{"id":"https://openalex.org/W4285088313","doi":"https://doi.org/10.1155/2022/6567998","title":"Identification of APC Mutation as a Potential Predictor for Immunotherapy in Colorectal Cancer","display_name":"Identification of APC Mutation as a Potential Predictor for Immunotherapy in Colorectal Cancer","publication_year":2022,"publication_date":"2022-07-13","ids":{"openalex":"https://openalex.org/W4285088313","doi":"https://doi.org/10.1155/2022/6567998","pmid":"https://pubmed.ncbi.nlm.nih.gov/35874638","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9300385"},"language":"en","primary_location":{"id":"doi:10.1155/2022/6567998","doi":"https://doi.org/10.1155/2022/6567998","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/6567998","pdf_url":"https://downloads.hindawi.com/journals/jo/2022/6567998.pdf","source":{"id":"https://openalex.org/S207014961","display_name":"Journal of Oncology","issn_l":"1687-8450","issn":["1687-8450","1687-8469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/jo/2022/6567998.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090440151","display_name":"Fen Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105740","display_name":"First People's Hospital of Foshan","ror":"https://ror.org/01cqwmh55","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fen Feng","raw_affiliation_strings":["Cancer Center, The First People\u2019s Hospital of Foshan City, Foshan 518100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, The First People\u2019s Hospital of Foshan City, Foshan 518100, China","institution_ids":["https://openalex.org/I4210105740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036359674","display_name":"Huake Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116575","display_name":"Guangzhou First People's Hospital","ror":"https://ror.org/02bwytq13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huake Sun","raw_affiliation_strings":["Department of Geriatrics, Guangzhou First People\u2019s Hospital, Guangzhou 510180, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Guangzhou First People\u2019s Hospital, Guangzhou 510180, China","institution_ids":["https://openalex.org/I4210116575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076392464","display_name":"Zhikun Zhao","orcid":"https://orcid.org/0000-0001-5161-7818","observed_orcids":["https://orcid.org/0000-0001-5161-7818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhikun Zhao","raw_affiliation_strings":["YuceBio Technology Co., Ltd., Shenzhen 518100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YuceBio Technology Co., Ltd., Shenzhen 518100, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044375127","display_name":"Chao Sun","orcid":"https://orcid.org/0000-0002-9855-6765","observed_orcids":["https://orcid.org/0000-0002-9855-6765"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chao Sun","raw_affiliation_strings":["YuceBio Technology Co., Ltd., Shenzhen 518100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YuceBio Technology Co., Ltd., Shenzhen 518100, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006280248","display_name":"Yongtian Zhao","orcid":"https://orcid.org/0000-0001-7842-5787","observed_orcids":["https://orcid.org/0000-0001-7842-5787"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongtian Zhao","raw_affiliation_strings":["YuceBio Technology Co., Ltd., Shenzhen 518100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YuceBio Technology Co., Ltd., Shenzhen 518100, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011631507","display_name":"Hanqing Lin","orcid":"https://orcid.org/0000-0003-3323-1828","observed_orcids":["https://orcid.org/0000-0003-3323-1828"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanqing Lin","raw_affiliation_strings":["YuceBio Technology Co., Ltd., Shenzhen 518100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YuceBio Technology Co., Ltd., Shenzhen 518100, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101773009","display_name":"Jie Yang","orcid":"https://orcid.org/0000-0003-1009-1607","observed_orcids":["https://orcid.org/0000-0003-1009-1607"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Yang","raw_affiliation_strings":["YuceBio Technology Co., Ltd., Shenzhen 518100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"YuceBio Technology Co., Ltd., Shenzhen 518100, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034440610","display_name":"Yajie Xiao","orcid":"https://orcid.org/0000-0002-0954-267X","observed_orcids":["https://orcid.org/0000-0002-0954-267X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yajie Xiao","raw_affiliation_strings":["YuceBio Technology Co., Ltd., Shenzhen 518100, China"],"raw_orcid":"https://orcid.org/0000-0002-0954-267X","affiliations":[{"raw_affiliation_string":"YuceBio Technology Co., Ltd., Shenzhen 518100, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071596917","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0001-5224-9359","observed_orcids":["https://orcid.org/0000-0001-5224-9359"]},"institutions":[{"id":"https://openalex.org/I4210105740","display_name":"First People's Hospital of Foshan","ror":"https://ror.org/01cqwmh55","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105740"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Cancer