{"id":"https://openalex.org/W4285028485","doi":"https://doi.org/10.1111/febs.16575","title":"Sac1 phosphatidylinositol 4\u2010phosphate phosphatase is a novel host cell factor regulating hepatitis B virus particles assembly and release","display_name":"Sac1 phosphatidylinositol 4\u2010phosphate phosphatase is a novel host cell factor regulating hepatitis B virus particles assembly and release","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4285028485","doi":"https://doi.org/10.1111/febs.16575","pmid":"https://pubmed.ncbi.nlm.nih.gov/35816160"},"language":"en","primary_location":{"id":"doi:10.1111/febs.16575","doi":"https://doi.org/10.1111/febs.16575","is_oa":false,"landing_page_url":"https://doi.org/10.1111/febs.16575","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066435406","display_name":"Mirela\u2010Andreea Popescu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160445","display_name":"Institute of Biochemistry","ror":"https://ror.org/054sgna66","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210160445"]},{"id":"https://openalex.org/I58077936","display_name":"Romanian Academy","ror":"https://ror.org/0561n6946","country_code":"RO","type":"archive","lineage":["https://openalex.org/I58077936"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Mirela\u2010Andreea Popescu","raw_affiliation_strings":["Institute of Biochemistry of the Romanian Academy, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry of the Romanian Academy, Bucharest, Romania","institution_ids":["https://openalex.org/I4210160445","https://openalex.org/I58077936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013334520","display_name":"David Sebastian Patriche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160445","display_name":"Institute of Biochemistry","ror":"https://ror.org/054sgna66","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210160445"]},{"id":"https://openalex.org/I58077936","display_name":"Romanian Academy","ror":"https://ror.org/0561n6946","country_code":"RO","type":"archive","lineage":["https://openalex.org/I58077936"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"David Patriche","raw_affiliation_strings":["Institute of Biochemistry of the Romanian Academy, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry of the Romanian Academy, Bucharest, Romania","institution_ids":["https://openalex.org/I4210160445","https://openalex.org/I58077936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065898875","display_name":"Mihaela\u2010Olivia Dobrica","orcid":"https://orcid.org/0000-0003-3622-712X","observed_orcids":["https://orcid.org/0000-0003-3622-712X"]},"institutions":[{"id":"https://openalex.org/I4210160445","display_name":"Institute of Biochemistry","ror":"https://ror.org/054sgna66","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210160445"]},{"id":"https://openalex.org/I58077936","display_name":"Romanian Academy","ror":"https://ror.org/0561n6946","country_code":"RO","type":"archive","lineage":["https://openalex.org/I58077936"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Mihaela\u2010Olivia Dobrica","raw_affiliation_strings":["Institute of Biochemistry of the Romanian Academy, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry of the Romanian Academy, Bucharest, Romania","institution_ids":["https://openalex.org/I4210160445","https://openalex.org/I58077936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036611032","display_name":"Ana\u2010Maria Pantazica","orcid":"https://orcid.org/0000-0001-7958-1474","observed_orcids":["https://orcid.org/0000-0001-7958-1474"]},"institutions":[{"id":"https://openalex.org/I4210160445","display_name":"Institute of Biochemistry","ror":"https://ror.org/054sgna66","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210160445"]},{"id":"https://openalex.org/I58077936","display_name":"Romanian Academy","ror":"https://ror.org/0561n6946","country_code":"RO","type":"archive","lineage":["https://openalex.org/I58077936"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Ana\u2010Maria Pantazica","raw_affiliation_strings":["Institute of Biochemistry of the Romanian Academy, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry of the Romanian Academy, Bucharest, Romania","institution_ids":["https://openalex.org/I4210160445","https://openalex.org/I58077936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053363988","display_name":"Petruta\u2010Ramona Flintoaca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160445","display_name":"Institute of Biochemistry","ror":"https://ror.org/054sgna66","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210160445"]},{"id":"https://openalex.org/I58077936","display_name":"Romanian Academy","ror":"https://ror.org/0561n6946","country_code":"RO","type":"archive","lineage":["https://openalex.org/I58077936"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Petruta\u2010Ramona Flintoaca (Alexandru)","raw_affiliation_strings":["Institute of Biochemistry of the Romanian Academy, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry of the Romanian Academy, Bucharest, Romania","institution_ids":["https://openalex.org/I4210160445","https://openalex.org/I58077936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073351964","display_name":"Yves Rouill\u00e9","orcid":"https://orcid.org/0000-0003-0788-9271","observed_orcids":["https://orcid.org/0000-0003-0788-9271"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210098529","display_name":"Center