{"id":"https://openalex.org/W4285079290","doi":"https://doi.org/10.17116/oftalma202213803182","title":"Fixed combination of latanoprost and timolol in the long-term treatment of patients with normal-tension glaucoma","display_name":"Fixed combination of latanoprost and timolol in the long-term treatment of patients with normal-tension glaucoma","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4285079290","doi":"https://doi.org/10.17116/oftalma202213803182","pmid":"https://pubmed.ncbi.nlm.nih.gov/35801885"},"language":"ru","primary_location":{"id":"doi:10.17116/oftalma202213803182","doi":"https://doi.org/10.17116/oftalma202213803182","is_oa":false,"landing_page_url":"https://doi.org/10.17116/oftalma202213803182","pdf_url":null,"source":{"id":"https://openalex.org/S2764585551","display_name":"Russian Annals of Ophthalmology","issn_l":"0042-465X","issn":["0042-465X","2309-1282"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320238","host_organization_name":"Meditsina","host_organization_lineage":["https://openalex.org/P4310320238"],"host_organization_lineage_names":["Meditsina"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vestnik oftal'mologii","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028035103","display_name":"\u0415. \u0412. \u041a\u0430\u0440\u043b\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0003-4929-8832","observed_orcids":["https://orcid.org/0000-0003-4929-8832"]},"institutions":[{"id":"https://openalex.org/I4210151766","display_name":"Samara Regional Clinical Hospital named after V.D. Seredavina","ror":"https://ror.org/04rwzz867","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210151766"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E.V. Karlova","raw_affiliation_strings":["Samara Regional Clinical Ophthalmological Hospital named after T.I. Eroshevsky, Samara, Russia"],"raw_orcid":"https://orcid.org/0000-0003-4929-8832","affiliations":[{"raw_affiliation_string":"Samara Regional Clinical Ophthalmological Hospital named after T.I. Eroshevsky, Samara, Russia","institution_ids":["https://openalex.org/I4210151766"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036637671","display_name":"A.V. Zolotarev","orcid":"https://orcid.org/0000-0002-9107-5221","observed_orcids":["https://orcid.org/0000-0002-9107-5221"]},"institutions":[{"id":"https://openalex.org/I4210151766","display_name":"Samara Regional Clinical Hospital named after V.D. Seredavina","ror":"https://ror.org/04rwzz867","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210151766"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A.V. Zolotarev","raw_affiliation_strings":["Samara Regional Clinical Ophthalmological Hospital named after T.I. Eroshevsky, Samara, Russia"],"raw_orcid":"https://orcid.org/0000-0002-9107-5221","affiliations":[{"raw_affiliation_string":"Samara Regional Clinical Ophthalmological Hospital named after T.I. Eroshevsky, Samara, Russia","institution_ids":["https://openalex.org/I4210151766"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210151766"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"138","issue":"3","first_page":"82","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/normal-tension-glaucoma","display_name":"normal-tension glaucoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/latanoprost","display_name":"latanoprost","score":0.9380000233650208},{"id":"https://openalex.org/keywords/timolol","display_name":"timolol","score":1.0},{"id":"https://openalex.org/keywords/fixed-dose-combination","display_name":"fixed-dose combination","score":0.8529999852180481},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.925000011920929},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.753000020980835},{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":0.8289999961853027},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7279999852180481},{"id":"https://openalex.org/keywords/intraocular-pressure-reduction","display_name":"intraocular pressure reduction","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2776740260","wikidata":"https://www.wikidata.org/wiki/Q634959","display_name":"Latanoprost","level":3,"score":0.923269510269165},{"id":"https://openalex.org/C2778073030","wikidata":"https://www.wikidata.org/wiki/Q413994","display_name":"Timolol","level":3,"score":0.9230532646179199},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.9068151712417603},{"id":"https://openalex.org/C2780179686","wikidata":"https://www.wikidata.org/wiki/Q17300307","display_name":"Normal tension glaucoma","level":4,"score":0.7645400166511536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7501084208488464},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.7206920385360718},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.6315179467201233},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48223623633384705},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.41554978489875793},{"id":"https://openalex.org/C2991803831","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Open