{"id":"https://openalex.org/W4284976869","doi":"https://doi.org/10.1016/j.jbc.2022.102242","title":"Tissue transglutaminase activates integrin-linked kinase and \u03b2-catenin in ovarian cancer","display_name":"Tissue transglutaminase activates integrin-linked kinase and \u03b2-catenin in ovarian cancer","publication_year":2022,"publication_date":"2022-07-08","ids":{"openalex":"https://openalex.org/W4284976869","doi":"https://doi.org/10.1016/j.jbc.2022.102242","pmid":"https://pubmed.ncbi.nlm.nih.gov/35810788","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9358478"},"language":"en","primary_location":{"id":"doi:10.1016/j.jbc.2022.102242","doi":"https://doi.org/10.1016/j.jbc.2022.102242","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2022.102242","pdf_url":"http://www.jbc.org/article/S0021925822006846/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.jbc.org/article/S0021925822006846/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076427573","display_name":"Salvatore Condello","orcid":"https://orcid.org/0000-0003-4979-3681","observed_orcids":["https://orcid.org/0000-0003-4979-3681"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4390039234","display_name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center","ror":"https://ror.org/00g1d7b60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039234","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Salvatore Condello","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA; Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA. Electronic address: salvcond@iu.edu","Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA","Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA"],"raw_orcid":"https://orcid.org/0000-0003-4979-3681","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA; Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA. Electronic address: salvcond@iu.edu","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4390039234","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4390039234","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068913591","display_name":"Mayuri Sinha Prasad","orcid":"https://orcid.org/0000-0003-0477-2369","observed_orcids":["https://orcid.org/0000-0003-0477-2369"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4390039234","display_name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center","ror":"https://ror.org/00g1d7b60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039234","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mayuri Prasad","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA; Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA","Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA","Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA; Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4390039234","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4390039234","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017106039","display_name":"Rula W. Atwani","orcid":"https://orcid.org/0009-0009-2851-7574","observed_orcids":["https://orcid.org/0009-0009-2851-7574"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4390039234","display_name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center","ror":"https://ror.org/00g1d7b60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039234","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rula Atwani","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA; Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA","Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA","Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA; Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4390039234","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4390039234","https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067743297","display_name":"Daniela Elena Matei","orcid":"https://orcid.org/0000-0003-2169-5035","observed_orcids":["https://orcid.org/0000-0003-2169-5035"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4210135737","display_name":"Jesse Brown VA Medical Center","ror":"https://ror.org/049qtwc86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210135737"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniela Matei","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; Robert H Lurie Comprehensive Cancer Center, Chicago, Illinois, USA; Jesse Brown VA Medical Center, Chicago, Illinois, USA","Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA","Jesse Brown VA Medical Center, Chicago, Illinois, USA","Robert H Lurie Comprehensive Cancer Center, Chicago, Illinois, USA"],"raw_orcid":"https://orcid.org/0000-0003-2169-5035","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; Robert H Lurie Comprehensive Cancer Center, Chicago, Illinois, USA; Jesse Brown VA Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4210135737","https://openalex.org/I4390039227"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Jesse Brown VA Medical Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I4210135737"]},{"raw_affiliation_string":"Robert H Lurie Comprehensive Cancer