{"id":"https://openalex.org/W4284965748","doi":"https://doi.org/10.1016/j.etap.2022.103928","title":"Multiomics analysis of the impact of polychlorinated biphenyls on environmental liver disease in a mouse model","display_name":"Multiomics analysis of the impact of polychlorinated biphenyls on environmental liver disease in a mouse model","publication_year":2022,"publication_date":"2022-07-06","ids":{"openalex":"https://openalex.org/W4284965748","doi":"https://doi.org/10.1016/j.etap.2022.103928","pmid":"https://pubmed.ncbi.nlm.nih.gov/35803474","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13669552"},"language":"en","primary_location":{"id":"doi:10.1016/j.etap.2022.103928","doi":"https://doi.org/10.1016/j.etap.2022.103928","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.etap.2022.103928","pdf_url":null,"source":{"id":"https://openalex.org/S108944336","display_name":"Environmental Toxicology and Pharmacology","issn_l":"1382-6689","issn":["1382-6689","1872-7077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Environmental Toxicology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.etap.2022.103928","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060527456","display_name":"Belinda J. Petri","orcid":"https://orcid.org/0000-0002-9248-9311","observed_orcids":["https://orcid.org/0000-0002-9248-9311"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Belinda J. Petri","raw_affiliation_strings":["Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine University of Louisville, Louisville, KY 40292, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine University of Louisville, Louisville, KY 40292, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047869650","display_name":"Kellianne M. Piell","orcid":"https://orcid.org/0000-0002-4132-7304","observed_orcids":["https://orcid.org/0000-0002-4132-7304"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kellianne M. Piell","raw_affiliation_strings":["Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine University of Louisville, Louisville, KY 40292, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine University of Louisville, Louisville, KY 40292, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004613586","display_name":"Banrida Wahlang","orcid":"https://orcid.org/0000-0002-4356-1743","observed_orcids":["https://orcid.org/0000-0002-4356-1743"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Banrida Wahlang","raw_affiliation_strings":["University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), USA; University of Louisville Hepatobiology and Toxicology Center, USA; The University of Louisville Superfund Research Center, USA; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Louisville School of Medicine, USA","Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Louisville School of Medicine, USA","The University of Louisville Superfund Research Center, USA","University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), USA","University of Louisville Hepatobiology and Toxicology Center, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), USA; University of Louisville Hepatobiology and Toxicology Center, USA; The University of Louisville Superfund Research Center, USA; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Louisville School of Medicine, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Louisville School of Medicine, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"The University of Louisville Superfund Research Center, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"University of Louisville Hepatobiology and Toxicology Center, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003018444","display_name":"Kimberly Z. Head","orcid":"https://orcid.org/0000-0003-4856-0077","observed_orcids":["https://orcid.org/0000-0003-4856-0077"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly Z. Head","raw_affiliation_strings":["University of Louisville Hepatobiology and Toxicology Center, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville Hepatobiology and Toxicology Center, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076892911","display_name":"Kalina Andreeva","orcid":"https://orcid.org/0000-0002-5206-532X","observed_orcids":["https://orcid.org/0000-0002-5206-532X"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalina Andreeva","raw_affiliation_strings":["KY INBRE Bioinformatics Core, University of Louisville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KY INBRE Bioinformatics Core, University of Louisville, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034707578","display_name":"Eric Christian Rouchka","orcid":"https://orcid.org/0000-0003-3487-6572","observed_orcids":["https://orcid.org/0000-0003-3487-6572"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric C. Rouchka","raw_affiliation_strings":["Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine University of Louisville, Louisville, KY 40292, USA; KY INBRE Bioinformatics Core, University of Louisville, USA","Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine University of Louisville, Louisville, KY 40292, USA","KY INBRE Bioinformatics Core, University of Louisville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine University of Louisville, Louisville, KY 40292, USA; KY INBRE Bioinformatics Core, University of Louisville, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine University of Louisville, Louisville, KY 40292, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"KY INBRE Bioinformatics Core, University of Louisville, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063421502","display_name":"Jianmin