{"id":"https://openalex.org/W4285087928","doi":"https://doi.org/10.1038/s41467-022-31769-4","title":"Integration of tumor extrinsic and intrinsic features associates with immunotherapy response in non-small cell lung cancer","display_name":"Integration of tumor extrinsic and intrinsic features associates with immunotherapy response in non-small cell lung cancer","publication_year":2022,"publication_date":"2022-07-13","ids":{"openalex":"https://openalex.org/W4285087928","doi":"https://doi.org/10.1038/s41467-022-31769-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/35831288","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9279502"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-022-31769-4","doi":"https://doi.org/10.1038/s41467-022-31769-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-31769-4","pdf_url":"https://www.nature.com/articles/s41467-022-31769-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-022-31769-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069507828","display_name":"Denise Lau","orcid":"https://orcid.org/0000-0001-8924-0171","observed_orcids":["https://orcid.org/0000-0001-8924-0171"]},"institutions":[{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Denise Lau","raw_affiliation_strings":["Tempus Labs, Inc., Chicago, IL, 60654, USA. publications@tempus.com","Tempus Labs, Inc., Chicago, IL, 60654, USA"],"raw_orcid":"https://orcid.org/0000-0001-8924-0171","affiliations":[{"raw_affiliation_string":"Tempus Labs, Inc., Chicago, IL, 60654, USA. publications@tempus.com","institution_ids":["https://openalex.org/I4210114883"]},{"raw_affiliation_string":"Tempus Labs, Inc., Chicago, IL, 60654, USA","institution_ids":["https://openalex.org/I4210114883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053326799","display_name":"Sonal Khare","orcid":"https://orcid.org/0000-0002-4044-3581","observed_orcids":["https://orcid.org/0000-0002-4044-3581"]},"institutions":[{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonal Khare","raw_affiliation_strings":["Tempus Labs, Inc., Chicago, IL, 60654, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tempus Labs, Inc., Chicago, IL, 60654, USA","institution_ids":["https://openalex.org/I4210114883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073815506","display_name":"Michelle M. Stein","orcid":"https://orcid.org/0000-0002-7680-9012","observed_orcids":["https://orcid.org/0000-0002-7680-9012"]},"institutions":[{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle M. Stein","raw_affiliation_strings":["Tempus Labs, Inc., Chicago, IL, 60654, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tempus Labs, Inc., Chicago, IL, 60654, USA","institution_ids":["https://openalex.org/I4210114883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102870023","display_name":"Prerna Jain","orcid":"https://orcid.org/0000-0002-7281-1369","observed_orcids":["https://orcid.org/0000-0002-7281-1369"]},"institutions":[{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prerna Jain","raw_affiliation_strings":["Tempus Labs, Inc., Chicago, IL, 60654, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tempus Labs, Inc., Chicago, IL, 60654, USA","institution_ids":["https://openalex.org/I4210114883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101644563","display_name":"Yinjie Gao","orcid":"https://orcid.org/0000-0001-6034-1999","observed_orcids":["https://orcid.org/0000-0001-6034-1999"]},"institutions":[{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yinjie Gao","raw_affiliation_strings":["Tempus Labs, Inc., Chicago, IL, 60654, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tempus Labs, Inc., Chicago, IL, 60654, USA","institution_ids":["https://openalex.org/I4210114883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061576838","display_name":"A\u00efcha BenTaieb","orcid":"https://orcid.org/0000-0002-7899-3327","observed_orcids":["https://orcid.org/0000-0002-7899-3327"]},"institutions":[{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aicha BenTaieb","raw_affiliation_strings":["Tempus Labs, Inc., Chicago, IL, 60654, USA"],"raw_orcid":"https://orcid.org/0000-0002-7899-3327","affiliations":[{"raw_affiliation_string":"Tempus Labs, Inc., Chicago, IL, 60654, USA","institution_ids":["https://openalex.org/I4210114883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035492969","display_name":"Tim Rand","orcid":"https://orcid.org/0000-0003-0758-9121","observed_orcids":["https://orcid.org/0000-0003-0758-9121"]},"institutions":[{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tim A. Rand","raw_affiliation_strings":["Tempus Labs, Inc., Chicago, IL, 60654, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tempus Labs, Inc., Chicago, IL, 60654, USA","institution_ids":["https://openalex.org/I4210114883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054698030","display_name":"Ameen Abdulla Salahudeen","orcid":"https://orcid.org/0000-0001-9037-3481","observed_orcids":["https://orcid.org/0000-0001-9037-3481"]},"institutions":[{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ameen