Center, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I4390039227"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5076427573"],"corresponding_institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4390039234","https://openalex.org/I4394709130","https://openalex.org/I55769427"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":3.2292,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.92319964,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"298","issue":"8","first_page":"102242","last_page":"102242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.8240000009536743},{"id":"https://openalex.org/keywords/tissue-transglutaminase","display_name":"tissue transglutaminase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/integrin-linked-kinase","display_name":"integrin-linked kinase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9290000200271606},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9079999923706055},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.8700000047683716},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7250000238418579},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8019999861717224},{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3","display_name":"glycogen synthase kinase-3","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6399999856948853},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C178498320","wikidata":"https://www.wikidata.org/wiki/Q14903608","display_name":"Tissue transglutaminase","level":3,"score":0.8214536309242249},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.588131844997406},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.5429655313491821},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.5220324993133545},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.48638108372688293},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.47839391231536865},{"id":"https://openalex.org/C66417403","wikidata":"https://www.wikidata.org/wiki/Q20970072","display_name":"Integrin-linked kinase","level":5,"score":0.4323990046977997},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4206305146217346},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4160040616989136},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.377519816160202},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3456762433052063},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3412497043609619},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3102097511291504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3087995648384094},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3073040246963501},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2918114960193634},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24710243940353394},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.23568683862686157},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.2065432369709015},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.15446153283119202},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.09380000829696655}],"mesh":[{"descriptor_ui":"D000091345","descriptor_name":"Protein Glutamine gamma Glutamyltransferase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000099200","descriptor_name":"Scaffold Protein ILK","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jbc.2022.102242","doi":"https://doi.org/10.1016/j.jbc.2022.102242","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2022.102242","pdf_url":"http://www.jbc.org/article/S0021925822006846/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9358478","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9358478","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:35810788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35810788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/34808","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/34808","pdf_url":"https://scholarworks.indianapolis.iu.edu/bitstreams/1fa31cad-b115-4a0b-be11-259a6b68274e/download","source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.jbc.2022.102242","doi":"https://doi.org/10.1016/j.jbc.2022.102242","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2022.102242","pdf_url":"http://www.jbc.org/article/S0021925822006846/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2900560653","display_name":null,"funder_award_id":"I01 BX000792","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G3892278961","display_name":"TARGETING OVARIAN CANCER STEM CELLS INTERACTIONS WITH THE NICHE","funder_award_id":"W81XWH1910008","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4254954259","display_name":null,"funder_award_id":"BX000792-06","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332961","display_name":"School of Medicine, Indiana University","ror":null},{"id":"https://openalex.org/F4320338505","display_name":"Ovarian Cancer Academy","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4284976869.pdf","grobid_xml":"https://content.openalex.org/works/W4284976869.