{"id":"https://openalex.org/W4285048689","doi":null,"title":"Increased FOXA1 levels induce apoptosis and inhibit proliferation in FOXA1-low expressing basal breast cancer cells.","display_name":"Increased FOXA1 levels induce apoptosis and inhibit proliferation in FOXA1-low expressing basal breast cancer cells.","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4285048689","pmid":"https://pubmed.ncbi.nlm.nih.gov/35812039","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9251680"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9251680","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9251680","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9251680","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005099065","display_name":"Ke Xia","orcid":"https://orcid.org/0000-0001-9699-9901","observed_orcids":["https://orcid.org/0000-0001-9699-9901"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Xia","raw_affiliation_strings":["State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan Engineering Research Center for Anticancer Targeted Protein Pharmaceuticals, Hunan University Changsha 410082, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan Engineering Research Center for Anticancer Targeted Protein Pharmaceuticals, Hunan University Changsha 410082, Hunan, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023652141","display_name":"Wenqiang Huang","orcid":"https://orcid.org/0009-0001-3144-0186","observed_orcids":["https://orcid.org/0009-0001-3144-0186","https://orcid.org/0009-0002-7932-064X","https://orcid.org/0009-0004-6194-7203","https://orcid.org/0000-0002-3633-2862"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenqiang Huang","raw_affiliation_strings":["State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan Engineering Research Center for Anticancer Targeted Protein Pharmaceuticals, Hunan University Changsha 410082, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan Engineering Research Center for Anticancer Targeted Protein Pharmaceuticals, Hunan University Changsha 410082, Hunan, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007864434","display_name":"Xiaoyun Zhao","orcid":"https://orcid.org/0000-0002-9975-6339","observed_orcids":["https://orcid.org/0000-0002-9975-6339"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyun Zhao","raw_affiliation_strings":["State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan Engineering Research Center for Anticancer Targeted Protein Pharmaceuticals, Hunan University Changsha 410082, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan Engineering Research Center for Anticancer Targeted Protein Pharmaceuticals, Hunan University Changsha 410082, Hunan, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaoqin Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoqin Huang","raw_affiliation_strings":["State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan Engineering Research Center for Anticancer Targeted Protein Pharmaceuticals, Hunan University Changsha 410082, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan Engineering Research Center for Anticancer Targeted Protein Pharmaceuticals, Hunan University Changsha 410082, Hunan, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378159","display_name":"Yan Chen","orcid":"https://orcid.org/0000-0003-3516-9546","observed_orcids":["https://orcid.org/0000-0003-3516-9546","https://orcid.org/0009-0007-5693-176X"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Chen","raw_affiliation_strings":["State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan Engineering Research Center for Anticancer Targeted Protein Pharmaceuticals, Hunan University Changsha 410082, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan Engineering Research Center for Anticancer Targeted Protein Pharmaceuticals, Hunan University Changsha 410082, Hunan, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100784536","display_name":"Yu Li","orcid":"https://orcid.org/0000-0003-3484-946X","observed_orcids":["https://orcid.org/0000-0003-3484-946X","https://orcid.org/0009-0000-1337-5774"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Yu","raw_affiliation_strings":["State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan Engineering Research Center for Anticancer Targeted Protein Pharmaceuticals, Hunan University Changsha 410082, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan Engineering Research Center for Anticancer Targeted Protein Pharmaceuticals, Hunan University Changsha 410082, Hunan, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055630098","display_name":"Yongjun Tan","orcid":"https://orcid.org/0000-0003-1367-1738","observed_orcids":["https://orcid.org/0000-0003-1367-1738"]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongjun Tan","raw_affiliation_strings":["State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan Engineering Research Center for Anticancer Targeted Protein Pharmaceuticals, Hunan University Changsha 410082, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan Engineering Research Center for Anticancer Targeted Protein