{"id":"https://openalex.org/W4285086264","doi":"https://doi.org/10.1001/jamadermatol.2022.2721","title":"Efficacy and Safety of Topical Nitric Oxide\u2212Releasing Berdazimer Gel in Patients With Molluscum Contagiosum: A Phase 3 Randomized Clinical Trial","display_name":"Efficacy and Safety of Topical Nitric Oxide\u2212Releasing Berdazimer Gel in Patients With Molluscum Contagiosum: A Phase 3 Randomized Clinical Trial","publication_year":2022,"publication_date":"2022-07-13","ids":{"openalex":"https://openalex.org/W4285086264","doi":"https://doi.org/10.1001/jamadermatol.2022.2721","pmid":"https://pubmed.ncbi.nlm.nih.gov/35830173","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9280611"},"language":"en","primary_location":{"id":"doi:10.1001/jamadermatol.2022.2721","doi":"https://doi.org/10.1001/jamadermatol.2022.2721","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamadermatol.2022.2721","pdf_url":null,"source":{"id":"https://openalex.org/S146641495","display_name":"JAMA Dermatology","issn_l":"2168-6068","issn":["2168-6068","2168-6084"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1001/jamadermatol.2022.2721","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032745734","display_name":"John Browning","orcid":"https://orcid.org/0000-0002-3708-2252","observed_orcids":["https://orcid.org/0000-0002-3708-2252"]},"institutions":[{"id":"https://openalex.org/I4210120826","display_name":"Texas Dermatology and Laser Specialists","ror":"https://ror.org/02vv8px12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210120826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Browning","raw_affiliation_strings":["Texas Dermatology and Laser Specialists, San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Dermatology and Laser Specialists, San Antonio","institution_ids":["https://openalex.org/I4210120826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075955900","display_name":"Carolyn Enloe","orcid":"https://orcid.org/0000-0001-5021-9201","observed_orcids":["https://orcid.org/0000-0001-5021-9201"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolyn Enloe","raw_affiliation_strings":["Novan Inc, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novan Inc, Durham, North Carolina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045892189","display_name":"Martina M. Cartwright","orcid":"https://orcid.org/0000-0001-7207-2810","observed_orcids":["https://orcid.org/0000-0001-7207-2810"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martina Cartwright","raw_affiliation_strings":["Novan Inc, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novan Inc, Durham, North Carolina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081828039","display_name":"Adelaide Ann Hebert","orcid":"https://orcid.org/0000-0002-9167-5729","observed_orcids":["https://orcid.org/0000-0002-9167-5729"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adelaide Hebert","raw_affiliation_strings":["University of Texas Health McGovern Medical School, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health McGovern Medical School, Houston, Texas","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020095047","display_name":"Amy S. Paller","orcid":"https://orcid.org/0000-0001-6187-6549","observed_orcids":["https://orcid.org/0000-0001-6187-6549"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy S. Paller","raw_affiliation_strings":["The Feinberg School of Medicine of Northwestern University, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Feinberg School of Medicine of Northwestern University, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David Hebert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093176","display_name":"Radius Health (United States)","ror":"https://ror.org/00m2x3q29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210093176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Hebert","raw_affiliation_strings":["Novan Inc, Durham, North Carolina","Radius Health Inc, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novan Inc, Durham, North Carolina","institution_ids":[]},{"raw_affiliation_string":"Radius Health Inc, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210093176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081862735","display_name":"Elaine K. Kowalewski","orcid":"https://orcid.org/0000-0002-7915-877X","observed_orcids":["https://orcid.org/0000-0002-7915-877X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine Kearney Kowalewski","raw_affiliation_strings":["Gillings School of Global Public Health, University of North Carolina, Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gillings School of Global Public Health, University of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065619082","display_name":"Tomoko