{"id":"https://openalex.org/W4285088554","doi":"https://doi.org/10.1038/s41598-022-16106-5","title":"Deficiency of protocadherin 9 leads to reduction in positive emotional behaviour","display_name":"Deficiency of protocadherin 9 leads to reduction in positive emotional behaviour","publication_year":2022,"publication_date":"2022-07-13","ids":{"openalex":"https://openalex.org/W4285088554","doi":"https://doi.org/10.1038/s41598-022-16106-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/35831353","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9279467"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-022-16106-5","doi":"https://doi.org/10.1038/s41598-022-16106-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-16106-5","pdf_url":"https://www.nature.com/articles/s41598-022-16106-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-022-16106-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110177190","display_name":"Masato Uemura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Uemura","raw_affiliation_strings":["Laboratory of Cell Biology, Faculty of Medicine, Kansai Medical University, Shinmachi 2-5-1, Hirakata City, Osaka, 573-1010, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, Faculty of Medicine, Kansai Medical University, Shinmachi 2-5-1, Hirakata City, Osaka, 573-1010, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022925712","display_name":"Tamio Furuse","orcid":"https://orcid.org/0000-0002-9276-6040","observed_orcids":["https://orcid.org/0000-0002-9276-6040"]},"institutions":[{"id":"https://openalex.org/I4210096362","display_name":"RIKEN BioResource Research Center","ror":"https://ror.org/00s05em53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210096362","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tamio Furuse","raw_affiliation_strings":["Technology and Development Team for Mouse Phenotype Analysis, Japan Mouse Clinic, RIKEN BioResource Research Center, Tsukuba, Ibaraki, 3050074, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology and Development Team for Mouse Phenotype Analysis, Japan Mouse Clinic, RIKEN BioResource Research Center, Tsukuba, Ibaraki, 3050074, Japan","institution_ids":["https://openalex.org/I4210096362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056771252","display_name":"Ikuko Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096362","display_name":"RIKEN BioResource Research Center","ror":"https://ror.org/00s05em53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210096362","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikuko Yamada","raw_affiliation_strings":["Technology and Development Team for Mouse Phenotype Analysis, Japan Mouse Clinic, RIKEN BioResource Research Center, Tsukuba, Ibaraki, 3050074, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology and Development Team for Mouse Phenotype Analysis, Japan Mouse Clinic, RIKEN BioResource Research Center, Tsukuba, Ibaraki, 3050074, Japan","institution_ids":["https://openalex.org/I4210096362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055037978","display_name":"Tomoko Kushida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096362","display_name":"RIKEN BioResource Research Center","ror":"https://ror.org/00s05em53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210096362","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Kushida","raw_affiliation_strings":["Technology and Development Team for Mouse Phenotype Analysis, Japan Mouse Clinic, RIKEN BioResource Research Center, Tsukuba, Ibaraki, 3050074, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology and Development Team for Mouse Phenotype Analysis, Japan Mouse Clinic, RIKEN BioResource Research Center, Tsukuba, Ibaraki, 3050074, Japan","institution_ids":["https://openalex.org/I4210096362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069805236","display_name":"Takaya Abe","orcid":"https://orcid.org/0000-0001-5885-4875","observed_orcids":["https://orcid.org/0000-0001-5885-4875"]},"institutions":[{"id":"https://openalex.org/I4210116810","display_name":"RIKEN Center for Biosystems Dynamics Research","ror":"https://ror.org/023rffy11","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210116810"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaya Abe","raw_affiliation_strings":["Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan","institution_ids":["https://openalex.org/I4210116810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086868829","display_name":"Keiko Imai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiko Imai","raw_affiliation_strings":["Laboratory of Cell Biology, Faculty of Medicine, Kansai Medical University, Shinmachi 2-5-1, Hirakata City, Osaka, 573-1010, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, Faculty of Medicine, Kansai Medical University, Shinmachi 2-5-1, Hirakata City, Osaka, 573-1010, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102922258","display_name":"Soichi