{"id":"https://openalex.org/W4285029397","doi":"https://doi.org/10.20344/amp.17680","title":"Portuguese Consensus Recommendations for Next-Generation Sequencing of Lung Cancer, Rare Tumors, and Cancers of Unknown Primary Origin in Clinical Practice","display_name":"Portuguese Consensus Recommendations for Next-Generation Sequencing of Lung Cancer, Rare Tumors, and Cancers of Unknown Primary Origin in Clinical Practice","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4285029397","doi":"https://doi.org/10.20344/amp.17680","pmid":"https://pubmed.ncbi.nlm.nih.gov/35816050"},"language":"en","primary_location":{"id":"doi:10.20344/amp.17680","doi":"https://doi.org/10.20344/amp.17680","is_oa":true,"landing_page_url":"https://doi.org/10.20344/amp.17680","pdf_url":"https://actamedicaportuguesa.com/revista/index.php/amp/article/download/17680/6694","source":{"id":"https://openalex.org/S147790641","display_name":"Acta M\u00e9dica Portuguesa","issn_l":"0870-399X","issn":["0870-399X","1646-0758"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","latindex","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318481","host_organization_name":"Ordem dos M\u00e9dicos","host_organization_lineage":["https://openalex.org/P4310318481"],"host_organization_lineage_names":["Ordem dos M\u00e9dicos"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta M\u00e9dica Portuguesa","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://actamedicaportuguesa.com/revista/index.php/amp/article/download/17680/6694","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047343715","display_name":"Manuel Rodrigues Teixeira","orcid":"https://orcid.org/0000-0002-4896-5982","observed_orcids":["https://orcid.org/0000-0002-4896-5982","https://orcid.org/0000-0002-3633-1659"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4405263123","display_name":"Instituto de Ci\u00eancias Biom\u00e9dicas Albel Salazar","ror":"https://ror.org/02trb6b02","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Manuel R. Teixeira","raw_affiliation_strings":["Servi\u00e7o de Gen\u00e9tica. Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil. Porto; Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar. Universidade do Porto. Porto. Portugal","Servi\u00e7o de Gen\u00e9tica. Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil. Porto. \nInstituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar. Universidade do Porto. Porto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servi\u00e7o de Gen\u00e9tica. Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil. Porto; Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar. Universidade do Porto. Porto. Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210111164","https://openalex.org/I4405263123"]},{"raw_affiliation_string":"Servi\u00e7o de Gen\u00e9tica. Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil. Porto. \nInstituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar. Universidade do Porto. Porto","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027200818","display_name":"J\u00falio Oliveira","orcid":"https://orcid.org/0000-0002-9576-3486","observed_orcids":["https://orcid.org/0000-0002-9576-3486"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"J\u00falio Oliveira","raw_affiliation_strings":["Servi\u00e7o de Oncologia M\u00e9dica. Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil. Porto. Portugal","Servi\u00e7o de Oncologia M\u00e9dica. Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil. Porto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servi\u00e7o de Oncologia M\u00e9dica. Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil. Porto. Portugal","institution_ids":["https://openalex.org/I4210111164"]},{"raw_affiliation_string":"Servi\u00e7o de Oncologia M\u00e9dica. Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil. Porto","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050041656","display_name":"Paula Borralho","orcid":"https://orcid.org/0000-0002-8556-2090","observed_orcids":["https://orcid.org/0000-0002-8556-2090"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4403386557","display_name":"Hospital CUF Descobertas","ror":"https://ror.org/05gsnx339","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4403386557"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Paula Borralho","raw_affiliation_strings":["Servi\u00e7o de Anatomia Patol\u00f3gica. Hospital CUF Descobertas. Lisboa. