{"id":"https://openalex.org/W4285086812","doi":"https://doi.org/10.1093/gerona/glac140","title":"Association of Proinflammatory Diet With Frailty Onset Among Adults With and Without Depressive Symptoms: Results From the Framingham Offspring Study","display_name":"Association of Proinflammatory Diet With Frailty Onset Among Adults With and Without Depressive Symptoms: Results From the Framingham Offspring Study","publication_year":2022,"publication_date":"2022-07-13","ids":{"openalex":"https://openalex.org/W4285086812","doi":"https://doi.org/10.1093/gerona/glac140","pmid":"https://pubmed.ncbi.nlm.nih.gov/35830506","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9951064"},"language":"en","primary_location":{"id":"doi:10.1093/gerona/glac140","doi":"https://doi.org/10.1093/gerona/glac140","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/glac140","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9951064","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001903146","display_name":"Courtney L. Millar","orcid":"https://orcid.org/0000-0002-1667-2106","observed_orcids":["https://orcid.org/0000-0002-1667-2106"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney L Millar","raw_affiliation_strings":["Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts , USA","Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife , Boston, Massachusetts , USA"],"raw_orcid":"https://orcid.org/0000-0002-1667-2106","affiliations":[{"raw_affiliation_string":"Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I4210123879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005528446","display_name":"Alyssa B. Dufour","orcid":"https://orcid.org/0000-0001-8061-9599","observed_orcids":["https://orcid.org/0000-0001-8061-9599"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alyssa B Dufour","raw_affiliation_strings":["Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts , USA","Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife , Boston, Massachusetts , USA"],"raw_orcid":"https://orcid.org/0000-0001-8061-9599","affiliations":[{"raw_affiliation_string":"Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I4210123879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038298202","display_name":"James R. H\u00e9bert","orcid":"https://orcid.org/0000-0002-0677-2672","observed_orcids":["https://orcid.org/0000-0002-0677-2672"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]},{"id":"https://openalex.org/I4210159880","display_name":"Connecting Health Innovations (United States)","ror":"https://ror.org/05g9y6w44","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159880"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R Hebert","raw_affiliation_strings":["Department of Epidemiology and Biostatistics and the Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina , Columbia, South Carolina , USA","Department of Nutrition, Connecting Health Innovations LLC , Columbia, South Carolina , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics and the Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina , Columbia, South Carolina , USA","institution_ids":["https://openalex.org/I155781252"]},{"raw_affiliation_string":"Department of Nutrition, Connecting Health Innovations LLC , Columbia, South Carolina , USA","institution_ids":["https://openalex.org/I4210159880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002637741","display_name":"Nitin Shivappa","orcid":"https://orcid.org/0000-0003-0441-8896","observed_orcids":["https://orcid.org/0000-0003-0441-8896"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]},{"id":"https://openalex.org/I4210159880","display_name":"Connecting Health Innovations (United States)","ror":"https://ror.org/05g9y6w44","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159880"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitin Shivappa","raw_affiliation_strings":["Department of Epidemiology and Biostatistics and the Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina , Columbia, South Carolina , USA","Department of Nutrition, Connecting Health Innovations LLC , Columbia, South Carolina , USA"],"raw_orcid":"https://orcid.org/0000-0003-0441-8896","affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics and the Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina , Columbia, South Carolina , USA","institution_ids":["https://openalex.org/I155781252"]},{"raw_affiliation_string":"Department of Nutrition, Connecting Health Innovations LLC , Columbia, South Carolina , USA","institution_ids":["https://openalex.org/I4210159880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049822346","display_name":"Olivia I. Okereke","orcid":"https://orcid.org/0000-0002-9523-2693","observed_orcids":["https://orcid.org/0000-0002-9523-2693"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivia I Okereke","raw_affiliation_strings":["Department of Epidemiology, Harvard TH Chan School of Public Health , Boston, Massachusetts , USA","Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Harvard TH Chan School of Public Health , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011048149","display_name":"Douglas P. Kiel","orcid":"https://orcid.org/0000-0001-8474-0310","observed_orcids":["https://orcid.org/0000-0001-8474-0310"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas P Kiel","raw_affiliation_strings":["Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts , USA","Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife , Boston, Massachusetts , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I4210123879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071917872","display_name":"Marian T. Hannan","orcid":"https://orcid.org/0000-0002-9586-6928","observed_orcids":["https://orcid.org/0000-0002-9586-6928"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marian