{"id":"https://openalex.org/W4285005940","doi":"https://doi.org/10.3390/cancers14143350","title":"Circulating Exosome Cargoes Contain Functionally Diverse Cancer Biomarkers: From Biogenesis and Function to Purification and Potential Translational Utility","display_name":"Circulating Exosome Cargoes Contain Functionally Diverse Cancer Biomarkers: From Biogenesis and Function to Purification and Potential Translational Utility","publication_year":2022,"publication_date":"2022-07-10","ids":{"openalex":"https://openalex.org/W4285005940","doi":"https://doi.org/10.3390/cancers14143350","pmid":"https://pubmed.ncbi.nlm.nih.gov/35884411","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9318395"},"language":"en","primary_location":{"id":"doi:10.3390/cancers14143350","doi":"https://doi.org/10.3390/cancers14143350","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14143350","pdf_url":"https://www.mdpi.com/2072-6694/14/14/3350/pdf?version=1657618323","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/14/14/3350/pdf?version=1657618323","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011682652","display_name":"Megan I. Mitchell","orcid":"https://orcid.org/0000-0002-1202-155X","observed_orcids":["https://orcid.org/0000-0002-1202-155X"]},"institutions":[{"id":"https://openalex.org/I4210148589","display_name":"Hackensack Meridian Health","ror":"https://ror.org/04p5zd128","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210148589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan I. Mitchell","raw_affiliation_strings":["Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA"],"raw_orcid":"https://orcid.org/0000-0002-1202-155X","affiliations":[{"raw_affiliation_string":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA","institution_ids":["https://openalex.org/I4210148589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042680625","display_name":"Junfeng Ma","orcid":"https://orcid.org/0000-0002-5183-5425","observed_orcids":["https://orcid.org/0000-0002-5183-5425"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junfeng Ma","raw_affiliation_strings":["Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA","institution_ids":["https://openalex.org/I2799903593","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064021094","display_name":"Claire L. Carter","orcid":"https://orcid.org/0000-0003-2996-7621","observed_orcids":["https://orcid.org/0000-0003-2996-7621","https://orcid.org/0009-0008-0979-8211"]},"institutions":[{"id":"https://openalex.org/I4210148589","display_name":"Hackensack Meridian Health","ror":"https://ror.org/04p5zd128","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210148589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire L. Carter","raw_affiliation_strings":["Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA","institution_ids":["https://openalex.org/I4210148589"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007117107","display_name":"Olivier D. Loudig","orcid":"https://orcid.org/0000-0001-5677-4716","observed_orcids":["https://orcid.org/0000-0001-5677-4716"]},"institutions":[{"id":"https://openalex.org/I4210148589","display_name":"Hackensack Meridian Health","ror":"https://ror.org/04p5zd128","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210148589"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Olivier Loudig","raw_affiliation_strings":["Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110, USA","institution_ids":["https://openalex.org/I4210148589"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007117107"],"corresponding_institution_ids":["https://openalex.org/I4210148589"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":0.492,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.46280011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"14","issue":"14","first_page":"3350","last_page":"3350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.8820000290870667},{"id":"https://openalex.org/keywords/circulating-tumor-markers","display_name":"circulating tumor markers","score":0.7559999823570251},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.8460000157356262},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.8059999942779541},{"id":"https://openalex.org/keywords/exosome-biogenesis","display_name":"exosome biogenesis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/exosome-isolation","display_name":"exosome isolation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/exosomal-rna","display_name":"exosomal