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal","Servi\u00e7o de Anatomia Patol\u00f3gica. Hospital CUF Descobertas. Lisboa. \nFaculdade de Medicina. Universidade de Lisboa. Lisboa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servi\u00e7o de Anatomia Patol\u00f3gica. Hospital CUF Descobertas. Lisboa. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4403386557"]},{"raw_affiliation_string":"Servi\u00e7o de Anatomia Patol\u00f3gica. Hospital CUF Descobertas. Lisboa. \nFaculdade de Medicina. Universidade de Lisboa. Lisboa","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4403386557"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria Gabriela O. Fernandes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Maria Gabriela O. Fernandes","raw_affiliation_strings":["Servi\u00e7o de Pneumologia. Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o. Porto. Departamento de Medicina. Faculdade de Medicina. Universidade do Porto. Porto. Institute of Molecular Pathology and Immunology. University of Porto. Porto. Portugal","Servi\u00e7o de Pneumologia. Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o. Porto. \nDepartamento de Medicina. Faculdade de Medicina. Universidade do Porto. Porto. \nInstitute of Molecular Pathology and Immunology. University of Porto. Porto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servi\u00e7o de Pneumologia. Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o. Porto. Departamento de Medicina. Faculdade de Medicina. Universidade do Porto. Porto. Institute of Molecular Pathology and Immunology. University of Porto. Porto. Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I3018176973"]},{"raw_affiliation_string":"Servi\u00e7o de Pneumologia. Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o. Porto. \nDepartamento de Medicina. Faculdade de Medicina. Universidade do Porto. Porto. \nInstitute of Molecular Pathology and Immunology. University of Porto. Porto","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I3018176973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054386763","display_name":"Teresa Almod\u00f4var","orcid":"https://orcid.org/0000-0001-8950-2100","observed_orcids":["https://orcid.org/0000-0001-8950-2100"]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Teresa Almodovar","raw_affiliation_strings":["Servi\u00e7o de Pneumologia. Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil. Lisboa. Portugal","Servi\u00e7o de Pneumologia. Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil. Lisboa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servi\u00e7o de Pneumologia. Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil. Lisboa. Portugal","institution_ids":["https://openalex.org/I4210103180"]},{"raw_affiliation_string":"Servi\u00e7o de Pneumologia. Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil. Lisboa","institution_ids":["https://openalex.org/I4210103180"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024006012","display_name":"Isabel Fernandes","orcid":"https://orcid.org/0000-0003-4032-7713","observed_orcids":["https://orcid.org/0000-0003-4032-7713"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4210114390","display_name":"Centro Hospitalar Lisboa Norte","ror":"https://ror.org/020sr6z07","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210114390","https://openalex.org/I4405255475"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Isabel Fernandes","raw_affiliation_strings":["Faculdade de Medicina. Universidade de Lisboa. Lisboa. Servi\u00e7o de Oncologia M\u00e9dica. Centro Hospitalar Universit\u00e1rio de Lisboa Norte. Lisboa. Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal","Faculdade de Medicina. Universidade de Lisboa. Lisboa. \nServi\u00e7o de Oncologia M\u00e9dica. Centro Hospitalar Universit\u00e1rio de Lisboa Norte. Lisboa. \nInstituto de Medicina Molecular Jo\u00e3o Lobo Antunes. Faculdade de Medicina. Universidade de Lisboa. Lisboa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Medicina. Universidade de Lisboa. Lisboa. Servi\u00e7o de Oncologia M\u00e9dica. Centro Hospitalar Universit\u00e1rio de Lisboa Norte. Lisboa. Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4210114390","https://openalex.org/I4392738257"]},{"raw_affiliation_string":"Faculdade de Medicina. Universidade de Lisboa. Lisboa. \nServi\u00e7o de Oncologia M\u00e9dica. Centro Hospitalar Universit\u00e1rio de Lisboa Norte. Lisboa. \nInstituto de Medicina Molecular Jo\u00e3o Lobo Antunes. Faculdade de Medicina. Universidade de Lisboa. Lisboa","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4210114390","https://openalex.org/I4392738257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059795130","display_name":"Daniela Macedo","orcid":"https://orcid.org/0000-0002-9681-1224","observed_orcids":["https://orcid.org/0000-0002-9681-1224"]},"institutions":[{"id":"https://openalex.org/I4405252676","display_name":"Hospital Lus\u00edadas Lisboa","ror":"https://ror.org/05rcbmq65","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4405252676"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Daniela Macedo","raw_affiliation_strings":["Centro de Oncologia. Hospital Lus\u00edadas Lisboa. Lisboa. Portugal","Centro de Oncologia. Hospital Lus\u00edadas Lisboa. Lisboa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Oncologia. Hospital Lus\u00edadas Lisboa. Lisboa. Portugal","institution_ids":["https://openalex.org/I4405252676"]},{"raw_affiliation_string":"Centro de Oncologia. Hospital Lus\u00edadas Lisboa. Lisboa","institution_ids":["https://openalex.org/I4405252676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041152282","display_name":"Ana Eliza Francisco Ferreira","orcid":"https://orcid.org/0009-0006-4367-6651","observed_orcids":["https://orcid.org/0009-0006-4367-6651"]},"institutions":[{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana Ferreira","raw_affiliation_strings":["Servi\u00e7o de Oncologia M\u00e9dica. Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil. Porto. Portugal","Servi\u00e7o de Oncologia M\u00e9dica. Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil. Porto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servi\u00e7o de Oncologia M\u00e9dica. Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil. Porto. Portugal","institution_ids":["https://openalex.org/I4210111164"]},{"raw_affiliation_string":"Servi\u00e7o de Oncologia M\u00e9dica. Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil. Porto","institution_ids":["https://openalex.org/I4210111164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001863309","display_name":"Ana Barroso","orcid":"https://orcid.org/0000-0001-9739-1965","observed_orcids":["https://orcid.org/0000-0001-9739-1965"]},"institutions":[{"id":"https://openalex.org/I4210141686","display_name":"Centro Hospitalar de Vila Nova de Gaia","ror":"https://ror.org/042jpy919","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210141686"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana Barroso","raw_affiliation_strings":["Unidade Multidisciplinar de Tumores Tor\u00e1cicos. Servi\u00e7o de Pneumologia. Centro Hospitalar de Vila Nova de Gaia/Espinho. Vila Nova de Gaia. Portugal","Unidade Multidisciplinar de Tumores Tor\u00e1cicos. Servi\u00e7o de Pneumologia. Centro Hospitalar de Vila Nova de Gaia/Espinho. Vila Nova de Gaia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidade Multidisciplinar de Tumores Tor\u00e1cicos. Servi\u00e7o de Pneumologia. Centro Hospitalar de Vila Nova de Gaia/Espinho. Vila Nova de Gaia. Portugal","institution_ids":["https://openalex.org/I4210141686"]},{"raw_affiliation_string":"Unidade Multidisciplinar de Tumores Tor\u00e1cicos. Servi\u00e7o de Pneumologia. Centro Hospitalar de Vila Nova de Gaia/Espinho. Vila Nova de Gaia","institution_ids":["https://openalex.org/I4210141686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108707375","display_name":"Encarna\u00e7\u00e3o Teixeira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114390","display_name":"Centro Hospitalar Lisboa