Pan","orcid":"https://orcid.org/0000-0002-5998-3481","observed_orcids":["https://orcid.org/0000-0002-5998-3481"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianmin Pan","raw_affiliation_strings":["Biostatistics and Bioinformatics Facility, Brown Cancer Center, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Bioinformatics Facility, Brown Cancer Center, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046209577","display_name":"Shesh Nath Rai","orcid":"https://orcid.org/0000-0002-8377-353X","observed_orcids":["https://orcid.org/0000-0002-8377-353X"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shesh N. Rai","raw_affiliation_strings":["University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), USA; University of Louisville Hepatobiology and Toxicology Center, USA; Biostatistics and Bioinformatics Facility, Brown Cancer Center, USA","Biostatistics and Bioinformatics Facility, Brown Cancer Center, USA","University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), USA","University of Louisville Hepatobiology and Toxicology Center, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), USA; University of Louisville Hepatobiology and Toxicology Center, USA; Biostatistics and Bioinformatics Facility, Brown Cancer Center, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Biostatistics and Bioinformatics Facility, Brown Cancer Center, USA","institution_ids":[]},{"raw_affiliation_string":"University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"University of Louisville Hepatobiology and Toxicology Center, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055645984","display_name":"Matthew C. Cave","orcid":"https://orcid.org/0000-0002-2560-6696","observed_orcids":["https://orcid.org/0000-0002-2560-6696"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew C. Cave","raw_affiliation_strings":["Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine University of Louisville, Louisville, KY 40292, USA; University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), USA; University of Louisville Hepatobiology and Toxicology Center, USA; The University of Louisville Superfund Research Center, USA; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Louisville School of Medicine, USA","Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine University of Louisville, Louisville, KY 40292, USA","Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Louisville School of Medicine, USA","The University of Louisville Superfund Research Center, USA","University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), USA","University of Louisville Hepatobiology and Toxicology Center, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine University of Louisville, Louisville, KY 40292, USA; University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), USA; University of Louisville Hepatobiology and Toxicology Center, USA; The University of Louisville Superfund Research Center, USA; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Louisville School of Medicine, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine University of Louisville, Louisville, KY 40292, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Louisville School of Medicine, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"The University of Louisville Superfund Research Center, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"University of Louisville Hepatobiology and Toxicology Center, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070981762","display_name":"Carolyn M. Klinge","orcid":"https://orcid.org/0000-0002-3358-4378","observed_orcids":["https://orcid.org/0000-0002-3358-4378"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carolyn M. Klinge","raw_affiliation_strings":["Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine University of Louisville, Louisville, KY 40292, USA; University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), USA. Electronic address: carolyn.klinge@louisville.edu","Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine University of Louisville, Louisville, KY 40292, USA","University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine University of Louisville, Louisville, KY 40292, USA; University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), USA. Electronic address: carolyn.klinge@louisville.edu","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Biochemistry & Molecular Genetics, Center for Genetics and Molecular Medicine University of Louisville, Louisville, KY 40292, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"University of Louisville Center for Integrative Environmental Health Sciences (CIEHS), USA","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070981762"],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":1.437,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.77542833,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"94","issue":null,"first_page":"103928","last_page":"103928"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polychlorinated-biphenyls","display_name":"polychlorinated biphenyls","score":1.0},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9800000190734863},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8159999847412109},{"id":"https://openalex.org/keywords/aroclor-1260","display_name":"Aroclor 1260","score":0.8930000066757202},{"id":"https://openalex.org/keywords/pcb-126","display_name":"PCB 126","score":0.8989999890327454},{"id":"https://openalex.org/keywords/persistent-organic-pollutants","display_name":"persistent organic pollutants","score":0.7450000047683716},{"id":"https://openalex.org/keywords/liver-transcriptome","display_name":"liver