{"id":"https://openalex.org/W4285077339","doi":"https://doi.org/10.1093/nar/gkac581","title":"In vitro reconstitution reveals a key role of human mitochondrial EXOG in RNA primer processing","display_name":"In vitro reconstitution reveals a key role of human mitochondrial EXOG in RNA primer processing","publication_year":2022,"publication_date":"2022-07-12","ids":{"openalex":"https://openalex.org/W4285077339","doi":"https://doi.org/10.1093/nar/gkac581","pmid":"https://pubmed.ncbi.nlm.nih.gov/35819194","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9371904"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkac581","doi":"https://doi.org/10.1093/nar/gkac581","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkac581","pdf_url":"https://academic.oup.com/nar/article-pdf/50/14/7991/45289663/gkac581.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/50/14/7991/45289663/gkac581.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002217109","display_name":"Anna Kar\u0142owicz","orcid":"https://orcid.org/0000-0002-6940-8210","observed_orcids":["https://orcid.org/0000-0002-6940-8210"]},"institutions":[{"id":"https://openalex.org/I40413290","display_name":"University of Gda\u0144sk","ror":"https://ror.org/011dv8m48","country_code":"PL","type":"education","lineage":["https://openalex.org/I40413290"]},{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anna Karlowicz","raw_affiliation_strings":["Structural Biology Laboratory, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk , ul. Abrahama 58, 80-307 Gdansk, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Biology Laboratory, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk , ul. Abrahama 58, 80-307 Gdansk, Poland","institution_ids":["https://openalex.org/I40413290","https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrzej B Dubiel","orcid":"https://orcid.org/0000-0002-2743-5122","observed_orcids":["https://orcid.org/0000-0002-2743-5122"]},"institutions":[{"id":"https://openalex.org/I40413290","display_name":"University of Gda\u0144sk","ror":"https://ror.org/011dv8m48","country_code":"PL","type":"education","lineage":["https://openalex.org/I40413290"]},{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Andrzej B Dubiel","raw_affiliation_strings":["Structural Biology Laboratory, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk , ul. Abrahama 58, 80-307 Gdansk, Poland"],"raw_orcid":"https://orcid.org/0000-0002-2743-5122","affiliations":[{"raw_affiliation_string":"Structural Biology Laboratory, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk , ul. Abrahama 58, 80-307 Gdansk, Poland","institution_ids":["https://openalex.org/I40413290","https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014548649","display_name":"Jolanta Czerwi\u0144ska","orcid":"https://orcid.org/0000-0002-3261-3819","observed_orcids":["https://orcid.org/0000-0002-3261-3819"]},"institutions":[{"id":"https://openalex.org/I4210128244","display_name":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences","ror":"https://ror.org/034tvp782","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210128244","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I4654613","display_name":"University of Warsaw","ror":"https://ror.org/039bjqg32","country_code":"PL","type":"education","lineage":["https://openalex.org/I4654613"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jolanta Czerwinska","raw_affiliation_strings":["Faculty of Biology, Institute of Genetics and Biotechnology, University of Warsaw , Warsaw 02-106, Poland","Institute of Biochemistry and Biophysics Polish Academy of Sciences , ul. Pawinskiego 5A, 02-106 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology, Institute of Genetics and Biotechnology, University of Warsaw , Warsaw 02-106, Poland","institution_ids":["https://openalex.org/I4654613"]},{"raw_affiliation_string":"Institute of Biochemistry and Biophysics Polish Academy of Sciences , ul. Pawinskiego 5A, 02-106 Warsaw, Poland","institution_ids":["https://openalex.org/I4210128244","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022993395","display_name":"Adela Bledea","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40413290","display_name":"University of