Pharmaceuticals, Hunan University Changsha 410082, Hunan, China","institution_ids":["https://openalex.org/I16609230"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I16609230"],"apc_list":null,"apc_paid":null,"fwci":0.6164,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.58124427,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"6","first_page":"2641","last_page":"2658"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6898999810218811,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6898999810218811,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.28220000863075256,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxa1","display_name":"FOXA1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/transcription-factor-expression","display_name":"transcription factor expression","score":0.4869999885559082},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C154456304","wikidata":"https://www.wikidata.org/wiki/Q18027046","display_name":"FOXA1","level":4,"score":0.9811368584632874},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7123410105705261},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6447700262069702},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6441527605056763},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6067314743995667},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5882207751274109},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5043781995773315},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4706296920776367},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34126365184783936},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06840687990188599},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0684036910533905},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05154260993003845}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:9251680","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9251680","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:35812039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35812039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9251680","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9251680","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W35060329","https://openalex.org/W1916777863","https://openalex.org/W1969037652","https://openalex.org/W1982378557","https://openalex.org/W1995462644","https://openalex.org/W1996060670","https://openalex.org/W2001488371","https://openalex.org/W2002262418","https://openalex.org/W2005144583","https://openalex.org/W2006198904","https://openalex.org/W2007151722","https://openalex.org/W2012468520","https://openalex.org/W2012794169","https://openalex.org/W2014278790","https://openalex.org/W2026531690","https://openalex.org/W2032551913","https://openalex.org/W2033029444","https://openalex.org/W2035913301","https://openalex.org/W2038149991","https://openalex.org/W2039576757","https://openalex.org/W2041905009","https://openalex.org/W2043861102","https://openalex.org/W2044702943","https://openalex.org/W2055026964","https://openalex.org/W2056242601","https://openalex.org/W2061727962","https://openalex.org/W2062219923","https://openalex.org/W2073131340","https://openalex.org/W2074950916","https://openalex.org/W2078556843","https://openalex.org/W2080482028","https://openalex.org/W2082804323","https://openalex.org/W2097255042","https://openalex.org/W2098211567","https://openalex.org/W2100715279","https://openalex.org/W2103010372","https://openalex.org/W2106850092","https://openalex.org/W2107800522","https://openalex.org/W2113002082","https://openalex.org/W2117111014","https://openalex.org/W2129036353","https://openalex.org/W2135738209","https://openalex.org/W2139557019","https://openalex.org/W2140503098","https://openalex.org/W2147789776","https://openalex.org/W2150163104","https://openalex.org/W2152295114","https://openalex.org/W2156933633","https://openalex.org/W2163107106","https://openalex.org/W2170829292","https://openalex.org/W2259802687","https://openalex.org/W2367392059","https://openalex.org/W2620624178","https://openalex.org/W2889646458","https://openalex.org/W2915046735"],"related_works":["https://openalex.org/W2032551913","https://openalex.org/W2074950916","https://openalex.org/W2419086000","https://openalex.org/W3119904495","https://openalex.org/W2598303070","https://openalex.org/W4409688691","https://openalex.org/W2075663330","https://openalex.org/W2083901790","https://openalex.org/W7208532426","https://openalex.org/W4313545769"],"abstract_inverted_index":{".":[0],"Our":[1],"cumulative":[2],"results":[3],"suggest":[4],"that":[5],"FOXA1":[6],"suppresses":[7],"the":[8],"basal":[9],"breast":[10,37],"cancer":[11],"cells":[12],"with":[13],"FOXA1-low":[14],"expressing":[15],"status":[16],"independent":[17],"of":[18,36],"ESR1":[19],"by":[20],"inducing":[21],"apoptosis":[22],"and":[23],"inhibiting":[24],"cell":[25],"proliferation,":[26],"thereby":[27],"implicating":[28],"its":[29],"potential":[30],"therapeutic":[31],"role":[32],"in":[33],"this":[34],"group":[35],"cancer.":[38]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-07-13T00:00:00"}