transcriptome","score":0.7730000019073486},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6010000109672546},{"id":"https://openalex.org/keywords/mir-192-5p","display_name":"miR-192-5p","score":0.9869999885559082},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hepatic-lipid-accumulation","display_name":"hepatic lipid accumulation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.921999990940094},{"id":"https://openalex.org/keywords/mirna-mrna-interactions","display_name":"miRNA-mRNA interactions","score":0.6430000066757202},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7680371403694153},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6917527914047241},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.6839725971221924},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6371877789497375},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6098686456680298},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.5560194253921509},{"id":"https://openalex.org/C2780473477","wikidata":"https://www.wikidata.org/wiki/Q3072135","display_name":"Toxicant","level":3,"score":0.5482913255691528},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5462446212768555},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.4780224561691284},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4628410041332245},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39199063181877136},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.37407100200653076},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3316456973552704},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29605984687805176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2603408098220825},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.20572662353515625},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19804659485816956},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.13952019810676575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09814950823783875}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011078","descriptor_name":"Polychlorinated Biphenyls","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011078","descriptor_name":"Polychlorinated Biphenyls","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.etap.2022.103928","doi":"https://doi.org/10.1016/j.etap.2022.103928","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.etap.2022.103928","pdf_url":null,"source":{"id":"https://openalex.org/S108944336","display_name":"Environmental Toxicology and Pharmacology","issn_l":"1382-6689","issn":["1382-6689","1872-7077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Environmental Toxicology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:35803474","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35803474","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental toxicology and pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13669552","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13669552/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13669552/pdf/nihms-2213167.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Environ Toxicol Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.etap.2022.103928","doi":"https://doi.org/10.1016/j.etap.2022.103928","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.etap.2022.103928","pdf_url":null,"source":{"id":"https://openalex.org/S108944336","display_name":"Environmental Toxicology and Pharmacology","issn_l":"1382-6689","issn":["1382-6689","1872-7077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Environmental Toxicology and Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2828812509","display_name":null,"funder_award_id":"T32ES011564","funder_id":"https://openalex.org/F4320310177","funder_display_name":"University of Louisville"},{"id":"https://openalex.org/G362814980","display_name":"m6A Epitranscriptomics in Toxicant Associated Steatohepatitis","funder_award_id":"R21ES031510","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4116127413","display_name":"Exposome and Precision Medicine in NAFLD","funder_award_id":"R01ES032189","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4151699032","display_name":null,"funder_award_id":"P42 ES023716","funder_id":"https://openalex.org/F4320313761","funder_display_name":"Kentucky Council on Postsecondary Education"},{"id":"https://openalex.org/G4335569013","display_name":null,"funder_award_id":"P30ES030283","funder_id":"https://openalex.org/F4320313761","funder_display_name":"Kentucky Council on Postsecondary Education"},{"id":"https://openalex.org/G5268660726","display_name":null,"funder_award_id":"ES031510-01S1","funder_id":"https://openalex.org/F4320313761","funder_display_name":"Kentucky Council on Postsecondary Education"},{"id":"https://openalex.org/G5796671578","display_name":"Environmental Liver Disease","funder_award_id":"R35ES028373","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6386156700","display_name":null,"funder_award_id":"R01ES032189","funder_id":"https://openalex.org/F4320313761","funder_display_name":"Kentucky Council on Postsecondary Education"},{"id":"https://openalex.org/G6579763053","display_name":null,"funder_award_id":"P20GM103436","funder_id":"https://openalex.org/F4320318958","funder_display_name":"Kentucky IDeA Networks of Biomedical Research Excellence"},{"id":"https://openalex.org/G7890109843","display_name":null,"funder_award_id":"PON2 415 1900002934","funder_id":"https://openalex.org/F4320313761","funder_display_name":"Kentucky Council on Postsecondary Education"},{"id":"https://openalex.org/G8072395732","display_name":null,"funder_award_id":"P20GM113226","funder_id":"https://openalex.org/F4320313761","funder_display_name":"Kentucky Council on Postsecondary