Gda\u0144sk","ror":"https://ror.org/011dv8m48","country_code":"PL","type":"education","lineage":["https://openalex.org/I40413290"]},{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Adela Bledea","raw_affiliation_strings":["Structural Biology Laboratory, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk , ul. Abrahama 58, 80-307 Gdansk, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Biology Laboratory, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk , ul. Abrahama 58, 80-307 Gdansk, Poland","institution_ids":["https://openalex.org/I40413290","https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081432168","display_name":"Piotr Purzycki","orcid":"https://orcid.org/0000-0002-8056-6252","observed_orcids":["https://orcid.org/0000-0002-8056-6252"]},"institutions":[{"id":"https://openalex.org/I40413290","display_name":"University of Gda\u0144sk","ror":"https://ror.org/011dv8m48","country_code":"PL","type":"education","lineage":["https://openalex.org/I40413290"]},{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Piotr Purzycki","raw_affiliation_strings":["Structural Biology Laboratory, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk , ul. Abrahama 58, 80-307 Gdansk, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Biology Laboratory, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk , ul. Abrahama 58, 80-307 Gdansk, Poland","institution_ids":["https://openalex.org/I40413290","https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084198274","display_name":"Marta Grzelewska","orcid":"https://orcid.org/0000-0003-4800-0600","observed_orcids":["https://orcid.org/0000-0003-4800-0600"]},"institutions":[{"id":"https://openalex.org/I40413290","display_name":"University of Gda\u0144sk","ror":"https://ror.org/011dv8m48","country_code":"PL","type":"education","lineage":["https://openalex.org/I40413290"]},{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marta Grzelewska","raw_affiliation_strings":["Structural Biology Laboratory, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk , ul. Abrahama 58, 80-307 Gdansk, Poland"],"raw_orcid":"https://orcid.org/0000-0003-4800-0600","affiliations":[{"raw_affiliation_string":"Structural Biology Laboratory, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk , ul. Abrahama 58, 80-307 Gdansk, Poland","institution_ids":["https://openalex.org/I40413290","https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088547148","display_name":"Ryan J. McAuley","orcid":"https://orcid.org/0000-0001-9857-4050","observed_orcids":["https://orcid.org/0000-0001-9857-4050"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan J McAuley","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, The University of Texas Medical Branch, 301 University Boulevard , Galveston, TX 77555, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, The University of Texas Medical Branch, 301 University Boulevard , Galveston, TX 77555, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086051241","display_name":"Roman J. Szcz\u0119sny","orcid":"https://orcid.org/0000-0002-0686-1632","observed_orcids":["https://orcid.org/0000-0002-0686-1632"]},"institutions":[{"id":"https://openalex.org/I4210128244","display_name":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences","ror":"https://ror.org/034tvp782","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210128244","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Roman J Szczesny","raw_affiliation_strings":["Institute of Biochemistry and Biophysics Polish Academy of Sciences , ul. Pawinskiego 5A, 02-106 Warsaw, Poland"],"raw_orcid":"https://orcid.org/0000-0002-0686-1632","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Biophysics Polish Academy of Sciences , ul. Pawinskiego 5A, 02-106 Warsaw, Poland","institution_ids":["https://openalex.org/I4210128244","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000354728","display_name":"Gabriela Brzuska","orcid":"https://orcid.org/0000-0001-5228-404X","observed_orcids":["https://orcid.org/0000-0001-5228-404X"]},"institutions":[{"id":"https://openalex.org/I40413290","display_name":"University of Gda\u0144sk","ror":"https://ror.org/011dv8m48","country_code":"PL","type":"education","lineage":["https://openalex.org/I40413290"]},{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Gabriela