Maeda\u2010Chubachi","orcid":"https://orcid.org/0000-0002-3614-1505","observed_orcids":["https://orcid.org/0000-0002-3614-1505"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tomoko Maeda-Chubachi","raw_affiliation_strings":["Novan Inc, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novan Inc, Durham, North Carolina","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5065619082"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5813,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.92141454,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"158","issue":"8","first_page":"871","last_page":"878"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.8779000043869019,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.8779000043869019,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12116","display_name":"Dermatological diseases and infestations","score":0.037700001150369644,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molluscum-contagiosum","display_name":"molluscum contagiosum","score":0.9990000128746033},{"id":"https://openalex.org/keywords/topical-antiviral-therapy","display_name":"topical antiviral therapy","score":0.847000002861023},{"id":"https://openalex.org/keywords/lesion-clearance","display_name":"lesion clearance","score":0.8149999976158142},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.5680000185966492},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7059999704360962},{"id":"https://openalex.org/keywords/scar-formation","display_name":"scar formation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.5699999928474426},{"id":"https://openalex.org/keywords/vehicle-controlled-comparison","display_name":"vehicle-controlled comparison","score":0.4519999921321869},{"id":"https://openalex.org/keywords/human-herpesvirus-7","display_name":"human herpesvirus 7","score":0.6840000152587891},{"id":"https://openalex.org/keywords/poxvirus-infection","display_name":"poxvirus infection","score":0.5379999876022339},{"id":"https://openalex.org/keywords/dermatology-clinic","display_name":"dermatology clinic","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9618145227432251},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7795121669769287},{"id":"https://openalex.org/C2776311326","wikidata":"https://www.wikidata.org/wiki/Q659584","display_name":"Molluscum contagiosum","level":2,"score":0.720452606678009},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6023918986320496},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6001055240631104},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5215651392936707},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4869171380996704},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33949416875839233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.336651086807251},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004890","descriptor_name":"Erythema","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008976","descriptor_name":"Molluscum Contagiosum","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1001/jamadermatol.2022.2721","doi":"https://doi.org/10.1001/jamadermatol.2022.2721","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamadermatol.2022.2721","pdf_url":null,"source":{"id":"https://openalex.org/S146641495","display_name":"JAMA Dermatology","issn_l":"2168-6068","issn":["2168-6068","2168-6084"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Dermatology","raw_type":"journal-article"},{"id":"pmid:35830173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35830173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA dermatology","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:pubmedcentral.nih.gov:9280611","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9280611/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Dermatol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1001/jamadermatol.2022.2721","doi":"https://doi.org/10.1001/jamadermatol.2022.2721","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamadermatol.2022.2721","pdf_url":null,"source":{"id":"https://openalex.org/S146641495","display_name":"JAMA Dermatology","issn_l":"2168-6068","issn":["2168-6068","2168-6084"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W50182562","https://openalex.org/W1969131237","https://openalex.org/W1989148828","https://openalex.org/W1998835796","https://openalex.org/W2120023855","https://openalex.org/W2133481096","https://openalex.org/W2139371581","https://openalex.org/W2144109738","https://openalex.org/W2150730235","https://openalex.org/W2171712055","https://openalex.org/W2190844163","https://openalex.org/W2615468896","https://openalex.org/W2794303728","https://openalex.org/W2799336214","https://openalex.org/W2962657781","https://openalex.org/W2977858693","https://openalex.org/W2990020471","https://openalex.org/W3088546246","https