Education"},{"id":"https://openalex.org/G8191284808","display_name":null,"funder_award_id":"P20GM103436","funder_id":"https://openalex.org/F4320313761","funder_display_name":"Kentucky Council on Postsecondary Education"},{"id":"https://openalex.org/G8204022981","display_name":"University of Louisville Center for Integrative Environmental Health Sciences","funder_award_id":"P30ES030283","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8638518721","display_name":null,"funder_award_id":"R35ES028373","funder_id":"https://openalex.org/F4320313761","funder_display_name":"Kentucky Council on Postsecondary Education"},{"id":"https://openalex.org/G9000858988","display_name":"Alcohol and tissue injury, from mechanisms to treatments","funder_award_id":"P50AA024333","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000873112","display_name":"The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ Injury","funder_award_id":"P50AA024337","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000886852","display_name":"Hepatobiology and Toxicology COBRE","funder_award_id":"P20GM113226","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000890563","display_name":"Environmental Exposure and Cardiometabolic Disease","funder_award_id":"P42ES023716","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000895881","display_name":"UOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAM","funder_award_id":"T32ES011564","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000896909","display_name":"IDeA Networks of Biomedical Research Excellence in Kentucky","funder_award_id":"P20GM103436","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320310177","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478"},{"id":"https://openalex.org/F4320313761","display_name":"Kentucky Council on Postsecondary Education","ror":"https://ror.org/016w1r206"},{"id":"https://openalex.org/F4320318958","display_name":"Kentucky IDeA Networks of Biomedical Research Excellence","ror":"https://ror.org/01jqq4q44"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4284965748.pdf","grobid_xml":"https://content.openalex.org/works/W4284965748.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W1525864426","https://openalex.org/W1528348540","https://openalex.org/W1915078082","https://openalex.org/W1964346105","https://openalex.org/W1973268693","https://openalex.org/W1974253904","https://openalex.org/W1977738457","https://openalex.org/W1996424780","https://openalex.org/W1999595538","https://openalex.org/W2013328321","https://openalex.org/W2016623506","https://openalex.org/W2018575064","https://openalex.org/W2019900254","https://openalex.org/W2026827182","https://openalex.org/W2040596806","https://openalex.org/W2056710301","https://openalex.org/W2064315476","https://openalex.org/W2065339494","https://openalex.org/W2069687969","https://openalex.org/W2072311845","https://openalex.org/W2087047837","https://openalex.org/W2095894499","https://openalex.org/W2104564665","https://openalex.org/W2107943478","https://openalex.org/W2112192177","https://openalex.org/W2114104545","https://openalex.org/W2117391818","https://openalex.org/W2130305733","https://openalex.org/W2131271579","https://openalex.org/W2134526812","https://openalex.org/W2141664611","https://openalex.org/W2146512944","https://openalex.org/W2147934487","https://openalex.org/W2157085831","https://openalex.org/W2164661590","https://openalex.org/W2166820820","https://openalex.org/W2169456326","https://openalex.org/W2170551349","https://openalex.org/W2179438025","https://openalex.org/W2233825900","https://openalex.org/W2277108569","https://openalex.org/W2293546533","https://openalex.org/W2495744039","https://openalex.org/W2502672822","https://openalex.org/W2511737947","https://openalex.org/W2533514457","https://openalex.org/W2535762306","https://openalex.org/W2580594600","https://openalex.org/W2585930139","https://openalex.org/W2733368201","https://openalex.org/W2753284523","https://openalex.org/W2772973693","https://openalex.org/W2782620426","https://openalex.org/W2788779164","https://openalex.org/W2805417682","https://openalex.org/W2807259057","https://openalex.org/W2894994091","https://openalex.org/W2900958958","https://openalex.org/W2916084686","https://openalex.org/W2930785527","https://openalex.org/W2945108378","https://openalex.org/W2947374360","https://openalex.org/W2960082800","https://openalex.org/W2980671377","https://openalex.org/W2980709466","https://openalex.org/W2982906949","https://openalex.org/W3005214954","https://openalex.org/W3013817403","https://openalex.org/W3024293031","https://openalex.org/W3031612395","https://openalex.org/W3032722056","https://openalex.org/W3033972611","https://openalex.org/W3034162475","https://openalex.org/W3037297377","https://openalex.org/W3043168565","https://openalex.org/W3043556768","https://openalex.org/W3047218830","https://openalex.org/W3086730844","https://openalex.org/W3094824630","https://openalex.org/W3108185722","https://openalex.org/W3121713467","https://openalex.org/W3131524023","https://openalex.org/W3134706919","https://openalex.org/W3156469832","https://openalex.org/W3157466769","https://openalex.org/W3179265187","https://openalex.org/W3201404475","https://openalex.org/W4205201788"],"related_works":["https://openalex.org/W4205201788","https://openalex.org/W2916084686","https://openalex.org/W4401513532","https://openalex.org/W4308036202","https://openalex.org/W2990340740","https://openalex.org/W4410599830","https://openalex.org/W2971857157","https://openalex.org/W2585930139","https://openalex.org/W3034666419","https://openalex.org/W3201404475"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-10T00:00:00"}