Nagao","orcid":"https://orcid.org/0000-0002-1643-4976","observed_orcids":["https://orcid.org/0000-0002-1643-4976"]},"institutions":[{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Soichi Nagao","raw_affiliation_strings":["Laboratory for Integrative Brain Function, Nozomi Hospital, Komuro 3170, Ina, Saitama, 362-0806, Japan","Laboratory for Motor Learning Control, RIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Integrative Brain Function, Nozomi Hospital, Komuro 3170, Ina, Saitama, 362-0806, Japan","institution_ids":[]},{"raw_affiliation_string":"Laboratory for Motor Learning Control, RIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan","institution_ids":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076387544","display_name":"Moeko Kudoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210103779","display_name":"National Center of Neurology and Psychiatry","ror":"https://ror.org/0254bmq54","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210103779"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4405287400","display_name":"National Institute of Neuroscience","ror":"https://ror.org/052fnx536","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210103779","https://openalex.org/I4405287400"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Moeko Kudoh","raw_affiliation_strings":["Department of Neurophysiology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan","Laboratory for Motor Learning Control, RIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurophysiology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan","institution_ids":["https://openalex.org/I4210103779","https://openalex.org/I4405287400"]},{"raw_affiliation_string":"Laboratory for Motor Learning Control, RIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan","institution_ids":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057826873","display_name":"Katsuhiko Yoshizawa","orcid":"https://orcid.org/0000-0002-3996-032X","observed_orcids":["https://orcid.org/0000-0002-3996-032X","https://orcid.org/0000-0002-2551-6201"]},"institutions":[{"id":"https://openalex.org/I112821123","display_name":"Mukogawa Women's University","ror":"https://ror.org/009x65438","country_code":"JP","type":"education","lineage":["https://openalex.org/I112821123"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuhiko Yoshizawa","raw_affiliation_strings":["Laboratory of Environmental Science, Department of Innovative Food Sciences, School of Food Sciences and Nutrition, Mukogawa Women's University, Nishinomiya, Hyogo, 663-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Environmental Science, Department of Innovative Food Sciences, School of Food Sciences and Nutrition, Mukogawa Women's University, Nishinomiya, Hyogo, 663-8558, Japan","institution_ids":["https://openalex.org/I112821123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101463467","display_name":"Masaru Tamura","orcid":"https://orcid.org/0000-0002-0311-8827","observed_orcids":["https://orcid.org/0000-0002-0311-8827"]},"institutions":[{"id":"https://openalex.org/I4210096362","display_name":"RIKEN BioResource Research Center","ror":"https://ror.org/00s05em53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210096362","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Tamura","raw_affiliation_strings":["Technology and Development Team for Mouse Phenotype Analysis, Japan Mouse Clinic, RIKEN BioResource Research Center, Tsukuba, Ibaraki, 3050074, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology and Development Team for Mouse Phenotype Analysis, Japan Mouse Clinic, RIKEN BioResource Research Center, Tsukuba, Ibaraki, 3050074, Japan","institution_ids":["https://openalex.org/I4210096362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034949085","display_name":"Hiroshi Kiyonari","orcid":"https://orcid.org/0000-0002-1509-8747","observed_orcids":["https://orcid.org/0000-0002-1509-8747"]},"institutions":[{"id":"https://openalex.org/I4210116810","display_name":"RIKEN Center for Biosystems Dynamics Research","ror":"https://ror.org/023rffy11","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210116810"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kiyonari","raw_affiliation_strings":["Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan","institution_ids":["https://openalex.org/I4210116810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064129668","display_name":"Shigeharu Wakana","orcid":"https://orcid.org/0000-0002-7037-8354","observed_orcids":["https://orcid.org/0000-0002-7037-8354","https://orcid.org/0000-0001-8532-0924"]},"institutions":[{"id":"https://openalex.org/I4210096362","display_name":"RIKEN BioResource Research Center","ror":"https://ror.org/00s05em53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210096362","https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210167395","display_name":"Foundation for Biomedical Research and