T Hannan","raw_affiliation_strings":["Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts , USA","Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife , Boston, Massachusetts , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I4210123879"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037873663","display_name":"Shivani Sahni","orcid":"https://orcid.org/0000-0002-9827-0986","observed_orcids":["https://orcid.org/0000-0002-9827-0986"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shivani Sahni","raw_affiliation_strings":["Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts , USA","Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife , Boston, Massachusetts , USA"],"raw_orcid":"https://orcid.org/0000-0002-9827-0986","affiliations":[{"raw_affiliation_string":"Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife , Boston, Massachusetts , USA","institution_ids":["https://openalex.org/I4210123879"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5037873663"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210123879"],"apc_list":{"value":4076,"currency":"USD","value_usd":4076},"apc_paid":null,"fwci":0.8118,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.6727041,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"78","issue":"2","first_page":"250","last_page":"257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.5059000253677368,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.5059000253677368,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.47850000858306885,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pro-inflammatory-diet","display_name":"pro-inflammatory diet","score":0.9110000133514404},{"id":"https://openalex.org/keywords/dietary-inflammation","display_name":"dietary inflammation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/depressive-symptoms","display_name":"depressive symptoms","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dietary-inflammatory-index","display_name":"Dietary Inflammatory Index","score":0.7689999938011169},{"id":"https://openalex.org/keywords/frailty-phenotype","display_name":"Fried frailty phenotype","score":0.8009999990463257},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7310000061988831},{"id":"https://openalex.org/keywords/inflammation-and-depression","display_name":"inflammation and depression","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.8565812110900879},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.6277996897697449},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5855404734611511},{"id":"https://openalex.org/C3019858935","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressive symptoms","level":3,"score":0.5801520347595215},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.5457146167755127},{"id":"https://openalex.org/C111815664","wikidata":"https://www.wikidata.org/wiki/Q1440693","display_name":"Framingham Heart Study","level":4,"score":0.5130211710929871},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42909711599349976},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.37363341450691223},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3682306408882141},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.33027034997940063},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3227139711380005},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2632526457309723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22944584488868713},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.142756849527359},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12982702255249023},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.10261353850364685},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.10242468118667603},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.09360405802726746},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/gerona/glac140","doi":"https://doi.org/10.1093/gerona/glac140","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/glac140","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9951064","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9951064","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gerontol A Biol Sci Med Sci","raw_type":"Text"},{"id":"pmid:35830506","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35830506","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journals of gerontology. Series A, Biological sciences and medical sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9951064","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9951064","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gerontol A Biol Sci Med Sci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1077163313","display_name":"Novel Factors for Muscle Mass and Strength in Adults","funder_award_id":"R01AG051728","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G250621538","display_name":null,"funder_award_id":"N01\u2010HC25195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G278200998","display_name":null,"funder_award_id":"HHSN268201500001I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3405256882","display_name":null,"funder_award_id":"HHSN268201500001C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5164707915","display_name":null,"funder_award_id":"N01-HC-025195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5659566681","display_name":null,"funder_award_id":"P30-AG031679","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5746560196","display_name":"Harvard Translational Research in Aging Training Program","funder_award_id":"T32AG023480","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G641917991","display_name":"The