Brzuska","raw_affiliation_strings":["Laboratory of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk , ul. Abrahama 58, 80-307 Gdansk, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk , ul. Abrahama 58, 80-307 Gdansk, Poland","institution_ids":["https://openalex.org/I40413290","https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078291340","display_name":"Ewelina Kr\u00f3l","orcid":"https://orcid.org/0000-0001-8573-4254","observed_orcids":["https://orcid.org/0000-0001-8573-4254"]},"institutions":[{"id":"https://openalex.org/I40413290","display_name":"University of Gda\u0144sk","ror":"https://ror.org/011dv8m48","country_code":"PL","type":"education","lineage":["https://openalex.org/I40413290"]},{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ewelina Krol","raw_affiliation_strings":["Laboratory of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk , ul. Abrahama 58, 80-307 Gdansk, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk , ul. Abrahama 58, 80-307 Gdansk, Poland","institution_ids":["https://openalex.org/I40413290","https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090643968","display_name":"Bartosz Szcz\u0119sny","orcid":"https://orcid.org/0000-0002-6196-3981","observed_orcids":["https://orcid.org/0000-0002-6196-3981"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bartosz Szczesny","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, The University of Texas Medical Branch, 301 University Boulevard , Galveston, TX 77555, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, The University of Texas Medical Branch, 301 University Boulevard , Galveston, TX 77555, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089575169","display_name":"Micha\u0142 R. Szyma\u0144ski","orcid":"https://orcid.org/0000-0001-9452-8508","observed_orcids":["https://orcid.org/0000-0001-9452-8508"]},"institutions":[{"id":"https://openalex.org/I40413290","display_name":"University of Gda\u0144sk","ror":"https://ror.org/011dv8m48","country_code":"PL","type":"education","lineage":["https://openalex.org/I40413290"]},{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Michal\u00a0R Szymanski","raw_affiliation_strings":["Structural Biology Laboratory, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk , ul. Abrahama 58, 80-307 Gdansk, Poland"],"raw_orcid":"https://orcid.org/0000-0001-9452-8508","affiliations":[{"raw_affiliation_string":"Structural Biology Laboratory, Intercollegiate Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, University of Gdansk , ul. Abrahama 58, 80-307 Gdansk, Poland","institution_ids":["https://openalex.org/I40413290","https://openalex.org/I75124487"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5089575169"],"corresponding_institution_ids":["https://openalex.org/I40413290","https://openalex.org/I75124487"],"apc_list":{"value":3876,"currency":"USD","value_usd":3876},"apc_paid":{"value":3876,"currency":"USD","value_usd":3876},"fwci":0.4897,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.53772518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"50","issue":"14","first_page":"7991","last_page":"8007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6503999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6503999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.3052000105381012,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-primer-removal","display_name":"RNA primer removal","score":0.7480000257492065},{"id":"https://openalex.org/keywords/mitochondrial-dna-replication","display_name":"mitochondrial DNA replication","score":0.9480000138282776},{"id":"https://openalex.org/keywords/5-3-exonuclease","display_name":"5'-3' exonuclease","score":0.8980000019073486},{"id":"https://openalex.org/keywords/rnase-h1","display_name":"RNase H1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dna-ligase-iii","display_name":"DNA ligase III","score":0.902999997138977},{"id":"https://openalex.org/keywords/fen1","display_name":"FEN1","score":0.8429999947547913},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8090000152587891},{"id":"https://openalex.org/keywords/in-vitro-reconstitution","display_name":"in vitro reconstitution","score":0.6549999713897705},{"id":"https://openalex.org/keywords/human-mitochondria","display_name":"human