{"id":"https://openalex.org/W4285007601","doi":"https://doi.org/10.1021/acs.chemrev.2c00106","title":"Designing Artificial Metalloenzymes by Tuning of the Environment beyond the Primary Coordination Sphere","display_name":"Designing Artificial Metalloenzymes by Tuning of the Environment beyond the Primary Coordination Sphere","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4285007601","doi":"https://doi.org/10.1021/acs.chemrev.2c00106","pmid":"https://pubmed.ncbi.nlm.nih.gov/35816578","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10199331"},"language":"en","primary_location":{"id":"doi:10.1021/acs.chemrev.2c00106","doi":"https://doi.org/10.1021/acs.chemrev.2c00106","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.chemrev.2c00106","pdf_url":null,"source":{"id":"https://openalex.org/S41143188","display_name":"Chemical Reviews","issn_l":"0009-2665","issn":["0009-2665","1520-6890"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10199331","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024807731","display_name":"Casey Van Stappen","orcid":"https://orcid.org/0000-0002-1770-2231","observed_orcids":["https://orcid.org/0000-0002-1770-2231"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Casey Van Stappen","raw_affiliation_strings":["Department of Chemistry, University of Texas at Austin, 105 East 24th Street, Austin, Texas 78712, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas at Austin, 105 East 24th Street, Austin, Texas 78712, United States","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009367805","display_name":"Yunling Deng","orcid":"https://orcid.org/0000-0001-7157-144X","observed_orcids":["https://orcid.org/0000-0001-7157-144X"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunling Deng","raw_affiliation_strings":["Department of Chemistry, University of Texas at Austin, 105 East 24th Street, Austin, Texas 78712, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas at Austin, 105 East 24th Street, Austin, Texas 78712, United States","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038617650","display_name":"Yiwei Liu","orcid":"https://orcid.org/0000-0002-7899-2279","observed_orcids":["https://orcid.org/0000-0002-7899-2279"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiwei Liu","raw_affiliation_strings":["Department of Chemistry, University of Illinois, Urbana-Champaign, 505 South Mathews Avenue, Urbana, Illinois 61801, United States"],"raw_orcid":"https://orcid.org/0000-0002-7899-2279","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois, Urbana-Champaign, 505 South Mathews Avenue, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092665183","display_name":"Hirbod Heidari","orcid":"https://orcid.org/0000-0002-5191-1512","observed_orcids":["https://orcid.org/0000-0002-5191-1512"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hirbod Heidari","raw_affiliation_strings":["Department of Chemistry, University of Texas at Austin, 105 East 24th Street, Austin, Texas 78712, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas at Austin, 105 East 24th Street, Austin, Texas 78712, United States","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049251309","display_name":"Jingxiang Wang","orcid":"https://orcid.org/0000-0003-3381-7976","observed_orcids":["https://orcid.org/0000-0003-3381-7976"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing-Xiang Wang","raw_affiliation_strings":["Department of Chemistry, University of Texas at Austin, 105 East 24th Street, Austin, Texas 78712, United States"],"raw_orcid":"https://orcid.org/0000-0003-3381-7976","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas at Austin, 105 East 24th Street, Austin, Texas 78712, United States","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024532179","display_name":"Yu Zhou","orcid":"https://orcid.org/0000-0002-1882-9891","observed_orcids":["https://orcid.org/0000-0002-1882-9891"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Zhou","raw_affiliation_strings":["Department of Chemistry, University of Texas at Austin, 105 East 24th Street, Austin, Texas 78712, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas at Austin, 105 East 24th Street, Austin, Texas 78712, United States","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008746701","display_name":"Aaron P. Ledray","orcid":"https://orcid.org/0000-0002-1829-1235","observed_orcids":["https://orcid.org/0000-0002-1829-1235"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron P. Ledray","raw_affiliation_strings":["Department of Chemistry, University of Texas at Austin, 105 East 24th Street, Austin, Texas 78712, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas at Austin, 105 East 24th Street, Austin, Texas 78712, United States","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100661754","display_name":"Yi Lu","orcid":"https://orcid.org/0000-0003-1221-6709","observed_orcids":["https://orcid.org/0000-0003-1221-6709"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yi Lu","raw_affiliation_strings":["Department of Chemistry, University of Illinois, Urbana-Champaign, 505 South Mathews Avenue, Urbana, Illinois 61801, United States","Department of Chemistry, University of Texas at Austin, 105 East 24th Street, Austin, Texas 78712, United States"],"raw_orcid":"https://orcid.org/0000-0003-1221-6709","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois, Urbana-Champaign, 505 South Mathews Avenue, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Chemistry, University of Texas at Austin, 105 East 24th Street, Austin, Texas 78712, United States","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100661754"],"corresponding_institution_ids":["https://openalex.org/I157725225","https://openalex.org/I86519309"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.9643,"has_fulltext":false,"cited_by_count":188,"citation_normalized_percentile":{"value":0.87125749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"122","issue":"14","first_page":"11974","last_page":"12045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.04149999842047691,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-metalloenzymes","display_name":"artificial metalloenzymes","score":1.0},{"id":"https://openalex.org/keywords/secondary-coordination-sphere","display_name":"second coordination sphere","score":0.9900000095367432},{"id":"https://openalex.org/keywords/protein-scaffolds","display_name":"protein scaffolds","score":0.7590000033378601},{"id":"https://openalex.org/keywords/heme-enzymes","display_name":"heme enzymes","score":0.7599999904632568},{"id":"https://openalex.org/keywords/nonheme-iron-enzymes","display_name":"non-heme iron enzymes","score":0.9679999947547913},{"id":"https://openalex.org/keywords/copper-enzymes","display_name":"copper enzymes","score":0.9739999771118164},{"id":"https://openalex.org/keywords/metal-ion-binding","display_name":"metal ion binding","score":0.6660000085830688},{"id":"https://openalex.org/keywords/enzyme-catalysis","display_name":"enzyme catalysis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.781000018119812},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.9819999933242798},{"id":"https://openalex.org/keywords/directed-evolution","display_name":"directed evolution","score":0.7680000066757202},{"id":"https://openalex.org/keywords/rational-protein-design","display_name":"rational protein design","score":0.7480000257492065},{"id":"https://openalex.org/keywords/computational-modeling","display_name":"computational modeling","score":0.4659999907016754},{"id":"https://openalex.org/keywords/metal-cofactors","display_name":"metal cofactors","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7971290349960327},{"id":"https://openalex.org/C11111787","wikidata":"https://www.wikidata.org/wiki/Q675972","display_name":"Coordination sphere","level":3,"score":0.7850455641746521},{"id":"https://openalex.org/C2777977315","wikidata":"https://www.wikidata.org/wiki/Q7243056","display_name":"Primary (astronomy)","level":2,"score":0.5511797666549683},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.5165778398513794},{"id":"https://openalex.org/C82714645","wikidata":"https://www.wikidata.org/wiki/Q438331","display_name":"Template","level":2,"score":0.5036386847496033},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.501488447189331},{"id":"https://openalex.org/C92381491","wikidata":"https://www.wikidata.org/wiki/Q5747409","display_name":"Heteronuclear molecule","level":3,"score":0.4826429486274719},{"id":"https://openalex.org/C68913812","wikidata":"https://www.wikidata.org/wiki/Q238156","display_name":"Coordination