Framingham Heart Study","funder_award_id":"n01hc25195-41-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G731837289","display_name":"The Gut Microbiome and Bone Microarchitecture","funder_award_id":"R01AR061445","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000857694","display_name":"Boston OAIC: A Translational Approach to Function Promoting Therapies","funder_award_id":"5p30ag031679-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000880538","display_name":"Novel Molecular Biomarkers of Bone Microarchitecture","funder_award_id":"R01AR041398","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1481441198","https://openalex.org/W1544712355","https://openalex.org/W1969691571","https://openalex.org/W2000081470","https://openalex.org/W2004243143","https://openalex.org/W2022288521","https://openalex.org/W2023453107","https://openalex.org/W2042084120","https://openalex.org/W2055416829","https://openalex.org/W2093505519","https://openalex.org/W2095439262","https://openalex.org/W2097740790","https://openalex.org/W2105061478","https://openalex.org/W2106158410","https://openalex.org/W2107105830","https://openalex.org/W2112778345","https://openalex.org/W2117807651","https://openalex.org/W2120021843","https://openalex.org/W2121076832","https://openalex.org/W2127983427","https://openalex.org/W2134026694","https://openalex.org/W2145573611","https://openalex.org/W2159476895","https://openalex.org/W2162156168","https://openalex.org/W2164059021","https://openalex.org/W2177078719","https://openalex.org/W2398010472","https://openalex.org/W2460740376","https://openalex.org/W2567621860","https://openalex.org/W2615179878","https://openalex.org/W2620955025","https://openalex.org/W2753583180","https://openalex.org/W2756550838","https://openalex.org/W2883826253","https://openalex.org/W2890795399","https://openalex.org/W2896492706","https://openalex.org/W2901525054","https://openalex.org/W2906887208","https://openalex.org/W2913909887","https://openalex.org/W2914618637","https://openalex.org/W2921196367","https://openalex.org/W2964153534","https://openalex.org/W2975901292","https://openalex.org/W2980502483","https://openalex.org/W3003852938","https://openalex.org/W3112171960","https://openalex.org/W3149615257","https://openalex.org/W3201476882","https://openalex.org/W4229997552","https://openalex.org/W4256152092","https://openalex.org/W6753708122"],"related_works":["https://openalex.org/W4405976467","https://openalex.org/W3172287676","https://openalex.org/W3201476882","https://openalex.org/W7131208797","https://openalex.org/W4390058794","https://openalex.org/W4401923026","https://openalex.org/W4388106868","https://openalex.org/W2756550838","https://openalex.org/W2795448956","https://openalex.org/W4400020877"],"abstract_inverted_index":{"BACKGROUND:":[0],"Dietary":[1],"inflammation":[2],"is":[3],"associated":[4,207,227],"with":[5,11,47,63,208,219,228,253],"increased":[6,210,230,244],"risk":[7,18],"of":[8,19,28,72,138,215,232,246],"frailty.":[9,216],"Those":[10],"depressive":[12,52,83,141,200,220,254],"symptoms":[13,84],"may":[14],"be":[15],"at":[16],"higher":[17,26,184,203,223],"frailty":[20,43,95,105,159,233,247],"onset":[21,44],"because":[22],"they":[23],"typically":[24],"have":[25],"levels":[27],"inflammation.":[29],"The":[30,238],"study":[31,57,167],"objective":[32],"was":[33,99,172,177,206,226],"to":[34,182],"determine":[35],"the":[36,70,86,134],"association":[37,239],"between":[38,156,240],"a":[39,187],"proinflammatory":[40,189],"diet":[41,242],"and":[42,48,93,118,150,158,175,191,243],"in":[45],"those":[46,196,218,252],"without":[49,197],"clinically":[50,139,198],"relevant":[51,140,199],"symptoms.":[53,255],"METHODS:":[54],"This":[55,256],"prospective":[56],"included":[58],"1":[59],"701":[60],"nonfrail":[61],"individuals":[62],"self-reported":[64,119],"baseline":[65,125],"(1998-2001)":[66],"data":[67],"available":[68],"for":[69,88,162],"evaluation":[71],"energy-adjusted":[73],"dietary":[74],"inflammatory":[75,241],"index":[76],"(E-DIITM;":[77],"calculated":[78],"from":[79],"food":[80],"frequency":[81],"questionnaires),":[82],"(from":[85],"Center":[87],"Epidemiologic":[89],"Studies":[90],"Depression;":[91],"CES-D),":[92],"follow-up":[94],"measurements":[96],"(2011-2014).":[97],"Frailty":[98],"defined":[100],"as":[101],"fulfilling":[102],"\u22653":[103],"Fried":[104],"criteria":[106],"(i.e.,":[107],"slow":[108],"gait,":[109],"weak":[110],"grip":[111],"strength,":[112],"unintentional":[113],"weightloss,":[114],"low":[115],"physical":[116],"activity,":[117],"exhaustion).":[120],"Results":[121],"are":[122],"presented":[123],"by":[124],"CES-D":[126],"scores":[127,185],"<16":[128],"or":[129,136],"\u226516":[130],"points,":[131],"which":[132],"denotes":[133],"absence":[135],"presence":[137],"symptoms,":[142,201,221],"respectively.":[143],"Logistic":[144],"regression":[145],"estimated":[146],"odds":[147,211,231,245],"ratios":[148],"(OR)":[149],"95%":[151],"confidence":[152],"intervals":[153],"(95%":[154,212,234],"CI)":[155],"E-DII":[157,176,204,224],"onset,":[160],"adjusting":[161],"confounders.":[163],"RESULTS:":[164],"In":[165,195,217],"all":[166],"participants,":[168],"mean":[169],"(SD)":[170],"age":[171],"58(8)":[173],"years":[174],"-1.95":[178],"(2.20;":[179],"range:":[180],"-6.71":[181],"+5.40,":[183],"denote":[186],"more":[188],"diet),":[190],"45%":[192],"were":[193],"male.":[194],"1-unit":[202,222],"score":[205,225],"14%":[209],"CI:":[213,235],"1.05-1.24)":[214],"55%":[229],"1.13-2.13).":[236],"CONCLUSIONS:":[237],"appeared":[248],"somewhat":[249],"stronger":[250],"among":[251],"preliminary":[257],"finding":[258],"warrants":[259],"further":[260],"investigation.":[261]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-07-14T00:00:00"}