Center, The First People\u2019s Hospital of Foshan City, Foshan 518100, China"],"raw_orcid":"https://orcid.org/0000-0001-5224-9359","affiliations":[{"raw_affiliation_string":"Cancer Center, The First People\u2019s Hospital of Foshan City, Foshan 518100, China","institution_ids":["https://openalex.org/I4210105740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032677311","display_name":"Dongfang Wu","orcid":"https://orcid.org/0000-0002-9811-2291","observed_orcids":["https://orcid.org/0000-0002-9811-2291"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dongfang Wu","raw_affiliation_strings":["YuceBio Technology Co., Ltd., Shenzhen 518100, China"],"raw_orcid":"https://orcid.org/0000-0002-9811-2291","affiliations":[{"raw_affiliation_string":"YuceBio Technology Co., Ltd., Shenzhen 518100, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032677311","https://openalex.org/A5034440610","https://openalex.org/A5071596917"],"corresponding_institution_ids":["https://openalex.org/I4210105740"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":4.0345,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.95110821,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"2022","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.4758000075817108,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.4758000075817108,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.3677000105381012,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.1453000009059906,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apc-mutation","display_name":"APC mutation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/immunotherapy-response-prediction","display_name":"immunotherapy response prediction","score":0.8119999766349792},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.7900000214576721},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.7310000061988831},{"id":"https://openalex.org/keywords/mismatch-repair-deficiency","display_name":"mismatch repair deficiency","score":0.8619999885559082},{"id":"https://openalex.org/keywords/immune-subtypes","display_name":"immune subtypes","score":0.5070000290870667},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.6800000071525574},{"id":"https://openalex.org/keywords/nkt-cells","display_name":"NKT cells","score":0.7390000224113464},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.6240000128746033},{"id":"https://openalex.org/keywords/hla-loss-of-heterozygosity","display_name":"HLA loss of heterozygosity","score":0.828000009059906},{"id":"https://openalex.org/keywords/ctnnb1","display_name":"CTNNB1","score":0.8420000076293945},{"id":"https://openalex.org/keywords/braf","display_name":"BRAF","score":0.8690000176429749},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7970192432403564},{"id":"https://openalex.org/C2778237340","wikidata":"https://www.wikidata.org/wiki/Q14883378","display_name":"Adenomatous polyposis coli","level":4,"score":0.7880530953407288},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.7469087839126587},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6735777854919434},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6505271196365356},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.513440728187561},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.48202621936798096},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47768956422805786},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47599685192108154},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44581887125968933},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44425323605537415},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.4406338036060333},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.41352778673171997},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.39888128638267517},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36017799377441406},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31369197368621826},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.2310217022895813},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.18215414881706238},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11764407157897949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11559787392616272}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2022/6567998","doi":"https://doi.org/10.1155/2022/6567998","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/6567998","pdf_url":"https://downloads.hindawi.com/journals/jo/2022/6567998.pdf","source":{"id":"https://openalex.org/S207014961","display_name":"Journal of Oncology","issn_l":"1687-8450","issn":["1687-8450","1687-8469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oncology","raw_type":"journal-article"},{"id":"pmid:35874638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35874638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9300385","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9300385/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5d7af0d5e8f54338abef0d11ef1f4705","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5d7af0d5e8f54338abef0d11ef1f4705","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Oncology, Vol 2022 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2022/6567998","doi":"https://doi.org/10.1155/2022/6567998","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/6567998","pdf_url":"https://downloads.hindawi.com/journals/jo/2022/6567998.pdf","source":{"id":"https://openalex.org/S207014961","display_name":"Journal of Oncology","issn_l":"1687-8450","issn":["1687-8450","1687-8469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285088313.pdf","grobid_xml":"https://content.openalex.org/works/W4285088313.