for Infection and Immunity of Lille","ror":"https://ror.org/00dyt5s15","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210096427","https://openalex.org/I4210098529"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yves Rouill\u00e9","raw_affiliation_strings":["Institut Pasteur de Lille, CHU Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, University of Lille, CNRS, Inserm, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Lille, CHU Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, University of Lille, CNRS, Inserm, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210098529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073926339","display_name":"Costin-Ioan Popescu","orcid":"https://orcid.org/0000-0003-1213-4623","observed_orcids":["https://orcid.org/0000-0003-1213-4623"]},"institutions":[{"id":"https://openalex.org/I4210160445","display_name":"Institute of Biochemistry","ror":"https://ror.org/054sgna66","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210160445"]},{"id":"https://openalex.org/I58077936","display_name":"Romanian Academy","ror":"https://ror.org/0561n6946","country_code":"RO","type":"archive","lineage":["https://openalex.org/I58077936"]}],"countries":["RO"],"is_corresponding":true,"raw_author_name":"Costin\u2010Ioan Popescu","raw_affiliation_strings":["Institute of Biochemistry of the Romanian Academy, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry of the Romanian Academy, Bucharest, Romania","institution_ids":["https://openalex.org/I4210160445","https://openalex.org/I58077936"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039169396","display_name":"Norica Branza\u2010Nichita","orcid":"https://orcid.org/0000-0001-7896-7930","observed_orcids":["https://orcid.org/0000-0001-7896-7930"]},"institutions":[{"id":"https://openalex.org/I4210160445","display_name":"Institute of Biochemistry","ror":"https://ror.org/054sgna66","country_code":"RO","type":"education","lineage":["https://openalex.org/I4210160445"]},{"id":"https://openalex.org/I58077936","display_name":"Romanian Academy","ror":"https://ror.org/0561n6946","country_code":"RO","type":"archive","lineage":["https://openalex.org/I58077936"]}],"countries":["RO"],"is_corresponding":true,"raw_author_name":"Norica Branza\u2010Nichita","raw_affiliation_strings":["Institute of Biochemistry of the Romanian Academy, Bucharest, Romania"],"raw_orcid":"https://orcid.org/0000-0001-7896-7930","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry of the Romanian Academy, Bucharest, Romania","institution_ids":["https://openalex.org/I4210160445","https://openalex.org/I58077936"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5039169396","https://openalex.org/A5073926339"],"corresponding_institution_ids":["https://openalex.org/I4210160445","https://openalex.org/I58077936"],"apc_list":{"value":4450,"currency":"USD","value_usd":4450},"apc_paid":null,"fwci":1.5462,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.7985065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"289","issue":"23","first_page":"7486","last_page":"7499"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sac1","display_name":"Sac1","score":0.8159999847412109},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9649999737739563},{"id":"https://openalex.org/keywords/virus-assembly","display_name":"viral assembly","score":0.6869999766349792},{"id":"https://openalex.org/keywords/virus-release","display_name":"virus release","score":0.824999988079071},{"id":"https://openalex.org/keywords/host-cell-factors","display_name":"host cell factors","score":0.5630000233650208},{"id":"https://openalex.org/keywords/phosphoinositide-metabolism","display_name":"phosphoinositide metabolism","score":0.9459999799728394},{"id":"https://openalex.org/keywords/trans-golgi-network","display_name":"trans-Golgi network","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hbv-envelope-proteins","display_name":"HBV envelope proteins","score":0.7730000019073486},{"id":"https://openalex.org/keywords/endosomal-trafficking","display_name":"endosomal trafficking","score":0.777999997138977},{"id":"https://openalex.org/keywords/envelopment","display_name":"envelopment","score":0.5960000157356262},{"id":"https://openalex.org/keywords/phospholipid-metabolism","display_name":"phospholipid metabolism","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.736114501953125},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5994862914085388},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5153231024742126},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.487588107585907},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4321771264076233},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4215736985206604},{"id":"https://openalex.org/C3020564189","wikidata":"https://www.wikidata.org/wiki/Q16963978","display_name":"Host