Norte","ror":"https://ror.org/020sr6z07","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210114390","https://openalex.org/I4405255475"]},{"id":"https://openalex.org/I4403386557","display_name":"Hospital CUF Descobertas","ror":"https://ror.org/05gsnx339","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4403386557"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Encarna\u00e7\u00e3o Teixeira","raw_affiliation_strings":["Servi\u00e7o de Pneumologia. Centro Hospitalar Universit\u00e1rio de Lisboa Norte. Lisboa. Servi\u00e7o de Pneumologia. Hospital CUF Descobertas. Lisboa. Servi\u00e7o de Pneumologia. Hospital CUF Tejo. Lisboa. Portugal","Servi\u00e7o de Pneumologia. Centro Hospitalar Universit\u00e1rio de Lisboa Norte. Lisboa. \nServi\u00e7o de Pneumologia. Hospital CUF Descobertas. Lisboa. \nServi\u00e7o de Pneumologia. Hospital CUF Tejo. Lisboa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servi\u00e7o de Pneumologia. Centro Hospitalar Universit\u00e1rio de Lisboa Norte. Lisboa. Servi\u00e7o de Pneumologia. Hospital CUF Descobertas. Lisboa. Servi\u00e7o de Pneumologia. Hospital CUF Tejo. Lisboa. Portugal","institution_ids":["https://openalex.org/I4210114390","https://openalex.org/I4403386557"]},{"raw_affiliation_string":"Servi\u00e7o de Pneumologia. Centro Hospitalar Universit\u00e1rio de Lisboa Norte. Lisboa. \nServi\u00e7o de Pneumologia. Hospital CUF Descobertas. Lisboa. \nServi\u00e7o de Pneumologia. Hospital CUF Tejo. Lisboa","institution_ids":["https://openalex.org/I4210114390","https://openalex.org/I4403386557"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018172201","display_name":"Jos\u00e9 Carlos Machado","orcid":"https://orcid.org/0000-0003-4741-8415","observed_orcids":["https://orcid.org/0000-0003-4741-8415"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Carlos Machado","raw_affiliation_strings":["Institute of Molecular Pathology and Immunology. University of Porto. Porto. Departamento de Patologia. Faculdade de Medicina. Universidade do Porto. Porto. Portugal","Institute of Molecular Pathology and Immunology. University of Porto. Porto. \nDepartamento de Patologia. Faculdade de Medicina. Universidade do Porto. Porto"],"raw_orcid":"https://orcid.org/0000-0003-4741-8415","affiliations":[{"raw_affiliation_string":"Institute of Molecular Pathology and Immunology. University of Porto. Porto. Departamento de Patologia. Faculdade de Medicina. Universidade do Porto. Porto. Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Institute of Molecular Pathology and Immunology. University of Porto. Porto. \nDepartamento de Patologia. Faculdade de Medicina. Universidade do Porto. Porto","institution_ids":["https://openalex.org/I182534213"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4364,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.7991739,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"35","issue":"9","first_page":"677","last_page":"690"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.17180000245571136,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/next-generation-sequencing","display_name":"next-generation sequencing","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9459999799728394},{"id":"https://openalex.org/keywords/rare-tumor","display_name":"rare tumor","score":0.777999997138977},{"id":"https://openalex.org/keywords/sarcoma","display_name":"sarcoma","score":0.6079999804496765},{"id":"https://openalex.org/keywords/cancer-of-unknown-primary","display_name":"cancer of unknown primary","score":0.9399999976158142},{"id":"https://openalex.org/keywords/gene-panel","display_name":"gene panel","score":0.7310000061988831},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.9269999861717224},{"id":"https://openalex.org/keywords/actionable-genomic-alterations","display_name":"actionable genomic alterations","score":0.7360000014305115},{"id":"https://openalex.org/keywords/non-squamous-non-small-cell-lung-cancer","display_name":"non-squamous non-small cell lung cancer","score":0.8080000281333923},{"id":"https://openalex.org/keywords/comprehensive-genomic-profiling","display_name":"comprehensive genomic