{"id":"https://openalex.org/W4285022343","doi":"https://doi.org/10.1242/dev.200335","title":"Mechanisms underlying WNT-mediated priming of human embryonic stem cells","display_name":"Mechanisms underlying WNT-mediated priming of human embryonic stem cells","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4285022343","doi":"https://doi.org/10.1242/dev.200335","pmid":"https://pubmed.ncbi.nlm.nih.gov/35815787","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9357376"},"language":"en","primary_location":{"id":"doi:10.1242/dev.200335","doi":"https://doi.org/10.1242/dev.200335","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.200335","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1242/dev.200335","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012905274","display_name":"Anna Yoney","orcid":"https://orcid.org/0000-0003-4988-9237","observed_orcids":["https://orcid.org/0000-0003-4988-9237"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Yoney","raw_affiliation_strings":["Center for Studies in Physics and Biology, The Rockefeller University","Laboratory of Stem Cell biology and Molecular Embryology, The Rockefeller University","Center for Studies in Physics and Biology, The Rockefeller University 1 , New York, NY 10065 , USA","The Rockefeller University 2 Laboratory of Synthetic Embryology , , New York, NY 10065 , USA"],"raw_orcid":"https://orcid.org/0000-0003-4988-9237","affiliations":[{"raw_affiliation_string":"Center for Studies in Physics and Biology, The Rockefeller University","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Stem Cell biology and Molecular Embryology, The Rockefeller University","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Center for Studies in Physics and Biology, The Rockefeller University 1 , New York, NY 10065 , USA","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"The Rockefeller University 2 Laboratory of Synthetic Embryology , , New York, NY 10065 , USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026169690","display_name":"Lu Bai","orcid":"https://orcid.org/0000-0003-3667-2944","observed_orcids":["https://orcid.org/0000-0003-3667-2944"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Bai","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Department of Physics, Center for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park","Center for Eukaryotic Gene Regulation, The Pennsylvania State University 3 Department of Biochemistry and Molecular Biology, Department of Physics , , University Park, PA 16802 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Department of Physics, Center for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Center for Eukaryotic Gene Regulation, The Pennsylvania State University 3 Department of Biochemistry and Molecular Biology, Department of Physics , , University Park, PA 16802 , USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016600632","display_name":"Ali H. Brivanlou","orcid":"https://orcid.org/0000-0002-1761-280X","observed_orcids":["https://orcid.org/0000-0002-1761-280X"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ali H. Brivanlou","raw_affiliation_strings":["Laboratory of Stem Cell biology and Molecular Embryology, The Rockefeller University","The Rockefeller University 2 Laboratory of Synthetic Embryology , , New York, NY 10065 , USA"],"raw_orcid":"https://orcid.org/0000-0002-1761-280X","affiliations":[{"raw_affiliation_string":"Laboratory of Stem Cell biology and Molecular Embryology, The Rockefeller University","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"The Rockefeller University 2 Laboratory of Synthetic Embryology , , New York, NY 10065 , USA","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036408112","display_name":"Eric D. Siggia","orcid":"https://orcid.org/0000-0001-7482-1854","observed_orcids":["https://orcid.org/0000-0001-7482-1854"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric D. Siggia","raw_affiliation_strings":["Center for Studies in Physics and Biology, The Rockefeller University","Center for Studies in Physics and Biology, The Rockefeller University 1 , New York, NY 10065 , USA"],"raw_orcid":"https://orcid.org/0000-0001-7482-1854","affiliations":[{"raw_affiliation_string":"Center for Studies in Physics and Biology, The Rockefeller University","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Center for Studies in Physics and Biology, The Rockefeller University 1 , New York, NY 10065 , USA","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016600632","https://openalex.org/A5036408112"],"corresponding_institution_ids":["https://openalex.org/I83399316"],"apc_list":null,"apc_paid":null,"fwci":0.9778,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.71529576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"149","issue":"20","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.459199994802475,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.459199994802475,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.4569999873638153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.06310000270605087,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9929999709129333},{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/cell-priming","display_name":"cell priming","score":0.6100000143051147},{"id":"https://openalex.org/keywords/activin-signaling","display_name":"activin signaling","score":0.7269999980926514},{"id":"https://openalex.org/keywords/smad2","display_name":"Smad2","score":0.878000020980835},{"id":"https://openalex.org/keywords/eomes","display_name":"Eomes","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mesendoderm-differentiation","display_name":"mesendoderm differentiation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cellular-memory","display_name":"cellular memory","score":0.7630000114440918},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.4659999907016754},{"id":"https://openalex.org/keywords/in-vitro-embryo-models","display_name":"in vitro embryo