factors","level":3,"score":0.4206651449203491},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.4133608341217041},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41081559658050537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33385777473449707},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2993675768375397},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.24089854955673218},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07267230749130249}],"mesh":[{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/febs.16575","doi":"https://doi.org/10.1111/febs.16575","is_oa":false,"landing_page_url":"https://doi.org/10.1111/febs.16575","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},{"id":"pmid:35816160","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35816160","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W263971884","https://openalex.org/W1588768449","https://openalex.org/W1723155917","https://openalex.org/W1968913867","https://openalex.org/W1977709885","https://openalex.org/W1984646698","https://openalex.org/W1997385930","https://openalex.org/W2001956269","https://openalex.org/W2011564077","https://openalex.org/W2020377485","https://openalex.org/W2022144068","https://openalex.org/W2028248159","https://openalex.org/W2040942663","https://openalex.org/W2043312574","https://openalex.org/W2043892409","https://openalex.org/W2044841339","https://openalex.org/W2049508769","https://openalex.org/W2061171442","https://openalex.org/W2063396120","https://openalex.org/W2065925117","https://openalex.org/W2069527559","https://openalex.org/W2075595885","https://openalex.org/W2088679015","https://openalex.org/W2089670256","https://openalex.org/W2092110803","https://openalex.org/W2113985215","https://openalex.org/W2122700485","https://openalex.org/W2124393593","https://openalex.org/W2135719897","https://openalex.org/W2136161036","https://openalex.org/W2158422128","https://openalex.org/W2162228329","https://openalex.org/W2164080428","https://openalex.org/W2171584951","https://openalex.org/W2191036287","https://openalex.org/W2201376437","https://openalex.org/W2209395704","https://openalex.org/W2254771637","https://openalex.org/W2381174496","https://openalex.org/W2510682999","https://openalex.org/W2600950260","https://openalex.org/W2761934676","https://openalex.org/W2768612971","https://openalex.org/W2785773239","https://openalex.org/W2786631445","https://openalex.org/W2789706707","https://openalex.org/W2912141593","https://openalex.org/W2972716999","https://openalex.org/W3005278177","https://openalex.org/W3015373708","https://openalex.org/W3082987907","https://openalex.org/W3134100017","https://openalex.org/W6600120041"],"related_works":["https://openalex.org/W4365816534","https://openalex.org/W3015373708","https://openalex.org/W2789706707","https://openalex.org/W2972716999","https://openalex.org/W2049508769","https://openalex.org/W2139250806","https://openalex.org/W2043892409","https://openalex.org/W1723155917","https://openalex.org/W7098765830","https://openalex.org/W4393382545"],"abstract_inverted_index":{"The":[0],"life-cycle":[1],"of":[2,15,29,70,92,104,125,152,178,196,203,237],"the":[3,13,26,30,39,57,68,93,102,105,110,119,123,130,204,209],"Hepatitis":[4],"B":[5],"Virus":[6],"(HBV),":[7],"an":[8],"enveloped":[9],"DNA":[10,239],"virus":[11,214],"affecting":[12],"lives":[14],"more":[16],"than":[17],"296":[18],"million":[19],"chronicallyinfected":[20],"people,":[21],"is":[22,54,90],"tightly":[23],"dependent":[24],"on":[25],"lipid":[27,40,127],"metabolism":[28,59],"host":[31,232],"cell.":[32],"Fatty":[33],"acids":[34],"and":[35,49,87,121,140,164,194,200,216],"cholesterol":[36],"are":[37,221],"among":[38],"factors":[41],"with":[42,78,98,171],"documented":[43],"roles":[44,226],"in":[45,60,81,84,158,187,191],"regulating":[46,235],"HBV":[47,85,167,205],"replication":[48],"infection,":[50],"respectively,":[51],"but":[52],"little":[53],"known":[55],"about":[56],"phosphoinositide":[58,97],"these":[61,219],"processes.":[62],"In":[63],"this":[64,126,159],"study,":[65],"we":[66,161],"investigated":[67],"role":[69],"Sac1,":[71,228],"a":[72,149,172,230,238],"highly":[73,111],"conserved":[74],"phosphatidylinositol-4-phosphate":[75],"(PI4P)":[76],"phosphatase,":[77],"essential":[79],"functions":[80,100],"phospholipid":[82],"metabolism,":[83],"assembly,":[86],"release.":[88],"PI4P":[89,198],"one":[91],"most":[94],"abundant":[95],"cellular":[96,169],"complex":[99],"at":[101,129],"level":[103],"secretory":[106],"pathway.":[107],"Owing":[108],"to":[109,208],"specific":[112,145],"phosphatase":[113],"activity":[114],"toward":[115],"PI4P,":[116],"Sac1":[117,153,179,185],"controls":[118],"levels":[120,193],"restricts":[122],"localization":[124],"particularly":[128],"trans-Golgi":[131],"network,":[132],"where":[133],"it":[134],"regulates":[135],"sphingolipid":[136],"synthesis,":[137],"proteins":[138,207],"sorting,":[139],"vesicles":[141],"budding,":[142],"by":[143],"recruiting":[144],"adaptor":[146],"proteins.":[147],"As":[148],"complete":[150],"loss":[151],"function":[154],"compromises":[155],"cell":[156,233],"viability,":[157],"work,":[160],"first":[162],"developed":[163],"characterized":[165],"several":[166],"replication-permissive":[168],"models":[170],"moderate,":[173],"transient,":[174],"or":[175],"stable":[176],"downregulation":[177],"expression.":[180],"Our":[181],"results":[182,190],"show":[183],"that":[184],"depletion":[186],"hepatic":[188],"cells":[189,220],"increased":[192],"redistribution":[195],"intracellular":[197],"pools":[199],"impaired":[201],"trafficking":[202],"envelope":[206],"endosomal":[210],"vesicular":[211],"network.":[212],"Importantly,":[213],"envelopment":[215],"release":[217],"from":[218],"significantly":[222],"inhibited,":[223],"revealing":[224],"novel":[225],"for":[227],"as":[229],"key":[231],"factor":[234],"morphogenesis":[236],"virus.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-12T00:00:00"}