mitochondria","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8168832063674927},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7862951159477234},{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.6762374639511108},{"id":"https://openalex.org/C2777563447","wikidata":"https://www.wikidata.org/wiki/Q7243397","display_name":"Primer (cosmetics)","level":2,"score":0.6739945411682129},{"id":"https://openalex.org/C69766542","wikidata":"https://www.wikidata.org/wiki/Q3430179","display_name":"RNase H","level":5,"score":0.5835424661636353},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48907047510147095},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.47932112216949463},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4158768653869629},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3951815962791443},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11534830927848816},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09309515357017517},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004720","descriptor_name":"Endonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045585","descriptor_name":"Flap Endonucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkac581","doi":"https://doi.org/10.1093/nar/gkac581","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkac581","pdf_url":"https://academic.oup.com/nar/article-pdf/50/14/7991/45289663/gkac581.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9371904","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9371904","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:35819194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35819194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkac581","doi":"https://doi.org/10.1093/nar/gkac581","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkac581","pdf_url":"https://academic.oup.com/nar/article-pdf/50/14/7991/45289663/gkac581.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2151624310","display_name":null,"funder_award_id":"POIR.04.04.00-00-5E63/18-00","funder_id":"https://openalex.org/F4320321042","funder_display_name":"Fundacja na rzecz Nauki Polskiej"},{"id":"https://openalex.org/G2318242395","display_name":null,"funder_award_id":"UMO-2016/21/P/NZ1/01085","funder_id":"https://openalex.org/F4320322650","funder_display_name":"Narodowym Centrum Nauki"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4480991676","display_name":null,"funder_award_id":"665778","funder_id":"https://openalex.org/F4320322650","funder_display_name":"Narodowym Centrum Nauki"},{"id":"https://openalex.org/G6603068871","display_name":"SUPPORTING MOBILITY IN THE ERA THROUGH AN INTERNATIONAL FELLOWSHIP PROGRAMME FOR DEVELOPEMENT OF BASIC RESEARCH IN POLAND","funder_award_id":"665778","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G735078438","display_name":null,"funder_award_id":"POIR.04.04","funder_id":"https://openalex.org/F4320321042","funder_display_name":"Fundacja na rzecz Nauki Polskiej"}],"funders":[{"id":"https://openalex.org/F4320307844","display_name":"European Molecular Biology Organization","ror":"https://ror.org/04wfr2810"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321042","display_name":"Fundacja na rzecz Nauki Polskiej","ror":"https://ror.org/048zd9m77"},{"id":"https://openalex.org/F4320322650","display_name":"Narodowym Centrum Nauki","ror":"https://ror.org/03ha2q922"},{"id":"https://openalex.org/F4320323873","display_name":"Uniwersytet Warszawski","ror":"https://ror.org/039bjqg32"},{"id":"https://openalex.org/F4320328494","display_name":"Mi\u0119dzynarodowy Instytut Biologii Molekularnej i Kom\u00f3rkowej w Warszawie","ror":"https://ror.org/01y3dkx74"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285077339.pdf","grobid_xml":"https://content.openalex.org/works/W4285077339.