{"id":"https://openalex.org/W4285019703","doi":"https://doi.org/10.1080/15287394.2022.2095546","title":"Cecropia pachystachya Tr\u00e9cul: identification, isolation of secondary metabolites, in silico study of toxicological evaluation and interaction with the enzymes 5-LOX and \u03b1-1-antitrypsin","display_name":"Cecropia pachystachya Tr\u00e9cul: identification, isolation of secondary metabolites, in silico study of toxicological evaluation and interaction with the enzymes 5-LOX and \u03b1-1-antitrypsin","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4285019703","doi":"https://doi.org/10.1080/15287394.2022.2095546","pmid":"https://pubmed.ncbi.nlm.nih.gov/35815836"},"language":"en","primary_location":{"id":"doi:10.1080/15287394.2022.2095546","doi":"https://doi.org/10.1080/15287394.2022.2095546","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287394.2022.2095546","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health, Part A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060854382","display_name":"Penina Sousa Mour\u00e3o","orcid":"https://orcid.org/0000-0001-7504-7258","observed_orcids":["https://orcid.org/0000-0001-7504-7258"]},"institutions":[{"id":"https://openalex.org/I3123346794","display_name":"Universidade Estadual do Piau\u00ed","ror":"https://ror.org/02na6tz09","country_code":"BR","type":"education","lineage":["https://openalex.org/I3123346794"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Penina Sousa Mour\u00e3o","raw_affiliation_strings":["Department of Chemistry, Natural Science Center, Piau\u00ed State University, Teresina, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-7504-7258","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Natural Science Center, Piau\u00ed State University, Teresina, Brazil","institution_ids":["https://openalex.org/I3123346794"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rafael de Oliveira Gomes","orcid":"https://orcid.org/0000-0003-4774-9839","observed_orcids":["https://orcid.org/0000-0003-4774-9839"]},"institutions":[{"id":"https://openalex.org/I3123346794","display_name":"Universidade Estadual do Piau\u00ed","ror":"https://ror.org/02na6tz09","country_code":"BR","type":"education","lineage":["https://openalex.org/I3123346794"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafael de Oliveira Gomes","raw_affiliation_strings":["Department of Chemistry, Natural Science Center, Piau\u00ed State University, Teresina, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-4774-9839","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Natural Science Center, Piau\u00ed State University, Teresina, Brazil","institution_ids":["https://openalex.org/I3123346794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080295191","display_name":"Clara Andrezza Cris\u00f3stomo Bezerra Costa","orcid":"https://orcid.org/0000-0002-6474-221X","observed_orcids":["https://orcid.org/0000-0002-6474-221X"]},"institutions":[{"id":"https://openalex.org/I4210155484","display_name":"Instituto Federal de Educa\u00e7\u00e3o, Ci\u00eancia e Tecnologia de Alagoas","ror":"https://ror.org/040ys9e84","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210155484"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Clara Andrezza Cris\u00f3stomo Bezerra Costa","raw_affiliation_strings":["Department of Chemistry, Federal Institute of Alagoas, Macei\u00f3, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-6474-221X","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Federal Institute of Alagoas, Macei\u00f3, Brazil","institution_ids":["https://openalex.org/I4210155484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063759454","display_name":"Orlando Francisco da Silva Moura","orcid":"https://orcid.org/0000-0002-1055-8564","observed_orcids":["https://orcid.org/0000-0002-1055-8564"]},"institutions":[{"id":"https://openalex.org/I4210155484","display_name":"Instituto Federal de Educa\u00e7\u00e3o, Ci\u00eancia e Tecnologia de Alagoas","ror":"https://ror.org/040ys9e84","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210155484"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Orlando Francisco da Silva Moura","raw_affiliation_strings":["Department of Chemistry, Federal Institute of Alagoas, Macei\u00f3, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-1055-8564","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Federal