profiling","score":0.7570000290870667},{"id":"https://openalex.org/keywords/pre-analytical-quality-control","display_name":"pre-analytical quality control","score":0.824999988079071},{"id":"https://openalex.org/keywords/multidisciplinary-tumor-board","display_name":"multidisciplinary tumor board","score":0.7829999923706055},{"id":"https://openalex.org/keywords/biomarker-driven-clinical-trials","display_name":"biomarker-driven clinical trials","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.7481692433357239},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6735763549804688},{"id":"https://openalex.org/C2775999482","wikidata":"https://www.wikidata.org/wiki/Q18031208","display_name":"ROS1","level":4,"score":0.6391764879226685},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5976166129112244},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4751427173614502},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4444357454776764},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43330082297325134},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4125477075576782},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37657904624938965},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35849758982658386},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.20039963722229004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1874581277370453},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.12609457969665527},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009382","descriptor_name":"Neoplasms, Unknown Primary","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009382","descriptor_name":"Neoplasms, Unknown Primary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011174","descriptor_name":"Portugal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.20344/amp.17680","doi":"https://doi.org/10.20344/amp.17680","is_oa":true,"landing_page_url":"https://doi.org/10.20344/amp.17680","pdf_url":"https://actamedicaportuguesa.com/revista/index.php/amp/article/download/17680/6694","source":{"id":"https://openalex.org/S147790641","display_name":"Acta M\u00e9dica Portuguesa","issn_l":"0870-399X","issn":["0870-399X","1646-0758"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","latindex","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318481","host_organization_name":"Ordem dos M\u00e9dicos","host_organization_lineage":["https://openalex.org/P4310318481"],"host_organization_lineage_names":["Ordem dos M\u00e9dicos"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta M\u00e9dica Portuguesa","raw_type":"journal-article"},{"id":"pmid:35816050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35816050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica portuguesa","raw_type":"Journal Article"},{"id":"pmh:oai:ojs.www.actamedicaportuguesa.com:article/17680","doi":null,"is_oa":true,"landing_page_url":"https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/17680","pdf_url":"https://www.actamedicaportuguesa.com/revista/index.php/amp/article/download/17680/6694","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"0870-399X","raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:6db7b99ec62f463f9c90b94b686aac13","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6db7b99ec62f463f9c90b94b686aac13","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta M\u00e9dica Portuguesa, Vol 35, Iss 9 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.20344/amp.17680","doi":"https://doi.org/10.20344/amp.17680","is_oa":true,"landing_page_url":"https://doi.org/10.20344/amp.17680","pdf_url":"https://actamedicaportuguesa.com/revista/index.php/amp/article/download/17680/6694","source":{"id":"https://openalex.org/S147790641","display_name":"Acta M\u00e9dica Portuguesa","issn_l":"0870-399X","issn":["0870-399X","1646-0758"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","latindex","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318481","host_organization_name":"Ordem dos M\u00e9dicos","host_organization_lineage":["https://openalex.org/P4310318481"],"host_organization_lineage_names":["Ordem dos M\u00e9dicos"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta M\u00e9dica