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W16266328","https://openalex.org/W201738796","https://openalex.org/W1192385391","https://openalex.org/W1913284131","https://openalex.org/W1939528983","https://openalex.org/W1966219094","https://openalex.org/W1968197570","https://openalex.org/W1979530771","https://openalex.org/W1980865093","https://openalex.org/W1985921871","https://openalex.org/W1995069073","https://openalex.org/W1997002747","https://openalex.org/W1997789055","https://openalex.org/W2001256046","https://openalex.org/W2001294987","https://openalex.org/W2007776623","https://openalex.org/W2010544809","https://openalex.org/W2019068162","https://openalex.org/W2020339673","https://openalex.org/W2030368407","https://openalex.org/W2032746255","https://openalex.org/W2037230363","https://openalex.org/W2043305070","https://openalex.org/W2045214360","https://openalex.org/W2055127290","https://openalex.org/W2058012269","https://openalex.org/W2064264662","https://openalex.org/W2087489218","https://openalex.org/W2089305866","https://openalex.org/W2095603792","https://openalex.org/W2107856790","https://openalex.org/W2115638153","https://openalex.org/W2117795149","https://openalex.org/W2127411392","https://openalex.org/W2127609664","https://openalex.org/W2139004599","https://openalex.org/W2142596193","https://openalex.org/W2144029907","https://openalex.org/W2147828523","https://openalex.org/W2163356737","https://openalex.org/W2170907533","https://openalex.org/W2171666431","https://openalex.org/W2333704821","https://openalex.org/W2398140809","https://openalex.org/W2524321401","https://openalex.org/W2566002255","https://openalex.org/W2611006674","https://openalex.org/W2742164331","https://openalex.org/W2790492473","https://openalex.org/W2805495256","https://openalex.org/W2809516596","https://openalex.org/W2885962205","https://openalex.org/W2922395101","https://openalex.org/W2930004525","https://openalex.org/W2950918805","https://openalex.org/W2951078503","https://openalex.org/W2990431816","https://openalex.org/W3124751356","https://openalex.org/W4210663723"],"related_works":["https://openalex.org/W2930004525","https://openalex.org/W3137680426","https://openalex.org/W2885962205","https://openalex.org/W1192385391","https://openalex.org/W1965582123","https://openalex.org/W4290989775","https://openalex.org/W1966778781","https://openalex.org/W1970381458","https://openalex.org/W2106488157","https://openalex.org/W2049033330"],"abstract_inverted_index":{"The":[0],"removal":[1,20,59,185],"of":[2,39,60,89,102,122,130,166],"RNA":[3,18,41,62,106,183,193],"primers":[4,42],"is":[5,92,108],"essential":[6],"for":[7,179,192],"mitochondrial":[8],"DNA":[9,45,114],"(mtDNA)":[10],"replication.":[11],"Several":[12],"nucleases":[13],"have":[14],"been":[15,29],"implicated":[16],"in":[17,21,35,58,73,125,138,141,196],"primer":[19,184,194],"human":[22,50,167,173,197],"mitochondria,":[23],"however,":[24],"no":[25],"conclusive":[26],"mechanism":[27],"has":[28],"elucidated.":[30],"Here,":[31],"we":[32,159,177],"reconstituted":[33],"minimal":[34],"vitro":[36,139],"system":[37],"capable":[38],"processing":[40,195],"into":[43],"ligatable":[44],"ends.":[46],"We":[47,117],"show":[48,119],"that":[49,85,100,120],"5'-3'":[51],"exonuclease,":[52],"EXOG,":[53,147],"plays":[54],"a":[55,189],"fundamental":[56],"role":[57],"the":[61,86,103,180],"primer.":[63],"EXOG":[64,123],"cleaves":[65],"short":[66],"and":[67,99,133,140,146,152,187],"long":[68],"RNA-containing":[69,80,97,131],"flaps":[70],"but":[71,155],"also":[72,118],"cooperation":[74],"with":[75],"RNase":[76,144],"H1,":[77],"processes":[78],"non-flap":[79,96],"intermediates.":[81],"Our":[82],"data":[83],"indicate":[84],"enzymatic":[87],"activity":[88],"both":[90,137],"enzymes":[91],"necessary":[93,109],"to":[94,111,161],"process":[95],"intermediates":[98],"regardless":[101],"pathway,":[104],"EXOG-mediated":[105],"cleavage":[107],"prior":[110],"ligation":[112,128],"by":[113],"Ligase":[115],"III.":[116],"upregulation":[121],"levels":[124],"mitochondria":[126,165],"increases":[127],"efficiency":[129],"substrates":[132],"discover":[134],"physical":[135],"interactions,":[136],"cellulo,":[142],"between":[143],"H1":[145],"Pol":[148,150],"\u03b3A,":[149],"\u03b3B":[151],"Lig":[153],"III":[154],"not":[156],"FEN1,":[157],"which":[158],"demonstrate":[160],"be":[162],"absent":[163],"from":[164],"lung":[168],"epithelial":[169],"cells.":[170],"Together,":[171],"using":[172],"mtDNA":[174],"replication":[175],"enzymes,":[176],"reconstitute":[178],"first":[181],"time":[182],"reaction":[186],"propose":[188],"novel":[190],"model":[191],"mitochondria.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-13T00:00:00"}