RNA","score":0.7269999980926514},{"id":"https://openalex.org/keywords/exosomal-dna","display_name":"exosomal DNA","score":0.9810000061988831},{"id":"https://openalex.org/keywords/exosomal-proteins","display_name":"exosomal proteins","score":0.925000011920929},{"id":"https://openalex.org/keywords/cancer-detection","display_name":"cancer detection","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.8329415917396545},{"id":"https://openalex.org/C2777002142","wikidata":"https://www.wikidata.org/wiki/Q5031432","display_name":"Cancer biomarkers","level":3,"score":0.7026489973068237},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.6605781316757202},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.6290066838264465},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.574891984462738},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.5621241331100464},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.554210364818573},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.5380086302757263},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5208471417427063},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5184428691864014},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5148152709007263},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5059396624565125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4772867262363434},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4534450173377991},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3955621123313904},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36486905813217163},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.336224228143692},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.23396605253219604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13915035128593445},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11369386315345764},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09509098529815674},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/cancers14143350","doi":"https://doi.org/10.3390/cancers14143350","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14143350","pdf_url":"https://www.mdpi.com/2072-6694/14/14/3350/pdf?version=1657618323","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9318395","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9318395","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:35884411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35884411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/cancers14143350","doi":"https://doi.org/10.3390/cancers14143350","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14143350","pdf_url":"https://www.mdpi.com/2072-6694/14/14/3350/pdf?version=1657618323","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285005940.pdf","grobid_xml":"https://content.openalex.org/works/W4285005940.grobid-xml"},"referenced_works_count":463,"referenced_works":["https://openalex.org/W3476039","https://openalex.org/W15114388","https://openalex.org/W26434078","https://openalex.org/W263086927","https://openalex.org/W301388723","https://openalex.org/W984557176","https://openalex.org/W1487818015","https://openalex.org/W1493754322","https://openalex.org/W1511964634","https://openalex.org/W1518095394","https://openalex.org/W1525762980","https://openalex.org/W1539227846","https://openalex.org/W1539572403","https://openalex.org/W1562385120","https://openalex.org/W1579511172","https://openalex.org/W1599718730","https://openalex.org/W1793480972","https://openalex.org/W1794677843","https://openalex.org/W1798331267","https://openalex.org/W1816746890","https://openalex.org/W1832220924","https://openalex.org/W1839188703","https://openalex.org/W1840700012","https://openalex.org/W1874379912","https://openalex.org/W1879553156","https://openalex.org/W1888751811","https://openalex.org/W1890513212","https://openalex.org/W1950118853","https://openalex.org/W1952144636","https://openalex.org/W1964232997","https://openalex.org/W1965315089","https://openalex.org/W1967427925","https://openalex.org/W1968359959","https://openalex.org/W1969064400","https://openalex.org/W1969095017","https://openalex.org/W1969738372","https://openalex.org/W1969847452","https://openalex.org/W1974343943","https://openalex.org/W1975355918","https://openalex.org/W1977560532","https://openalex.org/W1977811325","https://openalex.org/W1979493465","https://openalex.org/W1981065957","https://openalex.org/W1981692037","https://openalex.org/W1982991544","https://openalex.org/W1983466841","https://openalex.org/W1984472621","https://openalex.org/W1985727076","https://openalex.org/W1985844219","https://openalex.org/W1986280009","https://openalex.org/W1991316122","https://openalex.org/W1991655565","https://openalex.org/W1993140699","https://openalex.org/W1993739335","https://openalex.org/W1994625058","https://openalex.org/W1995454576","https://openalex.org/W1995830102","https://openalex.org/W1996963134","https://openalex.org/W1997739354","https://openalex.org/W2004280628","https://openalex.org/W2004773897","https://openalex.org/W2005791622","https://openalex.org/W2005993715","https://openalex.org/W2006191177","https://openalex.org/W2006247279","https://openalex.org/W2007106590","https://openalex.org/W2009962397","https://openalex.org/W2010661135","https://openalex.org/W2018242510","https://openalex.org/W2021065026","https://openalex.org/W2022805251","https://openalex.org/W2024510835","https://openalex.org/W2024532702","https://openalex.org/W2025612331","https://openalex.org/W2027167191","https://openalex.org/W2028160632","https://openalex.org/W2029428477","https://openalex.org/W2030701238","https://openalex.org/W2032735323","https://openalex.org/W2034269086","https://openalex.org/W2035844407","https://openalex.org/W2037320975","https://openalex.org/W2039313867","https://openalex.org/W2040409775","https://openalex.org/W2040553447","https://openalex.org/W2041302454","https://openalex.org/W2042194227","https://openalex.org/W2043054174","https://openalex.org/W2044643945","https://openalex.org/W2046271059","https://openalex.org/W2050668495","https://openalex.org/W2054410308","https://openalex.org/W2055313665","https://openalex.org/W2056094172","https://openalex.org/W2056827921","https://openalex.org/W2057713753","https://openalex.org/W2062984171","https://openalex.org/W2064543601","https://openalex.org/W2064555156","https://openalex.org/W2065236536","https://openalex.org/W2067754261","https://openalex.org/W2069295843","https://openalex.org/W2069437848","https://openalex.org/W2071015335","https://openalex.org/W2072063027","https://openalex.org/W2074892413","https://openalex.org/W2077882252","https://openalex.org/W2078818962","https://openalex.org/W2079174568","https://openalex.org/W2084648314","https://openalex.org/W2084770914","https://openalex.org/W2085322507","https://openalex.org/W2085462535","https://openalex.org/W2086518820","https://openalex.org/W2089081493","https://openalex.org/W2089154872","https://openalex.org/W2089713288","https://openalex.org/W2094386178","https://openalex.org/W2095554214","https://openalex.org/W2096643260","https://openalex.org/W2097971021","https://openalex.org/W2098202316","https://openalex.org/W2098259366","https://openalex.org/W2104678766","https://openalex.org/W2109691647","https://openalex.org/W2112003767","https://openalex.org/W2114599883","https://openalex.org/W2114938026","https://openalex.org/W2116178187","https://openalex.org/W2116687544","https://openalex.org/W2117692326","https://openalex.org/W2119914706","https://openalex.org/W2122635106","https://openalex.org/W2126210405","https://openalex.org/W2128340149","https://openalex.org/W2128381498","https://openalex.org/W2128566126","https://openalex.org/W2128817061","https://openalex.org/W2128891846","https://openalex.org/W2131409719","https://openalex.org/W2135611076","https://openalex.org/W2136510984","https://openalex.org/W2137010533","https://openalex.org/W2145625720","https://openalex.org/W2147524926","https://openalex.org/W2148230934","https://openalex.org/W2150079601","https://openalex.org/W2150767213","https://openalex.org/W2154203178","https://openalex.org/W2154428013","https://openalex.org/W2155504018","https://openalex.org/W2156281143","https://openalex.org/W2157792277","https://openalex.org/W2159835130","https://openalex.org/W2160025183","https://openalex.org/W2160436654","https://openalex.org/W2161475018","https://openalex.org/W2162711454","https://openalex.org/W2164421236","https://openalex.org/W2169599832","https://openalex.org/W2170852633","https://openalex.org/W2171446213","https://openalex.org/W2172096113","https://openalex.org/W2176694530","https://openalex.org/W2210380411","https://openalex.org/W2232601925","https://openalex.org/W2256704142","https://openalex.org/W2259481044","https://openalex.org/W2267616339","https://openalex.org/W2272204389","https://openalex.org/W2274237531","https://openalex.org/W2274860869","https://openalex.org/W2297065553","https://openalex.org/W2301078386","https://openalex.org/W2312836697","https://openalex.org/W2324239230","https://openalex.org/W2324322428","https://openalex.org/W2325280034","https://openalex.org/W2325305253","https://openalex.org/W2343797741","https://openalex.org/W2345023278","https://openalex.org/W2345715888","https://openalex.org/W2345920029","https://openalex.org/W2346631274","https://openalex.org/W2400302671","https://openalex.org/W2401840403","https://openalex.org/W2405705091","https://openalex.org/W2414083225","https://openalex.org/W2418959584","https://openalex.org/W2421126119","https://openalex.org/W2431996803","https://openalex.org/W2460208024","https://openalex.org/W2465815646","https://openalex.org/W2467302424","https://openalex.org/W2474208774","https://openalex.org/W2510962431","https://openalex.org/W2511990668","https://openalex.org/W2514098176","https://openalex.org/W2515067935","https://openalex.org/W2517221242","https://openalex.org/W2521381098","https://openalex.org/W2522821491","https://openalex.org/W2524787240","https://openalex.org/W2525206927","https://openalex.org/W2532302047","https://openalex.org/W2537882427","https://openalex.org/W2545226662","https://openalex.org/W2548239247","https://openalex.org/W2551415529","https://openalex.org/W2553886049","https://openalex.org/W2555860266","https://openalex.org/W2557552778","https://openalex.org/W2562337654","https://openalex.org/W2565271826","https://openalex.org/W2567198868","https://openalex.org/W2580175309","https://openalex.org/W2580746697","https://openalex.org/W2582368205","https://openalex.org/W2586195606","https://openalex.org/W2587227416","https://openalex.org/W2588583929","https://openalex.org/W2589694509","https://openalex.org/W2594408608","https://openalex.org/W2594538327","https://openalex.org/W2595148454","https://openalex.org/W2600094664","https://openalex.org/W2601301923","https://openalex.org/W2606382276","https://openalex.org/W2606793345","https://openalex.org/W2607481912","https://openalex.org/W2608202513","https://openalex.org/W2615378556","https://openalex.org/W2622510831","https://openalex.org/W2625836171","https://openalex.org/W2626420049","https://openalex.org/W2640213649","https://openalex.org/W2724720631","https://openalex.org/W2727069564","https://openalex.org/W2727282010","https://openalex.org/W2727977279","https://openalex.org/W2728222661","https://openalex.org/W2734838770","https://openalex.org/W2738491178","https://openalex.org/W2742019858","https://openalex.org/W2744528944","https://openalex.org/W2750465430","https://openalex.org/W2752823190","https://openalex.org/W2754283165","https://openalex.org/W2756630266","https://openalex.org/W2757504354","https://openalex.org/W2759415766","https://openalex.org/W2760867057","https://openalex.org/W2761699988","https://openalex.org/W2764195238","https://openalex.org/W2765601065","https://openalex.org/W2765997581","https://openalex.org/W2769413428","https://openalex.org/W2770188847","https://openalex.org/W2771171260","https://openalex.org/W2771557629","https://openalex.org/W2772221743","https://openalex.org/W2773899600","https://openalex.org/W2774281740","https://openalex.org/W2782865844","https://openalex.org/W2784057214","https://openalex.org/W2786514708","https://openalex.org/W2787148816","https://openalex.org/W2787963369","https://openalex.org/W2790486047","https://openalex.org/W2791986466","https://openalex.org/W2792364195","https://openalex.org/W2792713198","https://openalex.org/W2794393331","https://openalex.org/W2794434465","https://openalex.org/W2798033749","https://openalex.org/W2800627402","https://openalex.org/W2801029790","https://openalex.org/W2801265165","https://openalex.org/W2801417961","https://openalex.org/W2802753913","https://openalex.org/W2802914200","https://openalex.org/W2804801146","https://openalex.org/W2805547508","https://openalex.org/W2806766954","https://openalex.org/W2806803654","https://openalex.org/W2808109470","https://openalex.org/W2809246284","https://openalex.org/W2809891495","https://openalex.org/W2810886104","https://openalex.org/W2856651205","https://openalex.org/W2883328413","https://openalex.org/W2883384367","https://openalex.org/W2884826672","https://openalex.org/W2884899054","https://openalex.org/W2885407408","https://openalex.org/W2885827769","https://openalex.org/W2887269406","https://openalex.org/W2887496785","https://openalex.org/W2887537157","https://openalex.org/W2889656970","https://openalex.org/W2890739664","https://openalex.org