Institute of Alagoas, Macei\u00f3, Brazil","institution_ids":["https://openalex.org/I4210155484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024200199","display_name":"Herbert Gonzaga Sousa","orcid":"https://orcid.org/0000-0001-8633-9918","observed_orcids":["https://orcid.org/0000-0001-8633-9918"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Herbert Gonzaga Sousa","raw_affiliation_strings":["Department of Chemistry, Natural Science Center, Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-8633-9918","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Natural Science Center, Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087722577","display_name":"George Roberto Lemos Martins J\u00fanior","orcid":"https://orcid.org/0000-0002-6784-1977","observed_orcids":["https://orcid.org/0000-0002-6784-1977"]},"institutions":[{"id":"https://openalex.org/I3123346794","display_name":"Universidade Estadual do Piau\u00ed","ror":"https://ror.org/02na6tz09","country_code":"BR","type":"education","lineage":["https://openalex.org/I3123346794"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"George Roberto Lemos Martins J\u00fanior","raw_affiliation_strings":["Health Sciences Department, Piau\u00ed State University, Teresina, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-6784-1977","affiliations":[{"raw_affiliation_string":"Health Sciences Department, Piau\u00ed State University, Teresina, Brazil","institution_ids":["https://openalex.org/I3123346794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000136218","display_name":"Danniel Cabral Le\u00e3o Ferreira","orcid":"https://orcid.org/0000-0002-0717-2900","observed_orcids":["https://orcid.org/0000-0002-0717-2900"]},"institutions":[{"id":"https://openalex.org/I3123346794","display_name":"Universidade Estadual do Piau\u00ed","ror":"https://ror.org/02na6tz09","country_code":"BR","type":"education","lineage":["https://openalex.org/I3123346794"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Danniel Cabral Le\u00e3o Ferreira","raw_affiliation_strings":["Health Sciences Department, Piau\u00ed State University, Teresina, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-0717-2900","affiliations":[{"raw_affiliation_string":"Health Sciences Department, Piau\u00ed State University, Teresina, Brazil","institution_ids":["https://openalex.org/I3123346794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017864347","display_name":"Ant\u00f4nio Lu\u00edz Martins Maia Filho","orcid":"https://orcid.org/0000-0001-6184-8003","observed_orcids":["https://orcid.org/0000-0001-6184-8003"]},"institutions":[{"id":"https://openalex.org/I3123346794","display_name":"Universidade Estadual do Piau\u00ed","ror":"https://ror.org/02na6tz09","country_code":"BR","type":"education","lineage":["https://openalex.org/I3123346794"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ant\u00f4nio Luiz Martins Maia Filho","raw_affiliation_strings":["Department of Chemistry, Natural Science Center, Piau\u00ed State University, Teresina, Brazil","Health Sciences Department, Piau\u00ed State University, Teresina, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-6184-8003","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Natural Science Center, Piau\u00ed State University, Teresina, Brazil","institution_ids":["https://openalex.org/I3123346794"]},{"raw_affiliation_string":"Health Sciences Department, Piau\u00ed State University, Teresina, Brazil","institution_ids":["https://openalex.org/I3123346794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082048954","display_name":"Johnnatan Duarte de Freitas","orcid":"https://orcid.org/0000-0002-6977-3322","observed_orcids":["https://orcid.org/0000-0002-6977-3322"]},"institutions":[{"id":"https://openalex.org/I4210155484","display_name":"Instituto Federal de Educa\u00e7\u00e3o, Ci\u00eancia e Tecnologia de Alagoas","ror":"https://ror.org/040ys9e84","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210155484"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Johnnatan Duarte de Freitas","raw_affiliation_strings":["Department of Chemistry, Federal Institute of Alagoas, Macei\u00f3, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-6977-3322","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Federal Institute of