models","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9051493406295776},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8497474193572998},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6909316778182983},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.672808825969696},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5475013852119446},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.508770763874054},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5075379610061646},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4649082124233246},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.4309561252593994},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.40327122807502747},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24557730555534363},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08525329828262329},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000066449","descriptor_name":"Human Embryonic Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028341","descriptor_name":"Activins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028341","descriptor_name":"Activins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1242/dev.200335","doi":"https://doi.org/10.1242/dev.200335","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.200335","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"doi:10.1101/2021.05.01.442278","doi":"https://doi.org/10.1101/2021.05.01.442278","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.05.01.442278","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/05/01/2021.05.01.442278.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:9357376","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9357376","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"Text"},{"id":"pmid:35815787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35815787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1242/dev.200335","doi":"https://doi.org/10.1242/dev.200335","is_oa":true,"landing_page_url":"https://doi.org/10.1242/dev.200335","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2378112088","display_name":"Mechanistic study of pioneer factors","funder_award_id":"R01GM121858","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4000699704","display_name":"Combining dynamics of ligand presentation with dynamics of hESC response in colonies with defined architecture","funder_award_id":"R01GM101653","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000873605","display_name":"Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation","funder_award_id":"R35GM139654","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285022343.pdf","grobid_xml":"https://content.openalex.org/works/W4285022343.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1531821806","https://openalex.org/W1963780732","https://openalex.org/W1967088584","https://openalex.org/W1970098795","https://openalex.org/W1977509897","https://openalex.org/W1980236812","https://openalex.org/W1994758141","https://openalex.org/W1996583924","https://openalex.org/W2002973634","https://openalex.org/W2007580726","https://openalex.org/W2008005638","https://openalex.org/W2008134301","https://openalex.org/W2012049188","https://openalex.org/W2013932533","https://openalex.org/W2024181148","https://openalex.org/W2036233315","https://openalex.org/W2038404321","https://openalex.org/W2038492487","https://openalex.org/W2040306164","https://openalex.org/W2040654271","https://openalex.org/W2049820630","https://openalex.org/W2053702504","https://openalex.org/W2057581247","https://openalex.org/W2059526735","https://openalex.org/W2070539534","https://openalex.org/W2074744546","https://openalex.org/W2074884450","https://openalex.org/W2082019843","https://openalex.org/W2086327775","https://openalex.org/W2095298909","https://openalex.org/W2098049105","https://openalex.org/W2101889783","https://openalex.org/W2102663142","https://openalex.org/W2104490470","https://openalex.org/W2121372493","https://openalex.org/W2132729210","https://openalex.org/W2144578935","https://openalex.org/W2156314428","https://openalex.org/W2156661861","https://openalex.org/W2158544588","https://openalex.org/W2160266371","https://openalex.org/W2161949020","https://openalex.org/W2165459289","https://openalex.org/W2170441682","https://openalex.org/W2176034226","https://openalex.org/W2179438025","https://openalex.org/W2225799406","https://openalex.org/W2555109040","https://openalex.org/W2750416916","https://openalex.org/W2781327172","https://openalex.org/W2800557011","https://openalex.org/W2804537880","https://openalex.org/W2916725746","https://openalex.org/W2946618087","https://openalex.org/W2949967751","https://openalex.org/W2950348262","https://openalex.org/W2990122700","https://openalex.org/W3008366397"],"related_works":["https://openalex.org/W2936095980","https://openalex.org/W2895148380","https://openalex.org/W2149660935","https://openalex.org/W2161949020","https://openalex.org/W2949967751","https://openalex.org/W2067056027","https://openalex.org/W7096354404","https://openalex.org/W2027310534","https://openalex.org/W4210553678","https://openalex.org/W2078093070"],"abstract_inverted_index":{"Embryogenesis":[0],"is":[1,20,117],"guided":[2],"by":[3,72,105],"a":[4,16,24],"limited":[5],"set":[6],"of":[7,27,39,58,109,115,123],"signaling":[8,18,63,74],"pathways":[9],"dynamically":[10],"expressed":[11],"in":[12,36,137],"different":[13],"places.":[14],"How":[15],"context-dependent":[17],"response":[19],"generated":[21],"has":[22],"been":[23,69],"central":[25],"question":[26],"developmental":[28],"biology,":[29],"which":[30],"can":[31,75],"now":[32],"be":[33],"addressed":[34],"with":[35],"vitro":[37],"models":[38],"human":[40],"embryos":[41],"that":[42,54,67,90],"are":[43],"derived":[44],"from":[45],"embryonic":[46],"stem":[47],"cells":[48,61,66],"(hESCs).":[49],"Our":[50],"previous":[51],"work":[52],"demonstrated":[53],"during":[55],"early":[56,138],"stages":[57],"hESC":[59],"differentiation,":[60,126],"chronicle":[62],"hierarchy.":[64],"Only":[65],"have":[68],"exposed":[70],"(primed)":[71],"WNT":[73,91,121],"respond":[76],"to":[77,83,119],"subsequent":[78],"activin":[79],"exposure":[80],"and":[81,134],"differentiate":[82],"mesendodermal":[84],"(ME)":[85],"fates.":[86],"Here,":[87],"we":[88],"show":[89],"priming":[92,133],"does":[93],"not":[94],"alter":[95],"SMAD2":[96,111],"binding":[97],"nor":[98],"its":[99],"chromatin":[100],"opening":[101],"but,":[102],"instead,":[103],"acts":[104],"inducing":[106],"the":[107,110,129],"expression":[108],"co-factor":[112],"EOMES.":[113],"Expression":[114],"EOMES":[116],"sufficient":[118],"replace":[120],"upstream":[122],"activin-mediated":[124],"ME":[125],"thus":[127],"unveiling":[128],"mechanistic":[130],"basis":[131],"for":[132],"cellular":[135],"memory":[136],"development.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-12T00:00:00"}