Portuguesa","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285029397.pdf","grobid_xml":"https://content.openalex.org/works/W4285029397.grobid-xml"},"referenced_works_count":137,"referenced_works":["https://openalex.org/W1727290854","https://openalex.org/W1810761522","https://openalex.org/W1901277137","https://openalex.org/W1967220865","https://openalex.org/W1975784282","https://openalex.org/W1996689640","https://openalex.org/W1997091549","https://openalex.org/W2022495797","https://openalex.org/W2040299716","https://openalex.org/W2054636737","https://openalex.org/W2062497242","https://openalex.org/W2076865561","https://openalex.org/W2081732737","https://openalex.org/W2091383172","https://openalex.org/W2098746581","https://openalex.org/W2103903744","https://openalex.org/W2104287359","https://openalex.org/W2107977954","https://openalex.org/W2111662961","https://openalex.org/W2112828605","https://openalex.org/W2118272646","https://openalex.org/W2120048439","https://openalex.org/W2126438085","https://openalex.org/W2129590156","https://openalex.org/W2132061714","https://openalex.org/W2132157071","https://openalex.org/W2132870547","https://openalex.org/W2136140939","https://openalex.org/W2142296095","https://openalex.org/W2153169173","https://openalex.org/W2154678665","https://openalex.org/W2155888371","https://openalex.org/W2159265519","https://openalex.org/W2168917479","https://openalex.org/W2228221433","https://openalex.org/W2255793217","https://openalex.org/W2296139876","https://openalex.org/W2310252196","https://openalex.org/W2335671095","https://openalex.org/W2335803166","https://openalex.org/W2364794827","https://openalex.org/W2372438220","https://openalex.org/W2478829584","https://openalex.org/W2508069933","https://openalex.org/W2509865886","https://openalex.org/W2514742214","https://openalex.org/W2521999166","https://openalex.org/W2525715627","https://openalex.org/W2544185683","https://openalex.org/W2560717039","https://openalex.org/W2567120741","https://openalex.org/W2586358969","https://openalex.org/W2592991260","https://openalex.org/W2601520864","https://openalex.org/W2604733575","https://openalex.org/W2622396222","https://openalex.org/W2736401362","https://openalex.org/W2749594696","https://openalex.org/W2752346196","https://openalex.org/W2753484208","https://openalex.org/W2760639821","https://openalex.org/W2765224350","https://openalex.org/W2770828094","https://openalex.org/W2770975168","https://openalex.org/W2773783066","https://openalex.org/W2783112448","https://openalex.org/W2789288884","https://openalex.org/W2792049071","https://openalex.org/W2797675588","https://openalex.org/W2807519281","https://openalex.org/W2811017319","https://openalex.org/W2825852176","https://openalex.org/W2884637608","https://openalex.org/W2885210084","https://openalex.org/W2889517321","https://openalex.org/W2893824814","https://openalex.org/W2899409885","https://openalex.org/W2903048600","https://openalex.org/W2909800464","https://openalex.org/W2910479322","https://openalex.org/W2917824139","https://openalex.org/W2921113926","https://openalex.org/W2921771746","https://openalex.org/W2924277568","https://openalex.org/W2924313489","https://openalex.org/W2925139051","https://openalex.org/W2937543111","https://openalex.org/W2938245541","https://openalex.org/W2942385532","https://openalex.org/W2945371661","https://openalex.org/W2946547124","https://openalex.org/W2947060664","https://openalex.org/W2948093186","https://openalex.org/W2953499653","https://openalex.org/W2953804209","https://openalex.org/W2968602885","https://openalex.org/W2988166991","https://openalex.org/W2990720871","https://openalex.org/W2992931937","https://openalex.org/W2995220921","https://openalex.org/W2996574710","https://openalex.org/W3000372555","https://openalex.org/W3002973089","https://openalex.org/W3006180292","https://openalex.org/W3008107700","https://openalex.org/W3013383466","https://openalex.org/W3018755081","https://openalex.org/W3020731568","https://openalex.org/W3022927431","https://openalex.org/W3032438306","https://openalex.org/W3039596678","https://openalex.org/W3046461280","https://openalex.org/W3046769031","https://openalex.org/W3047533221","