{"id":"https://openalex.org/W4285043344","doi":"https://doi.org/10.1080/03007995.2022.2100653","title":"Overall survival indirect treatment comparison between brigatinib and alectinib for the treatment of front-line anaplastic lymphoma kinase\u2013positive non\u2013small cell lung cancer using data from ALEX and final results from ALTA-1L","display_name":"Overall survival indirect treatment comparison between brigatinib and alectinib for the treatment of front-line anaplastic lymphoma kinase\u2013positive non\u2013small cell lung cancer using data from ALEX and final results from ALTA-1L","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4285043344","doi":"https://doi.org/10.1080/03007995.2022.2100653","pmid":"https://pubmed.ncbi.nlm.nih.gov/35815801"},"language":"en","primary_location":{"id":"doi:10.1080/03007995.2022.2100653","doi":"https://doi.org/10.1080/03007995.2022.2100653","is_oa":true,"landing_page_url":"https://doi.org/10.1080/03007995.2022.2100653","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/03007995.2022.2100653?needAccess=true","source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/03007995.2022.2100653?needAccess=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051283101","display_name":"Karen L. Reckamp","orcid":"https://orcid.org/0000-0002-9213-0325","observed_orcids":["https://orcid.org/0000-0002-9213-0325"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karen L. Reckamp","raw_affiliation_strings":["Division of Medical Oncology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-9213-0325","affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013551992","display_name":"Huamao Mark Lin","orcid":"https://orcid.org/0000-0002-8399-8966","observed_orcids":["https://orcid.org/0000-0002-8399-8966"]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huamao M. Lin","raw_affiliation_strings":["Global Evidence and Outcome, Takeda Development Center Americas Inc., Lexington, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-8399-8966","affiliations":[{"raw_affiliation_string":"Global Evidence and Outcome, Takeda Development Center Americas Inc., Lexington, MA, USA","institution_ids":["https://openalex.org/I4210140176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023593985","display_name":"Holly Cranmer","orcid":"https://orcid.org/0000-0002-9067-3422","observed_orcids":["https://orcid.org/0000-0002-9067-3422"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Holly Cranmer","raw_affiliation_strings":["Global Market Access, Takeda Pharmaceuticals International Co., London, UK"],"raw_orcid":"https://orcid.org/0000-0002-9067-3422","affiliations":[{"raw_affiliation_string":"Global Market Access, Takeda Pharmaceuticals International Co., London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103242869","display_name":"Yanyu Wu","orcid":"https://orcid.org/0000-0003-0773-5854","observed_orcids":["https://orcid.org/0000-0003-0773-5854"]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanyu Wu","raw_affiliation_strings":["Global Evidence and Outcome, Takeda Development Center Americas Inc., Lexington, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Evidence and Outcome, Takeda Development Center Americas Inc., Lexington, MA, USA","institution_ids":["https://openalex.org/I4210140176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047349474","display_name":"Pingkuan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pingkuan Zhang","raw_affiliation_strings":["Clinical Science; Takeda Development Center Americas Inc., Lexington, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Science; Takeda Development Center Americas Inc., Lexington, MA, USA","institution_ids":["https://openalex.org/I4210140176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086765625","display_name":"Stephen Kay","orcid":"https://orcid.org/0000-0002-2104-7460","observed_orcids":["https://orcid.org/0000-0002-2104-7460"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Kay","raw_affiliation_strings":["Department of Statistics, Model Outcomes Ltd., Cheshire, UK"],"raw_orcid":"https://orcid.org/0000-0002-2104-7460","affiliations":[{"raw_affiliation_string":"Department of Statistics, Model Outcomes Ltd., Cheshire, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083773336","display_name":"Laura Walton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086742","display_name":"Takeda (Switzerland)","ror":"https://ror.org/002ysmy84","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210086742","https://openalex.org/I44892455"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Laura J. Walton","raw_affiliation_strings":["Global Value and Access, Takeda Pharmaceuticals International AG, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Value