complex","level":3,"score":0.47566527128219604},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.400779128074646},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.36363232135772705},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.2966082990169525},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.17588603496551514},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11028319597244263},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.07578375935554504},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008667","descriptor_name":"Metalloproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008670","descriptor_name":"Metals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.chemrev.2c00106","doi":"https://doi.org/10.1021/acs.chemrev.2c00106","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.chemrev.2c00106","pdf_url":null,"source":{"id":"https://openalex.org/S41143188","display_name":"Chemical Reviews","issn_l":"0009-2665","issn":["0009-2665","1520-6890"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Reviews","raw_type":"journal-article"},{"id":"pmid:35816578","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35816578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical reviews","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10199331","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10199331","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Rev","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10199331","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10199331","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Rev","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1432597464","display_name":null,"funder_award_id":"CHE-2108837","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G453706339","display_name":null,"funder_award_id":"F-0020","funder_id":"https://openalex.org/F4320306196","funder_display_name":"Welch Foundation"},{"id":"https://openalex.org/G9000856217","display_name":"Design and Selection of Novel Metalloenzymes for Biocatalysis, Bioimaging, and Genetic Engineering","funder_award_id":"R35GM141931","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":601,"referenced_works":["https://openalex.org/W13011787","https://openalex.org/W49669251","https://openalex.org/W284473250","https://openalex.org/W880271322","https://openalex.org/W1031680929","https://openalex.org/W1485088497","https://openalex.org/W1504677789","https://openalex.org/W1510114475","https://openalex.org/W1511420732","https://openalex.org/W1516150813","https://openalex.org/W1516276654","https://openalex.org/W1517773809","https://openalex.org/W1533933556","https://openalex.org/W1548765086","https://openalex.org/W1558343448","https://openalex.org/W1563946531","https://openalex.org/W1575468184","https://openalex.org/W1577480562","https://openalex.org/W1598451418","https://openalex.org/W1602362322","https://openalex.org/W1677486761","https://openalex.org/W1769480844","https://openalex.org/W1769489414","https://openalex.org/W1788645855","https://openalex.org/W1849447163","https://openalex.org/W1866116049","https://openalex.org/W1937431683","https://openalex.org/W1950189156","https://openalex.org/W1955811668","https://openalex.org/W1963565399","https://openalex.org/W1963669773","https://openalex.org/W1964413981","https://openalex.org/W1965134106","https://openalex.org/W1965277066","https://openalex.org/W1965637904","https://openalex.org/W1965970124","https://openalex.org/W1965990324","https://openalex.org/W1966013120","https://openalex.org/W1966080061","https://openalex.org/W1966811777","https://openalex.org/W1966935274","https://openalex.org/W1967055939","https://openalex.org/W1967226836","https://openalex.org/W1967554356","https://openalex.org/W1970405659","https://openalex.org/W1971018890","https://openalex.org/W1971182909","https://openalex.org/W1971435128","https://openalex.org/W1971948710","https://openalex.org/W1972433518","https://openalex.org/W1973074311","https://openalex.org/W1973721002","https://openalex.org/W1974799534","https://openalex.org/W1976053344","https://openalex.org/W1976591534","https://openalex.org/W1977705137","https://openalex.org/W1978396571","https://openalex.org/W1979202748","https://openalex.org/W1979204707","https://openalex.org/W1979209970","https://openalex.org/W1980711521","https://openalex.org/W1980725840","https://openalex.org/W1981503185","https://openalex.org/W1981704948","https://openalex.org/W1985729209","https://openalex.org/W1987158549","https://openalex.org/W1987587964","https://openalex.org/W1988839383","https://openalex.org/W1988841674","https://openalex.org/W1990095828","https://openalex.org/W1991354940","https://openalex.org/W1993041353","https://openalex.org/W1993