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1536067283","https://openalex.org/W1817697566","https://openalex.org/W1916715636","https://openalex.org/W1963811337","https://openalex.org/W1967640121","https://openalex.org/W1984619334","https://openalex.org/W1987483436","https://openalex.org/W2001339111","https://openalex.org/W2002404925","https://openalex.org/W2004806132","https://openalex.org/W2009213090","https://openalex.org/W2012039807","https://openalex.org/W2013689372","https://openalex.org/W2014683547","https://openalex.org/W2022112198","https://openalex.org/W2023081206","https://openalex.org/W2024997708","https://openalex.org/W2030774127","https://openalex.org/W2035966370","https://openalex.org/W2036806537","https://openalex.org/W2038468856","https://openalex.org/W2046713135","https://openalex.org/W2046853446","https://openalex.org/W2050946558","https://openalex.org/W2051467321","https://openalex.org/W2053237419","https://openalex.org/W2055866442","https://openalex.org/W2060115924","https://openalex.org/W2060263755","https://openalex.org/W2065994341","https://openalex.org/W2067146344","https://openalex.org/W2069299583","https://openalex.org/W2095512379","https://openalex.org/W2099540110","https://openalex.org/W2106237123","https://openalex.org/W2106842254","https://openalex.org/W2107648723","https://openalex.org/W2107917016","https://openalex.org/W2108779312","https://openalex.org/W2109032682","https://openalex.org/W2115978612","https://openalex.org/W2120565161","https://openalex.org/W2122835088","https://openalex.org/W2133056134","https://openalex.org/W2143017330","https://openalex.org/W2143202717","https://openalex.org/W2145878813","https://openalex.org/W2158478967","https://openalex.org/W2160159092","https://openalex.org/W2165526821","https://openalex.org/W2167803193","https://openalex.org/W2293432961","https://openalex.org/W2330457397","https://openalex.org/W2395618555","https://openalex.org/W2517925871","https://openalex.org/W2750499920","https://openalex.org/W2792582780","https://openalex.org/W2794446484","https://openalex.org/W2807649309","https://openalex.org/W2942207677","https://openalex.org/W2994758603","https://openalex.org/W3014637457","https://openalex.org/W3032397400","https://openalex.org/W3119005666","https://openalex.org/W3164152602","https://openalex.org/W6667078964","https://openalex.org/W7074066932"],"related_works":["https://openalex.org/W4282924160","https://openalex.org/W2063247389","https://openalex.org/W2106842254","https://openalex.org/W2237675218","https://openalex.org/W2887780345","https://openalex.org/W2048349559","https://openalex.org/W2885858372","https://openalex.org/W2009213090","https://openalex.org/W2332381163","https://openalex.org/W1817697566"],"abstract_inverted_index":{"Ovarian":[0],"cancer":[1,69],"(OC)":[2],"is":[3,40,72,108],"the":[4,46,56,63,84,89,172,178,183],"most":[5],"lethal":[6],"gynecological":[7],"cancer.":[8],"OC":[9,112,206],"cells":[10,114,207],"have":[11],"high":[12],"proliferative":[13],"capacity,":[14],"are":[15],"invasive,":[16],"resist":[17],"apoptosis,":[18],"and":[19,55,82,86,102,127,151,158,186,191,202,208,210,236],"tumors":[20,209],"often":[21],"display":[22],"rearrangement":[23,235],"of":[24,66,88,125,143,156,230],"extracellular":[25],"matrix":[26],"(ECM)":[27],"components,":[28],"contributing":[29],"to":[30,42,171,182],"accelerated":[31],"tumor":[32,47],"progression.":[33],"The":[34],"multifunctional":[35],"protein":[36,92],"tissue":[37],"transglutaminase":[38],"(TG2)":[39],"known":[41],"be":[43],"secreted":[44],"in":[45,68,110,205,222,233,249],"microenvironment,":[48],"where":[49],"it":[50],"interacts":[51,80,200],"with":[52,81,130,201,219],"fibronectin":[53],"(FN)":[54],"cell":[57,70,169,188],"surface":[58],"receptor":[59,180],"integrin":[60,90],"\u03b21.":[61],"However,":[62],"mechanistic":[64],"role":[65,229],"TG2":[67,78,101,157,198],"proliferation":[71],"unknown.":[73],"Here,":[74],"we":[75,121,135,195],"demonstrate":[76,136,196],"that":[77,100,107,123,137,197,215,238],"directly":[79,199],"facilitates":[83],"phosphorylation":[85,142],"activation":[87,140],"effector":[91,240],"integrin-linked":[93],"kinase":[94],"(ILK)":[95],"at":[96],"Ser246.":[97],"We":[98],"show":[99,122],"p-Ser246-ILK":[103],"form":[104],"a":[105,212,227,244],"complex":[106],"detectable":[109],"patient-derived":[111],"primary":[113],"grown":[115],"on":[116],"FN-coated":[117],"slides.":[118],"In":[119,193],"addition,":[120],"coexpression":[124],"TGM2":[126],"ILK":[128,139,159,204,241],"correlates":[129],"poor":[131],"clinical":[132],"outcome.":[133],"Mechanistically,":[134],"TG2-mediated":[138],"causes":[141],"glycogen":[144],"synthase":[145],"kinase-3\u03b1/\u03b2,":[146],"allowing":[147],"\u03b2-catenin":[148,220],"nuclear":[149],"translocation":[150],"transcriptional":[152],"activity.":[153],"Furthermore,":[154],"inhibition":[155],"using":[160],"small":[161],"molecules,":[162],"neutralizing":[163],"antibodies,":[164],"or":[165],"shRNA-mediated":[166],"knockdown":[167],"blocks":[168],"adhesion":[170],"FN":[173],"matrix,":[174],"as":[175,177],"well":[176],"Wnt":[179],"response":[181],"Wnt-3A":[184],"ligand,":[185],"ultimately,":[187],"adhesion,":[189],"growth,":[190],"migration.":[192],"conclusion,":[194],"activates":[203],"define":[211],"new":[213,246],"mechanism":[214],"links":[216],"ECM":[217,234],"cues":[218],"signaling":[221],"OC.":[223,250],"These":[224],"results":[225],"suggest":[226],"central":[228],"TG2-FN-integrin":[231],"clusters":[232],"indicate":[237],"downstream":[239],"may":[242],"represent":[243],"potential":[245],"therapeutic":[247],"target":[248]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-10T00:00:00"}