Alagoas, Macei\u00f3, Brazil","institution_ids":["https://openalex.org/I4210155484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011683136","display_name":"Mahendra Rai","orcid":"https://orcid.org/0000-0003-0291-0422","observed_orcids":["https://orcid.org/0000-0003-0291-0422"]},"institutions":[{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Mahendra Rai","raw_affiliation_strings":["Department of Microbiology, Nicolaus Copernicus University, Torun, Poland"],"raw_orcid":"https://orcid.org/0000-0003-0291-0422","affiliations":[{"raw_affiliation_string":"Department of Microbiology, Nicolaus Copernicus University, Torun, Poland","institution_ids":["https://openalex.org/I3019271933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113161846","display_name":"Francisco das Chagas Alves Lima","orcid":"https://orcid.org/0000-0002-0447-4911","observed_orcids":["https://orcid.org/0000-0002-0447-4911"]},"institutions":[{"id":"https://openalex.org/I3123346794","display_name":"Universidade Estadual do Piau\u00ed","ror":"https://ror.org/02na6tz09","country_code":"BR","type":"education","lineage":["https://openalex.org/I3123346794"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Francisco Das Chagas Alves Lima","raw_affiliation_strings":["Biotechnology Department, Piau\u00ed State University, Teresina, Brazil","Department of Chemistry, Natural Science Center, Piau\u00ed State University, Teresina, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-0447-4911","affiliations":[{"raw_affiliation_string":"Biotechnology Department, Piau\u00ed State University, Teresina, Brazil","institution_ids":["https://openalex.org/I3123346794"]},{"raw_affiliation_string":"Department of Chemistry, Natural Science Center, Piau\u00ed State University, Teresina, Brazil","institution_ids":["https://openalex.org/I3123346794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102985161","display_name":"Ant\u00f4nio Euz\u00e9bio Goulart Santana","orcid":"https://orcid.org/0000-0002-3750-438X","observed_orcids":["https://orcid.org/0000-0002-3750-438X"]},"institutions":[{"id":"https://openalex.org/I79889768","display_name":"Universidade Federal de Alagoas","ror":"https://ror.org/00dna7t83","country_code":"BR","type":"education","lineage":["https://openalex.org/I79889768"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Antonio Euz\u00e9bio Gourlart Santana","raw_affiliation_strings":["Center of Engineering and Agrarian Science, Federal University of Alagoas, Rio Largo, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-3750-438X","affiliations":[{"raw_affiliation_string":"Center of Engineering and Agrarian Science, Federal University of Alagoas, Rio Largo, Brazil","institution_ids":["https://openalex.org/I79889768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001253459","display_name":"Mariana Helena Chaves","orcid":"https://orcid.org/0000-0003-1541-6757","observed_orcids":["https://orcid.org/0000-0003-1541-6757"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mariana Helena Chaves","raw_affiliation_strings":["Department of Chemistry, Natural Science Center, Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-1541-6757","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Natural Science Center, Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066988720","display_name":"Wellington dos Santos Alves","orcid":"https://orcid.org/0000-0003-1114-773X","observed_orcids":["https://orcid.org/0000-0003-1114-773X"]},"institutions":[{"id":"https://openalex.org/I3123346794","display_name":"Universidade Estadual do Piau\u00ed","ror":"https://ror.org/02na6tz09","country_code":"BR","type":"education","lineage":["https://openalex.org/I3123346794"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Wellington Dos Santos Alves","raw_affiliation_strings":["Health Sciences Department, Piau\u00ed State University, Teresina, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-1114-773X","affiliations":[{"raw_affiliation_string":"Health Sciences Department, Piau\u00ed State University, Teresina, Brazil","institution_ids":["https://openalex.org/I3123346794"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054723275","display_name":"Valdil\u00e9ia Teixeira Uch\u00f4a","orcid":"https://orcid.org/0000-0001-8080-6335","observed_orcids":["https://orcid.org/0000-0001-8080-6335"]},"institutions":[{"id":"https://openalex.org/I3123346794","display_name":"Universidade Estadual do Piau\u00ed","ror":"https://ror.org/02na6tz09","country_code":"BR","type":"education","lineage":["https://openalex.org/I3123346794"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Valdil\u00e9ia Teixeira Uch\u00f4a","raw_affiliation_strings":["Department of Chemistry, Natural Science Center, Piau\u00ed State University, Teresina, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-8080-6335","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Natural Science Center, Piau\u00ed State University, Teresina, Brazil","institution_ids":["https://openalex.org/I3123346794"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5054723275"],"corresponding_institution_ids":["https://openalex.org/I3123346794"],"apc_list":null,"apc_paid":null,"fwci":1.0422,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.7185923,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"85","issue":"20","first_page":"827","last_page":"849"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cecropia-pachystachya","display_name":"Cecropia pachystachya","score":0.984000027179718},{"id":"https://openalex.org/keywords/secondary-metabolites","display_name":"secondary metabolites","score":0.8650000095367432},{"id":"https://openalex.org/keywords/5-lipoxygenase","display_name":"5-lipoxygenase","score":0.8330000042915344},{"id":"https://openalex.org/keywords/alpha-1-antitrypsin","display_name":"alpha-1-antitrypsin","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tormentic-acid","display_name":"tormentic acid","score":0.5820000171661377},{"id":"https://openalex.org/keywords/lupeol","display_name":"lupeol","score":0.6359999775886536},{"id":"https://openalex.org/keywords/chlorogenic-acid","display_name":"chlorogenic acid","score":0.5479999780654907},{"id":"https://openalex.org/keywords/catechins","display_name":"catechins","score":0.6159999966621399},{"id":"https://openalex.org/keywords/amyrin","display_name":"amyrin","score":0.47999998927116394},{"id":"https://openalex.org/keywords/admet-prediction","display_name":"ADMET prediction","score":0.6240000128746033},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8849999904632568},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.5989999771118164},{"id":"https://openalex.org/keywords/chronic-lung-disease","display_name":"chronic lung disease","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7709786891937256},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6206081509590149},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5759504437446594},{"id":"https://openalex.org/C2779782153","wikidata":"https://www.wikidata.org/wiki/Q409366","display_name":"Lupeol","level":2,"score":0.5127692818641663},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.48950088024139404},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.33900418877601624},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000515","descriptor_name":"alpha 1-Antitrypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001094","descriptor_name":"Arachidonate 5-Lipoxygenase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035702","descriptor_name":"Cecropia Plant","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/15287394.2022.2095546","doi":"https://doi.org/10.1080/15287394.2022.2095546","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15287394.2022.2095546","pdf_url":null,"source":{"id":"https://openalex.org/S85071590","display_name":"Journal of Toxicology and Environmental Health","issn_l":"0098-4108","issn":["0098-4108","1087-2620"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Toxicology and Environmental Health, Part A","raw_type":"journal-article"},{"id":"pmid:35815836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35815836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of toxicology and environmental health. Part