753759","https://openalex.org/W1994887179","https://openalex.org/W1995147696","https://openalex.org/W1995241084","https://openalex.org/W1995612596","https://openalex.org/W1996142946","https://openalex.org/W1996350754","https://openalex.org/W1996483627","https://openalex.org/W1996885557","https://openalex.org/W1998322168","https://openalex.org/W1998966240","https://openalex.org/W1999288756","https://openalex.org/W1999477766","https://openalex.org/W1999491456","https://openalex.org/W1999718832","https://openalex.org/W2001281322","https://openalex.org/W2002495053","https://openalex.org/W2003152730","https://openalex.org/W2004200814","https://openalex.org/W2006724140","https://openalex.org/W2006999117","https://openalex.org/W2007203272","https://openalex.org/W2008209363","https://openalex.org/W2008279485","https://openalex.org/W2008816511","https://openalex.org/W2008831658","https://openalex.org/W2009121238","https://openalex.org/W2009485848","https://openalex.org/W2009774095","https://openalex.org/W2010890801","https://openalex.org/W2012115809","https://openalex.org/W2012159502","https://openalex.org/W2012348445","https://openalex.org/W2012684695","https://openalex.org/W2013072084","https://openalex.org/W2013325632","https://openalex.org/W2013470567","https://openalex.org/W2013784764","https://openalex.org/W2015503736","https://openalex.org/W2015638142","https://openalex.org/W2015978054","https://openalex.org/W2016080320","https://openalex.org/W2016189010","https://openalex.org/W2016289343","https://openalex.org/W2016349058","https://openalex.org/W2016401253","https://openalex.org/W2016752892","https://openalex.org/W2016848814","https://openalex.org/W2017258500","https://openalex.org/W2018796932","https://openalex.org/W2019278594","https://openalex.org/W2019555995","https://openalex.org/W2020108475","https://openalex.org/W2020641372","https://openalex.org/W2020646508","https://openalex.org/W2020732164","https://openalex.org/W2021672377","https://openalex.org/W2022454912","https://openalex.org/W2022471606","https://openalex.org/W2022993360","https://openalex.org/W2025092433","https://openalex.org/W2025603698","https://openalex.org/W2026036565","https://openalex.org/W2026188828","https://openalex.org/W2026594509","https://openalex.org/W2027140236","https://openalex.org/W2027640345","https://openalex.org/W2028268572","https://openalex.org/W2028291957","https://openalex.org/W2029646041","https://openalex.org/W2032839609","https://openalex.org/W2033164164","https://openalex.org/W2033287137","https://openalex.org/W2034063871","https://openalex.org/W2034572578","https://openalex.org/W2034672440","https://openalex.org/W2034796508","https://openalex.org/W2038201483","https://openalex.org/W2039892768","https://openalex.org/W2040866864","https://openalex.org/W2041230004","https://openalex.org/W2041579378","https://openalex.org/W2042650553","https://openalex.org/W2044416943","https://openalex.org/W2045109232","https://openalex.org/W2046107417","https://openalex.org/W2049661339","https://openalex.org/W2049694867","https://openalex.org/W2050371810","https://openalex.org/W2050462483","https://openalex.org/W2050517955","https://openalex.org/W2050886366","https://openalex.org/W2050888116","https://openalex.org/W2051341954","https://openalex.org/W2051362165","https://openalex.org/W2051654117","https://openalex.org/W2052498582","https://openalex.org/W2052550185","https://openalex.org/W2052743745","https://openalex.org/W2052845856","https://openalex.org/W2052964842","https://openalex.org/W2053705771","https://openalex.org/W2054774747","https://openalex.org/W2055300232","https://openalex.org/W2056267948","https://openalex.org/W2056271095","https://openalex.org/W2057125903","https://openalex.org/W2057583752","https://openalex.org/W2058638082","https://openalex.org/W2058949520","https://openalex.org/W2059050788","https://openalex.org/W2059145970","https://openalex.org/W2059781874","https://openalex.org/W2059997435","https://openalex.org/W2060408358","https://openalex.org/W2060470134","https://openalex.org/W2061370608","https://openalex.org/W2061393862","https://openalex.org/W2061898751","https://openalex.org/W2061939602","https://openalex.org/W2061989992","https://openalex.org/W2062751026","https://openalex.org/W2064013442","https://openalex.org/W2064189254","https://openalex.org/W2064275833","https://openalex.org/W2064337193","https://openalex.org/W2064413958","https://openalex.org/W2064799254","