,143],"classification":[76],"origin":[78],"EPCs.":[80],"This":[81],"manuscript":[82,120],"attempts":[83],"highlight":[85],"concept":[87],"a":[91],"sequential":[92],"manner,":[93],"from":[94],"initial":[96],"discovery":[97],"present":[100],"(origin,":[101],"EPCs,":[104],"isolation,":[105],"identification":[107],"techniques).":[108],"Human":[109],"murine":[111],"EPC":[112],"marker":[113],"diversity":[114],"is":[115,121],"also":[116],"Additionally,":[118],"this":[119],"aimed":[122],"at":[123],"summarizing":[124],"our":[125],"future":[128],"prospects":[129],"crosstalk":[132],"with":[135],"biology":[137],"hematopoietic":[139],"culture":[142],"context":[146],"regeneration-associated":[148],"(RACs).":[150]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-14T00:00:00"}