https://openalex.org/W3049104202","https://openalex.org/W3080458669","https://openalex.org/W3082015854","https://openalex.org/W3082458631","https://openalex.org/W3086278271","https://openalex.org/W3088519161","https://openalex.org/W3093065681","https://openalex.org/W3093291585","https://openalex.org/W3093855610","https://openalex.org/W3094617408","https://openalex.org/W3094826614","https://openalex.org/W3118976699","https://openalex.org/W3124985277","https://openalex.org/W3128527220","https://openalex.org/W3149117720","https://openalex.org/W3164126191","https://openalex.org/W4205145334","https://openalex.org/W4210992155","https://openalex.org/W4234081105","https://openalex.org/W4237201067","https://openalex.org/W4239818044","https://openalex.org/W4406564873","https://openalex.org/W7075283865"],"related_works":["https://openalex.org/W2252646977","https://openalex.org/W2983001201","https://openalex.org/W2322775477","https://openalex.org/W4415520293","https://openalex.org/W4379283383","https://openalex.org/W2898298556","https://openalex.org/W3080458669","https://openalex.org/W3092835998","https://openalex.org/W4237472229","https://openalex.org/W2938020538"],"abstract_inverted_index":{"Next-generation":[0],"sequencing":[1],"(NGS)":[2],"has":[3],"been":[4],"implemented":[5],"in":[6,20,63,163,192,243,256],"clinical":[7,194,236],"oncology":[8],"for":[9,31,67,219,238],"diagnosis,":[10],"prognosis,":[11],"and":[12,37,46,51,70,80,84,91,96,120,137,148,235,251],"therapeutic":[13,38],"guidance.":[14],"Among":[15],"the":[16,26,64,73,159,175,200,205,216,239,244],"various":[17],"NGS":[18,42,74,118,162,170,242],"applications":[19],"molecular":[21],"oncology,":[22],"we":[23],"focused":[24],"on":[25,41],"following":[27],"topics:":[28],"laboratory":[29,97,234],"standards":[30],"targeted":[32,129],"gene":[33],"panels":[34,171],"(somatic":[35],"mutations)":[36],"guidance":[39],"based":[40],"of":[43,53,72,155,161,202,241,246,253],"lung":[44,103,111,247],"cancer":[45,112,252],"rare":[47,164,249],"cancers,":[48],"namely":[49],"sarcomas":[50],"cancers":[52],"unknown":[54,254],"primary.":[55],"Multiple":[56],"quality":[57,69],"control":[58],"checkpoints":[59],"should":[60,113,122],"be":[61,114],"addressed":[62],"pre-analytical":[65],"phase":[66],"good":[68],"interpretation":[71],"results.":[75],"It":[76],"includes":[77],"tumor":[78,86,88,197],"size":[79],"cellularity,":[81],"tissue":[82],"processing":[83],"decalcification,":[85],"fraction,":[87],"viability,":[89],"fixatives,":[90],"staining.":[92],"Communication":[93],"between":[94],"clinicians":[95],"support":[98],"is":[99,152],"also":[100,140],"essential.":[101],"In":[102],"cancer,":[104,248],"all":[105],"patients":[106,181],"with":[107,116,127,142,182,199,204],"non-squamous":[108],"non-small":[109],"cell":[110],"tested":[115],"a":[117,153],"panel,":[119],"it":[121],"include":[123],"not":[124],"only":[125],"genes":[126,141],"approved":[128],"therapies":[130],"(ALK,":[131],"BRAF,":[132],"EGFR,":[133],"MET,":[134],"NTRK,":[135],"RET,":[136],"ROS1)":[138],"but":[139],"potentially":[143],"actionable":[144],"genomic":[145,168,209],"alterations":[146],"(HER2":[147],"KRAS).":[149],"Since":[150],"there":[151,224],"lack":[154],"extensive":[156],"knowledge":[157],"regarding":[158],"use":[160,240],"tumors":[165,186],"performing":[166],"comprehensive":[167],"profiling,":[169],"to":[172,207,214,232],"better":[173],"manage":[174],"disease":[176],"are":[177,212,225],"recommended.":[178],"Moreover,":[179],"other":[180,183],"incurable":[184],"solid":[185],"may":[187],"benefit":[188],"from":[189],"being":[190],"included":[191],"biomarker-driven":[193],"trials.":[195],"Multidisciplinary":[196],"boards":[198],"participation":[201],"experts":[203],"ability":[206],"integrate":[208],"profiling":[210],"data":[211],"essential":[213],"tailor":[215],"best":[217],"strategy":[218],"each":[220],"patient.":[221],"Considering":[222],"that":[223],"no":[226],"national":[227],"guidelines,":[228],"this":[229],"article":[230],"aims":[231],"guide":[233],"practice":[237],"context":[245],"tumors,":[250],"primary":[255],"Portugal.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-07-12T00:00:00"}