https://openalex.org/W2065014667","https://openalex.org/W2065382671","https://openalex.org/W2065622899","https://openalex.org/W2066056623","https://openalex.org/W2066222983","https://openalex.org/W2066847890","https://openalex.org/W2067154055","https://openalex.org/W2067547041","https://openalex.org/W2068017837","https://openalex.org/W2069116750","https://openalex.org/W2069269641","https://openalex.org/W2069384066","https://openalex.org/W2069688986","https://openalex.org/W2070904188","https://openalex.org/W2072309870","https://openalex.org/W2073039007","https://openalex.org/W2073302448","https://openalex.org/W2073347601","https://openalex.org/W2073458761","https://openalex.org/W2073722866","https://openalex.org/W2073955982","https://openalex.org/W2074013821","https://openalex.org/W2074306377","https://openalex.org/W2074335496","https://openalex.org/W2074452399","https://openalex.org/W2075336631","https://openalex.org/W2075365129","https://openalex.org/W2075589177","https://openalex.org/W2076047438","https://openalex.org/W2076466885","https://openalex.org/W2076581207","https://openalex.org/W2077621515","https://openalex.org/W2078531329","https://openalex.org/W2078533885","https://openalex.org/W2079193378","https://openalex.org/W2079651052","https://openalex.org/W2081048082","https://openalex.org/W2081518130","https://openalex.org/W2081653044","https://openalex.org/W2081729587","https://openalex.org/W2082334266","https://openalex.org/W2082341001","https://openalex.org/W2082948336","https://openalex.org/W2083112939","https://openalex.org/W2083805043","https://openalex.org/W2084410642","https://openalex.org/W2084493621","https://openalex.org/W2084667964","https://openalex.org/W2085266874","https://openalex.org/W2085472819","https://openalex.org/W2085560162","https://openalex.org/W2085679625","https://openalex.org/W2085972813","https://openalex.org/W2086036453","https://openalex.org/W2086187832","https://openalex.org/W2086847055","https://openalex.org/W2087002393","https://openalex.org/W2088556413","https://openalex.org/W2089566928","https://openalex.org/W2089638668","https://openalex.org/W2091883778","https://openalex.org/W2091970958","https://openalex.org/W2092019850","https://openalex.org/W2092102609","https://openalex.org/W2092529814","https://openalex.org/W2093033663","https://openalex.org/W2093238015","https://openalex.org/W2093352710","https://openalex.org/W2093398608","https://openalex.org/W2094273232","https://openalex.org/W2094805143","https://openalex.org/W2096370166","https://openalex.org/W2096700300","https://openalex.org/W2097284195","https://openalex.org/W2097971843","https://openalex.org/W2098089372","https://openalex.org/W2098420584","https://openalex.org/W2098789742","https://openalex.org/W2099066840","https://openalex.org/W2099282718","https://openalex.org/W2100032379","https://openalex.org/W2101053825","https://openalex.org/W2101422765","https://openalex.org/W2101683782","https://openalex.org/W2102416893","https://openalex.org/W2103385859","https://openalex.org/W2104554134","https://openalex.org/W2104963248","https://openalex.org/W2105199418","https://openalex.org/W2108738397","https://openalex.org/W2110069436","https://openalex.org/W2110260818","https://openalex.org/W2110770347","https://openalex.org/W2110810524","https://openalex.org/W2111016129","https://openalex.org/W2112593855","https://openalex.org/W2113977229","https://openalex.org/W2115938039","https://openalex.org/W2116248072","https://openalex.org/W2118076612","https://openalex.org/W2118088141","https://openalex.org/W2118363414","https://openalex.org/W2118492250","https://openalex.org/W2119557075","https://openalex.org/W2120599967","https://openalex.org/W2120852426","https://openalex.org/W2121096033","https://openalex.org/W2121254593","https://openalex.org/W2121967553","https://openalex.org/W2123771203","https://openalex.org/W2124124969","https://openalex.org/W2124163461","https://openalex.org/W2124724441","https://openalex.org/W2125247340","https://openalex.org/W2127380196","https://openalex.org/W2127599923","https://openalex.org/W2127604495","https://openalex.org/W2127664963","https://openalex.org/W2127666353","https://openalex.org/W2128430676","https://openalex.org/W2130793963","https://openalex.org/W2131351657","https://openalex.org/W2132291850","https://openalex.org/W2132397429","https://openalex.org/W2132629607","https://openalex.org/W2132911570","https://openalex.org/W2134248388","https://