A","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322989","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Piau\u00ed","ror":"https://ror.org/026zht694"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1488179916","https://openalex.org/W1541300744","https://openalex.org/W1547040326","https://openalex.org/W1574979166","https://openalex.org/W1967384196","https://openalex.org/W1978589460","https://openalex.org/W1981737096","https://openalex.org/W1984930439","https://openalex.org/W1989783793","https://openalex.org/W1991636410","https://openalex.org/W2002530575","https://openalex.org/W2004977808","https://openalex.org/W2010463159","https://openalex.org/W2010661807","https://openalex.org/W2017476679","https://openalex.org/W2021982728","https://openalex.org/W2024145278","https://openalex.org/W2025505123","https://openalex.org/W2026026958","https://openalex.org/W2027618337","https://openalex.org/W2030400405","https://openalex.org/W2035143882","https://openalex.org/W2067460327","https://openalex.org/W2075890649","https://openalex.org/W2078597534","https://openalex.org/W2083320711","https://openalex.org/W2086460016","https://openalex.org/W2091271911","https://openalex.org/W2092815169","https://openalex.org/W2098655668","https://openalex.org/W2099306873","https://openalex.org/W2102247255","https://openalex.org/W2113997750","https://openalex.org/W2119126597","https://openalex.org/W2123601953","https://openalex.org/W2127842194","https://openalex.org/W2132629607","https://openalex.org/W2160385021","https://openalex.org/W2171528706","https://openalex.org/W2232069134","https://openalex.org/W2253312929","https://openalex.org/W2488935454","https://openalex.org/W2594248518","https://openalex.org/W2597756443","https://openalex.org/W2604562184","https://openalex.org/W2763702754","https://openalex.org/W2788305318","https://openalex.org/W2790149603","https://openalex.org/W2887349339","https://openalex.org/W2888202503","https://openalex.org/W2925866325","https://openalex.org/W2975758310","https://openalex.org/W3005515261","https://openalex.org/W3023385072","https://openalex.org/W3035666831","https://openalex.org/W3048986564","https://openalex.org/W3081729551","https://openalex.org/W3092071449","https://openalex.org/W3094211379","https://openalex.org/W3094697182","https://openalex.org/W3110289784","https://openalex.org/W3115620230","https://openalex.org/W3116139854","https://openalex.org/W3123654431","https://openalex.org/W3154980799","https://openalex.org/W3162375509","https://openalex.org/W3178383483","https://openalex.org/W3178608774","https://openalex.org/W3182311432","https://openalex.org/W3182980422","https://openalex.org/W3185997879","https://openalex.org/W3201520849","https://openalex.org/W3204198115","https://openalex.org/W4231089776","https://openalex.org/W4232345075","https://openalex.org/W4239599512"],"related_works":["https://openalex.org/W4393870551","https://openalex.org/W2977010615","https://openalex.org/W2614539023","https://openalex.org/W4414172179","https://openalex.org/W2804209525","https://openalex.org/W7217033979","https://openalex.org/W1637705076","https://openalex.org/W3171504286","https://openalex.org/W7218087054","https://openalex.org/W2922671724"],"abstract_inverted_index":{"Cecropia":[0],"pachystachya":[1,65,222],"Tr\u00e9c.,":[2],"popularly":[3],"known":[4],"as":[5,30,68,70,243],"emba\u00faba,":[6],"belongs":[7],"to":[8,51,117,290],"the":[9,16,20,60,73,79,110,118,207,228,319,416],"Cecropiaceae":[10],"family":[11],"and":[12,29,40,54,83,99,107,128,146,165,172,182,231,300,373],"is":[13],"used":[14],"by":[15,124,149,156,167],"native":[17],"population":[18],"in":[19,86,119,238,239],"treatment":[21,248],"of":[22,47,63,75,109,216,246,318,321,415,423],"bronchitis,":[23],"asthma,":[24],"high":[25],"blood":[26],"pressure,":[27],"fever,":[28],"a":[31,194,203,213,244],"diuretic.":[32],"The":[33,45,132,176],"pharmacological":[34],"actions":[35],"including":[36],"anti-inflammatory,":[37],"antioxidant,":[38],"cardiotonic":[39],"sedative":[41],"were":[42,92,115,136,185],"previously":[43],"reported.":[44],"objective":[46],"this":[48],"study":[49],"was":[50],"(1)":[52],"isolate":[53],"identify":[55],"bioactive":[56,133,189],"compounds":[57,134],"extracted":[58],"from":[59,220],"ethanolic":[61],"extract":[62,317],"C.":[64,221,322],"roots":[66,320],"(ERCP),":[67],"well":[69],"(2)":[71],"verify":[72],"affinity":[74,196,205],"these":[76,113],"metabolites":[77,218],"with":[78,227,380,406,413],"enzymes":[80,229],"5-lipoxygenase":[81],"(5-LOX)":[82],"\u03b1-1-antitrypsin":[84,208],"through":[85],"silico":[87,120],"tests.":[88],"Isolation":[89],"and/or":[90],"identification":[91,108],"performed":[93],"using":[94],"GC-MS,":[95],"HPLC,":[96],"Infrared":[97],"(IR),":[98],"nuclear":[100],"magnetic":[