A. Salahudeen","raw_affiliation_strings":["Tempus Labs, Inc., Chicago, IL, 60654, USA"],"raw_orcid":"https://orcid.org/0000-0001-9037-3481","affiliations":[{"raw_affiliation_string":"Tempus Labs, Inc., Chicago, IL, 60654, USA","institution_ids":["https://openalex.org/I4210114883"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006360401","display_name":"Aly Azeem Khan","orcid":"https://orcid.org/0000-0003-3933-8538","observed_orcids":["https://orcid.org/0000-0003-3933-8538"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aly A. Khan","raw_affiliation_strings":["Department of Pathology, University of Chicago, Chicago, IL, 60637, USA. aakhan@uchicago.edu","Tempus Labs, Inc., Chicago, IL, 60654, USA. aakhan@uchicago.edu","Department of Pathology, University of Chicago, Chicago, IL, 60637, USA"],"raw_orcid":"https://orcid.org/0000-0003-3933-8538","affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Chicago, Chicago, IL, 60637, USA. aakhan@uchicago.edu","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Tempus Labs, Inc., Chicago, IL, 60654, USA. aakhan@uchicago.edu","institution_ids":["https://openalex.org/I4210114883"]},{"raw_affiliation_string":"Department of Pathology, University of Chicago, Chicago, IL, 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006360401","https://openalex.org/A5069507828"],"corresponding_institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210114883"],"apc_list":{"value":5890,"currency":"USD","value_usd":5890},"apc_paid":{"value":5890,"currency":"USD","value_usd":5890},"fwci":2.7187,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.92873346,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"4053","last_page":"4053"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9779999852180481},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.9670000076293945},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.847000002861023},{"id":"https://openalex.org/keywords/cytotoxic-cd4-t-cells","display_name":"cytotoxic CD4+ T cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.746999979019165},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7429999709129333},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.7950000166893005},{"id":"https://openalex.org/keywords/time-to-progression","display_name":"time to progression","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7803285121917725},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6082157492637634},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.5943445563316345},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5798779129981995},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5748388171195984},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5672271251678467},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.520899772644043},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.48682230710983276},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4810102880001068},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.46534761786460876},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4567625820636749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4523029923439026},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.4187556505203247},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36346352100372314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31115472316741943},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2810435891151428},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23082038760185242},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.18998444080352783},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.08881548047065735},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08251982927322388},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41467-022-31769-4","doi":"https://doi.org/10.1038/s41467-022-31769-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-31769-4","pdf_url":"https://www.nature.com/articles/s41467-022-31769-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9279502","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9279502","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:35831288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35831288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31769-4","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-022-31769-4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:c4b01b42753d4ca0bd0b71c82d76931e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c4b01b42753d4ca0bd0b71c82d76931e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-022-31769-4","doi":"https://doi.org/10.1038/s41467-022-31769-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-022-31769-4","pdf_url":"https://www.nature.com/articles/s41467-022-31769-4.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285087928.pdf","grobid_xml":"https://content.openalex.org/works/W4285087928.