openalex.org/W2135361855","https://openalex.org/W2135598762","https://openalex.org/W2135815512","https://openalex.org/W2138516874","https://openalex.org/W2139567375","https://openalex.org/W2139607159","https://openalex.org/W2140899967","https://openalex.org/W2143225085","https://openalex.org/W2143535440","https://openalex.org/W2145550766","https://openalex.org/W2146134187","https://openalex.org/W2147289060","https://openalex.org/W2148012276","https://openalex.org/W2150394181","https://openalex.org/W2150911938","https://openalex.org/W2151341878","https://openalex.org/W2153089815","https://openalex.org/W2154158126","https://openalex.org/W2154598050","https://openalex.org/W2155454872","https://openalex.org/W2156684055","https://openalex.org/W2156782854","https://openalex.org/W2157147573","https://openalex.org/W2157220953","https://openalex.org/W2158268887","https://openalex.org/W2159097848","https://openalex.org/W2159468231","https://openalex.org/W2160707575","https://openalex.org/W2161149444","https://openalex.org/W2161384956","https://openalex.org/W2161980841","https://openalex.org/W2162636743","https://openalex.org/W2162709361","https://openalex.org/W2162853795","https://openalex.org/W2163087001","https://openalex.org/W2165178969","https://openalex.org/W2165547557","https://openalex.org/W2165788095","https://openalex.org/W2165898505","https://openalex.org/W2166258960","https://openalex.org/W2166986808","https://openalex.org/W2167008580","https://openalex.org/W2167567210","https://openalex.org/W2167958276","https://openalex.org/W2169880270","https://openalex.org/W2171878324","https://openalex.org/W2175552173","https://openalex.org/W2176126080","https://openalex.org/W2185747041","https://openalex.org/W2197954584","https://openalex.org/W2201713963","https://openalex.org/W2209652843","https://openalex.org/W2210228437","https://openalex.org/W2217153683","https://openalex.org/W2230694817","https://openalex.org/W2238247105","https://openalex.org/W2255666688","https://openalex.org/W2269688327","https://openalex.org/W2278519211","https://openalex.org/W2282106008","https://openalex.org/W2283136192","https://openalex.org/W2293273993","https://openalex.org/W2294376465","https://openalex.org/W2302161594","https://openalex.org/W2312455466","https://openalex.org/W2313035794","https://openalex.org/W2315017718","https://openalex.org/W2317515738","https://openalex.org/W2317873538","https://openalex.org/W2320206180","https://openalex.org/W2321038980","https://openalex.org/W2321271242","https://openalex.org/W2321375944","https://openalex.org/W2321579512","https://openalex.org/W2328143741","https://openalex.org/W2329280385","https://openalex.org/W2330066864","https://openalex.org/W2330157343","https://openalex.org/W2330974483","https://openalex.org/W2331937820","https://openalex.org/W2338646002","https://openalex.org/W2343627403","https://openalex.org/W2344156231","https://openalex.org/W2378422776","https://openalex.org/W2401538503","https://openalex.org/W2412062552","https://openalex.org/W2412078865","https://openalex.org/W2415341105","https://openalex.org/W2416087370","https://openalex.org/W2438451313","https://openalex.org/W2461774963","https://openalex.org/W2464204634","https://openalex.org/W2465674018","https://openalex.org/W2480691700","https://openalex.org/W2507192932","https://openalex.org/W2508778462","https://openalex.org/W2517883330","https://openalex.org/W2519539312","https://openalex.org/W2520880712","https://openalex.org/W2522606101","https://openalex.org/W2528494713","https://openalex.org/W2529265994","https://openalex.org/W2534014350","https://openalex.org/W2537165710","https://openalex.org/W2554142923","https://openalex.org/W2554528613","https://openalex.org/W2556530428","https://openalex.org/W2567582035","https://openalex.org/W2568939177","https://openalex.org/W2597349977","https://openalex.org/W2600461956","https://openalex.org/W2603561992","https://openalex.org/W2614040182","https://openalex.org/W2617140651","https://openalex.org/W2618860683","https://openalex.org/W2620546838","https://openalex.org/W2623250387","https://openalex.org/W2732708569","https://openalex.org/W2734386232","https://openalex.org/W2735208100","https://openalex.org/W2735839143","https://openalex.org/W2737968374","https://openalex.org/W2744465372","https://openalex.org/W2746397541","https://openalex.org/W2753393433","https://openalex.org/W2762800332","https://openalex.org/W2767021870","https://openalex.