/W2891272237","https://openalex.org/W2892744778","https://openalex.org/W2896958491","https://openalex.org/W2897270659","https://openalex.org/W2898632247","https://openalex.org/W2900756811","https://openalex.org/W2901031021","https://openalex.org/W2903677975","https://openalex.org/W2904802348","https://openalex.org/W2907038540","https://openalex.org/W2908122377","https://openalex.org/W2912279203","https://openalex.org/W2912505459","https://openalex.org/W2912544859","https://openalex.org/W2913695190","https://openalex.org/W2914419976","https://openalex.org/W2916210549","https://openalex.org/W2917401432","https://openalex.org/W2917570556","https://openalex.org/W2919541686","https://openalex.org/W2921772310","https://openalex.org/W2925330066","https://openalex.org/W2929863582","https://openalex.org/W2932972562","https://openalex.org/W2933960973","https://openalex.org/W2938403043","https://openalex.org/W2939811893","https://openalex.org/W2942421163","https://openalex.org/W2943261504","https://openalex.org/W2943403839","https://openalex.org/W2946464891","https://openalex.org/W2946766521","https://openalex.org/W2946939927","https://openalex.org/W2947791494","https://openalex.org/W2949462030","https://openalex.org/W2953897714","https://openalex.org/W2956759516","https://openalex.org/W2964243955","https://openalex.org/W2964382846","https://openalex.org/W2966670499","https://openalex.org/W2966680167","https://openalex.org/W2967213355","https://openalex.org/W2967816246","https://openalex.org/W2969412263","https://openalex.org/W2969587497","https://openalex.org/W2969837995","https://openalex.org/W2970593976","https://openalex.org/W2971796232","https://openalex.org/W2972008302","https://openalex.org/W2972228663","https://openalex.org/W2972682131","https://openalex.org/W2973748748","https://openalex.org/W2980151372","https://openalex.org/W2982312895","https://openalex.org/W2986710063","https://openalex.org/W2989948182","https://openalex.org/W2989955814","https://openalex.org/W2992695309","https://openalex.org/W2993516018","https://openalex.org/W2993902820","https://openalex.org/W2998799555","https://openalex.org/W3000879095","https://openalex.org/W3001058124","https://openalex.org/W3004421537","https://openalex.org/W3005104290","https://openalex.org/W3005622563","https://openalex.org/W3007539087","https://openalex.org/W3007702902","https://openalex.org/W3008588181","https://openalex.org/W3009456598","https://openalex.org/W3010132504","https://openalex.org/W3011484207","https://openalex.org/W3012680772","https://openalex.org/W3012882288","https://openalex.org/W3014133149","https://openalex.org/W3014335029","https://openalex.org/W3016429216","https://openalex.org/W3017948648","https://openalex.org/W3018558498","https://openalex.org/W3028960763","https://openalex.org/W3030223964","https://openalex.org/W3034539442","https://openalex.org/W3034586668","https://openalex.org/W3037567166","https://openalex.org/W3042851164","https://openalex.org/W3044261814","https://openalex.org/W3044908880","https://openalex.org/W3045057048","https://openalex.org/W3046071390","https://openalex.org/W3046668398","https://openalex.org/W3048247311","https://openalex.org/W3081179837","https://openalex.org/W3085616253","https://openalex.org/W3087899116","https://openalex.org/W3088621202","https://openalex.org/W3088865755","https://openalex.org/W3090329944","https://openalex.org/W3090980144","https://openalex.org/W3092677976","https://openalex.org/W3094743157","https://openalex.org/W3096843727","https://openalex.org/W3101998156","https://openalex.org/W3107933303","https://openalex.org/W3109744624","https://openalex.org/W3109961002","https://openalex.org/W3111226847","https://openalex.org/W3111315732","https://openalex.org/W3118298225","https://openalex.org/W3121118670","https://openalex.org/W3122824372","https://openalex.org/W3123168270","https://openalex.org/W3128994933","https://openalex.org/W3129467510","https://openalex.org/W3135617549","https://openalex.org/W3136105262","https://openalex.org/W3138805442","https://openalex.org/W3151098575","https://openalex.org/W3157006762","https://openalex.org/W3157600643","https://openalex.org/W3159261950","https://openalex.org/W3162272338","https://openalex.org/W3164460400","https://openalex.org/W3165561827","https://openalex.org/W3165720345","https://openalex.org/W3168265815","https://openalex.org/W3169573297","https://openalex.org/W3171294431","https://openalex.org/W3172574923","https://openalex.org/W3