Innovation","ror":"https://ror.org/05xe40a72","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210167395"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeharu Wakana","raw_affiliation_strings":["Department of Animal Experimentation, Foundation for Biomedical Research and Innovation at Kobe, Kobe, 650-0047, Japan","Technology and Development Team for Mouse Phenotype Analysis, Japan Mouse Clinic, RIKEN BioResource Research Center, Tsukuba, Ibaraki, 3050074, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Experimentation, Foundation for Biomedical Research and Innovation at Kobe, Kobe, 650-0047, Japan","institution_ids":["https://openalex.org/I4210167395"]},{"raw_affiliation_string":"Technology and Development Team for Mouse Phenotype Analysis, Japan Mouse Clinic, RIKEN BioResource Research Center, Tsukuba, Ibaraki, 3050074, Japan","institution_ids":["https://openalex.org/I4210096362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103100438","display_name":"Shinji Hirano","orcid":"https://orcid.org/0000-0002-1403-2471","observed_orcids":["https://orcid.org/0000-0002-1403-2471","https://orcid.org/0000-0002-6171-5523"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shinji Hirano","raw_affiliation_strings":["Laboratory of Cell Biology, Faculty of Medicine, Kansai Medical University, Shinmachi 2-5-1, Hirakata City, Osaka, 573-1010, Japan. s-hirano@hirakata.kmu.ac.jp","Laboratory of Cell Biology, Faculty of Medicine, Kansai Medical University, Shinmachi 2-5-1, Hirakata City, Osaka, 573-1010, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, Faculty of Medicine, Kansai Medical University, Shinmachi 2-5-1, Hirakata City, Osaka, 573-1010, Japan. s-hirano@hirakata.kmu.ac.jp","institution_ids":["https://openalex.org/I126884977"]},{"raw_affiliation_string":"Laboratory of Cell Biology, Faculty of Medicine, Kansai Medical University, Shinmachi 2-5-1, Hirakata City, Osaka, 573-1010, Japan","institution_ids":["https://openalex.org/I126884977"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5103100438"],"corresponding_institution_ids":["https://openalex.org/I126884977"],"apc_list":{"value":2190,"currency":"USD","value_usd":2190},"apc_paid":{"value":2190,"currency":"USD","value_usd":2190},"fwci":1.5557,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.81111363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"12","issue":"1","first_page":"11933","last_page":"11933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.10499999672174454,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fear-extinction","display_name":"fear extinction","score":0.9760000109672546},{"id":"https://openalex.org/keywords/basolateral-amygdala","display_name":"basolateral amygdala","score":0.9589999914169312},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7369999885559082},{"id":"https://openalex.org/keywords/synapses","display_name":"synapses","score":0.453000009059906},{"id":"https://openalex.org/keywords/optokinetic-reflex","display_name":"optokinetic response","score":0.8460000157356262},{"id":"https://openalex.org/keywords/darpp-32","display_name":"DARPP-32","score":0.828000009059906},{"id":"https://openalex.org/keywords/limbic-system","display_name":"limbic system","score":0.7059999704360962},{"id":"https://openalex.org/keywords/cadherins","display_name":"cadherins","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6974638104438782},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.6530754566192627},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.6307224631309509},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.593798816204071},{"id":"https://openalex.org/C101991246","wikidata":"https://www.wikidata.org/wiki/Q5422078","display_name":"Extinction (optical mineralogy)","level":2,"score":0.5355700254440308},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5248903036117554},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.5173037052154541},{"id":"https://openalex.org/C191789040","wikidata":"https://www.wikidata.org/wiki/Q912716","display_name":"Optokinetic reflex","level":3,"score":0.4926157593727112},{"id":"https://openalex.org/C163911330","wikidata":"https://www.wikidata.org/wiki/Q7251899","display_name":"Protocadherin","level":4,"score":0.48209813237190247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4553946852684021},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4144657552242279},{"id":"https://openalex.org/C190041318","wikidata":"https://www.wikidata.org/wiki/Q596832","display_name":"Vestibular