org/W2767307166","https://openalex.org/W2768059701","https://openalex.org/W2768252314","https://openalex.org/W2769735050","https://openalex.org/W2770517083","https://openalex.org/W2777679640","https://openalex.org/W2780590919","https://openalex.org/W2782674965","https://openalex.org/W2783223544","https://openalex.org/W2785178119","https://openalex.org/W2786747858","https://openalex.org/W2788411992","https://openalex.org/W2791594771","https://openalex.org/W2791933206","https://openalex.org/W2795624245","https://openalex.org/W2796309353","https://openalex.org/W2801142442","https://openalex.org/W2801390591","https://openalex.org/W2803730805","https://openalex.org/W2804973580","https://openalex.org/W2807909133","https://openalex.org/W2808649653","https://openalex.org/W2810761825","https://openalex.org/W2883803427","https://openalex.org/W2885883963","https://openalex.org/W2886286651","https://openalex.org/W2887132644","https://openalex.org/W2889223343","https://openalex.org/W2889486546","https://openalex.org/W2890024390","https://openalex.org/W2891766517","https://openalex.org/W2892068522","https://openalex.org/W2892150663","https://openalex.org/W2892705846","https://openalex.org/W2895424258","https://openalex.org/W2896446106","https://openalex.org/W2897954952","https://openalex.org/W2898490517","https://openalex.org/W2899053766","https://openalex.org/W2899896021","https://openalex.org/W2901526026","https://openalex.org/W2905500176","https://openalex.org/W2906107714","https://openalex.org/W2908290021","https://openalex.org/W2908452108","https://openalex.org/W2909057819","https://openalex.org/W2910306010","https://openalex.org/W2911016087","https://openalex.org/W2911874229","https://openalex.org/W2912115890","https://openalex.org/W2912326177","https://openalex.org/W2915890876","https://openalex.org/W2915952143","https://openalex.org/W2923384196","https://openalex.org/W2944003111","https://openalex.org/W2944972069","https://openalex.org/W2946296022","https://openalex.org/W2946390641","https://openalex.org/W2948457859","https://openalex.org/W2950545308","https://openalex.org/W2950685263","https://openalex.org/W2951173549","https://openalex.org/W2952953177","https://openalex.org/W2959382133","https://openalex.org/W2961679963","https://openalex.org/W2965423079","https://openalex.org/W2965796251","https://openalex.org/W2965856049","https://openalex.org/W2969333523","https://openalex.org/W2971123857","https://openalex.org/W2971717822","https://openalex.org/W2972475246","https://openalex.org/W2983465586","https://openalex.org/W2987964167","https://openalex.org/W2996162577","https://openalex.org/W2999044305","https://openalex.org/W3000439536","https://openalex.org/W3005446012","https://openalex.org/W3005709543","https://openalex.org/W3007181325","https://openalex.org/W3008437665","https://openalex.org/W3010020074","https://openalex.org/W3012946231","https://openalex.org/W3013167796","https://openalex.org/W3013695388","https://openalex.org/W3014641996","https://openalex.org/W3016753178","https://openalex.org/W3016878001","https://openalex.org/W3018667363","https://openalex.org/W3022203939","https://openalex.org/W3026121095","https://openalex.org/W3029412352","https://openalex.org/W3030842661","https://openalex.org/W3043145590","https://openalex.org/W3043787755","https://openalex.org/W3045920060","https://openalex.org/W3048322608","https://openalex.org/W3083432387","https://openalex.org/W3086845129","https://openalex.org/W3087157678","https://openalex.org/W3092624514","https://openalex.org/W3092692805","https://openalex.org/W3094231291","https://openalex.org/W3094279133","https://openalex.org/W3108559518","https://openalex.org/W3117169675","https://openalex.org/W3118993215","https://openalex.org/W3119963450","https://openalex.org/W3122445055","https://openalex.org/W3123776560","https://openalex.org/W3124019381","https://openalex.org/W3124795259","https://openalex.org/W3125046798","https://openalex.org/W3126550219","https://openalex.org/W3128831519","https://openalex.org/W3134035899","https://openalex.org/W3136717788","https://openalex.org/W3141299283","https://openalex.org/W3158747957","https://openalex.org/W3159644469","https://openalex.org/W3163260644","https://openalex.org/W3167047588","https://openalex.org/W3170842991","https://openalex.org/W3177828909","https://openalex.org/W3184152800","https://openalex.org/W3185760697","https://openalex.org/W3189533013","https://openalex.org/W3198060