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W2028433016","https://openalex.org/W2052923881","https://openalex.org/W2053967595","https://openalex.org/W2060468723","https://openalex.org/W2073469946","https://openalex.org/W2077020097","https://openalex.org/W2114843025","https://openalex.org/W2116453691","https://openalex.org/W2122261315","https://openalex.org/W2135905952","https://openalex.org/W2138397823","https://openalex.org/W2144353489","https://openalex.org/W2150056019","https://openalex.org/W2169064676","https://openalex.org/W2180481128","https://openalex.org/W2216513663","https://openalex.org/W2301707196","https://openalex.org/W2465860350","https://openalex.org/W2521492299","https://openalex.org/W2578841491","https://openalex.org/W2613155082","https://openalex.org/W2648573262","https://openalex.org/W2655262992","https://openalex.org/W2741601602","https://openalex.org/W2763186529","https://openalex.org/W2765417948","https://openalex.org/W2766209631","https://openalex.org/W2774712455","https://openalex.org/W2789574985","https://openalex.org/W2796582438","https://openalex.org/W2804412041","https://openalex.org/W2807534769","https://openalex.org/W2808837841","https://openalex.org/W2817838603","https://openalex.org/W2849303123","https://openalex.org/W2883970691","https://openalex.org/W2884259031","https://openalex.org/W2884754721","https://openalex.org/W2886498337","https://openalex.org/W2897815318","https://openalex.org/W2918954087","https://openalex.org/W2922408859","https://openalex.org/W2944381634","https://openalex.org/W2950372712","https://openalex.org/W2952001873","https://openalex.org/W2967177832","https://openalex.org/W2967365762","https://openalex.org/W2976744492","https://openalex.org/W2977196140","https://openalex.org/W2977498449","https://openalex.org/W2978609674","https://openalex.org/W2980495554","https://openalex.org/W2982049472","https://openalex.org/W2999445610","https://openalex.org/W2999450347","https://openalex.org/W3000174416","https://openalex.org/W3001381700","https://openalex.org/W3003499321","https://openalex.org/W3012475590","https://openalex.org/W3016494012","https://openalex.org/W3017200036","https://openalex.org/W3018397805","https://openalex.org/W3032968363","https://openalex.org/W3039869988","https://openalex.org/W3048641542","https://openalex.org/W3088005314","https://openalex.org/W3096956635","https://openalex.org/W3120933346","https://openalex.org/W3129983476","https://openalex.org/W3130718611","https://openalex.org/W3183641295","https://openalex.org/W3217307638","https://openalex.org/W4200244347","https://openalex.org/W4206028884","https://openalex.org/W4210297691","https://openalex.org/W4214873606","https://openalex.org/W4229030906","https://openalex.org/W4281485043","https://openalex.org/W4298328151"],"related_works":["https://openalex.org/W3177940890","https://openalex.org/W2912282469","https://openalex.org/W2954988528","https://openalex.org/W4308375783","https://openalex.org/W4391647814","https://openalex.org/W3136939200","https://openalex.org/W4362534924","https://openalex.org/W3175286263","https://openalex.org/W7214776432","https://openalex.org/W4232699332"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"efficacy":[2],"of":[3,19,142],"immune":[4,32],"checkpoint":[5],"blockade":[6],"(ICB)":[7],"varies":[8],"greatly":[9],"among":[10],"metastatic":[11],"non-small":[12],"cell":[13,110],"lung":[14],"cancer":[15],"(NSCLC)":[16],"patients.":[17],"Loss":[18],"heterozygosity":[20],"at":[21],"the":[22],"HLA-I":[23,37],"locus":[24],"(HLA-LOH)":[25],"has":[26],"been":[27],"identified":[28],"as":[29],"an":[30],"important":[31],"escape":[33],"mechanism.":[34],"However,":[35],"despite":[36],"disruptions":[38],"in":[39,59,116,138],"their":[40],"tumor,":[41],"many":[42],"patients":[43,145],"have":[44],"durable":[45],"ICB":[46,57,114,148],"responses.":[47],"Here":[48],"we":[49],"seek":[50],"to":[51,65,112,136],"identify":[52,66],"HLA-I-independent":[53],"features":[54],"associated":[55,132],"with":[56,84,127,133,147,152],"response":[58,115],"NSCLC.":[60,117],"We":[61,88,118],"use":[62],"single-cell":[63],"profiling":[64],"tumor-infiltrating,":[67],"clonally":[68],"expanded":[69],"CD4":[70,91],"+":[71,92,108],"T":[72,93,109],"cells":[73,83,94,102],"that":[74,120],"express":[75],"a":[76,139],"canonical":[77],"cytotoxic":[78,90,106,124],"gene":[79,125],"program":[80],"and":[81,103],"NSCLC":[82,144],"elevated":[85],"HLA-II":[86,99],"expression.":[87],"postulate":[89],"mediate":[95],"anti-tumor":[96],"activity":[97],"via":[98],"on":[100],"tumor":[101,122,128],"augment":[104],"HLA-I-dependent":[105],"CD8":[107],"interactions":[111],"drive":[113],"show":[119],"integrating":[121],"extrinsic":[123],"expression":[126],"mutational":[129],"burden":[130],"is":[131],"longer":[134],"time":[135],"progression":[137],"real-world":[140],"cohort":[141],"123":[143],"treated":[146],"regimens,":[149],"including":[150],"those":[151],"HLA-LOH.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-14T00:00:00"}