and Access, Takeda Pharmaceuticals International AG, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210086742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113059947","display_name":"Junwu Shen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junwu Shen","raw_affiliation_strings":["Statistics, Takeda Development Center Americas Inc., Lexington, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistics, Takeda Development Center Americas Inc., Lexington, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048231332","display_name":"Sanjay Popat","orcid":"https://orcid.org/0000-0003-2087-4963","observed_orcids":["https://orcid.org/0000-0003-2087-4963"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sanjay Popat","raw_affiliation_strings":["Lung Unit, Royal Marsden Hospital and The Institute of Cancer Research, London, UK"],"raw_orcid":"https://orcid.org/0000-0003-2087-4963","affiliations":[{"raw_affiliation_string":"Lung Unit, Royal Marsden Hospital and The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I4210121186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082517668","display_name":"D. Ross Camidge","orcid":"https://orcid.org/0000-0003-3430-3213","observed_orcids":["https://orcid.org/0000-0003-3430-3213"]},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Ross Camidge","raw_affiliation_strings":["Medical Oncology, University of Colorado Cancer Center, Aurora, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, University of Colorado Cancer Center, Aurora, CO, USA","institution_ids":["https://openalex.org/I4210134151"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5051283101"],"corresponding_institution_ids":["https://openalex.org/I1282927834"],"apc_list":null,"apc_paid":null,"fwci":0.8219,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.70636244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"38","issue":"9","first_page":"1587","last_page":"1593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brigatinib","display_name":"brigatinib","score":0.9900000095367432},{"id":"https://openalex.org/keywords/alectinib","display_name":"alectinib","score":1.0},{"id":"https://openalex.org/keywords/anaplastic-lymphoma-kinase","display_name":"anaplastic lymphoma kinase","score":0.8920000195503235},{"id":"https://openalex.org/keywords/alk-positive-non-small-cell-lung-cancer","display_name":"ALK-positive non-small cell lung cancer","score":0.968999981880188},{"id":"https://openalex.org/keywords/indirect-treatment-comparison","display_name":"indirect treatment comparison","score":0.7639999985694885},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8270000219345093},{"id":"https://openalex.org/keywords/alex-trial","display_name":"ALEX trial","score":0.9890000224113464},{"id":"https://openalex.org/keywords/bucher-method","display_name":"Bucher method","score":0.8240000009536743},{"id":"https://openalex.org/keywords/rank-preserving-structural-failure-time-model","display_name":"rank-preserving structural failure time model","score":0.8270000219345093},{"id":"https://openalex.org/keywords/alk-inhibitors","display_name":"ALK inhibitors","score":0.7549999952316284},{"id":"https://openalex.org/keywords/head-to-head-comparison","display_name":"head-to-head comparison","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2779220645","wikidata":"https://www.wikidata.org/wiki/Q21099132","display_name":"Alectinib","level":5,"score":0.9319272041320801},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8884234428405762},{"id":"https://openalex.org/C117643217","wikidata":"https://www.wikidata.org/wiki/Q17824987","display_name":"Anaplastic lymphoma kinase","level":4,"score":0.8083096742630005},{"id":"https://openalex.org/C2779750558","wikidata":"https://www.wikidata.org/wiki/Q21011233","display_name":"Ceritinib","level":5,"score":0.6796820163726807},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6129836440086365},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.579809844493866},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5492390394210815},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5176246762275696},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4790533781051636},{"id":"https://openalex.org/C2779422266","wikidata":"https://www.wikidata.org/wiki/Q5186964","display_name":"Crizotinib","level":4,"score":0.4542763829231262},{"id":"https://openalex.org/C137668524","wikidata":"https://www.wikidata.org/wiki/Q189813","display_name":"Censoring (clinical trials)","level":2,"score":0.4110390543937683},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.3864751160144806},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08580577373504639},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C2776232967","wikidata":"https://www.wikidata.org/wiki/Q6743514","display_name":"Malignant