://openalex.org/W3159769837","https://openalex.org/W4230437339","https://openalex.org/W4245932343","https://openalex.org/W6770207132"],"related_works":["https://openalex.org/W4386817663","https://openalex.org/W4387378138","https://openalex.org/W2977858693","https://openalex.org/W4406054046","https://openalex.org/W4387014385","https://openalex.org/W4403117872","https://openalex.org/W4392772554","https://openalex.org/W4304480844","https://openalex.org/W2969602545","https://openalex.org/W4406678730"],"abstract_inverted_index":{"Importance:":[0],"Molluscum":[1],"contagiosum":[2],"(MC)":[3],"is":[4],"a":[5,42,59,134,256],"highly":[6],"contagious":[7],"skin":[8,178,367],"condition.":[9],"Lesions":[10],"may":[11],"persist":[12],"for":[13,142,382],"months":[14,92],"to":[15,84,99,123,137,190,203,221,345,371,385],"years,":[16],"and":[17,21,36,55,75,95,147,165,172,174,180,219,247,336,355,375,389],"no":[18],"US":[19,79],"Food":[20],"Drug":[22],"Administration-approved":[23],"medications":[24],"are":[25],"currently":[26],"available":[27],"in":[28,48,70,77,113,243,251,269,284,340],"the":[29,34,49,78,114,237,244,252,270,285,305,320,352,360],"US.":[30],"Objective:":[31],"To":[32],"assess":[33],"efficacy":[35,151,388],"safety":[37,390],"of":[38,51,157,176,197,276,304,311,319,351,359,378],"berdazimer":[39,126,245,271,306,353,379],"gel,":[40,127,131,380],"10.3%,":[41,128,381],"novel":[43],"topical":[44],"nitric":[45],"oxide-releasing":[46],"medication,":[47],"treatment":[50,124,309],"MC.":[52],"Design,":[53],"Setting,":[54],"Participants:":[56],"This":[57],"was":[58,154,369],"multicenter,":[60],"vehicle-controlled,":[61],"double-blind,":[62],"phase":[63],"3":[64,98],"randomized":[65,122],"clinical":[66],"trial":[67],"(B-SIMPLE4)":[68],"conducted":[69],"55":[71],"clinics":[72],"(mostly":[73],"dermatology":[74],"pediatric)":[76],"from":[80,97,186],"September":[81,191],"1,":[82],"2020,":[83],"July":[85],"21,":[86],"2021.":[87,193],"Eligible":[88],"participants":[89,199],"were":[90,117,121,184,200,326,333],"6":[91],"or":[93,109,129],"older":[94],"had":[96,255],"70":[100],"raised":[101],"MC":[102,108,111,159,277,312,383],"lesions.":[103],"Patients":[104,120],"with":[105,110,125,280,300,315,391],"sexually":[106],"transmitted":[107],"only":[112],"periocular":[115],"area":[116],"excluded.":[118],"Interventions:":[119],"vehicle":[130,222,253,286,321,361],"applied":[132],"as":[133],"thin":[135],"layer":[136],"all":[138,158],"lesions":[139,160,278],"once":[140],"daily":[141],"12":[143],"weeks.":[144],"Main":[145],"Outcomes":[146],"Measures:":[148],"The":[149,328,363],"primary":[150],"end":[152],"point":[153],"complete":[155,274],"clearance":[156,275,313],"at":[161,260],"week":[162,261,264],"12.":[163,262],"Safety":[164],"tolerability":[166],"measures":[167],"included":[168],"adverse":[169,331,393],"event":[170,324,394],"frequency":[171],"severity,":[173],"assessment":[175],"local":[177,366],"reactions":[179],"scarring.":[181],"Data":[182],"analyses":[183],"performed":[185,259],"August":[187],"31,":[188],"2021,":[189],"14,":[192],"Results:":[194],"A":[195],"total":[196],"891":[198],"randomized,":[201],"444":[202],"berdazimer,":[204],"10.3%":[205],"(mean":[206,223],"[range]":[207,224],"age,":[208,225],"6.6":[209],"[0.9-47.5]":[210],"years;":[211,228],"228":[212],"[51.4%]":[213],"male;":[214],"387":[215],"[87.2%]":[216],"White":[217,234],"individuals),":[218],"447":[220],"6.5":[226],"[1.3-49.0]":[227],"234":[229],"[52.3%]":[230],"female;":[231],"382":[232],"[85.5%]":[233],"individuals).":[235],"In":[236],"intention-to-treat":[238],"population,":[239],"88.5%":[240],"(393":[241],"patients)":[242,250,268,283,303,318,350,358],"group":[246,254,272,287,307,354],"88.8%":[248],"(397":[249],"lesion":[257],"count":[258],"At":[263],"12,":[265],"32.4%":[266],"(144":[267],"achieved":[273],"compared":[279,314],"19.7%":[281],"(88":[282],"(absolute":[288],"difference,":[289],"12.7%;":[290],"odds":[291],"ratio,":[292],"2.0;":[293],"95%":[294],"CI,":[295],"1.5-2.8;":[296],"P":[297],"<":[298],".001)":[299],"14.4%":[301],"(64":[302],"discontinuing":[308],"because":[310],"8.9%":[316],"(40":[317],"group.":[322,362],"Adverse":[323,342],"rates":[325],"low.":[327],"most":[329,364],"common":[330,365],"events":[332,343],"application-site":[334],"pain":[335],"erythema,":[337],"mostly":[338],"mild":[339,370],"severity.":[341],"leading":[344],"discontinuation":[346],"affected":[347],"4.1%":[348],"(18":[349],"0.7%":[356],"(3":[357],"reaction":[368],"moderate":[372],"erythema.":[373],"Conclusions":[374],"Relevance:":[376],"Use":[377],"appears":[384],"demonstrate":[386],"favorable":[387],"low":[392],"rates.":[395],"Trial":[396],"Registration:":[397],"ClinicalTrials.gov":[398],"Identifier:":[399],"NCT04535531.":[400]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-07-14T00:00:00"}