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W842094027","https://openalex.org/W2093699479","https://openalex.org/W2117564738","https://openalex.org/W2123036315","https://openalex.org/W2148883613","https://openalex.org/W2150056019","https://openalex.org/W2158021558","https://openalex.org/W2172012292","https://openalex.org/W2583869923","https://openalex.org/W2605230952","https://openalex.org/W2766209631","https://openalex.org/W2782949806","https://openalex.org/W2783151045","https://openalex.org/W2793358229","https://openalex.org/W2796207838","https://openalex.org/W2804957255","https://openalex.org/W2811121118","https://openalex.org/W2889646458","https://openalex.org/W2900082702","https://openalex.org/W2912418732","https://openalex.org/W2919091706","https://openalex.org/W2952001873","https://openalex.org/W2957229748","https://openalex.org/W2962043907","https://openalex.org/W2969233593","https://openalex.org/W3031994575","https://openalex.org/W3042459079","https://openalex.org/W3049643238","https://openalex.org/W3115939134","https://openalex.org/W3119764699","https://openalex.org/W3122783793","https://openalex.org/W3127698360","https://openalex.org/W3134794896","https://openalex.org/W3141168022","https://openalex.org/W3143198661","https://openalex.org/W3149294290","https://openalex.org/W3152884498","https://openalex.org/W4200438463","https://openalex.org/W4220995436"],"related_works":["https://openalex.org/W4361219294","https://openalex.org/W4366782762","https://openalex.org/W4401324272","https://openalex.org/W4288052556","https://openalex.org/W2891412811","https://openalex.org/W4285726464","https://openalex.org/W3005417168","https://openalex.org/W3165359294","https://openalex.org/W4282971032","https://openalex.org/W4405923381"],"abstract_inverted_index":{"To":[0],"date,":[1],"anticancer":[2],"immunotherapy":[3,84,251,271],"has":[4],"presented":[5],"some":[6],"clinical":[7,59],"benefits":[8],"to":[9,25,30],"most":[10,192],"of":[11,36,48,97,149,154,193,217,256],"advanced":[12],"mismatch":[13],"repair":[14],"deficient":[15],"(dMMR)/microsatellite":[16],"instability-high":[17],"(MSI-H)":[18],"colorectal":[19],"cancer":[20],"(CRC)":[21],"patients.":[22,45],"In":[23,213,240],"addition":[24],"MSI":[26,94,257],"status,":[27,95],"we":[28],"aimed":[29],"reveal":[31],"the":[32,78,100,117,174,179,196,210,215],"potential":[33,268],"predictive":[34],"value":[35],"adenomatous":[37],"polyposis":[38],"coli":[39],"(APC)":[40],"gene":[41,62,263],"mutations":[42,144,153,243,264],"in":[43,64,131,173,178,195,209,228,232,252,272],"CRC":[44,51,253],"A":[46],"total":[47],"238":[49],"Chinese":[50],"patients":[52,133,194,230,234,254],"was":[53,128,171],"retrospectively":[54],"identified":[55],"and":[56,61,68,82,106,120,151,158,223],"analyzed":[57],"for":[58,142,250,270],"features":[60],"alternations":[63],"APC-mutant":[65],"type":[66],"(MT)":[67],"APC-wild-type":[69],"(WT)":[70],"groups.":[71],"Clinical":[72],"responses":[73],"were":[74,112,199,226],"then":[75],"evaluated":[76],"from":[77,168],"public":[79],"TCGA":[80],"database":[81],"MSKCC":[83],"database.":[85],"Although":[86],"programmed":[87],"cell":[88],"death":[89],"ligand":[90],"1":[91],"(PD-L1)":[92],"level,":[93],"loss":[96],"heterogeneity":[98],"at":[99],"human":[101],"leukocyte":[102],"antigen":[103],"(HLA":[104],"LOH),":[105],"tumor":[107,123],"neoantigen":[108],"burden":[109,125],"(TNB)":[110],"level":[111,127],"not":[113],"statistically":[114],"different":[115],"between":[116],"APC-MT":[118,132,180,211,233],"group":[119,176,181,198],"APC-WT":[121,175,197,229],"group,":[122],"mutation":[124],"(TMB)":[126],"significantly":[129],"higher":[130,227],"(":[134,160,235],"P":[135,161,187,236],"<":[136,162,188,237],"0.05":[137,163,189,238],").":[138,164,190,239],"Furthermore,":[139,191],"comutation":[140],"analysis":[141],"APC":[143,242,262],"revealed":[145],"co-occurring":[146],"genomic":[147],"alterations":[148],"PCDHB7":[150],"exclusive":[152],"CTNNB1,":[155],"BRAF,":[156],"AFF3,":[157],"SNX25":[159],"Besides,":[165],"overall":[166],"survival":[167],"MSKCC-CRC":[169],"cohort":[170],"longer":[172],"than":[177,231],"(HR":[182],"2.26":[183],"(95%":[184],"CI":[185],"1.05\u20134.88),":[186],"detected":[200],"as":[201],"high-grade":[202],"immune":[203],"subtypes":[204],"(C2\u2013C4)":[205],"comparing":[206],"with":[207,247],"those":[208],"group.":[212],"addition,":[214],"percentages":[216],"NK":[218],"T":[219],"cells,":[220,222],"Treg":[221],"fibroblasts":[224],"cells":[225],"summary,":[241],"might":[244,265],"be":[245,266],"associated":[246],"poor":[248],"outcomes":[249],"regardless":[255],"status.":[258],"This":[259],"study":[260],"suggested":[261],"a":[267],"predictor":[269],"CRC.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-14T00:00:00"}