pleural effusion","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077547","descriptor_name":"Crizotinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077548","descriptor_name":"Anaplastic Lymphoma Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/03007995.2022.2100653","doi":"https://doi.org/10.1080/03007995.2022.2100653","is_oa":true,"landing_page_url":"https://doi.org/10.1080/03007995.2022.2100653","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/03007995.2022.2100653?needAccess=true","source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},{"id":"pmid:35815801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35815801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medical research and opinion","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1080/03007995.2022.2100653","doi":"https://doi.org/10.1080/03007995.2022.2100653","is_oa":true,"landing_page_url":"https://doi.org/10.1080/03007995.2022.2100653","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/03007995.2022.2100653?needAccess=true","source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4285043344.pdf"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W2005947177","https://openalex.org/W2017979374","https://openalex.org/W2031494655","https://openalex.org/W2043976215","https://openalex.org/W2071066672","https://openalex.org/W2168106545","https://openalex.org/W2172010139","https://openalex.org/W2624310346","https://openalex.org/W2802389870","https://openalex.org/W2894476389","https://openalex.org/W2973740803","https://openalex.org/W2991627091","https://openalex.org/W3007156832","https://openalex.org/W3022131485","https://openalex.org/W3022263550","https://openalex.org/W3030700619","https://openalex.org/W3128646645","https://openalex.org/W3168056273","https://openalex.org/W3200994971","https://openalex.org/W4281394950"],"related_works":["https://openalex.org/W4281394950","https://openalex.org/W4205577426","https://openalex.org/W2905116295","https://openalex.org/W3138127706","https://openalex.org/W3015280903","https://openalex.org/W4410804150","https://openalex.org/W4384277484","https://openalex.org/W2890575677","https://openalex.org/W2894989588","https://openalex.org/W4283511456"],"abstract_inverted_index":{"BACKGROUND:":[0],"-positive":[1],"non-small":[2],"cell":[3],"lung":[4],"cancer":[5],"(NSCLC).":[6],"No":[7],"head-to-head":[8],"data":[9,49,57],"are":[10],"currently":[11],"available":[12],"for":[13,29,135,139,175],"brigatinib":[14,30,136],"vs":[15,31,137],"alectinib":[16,32,138],"in":[17,85,117,155],"the":[18,24,51,156,165],"ALK-TKI-naive":[19],"population.":[20],"OBJECTIVE:":[21],"To":[22],"estimate":[23,70],"relative":[25,71,140,176],"overall":[26],"survival":[27,198],"(OS)":[28],"with":[33,119,205],"indirect":[34,77],"treatment":[35,66,88,120,146,170],"comparisons":[36,78],"(ITCs)":[37],"using":[38,164],"ALEX":[39,52],"and":[40,54,80,103,126],"ALTA-1L":[41,59],"clinical":[42],"trial":[43,53],"data.":[44],"METHODS:":[45],"The":[46],"latest":[47],"aggregate":[48],"from":[50,58,143,150,179,190],"final":[55],"patient-level":[56],"were":[60,63,83,115,131],"used.":[61],"ITCs":[62,86,118,144,192],"conducted":[64],"with/without":[65],"crossover":[67,89,121,147],"adjustments":[68,148,172],"to":[69,159,184],"OS.":[72],"Bucher":[73,166],"methods,":[74],"anchored":[75,113],"matching-adjusted":[76],"(MAICs)":[79],"unanchored":[81,157],"MAICs":[82],"employed":[84],"without":[87,145],"adjustments.":[90,122],"An":[91],"inverse":[92],"probability":[93],"of":[94],"censoring":[95],"weight":[96],"Cox":[97],"model,":[98],"a":[99],"marginal":[100],"structure":[101],"model":[102],"rank-preserving":[104],"structural":[105],"failure":[106],"time":[107],"models":[108],"(with/without":[109],"re-censoring)":[110],"within":[111],"an":[112,206],"MAIC":[114,158],"used":[116],"Hazard":[123],"ratios":[124],"(HRs)":[125],"95%":[127],"confidence":[128],"intervals":[129],"(CIs)":[130],"reported.":[132],"RESULTS:":[133],"HRs":[134,174],"OS":[141,177],"generated":[142],"ranged":[149],"0.90":[151],"(95%":[152,161,181,186],"CI:":[153,162,182,187],"0.59-1.38)":[154],"1.20":[160],"0.69-2.11)":[163],"method.":[167],"Methods":[168],"employing":[169],"switching":[171],"estimated":[173],"ranging":[178],"0.74":[180],"0.38-1.45)":[183],"1.11":[185],"0.63-1.94).":[188],"Results":[189],"all":[191],"did":[193],"not":[194],"indicate":[195],"statistically":[196],"different":[197],"profiles.":[199],"CONCLUSION:":[200],"+":[201],"NSCLC":[202],"previously":[203],"untreated":[204],"ALK":[207],"inhibitor.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-13T00:00:00"}