101],"resonance":[102],"(NMR)":[103],"techniques.":[104,175],"After":[105],"isolation":[106],"active":[111],"compounds,":[112],"substances":[114],"subjected":[116],"investigation":[121],"that":[122,223],"proceeded":[123],"performing":[125],"PreADMET":[126],"simulations":[127],"molecular":[129],"docking":[130],"calculations.":[131],"identified":[135],"1-(+)-ascorbic":[137],"acid":[138,192],"2,6-dihexadecanoate,":[139],"ethyl":[140,142,144,147],"hexadecanoate,":[141],"(9E,12E)-octadec-9,12-dienoate,":[143],"(Z)-octadec-9-enoate":[145],"octadecanoate":[148],"GC-MS;":[150],"chlorogenic":[151],"acid,":[152,162],"catechin,":[153],"epicatechin,":[154],"syringaldehyde":[155],"HPLC;":[157],"\u03b2-sitosterol,":[158],"sitostenone,":[159],"beccaridiol,":[160],"tormentic":[161],"lupeol,":[163],"\u03b1-":[164],"\u03b2-amyrin":[166],"classical":[168],"chromatography,":[169],"IR,":[170],"1H":[171],"13C":[173],"NMR":[174],"ADMET":[177],"(absorption,":[178],"distribution,":[179],"metabolism,":[180],"excretion,":[181],"toxicity)":[183],"properties":[184],"determined":[186],"for":[187,197,206,249],"each":[188],"compound.":[190],"Tormentic":[191],"demonstrated":[193,202,212],"greater":[195],"5-LOX":[198,230],"enzyme":[199],"while":[200],"sitostenone":[201],"higher":[204],"enzyme.":[209],"Our":[210],"findings":[211],"diverse":[214],"range":[215],"secondary":[217],"isolated":[219],"showed":[224],"relevant":[225],"interactions":[226],"\u03b1-1-antitrypsin.":[232],"Thus,":[233],"\u201cemba\u00faba\u201d":[234],"may":[235],"be":[236],"employed":[237],"vivo":[240],"experimental":[241],"studies":[242],"form":[245],"alternative":[247],"chronic":[250],"lung":[251,426],"diseases.Abbreviations:":[252],"ADT:":[253],"Autodock":[254],"Tools;":[255],"BBB:":[256],"Blood-brain":[257],"barrier;":[258],"CaCo2:":[259],"Human":[260,333],"colonic":[261],"adenocarcinoma":[262],"cells;":[263,428],"CC:":[264],"Classic/open":[265],"Column;":[266],"TLC:":[267],"Thin":[268],"Layer":[269],"Chromatography;":[270,296],"CD40:":[271],"Differentiation":[272],"Cluster":[273],"40;":[274],"CENAUREMN:":[275],"Centro":[276],"Nordestino":[277],"de":[278,326,390,392],"Aplica\u00e7\u00e3o":[279],"e":[280,395],"Uso":[281],"da":[282],"Resson\u00e2ncia":[283],"Magn\u00e9tica":[284],"Nuclear;":[285],"GC-MS:":[286],"Gas":[287],"Chromatography":[288],"coupled":[289],"mass":[291],"spectrometry;":[292],"HPLC:":[293],"High-Perfomance":[294],"Liquid":[295],"CYP2C9,":[297],"CYP2C19,":[298],"CYP2D6":[299],"CYP3A4:":[301],"Cytochrome":[302],"P450":[303],"isoenzymes;":[304],"COPD:":[305],"Chronic":[306],"Obstructive":[307],"Pulmonary":[308],"Disease;":[309],"DRX-500:":[310],"X-Ray":[311],"Diffraction":[312],"\u2013":[313],"500;":[314],"ERCP:":[315],"Ethanolic":[316],"pachystachya;":[323],"FAPEPI:":[324],"Funda\u00e7\u00e3o":[325],"Amparo":[327],"\u00e0":[328],"Pesquisa":[329],"do":[330,396],"Piau\u00ed;":[331,424],"HIA:":[332],"Intestinal":[334],"Absorption;":[335],"IR:":[336],"Infrared;":[337],"Ki:":[338],"Inhibition":[339],"constant;":[340],"5-LOX:":[341],"5-Lipoxygenase;":[342],"mM:":[343],"miliMolar;":[344],"nM:":[345],"nanoMolar;":[346],"OECD423:":[347],"acute":[348],"toxic":[349],"class":[350],"method;":[351],"PDB:":[352],"Protein":[353,365],"Data":[354],"Bank;":[355],"P-gP:":[356],"P-glycoprotein;":[357],"PM2,5:":[358],"Small":[359],"inhalable":[360],"particles":[361],"2,5;":[362],"PPB:":[363],"Plasm":[364],"Binding;":[366],"PreADMET:":[367],"Prediction":[368],"Absorption,":[369],"Distribution,":[370],"Metabolization,":[371],"Excretion":[372],"Toxicity;":[374],"NMR:":[375],"Nuclear":[376],"Magnetic":[377],"Resonance;":[378],"+S9:":[379],"metabolic":[381,385],"activation;":[382,386],"-S9:":[383],"no":[384],"SisGen:":[387],"Sistema":[388],"Nacional":[389],"Gest\u00e3o":[391],"Patrim\u00f4nio":[393],"Gen\u00e9tico":[394],"Conhecimento":[397],"Tradicional":[398],"Associado;":[399],"RT:":[400],"Retention":[401],"time;":[402],"TA100:":[403],"Ames":[404,411],"test":[405,412],"TA100":[407],"cells":[408,414],"line;":[409,419],"TA1535:":[410],"TA1535":[417],"cell":[418],"UESPI:":[420],"State":[421],"University":[422],"V79:":[425],"fibroblast":[427],"\u0394G:":[429],"Gibbs":[430],"free":[431],"energy":[432],"(Kcal/mol);":[433],"\u03bcM:":[434],"microMolar.":[435]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-07-12T00:00:00"}