172715768","https://openalex.org/W3172985871","https://openalex.org/W3178463557","https://openalex.org/W3182917488","https://openalex.org/W3185779416","https://openalex.org/W3196214328","https://openalex.org/W3199502028","https://openalex.org/W3205213125","https://openalex.org/W3206682079","https://openalex.org/W3213675969","https://openalex.org/W3216241483","https://openalex.org/W4205129753","https://openalex.org/W4205145746","https://openalex.org/W4205525895","https://openalex.org/W4206196136","https://openalex.org/W4206315850","https://openalex.org/W4206324811","https://openalex.org/W4206745752","https://openalex.org/W4210310783","https://openalex.org/W4210503972","https://openalex.org/W4210827885","https://openalex.org/W4212962718","https://openalex.org/W4214933741","https://openalex.org/W4220955263","https://openalex.org/W4226083976","https://openalex.org/W4229000978","https://openalex.org/W4231565477","https://openalex.org/W4231784055","https://openalex.org/W4243461295","https://openalex.org/W4251253146","https://openalex.org/W6600653411","https://openalex.org/W6609840529","https://openalex.org/W6726128281","https://openalex.org/W6770331849"],"related_works":["https://openalex.org/W2761917816","https://openalex.org/W2117909529","https://openalex.org/W3128429908","https://openalex.org/W2894872694","https://openalex.org/W4410806526","https://openalex.org/W3036316915","https://openalex.org/W3127264549","https://openalex.org/W4404614784","https://openalex.org/W2894756825","https://openalex.org/W4387515818"],"abstract_inverted_index":{"Although":[0],"diagnostic":[1,54],"and":[2,31,62,98,129,186,198,214,222,238],"therapeutic":[3],"treatments":[4],"of":[5,18,42,51,82,116,132,144,148,181,196,207,225,231,241,250],"cancer":[6,46,167,199],"have":[7,35,72,106,170],"tremendously":[8],"improved":[9],"over":[10],"the":[11,15,39,49,70,79,103,141,179,194,205,208,210,215,232,235,248],"past":[12],"two":[13],"decades,":[14],"indolent":[16],"nature":[17],"its":[19],"symptoms":[20],"has":[21],"made":[22],"early":[23],"detection":[24,81,143],"challenging.":[25],"Thus,":[26],"inter-disciplinary":[27],"(genomic,":[28],"transcriptomic,":[29,220],"proteomic,":[30,221],"lipidomic)":[32],"research":[33],"efforts":[34],"been":[36,107,171],"focused":[37,172],"on":[38,173,204],"non-invasive":[40,80,142],"identification":[41,249],"unique":[43,161],"\"silver":[44],"bullet\"":[45],"biomarkers":[47],"for":[48,78,110,140,178,218,247],"design":[50],"ultra-sensitive":[52],"molecular":[53],"assays.":[55],"Circulating":[56],"tumor":[57,96,252],"biomarkers,":[58],"such":[59],"as":[60,113,243],"CTCs":[61],"ctDNAs,":[63],"which":[64],"are":[65,89,121],"released":[66],"by":[67,92],"tumors":[68],"in":[69,102],"circulation,":[71,104],"already":[73],"demonstrated":[74],"their":[75,111,174,182,226],"clinical":[76],"utility":[77],"certain":[83],"solid":[84],"tumors.":[85],"Considering":[86],"that":[87,136],"exosomes":[88,242],"actively":[90],"produced":[91],"all":[93],"cells,":[94,97],"including":[95],"can":[99],"be":[100,138],"found":[101],"they":[105,125,159],"extensively":[108],"assessed":[109],"potential":[112],"a":[114,127,244],"source":[115],"circulating":[117,251],"cell-specific":[118],"biomarkers.":[119,253],"Exosomes":[120],"particularly":[122],"appealing":[123],"because":[124,158],"represent":[126],"stable":[128],"encapsulated":[130],"reservoir":[131],"active":[133],"biological":[134],"compounds":[135],"may":[137],"useful":[139],"cancer.":[145],"T":[146],"biogenesis":[147,195],"these":[149],"extracellular":[150],"vesicles":[151],"is":[152],"profoundly":[153],"altered":[154],"during":[155],"carcinogenesis,":[156],"but":[157],"harbor":[160],"or":[162],"uniquely":[163],"combined":[164],"surface":[165],"proteins,":[166],"biomarker":[168],"studies":[169],"purification":[175,212],"from":[176],"biofluids,":[177],"analysis":[180],"RNA,":[183],"DNA,":[184],"protein,":[185],"lipid":[187],"cargoes.":[188,227],"In":[189],"this":[190],"review,":[191],"we":[192],"evaluate":[193],"normal":[197],"exosomes,":[200],"provide":[201],"extensive":[202],"information":[203],"state":[206],"art,":[209],"current":[211,236],"methods,":[213],"technologies":[216],"employed":[217],"genomic,":[219],"lipidomic":[223],"evaluation":[224],"Our":[228],"thorough":[229],"examination":[230],"literature":[233],"highlights":[234],"limitations":[237],"promising":[239],"future":[240],"liquid":[245],"biopsy":[246]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-12T00:00:00"}