angle glaucoma","level":3,"score":0.3964555859565735},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18001624941825867},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.16479825973510742},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.14549008011817932}],"mesh":[{"descriptor_ui":"D000077338","descriptor_name":"Latanoprost","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009798","descriptor_name":"Ocular Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011461","descriptor_name":"Prostaglandins F, Synthetic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013999","descriptor_name":"Timolol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057066","descriptor_name":"Low Tension Glaucoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D057066","descriptor_name":"Low Tension Glaucoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.17116/oftalma202213803182","doi":"https://doi.org/10.17116/oftalma202213803182","is_oa":false,"landing_page_url":"https://doi.org/10.17116/oftalma202213803182","pdf_url":null,"source":{"id":"https://openalex.org/S2764585551","display_name":"Russian Annals of Ophthalmology","issn_l":"0042-465X","issn":["0042-465X","2309-1282"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320238","host_organization_name":"Meditsina","host_organization_lineage":["https://openalex.org/P4310320238"],"host_organization_lineage_names":["Meditsina"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vestnik oftal'mologii","raw_type":"journal-article"},{"id":"pmid:35801885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35801885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vestnik oftalmologii","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W149337492","https://openalex.org/W1994799685","https://openalex.org/W1996533189","https://openalex.org/W2010244036","https://openalex.org/W2024165855","https://openalex.org/W2065005955","https://openalex.org/W2071437570","https://openalex.org/W2077037485","https://openalex.org/W2080015018","https://openalex.org/W2083582367","https://openalex.org/W2131063971","https://openalex.org/W2174239938","https://openalex.org/W2317229735","https://openalex.org/W2345711140","https://openalex.org/W2555997181","https://openalex.org/W2616310970","https://openalex.org/W2739105809","https://openalex.org/W2794816889","https://openalex.org/W2805758903","https://openalex.org/W2890794899","https://openalex.org/W2972485229","https://openalex.org/W2977587116","https://openalex.org/W3008326380","https://openalex.org/W3021862427","https://openalex.org/W3087517087","https://openalex.org/W3093651684","https://openalex.org/W3134730147","https://openalex.org/W3209975881"],"related_works":["https://openalex.org/W7100855925","https://openalex.org/W2418959319","https://openalex.org/W2167405358","https://openalex.org/W2607109080","https://openalex.org/W2011419937","https://openalex.org/W2013186162","https://openalex.org/W2161833613","https://openalex.org/W2003292607","https://openalex.org/W2156114539","https://openalex.org/W6963571136"],"abstract_inverted_index":{"The":[0,135],"most":[1],"well-studied":[2],"and":[3,34,50,85,119,144],"widely":[4],"prescribed":[5],"fixed-combination":[6],"drug":[7,49,84],"for":[8,38,43,73,149],"open-angle":[9],"glaucoma":[10,63],"is":[11,17,139],"latanoprost/timolol.":[12],"Its":[13],"significant":[14],"hypotensive":[15],"effect":[16],"especially":[18],"important":[19],"in":[20,104,132],"challenging":[21],"cases,":[22],"among":[23],"which":[24],"are":[25,41],"patients":[26,60,77],"with":[27,61],"normal-tension":[28,62,150],"glaucoma.":[29,151],"With":[30],"long":[31],"life":[32,89],"expectancy":[33],"the":[35,45,48,68,83,116,124,127],"constant":[36],"need":[37],"treatment,":[39],"requirements":[40],"high":[42],"both":[44],"effectiveness":[46],"of":[47,58,71,88,95,110,123,126],"its":[51],"tolerability.":[52],"This":[53],"paper":[54],"presents":[55],"a":[56,140],"follow-up":[57],"7":[59],"who":[64],"have":[65],"been":[66],"using":[67],"fixed":[69,137],"combination":[70,138],"latanoprost/timolol":[72,136],"10":[74],"years.":[75],"All":[76],"showed":[78],"very":[79],"good":[80],"tolerability":[81],"to":[82,99,115],"their":[86],"quality":[87],"was":[90,102,130],"preserved.":[91],"A":[92,107],"moderate":[93],"rate":[94],"disease":[96],"progression":[97],"according":[98,114],"static":[100],"perimetry":[101],"noted":[103],"one":[105,133],"case.":[106],"mild":[108],"degree":[109],"dry":[111],"eye":[112],"syndrome":[113],"OSDI":[117],"questionnaire":[118],"an":[120],"objective":[121],"assessment":[122],"state":[125],"ocular":[128],"surface":[129],"observed":[131],"patient.":[134],"well-tolerated,":[141],"highly":[142],"effective":[143],"safe":[145],"long-term":[146],"treatment":[147],"choice":[148]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-13T00:00:00"}