971","https://openalex.org/W3198087138","https://openalex.org/W3198892619","https://openalex.org/W3200686549","https://openalex.org/W3202571545","https://openalex.org/W3212248990","https://openalex.org/W4200074081","https://openalex.org/W4206065663","https://openalex.org/W4211159207","https://openalex.org/W4211172071","https://openalex.org/W4230438910","https://openalex.org/W4243701392","https://openalex.org/W4246672322","https://openalex.org/W4247702607","https://openalex.org/W4247956809","https://openalex.org/W4248412843","https://openalex.org/W4252784541","https://openalex.org/W4256321774","https://openalex.org/W4285056727","https://openalex.org/W4285724617"],"related_works":["https://openalex.org/W2989649486","https://openalex.org/W2923384196","https://openalex.org/W4213193226","https://openalex.org/W4401287879","https://openalex.org/W3037656691","https://openalex.org/W7164052601","https://openalex.org/W2296423762","https://openalex.org/W1966935274","https://openalex.org/W2569641753","https://openalex.org/W2961566029"],"abstract_inverted_index":{"Metalloenzymes":[0],"catalyze":[1],"a":[2,7,49,152,224,252,260,279],"variety":[3,284],"of":[4,10,52,80,82,97,117,130,139,154,196,215,229,255,263,278,285],"reactions":[5],"using":[6],"limited":[8],"number":[9],"natural":[11],"amino":[12],"acids":[13],"and":[14,32,66,100,122,165,172,185,206,213,245,271,281],"metallocofactors.":[15],"Therefore,":[16],"the":[17,20,57,60,78,95,113,128,137,197,200,211,239,243,256,264,276],"environment":[18],"beyond":[19,59],"primary":[21,44,61],"coordination":[22,45,62,115,202,258],"sphere":[23,63,259,267],"must":[24],"play":[25],"an":[26,90,236],"important":[27],"role":[28],"in":[29,160,199,223,242,272],"both":[30,155],"conferring":[31],"tuning":[33,79,214],"their":[34],"phenomenal":[35],"catalytic":[36],"properties,":[37],"enabling":[38],"active":[39],"sites":[40],"with":[41,124,181],"otherwise":[42],"similar":[43],"environments":[46],"to":[47,72,93,101,219,268,274],"perform":[48],"diverse":[50],"array":[51],"biological":[53,105],"functions.":[54],"However,":[55],"since":[56],"interactions":[58,99,198],"are":[64],"numerous":[65],"weak,":[67],"it":[68],"has":[69],"been":[70],"difficult":[71],"pinpoint":[73],"structural":[74],"features":[75],"responsible":[76],"for":[77,136,251],"activities":[81],"native":[83,131,230],"enzymes.":[84,231],"Designing":[85],"artificial":[86],"metalloenzymes":[87,169],"(ArMs)":[88],"offers":[89],"excellent":[91],"basis":[92],"elucidate":[94],"roles":[96],"these":[98,216],"further":[102],"develop":[103],"practical":[104],"catalysts.":[106],"In":[107,157],"this":[108],"review,":[109],"we":[110,187],"highlight":[111],"how":[112,193],"secondary":[114,201,257,265],"spheres":[116],"ArMs":[118,140,174],"influence":[119],"metal":[120,177,183],"binding":[121],"catalysis,":[123],"particular":[125],"focus":[126],"on":[127,192,238],"use":[129],"protein":[132],"scaffolds":[133],"as":[134],"templates":[135],"design":[138,144,277],"by":[141,146],"either":[142],"rational":[143],"aided":[145],"computational":[147],"modeling,":[148],"directed":[149],"evolution,":[150],"or":[151],"combination":[153],"approaches.":[156],"describing":[158],"successes":[159],"designing":[161],"heme,":[162,171],"nonheme":[163],"Fe,":[164],"Cu":[166],"metalloenzymes,":[167],"heteronuclear":[168],"containing":[170,175],"those":[173,180,228],"other":[176],"centers":[178],"(including":[179],"non-native":[182],"ions":[184],"metallocofactors),":[186],"have":[188,233],"summarized":[189],"insights":[190],"gained":[191],"careful":[194],"controls":[195],"sphere,":[203],"including":[204],"hydrophobic":[205],"hydrogen":[207],"bonding":[208],"interactions,":[209],"allow":[210,250],"generation":[212],"respective":[217],"systems":[218],"approach,":[220],"rival,":[221],"and,":[222],"few":[225],"cases,":[226],"exceed":[227],"We":[232],"also":[234],"provided":[235],"outlook":[237],"remaining":[240],"challenges":[241],"field":[244],"future":[246],"directions":[247],"that":[248],"will":[249],"deeper":[253,261],"understanding":[254,262],"coordintion":[266],"be":[269],"gained,":[270],"turn":[273],"guide":[275],"broader":[280],"more":[282],"efficient":[283],"ArMs.":[286]},"counts_by_year":[{"year":2026,"cited_by_count":47},{"year":2025,"cited_by_count":51},{"year":2024,"cited_by_count":38},{"year":2023,"cited_by_count":42},{"year":2022,"cited_by_count":10}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2022-07-12T00:00:00"}