system","level":2,"score":0.41029149293899536},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14778932929039001},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09392809867858887},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.06745293736457825},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000091363","descriptor_name":"Protocadherins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005108","descriptor_name":"Extinction, Psychological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005239","descriptor_name":"Fear","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-022-16106-5","doi":"https://doi.org/10.1038/s41598-022-16106-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-16106-5","pdf_url":"https://www.nature.com/articles/s41598-022-16106-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9279467","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9279467","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:35831353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35831353","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:aae1078fad7b415d9b5eaa507b8b9587","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/aae1078fad7b415d9b5eaa507b8b9587","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-022-16106-5","doi":"https://doi.org/10.1038/s41598-022-16106-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-022-16106-5","pdf_url":"https://www.nature.com/articles/s41598-022-16106-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3711327859","display_name":"A Study on function of protocadherin 1 cell adhesion molecule in the nervous system.","funder_award_id":"18K06230","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G399194480","display_name":null,"funder_award_id":"S1201038","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320310657","display_name":"Sumitomo Foundation","ror":"https://ror.org/01nmpj461"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320327590","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285088554.pdf","grobid_xml":"https://content.openalex.org/works/W4285088554.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1506292767","https://openalex.org/W2003628169","https://openalex.org/W2017265063","https://openalex.org/W2026089426","https://openalex.org/W2030078833","https://openalex.org/W2036236109","https://openalex.org/W2044911589","https://openalex.org/W2053071361","https://openalex.org/W2058350388","https://openalex.org/W2066673889","https://openalex.org/W2075881739","https://openalex.org/W2079768191","https://openalex.org/W2093802594","https://openalex.org/W2104202813","https://openalex.org/W2520331243","https://openalex.org/W2522921818","https://openalex.org/W2534475745","https://openalex.org/W2602799162","https://openalex.org/W2792854467","https://openalex.org/W2904369814","https://openalex.org/W2999741028","https://openalex.org/W3044954929","https://openalex.org/W3163585592","https://openalex.org/W4235754768"],"related_works":["https://openalex.org/W3208857826","https://openalex.org/W2768744492","https://openalex.org/W3042744521","https://openalex.org/W2157583031","https://openalex.org/W4361273773","https://openalex.org/W2036236109","https://openalex.org/W7125913604","https://openalex.org/W7135161512","https://openalex.org/W3036796569","https://openalex.org/W2735314073"],"abstract_inverted_index":{"Protocadherin":[0],"9":[1],"(Pcdh9)":[2],"is":[3,11,158],"a":[4,115],"member":[5],"of":[6,31,39,68,86,102,121],"the":[7,15,29,34,50,65,69,77,87,92,112,118,125,135,151,171,177],"cadherin":[8],"superfamily":[9],"and":[10,17,37,81,144,180],"uniquely":[12],"expressed":[13,48],"in":[14,33,49,64,76,111,117,160,170,176,185],"vestibular":[16],"limbic":[18,35],"systems;":[19],"however,":[20],"its":[21],"physiological":[22],"role":[23],"remains":[24],"unclear.":[25],"Here,":[26],"we":[27],"studied":[28],"expression":[30],"Pcdh9":[32,45,93,103,126,157],"system":[36],"phenotypes":[38],"Pcdh9-knock-out":[40],"mice":[41,105,128],"(Pcdh9":[42],"KO":[43,104,127],"mice).":[44],"mRNA":[46],"was":[47,95],"fear":[51,146,167],"extinction":[52,147,168],"neurons":[53,85,169],"that":[54,91,156],"express":[55],"protein":[56,94],"phosphatase":[57],"1":[58,61],"regulatory":[59],"subunit":[60],"B":[62],"(Ppp1r1b)":[63],"posterior":[66],"part":[67],"basolateral":[70],"amygdala":[71],"(pBLA),":[72],"as":[73,75,134],"well":[74],"Cornu":[78],"Ammonis":[79],"(CA)":[80],"Dentate":[82],"Gyrus":[83],"(DG)":[84],"hippocampus.":[88],"We":[89],"show":[90],"often":[96],"localised":[97],"at":[98],"synapses.":[99],"Phenotypic":[100],"analysis":[101],"revealed":[106],"no":[107],"apparent":[108],"morphological":[109],"abnormalities":[110],"pBLA":[113,172],"but":[114],"decrease":[116],"spine":[119],"number":[120],"CA":[122],"neurons.":[123,189],"Further,":[124],"were":[129],"related":[130],"to":[131,141],"features":[132],"such":[133],"abnormal":[136],"optokinetic":[137,182,187],"response,":[138],"less":[139],"approach":[140],"novel":[142],"objects,":[143],"reduced":[145],"during":[148],"recovery":[149],"from":[150],"fear.":[152],"These":[153],"results":[154],"suggest":[155],"involved":[159],"eliciting":[161],"positive":[162],"emotional":[163],"behaviours,":[164],"possibly":[165],"via":[166],"and/or":[173],"synaptic":[174],"activity":[175],"hippocampal":[178],"neurons,":[179],"normal":[181],"eye":[183],"movement":[184],"brainstem":[186],"system-related":[188]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-07-14T00:00:00"}