{"id":"https://openalex.org/W4284957890","doi":"https://doi.org/10.1080/1120009x.2022.2095155","title":"Meta-analysis of echinocandins combined with trimethoprim-sulfamethoxazole for treatment of Pneumocystis pneumonia","display_name":"Meta-analysis of echinocandins combined with trimethoprim-sulfamethoxazole for treatment of Pneumocystis pneumonia","publication_year":2022,"publication_date":"2022-07-09","ids":{"openalex":"https://openalex.org/W4284957890","doi":"https://doi.org/10.1080/1120009x.2022.2095155","pmid":"https://pubmed.ncbi.nlm.nih.gov/35815561"},"language":"en","primary_location":{"id":"doi:10.1080/1120009x.2022.2095155","doi":"https://doi.org/10.1080/1120009x.2022.2095155","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1120009x.2022.2095155","pdf_url":null,"source":{"id":"https://openalex.org/S127202688","display_name":"Journal of Chemotherapy","issn_l":"1120-009X","issn":["1120-009X","1973-9478"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077030094","display_name":"Jiayu Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayu Guo","raw_affiliation_strings":["Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005505826","display_name":"Zhongbao Chen","orcid":"https://orcid.org/0000-0002-1876-7838","observed_orcids":["https://orcid.org/0000-0002-1876-7838"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongbao Chen","raw_affiliation_strings":["Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077200390","display_name":"Chenyang Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenyang Kong","raw_affiliation_strings":["Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100405522","display_name":"Bo Yu","orcid":"https://orcid.org/0000-0003-2041-0050","observed_orcids":["https://orcid.org/0000-0003-2041-0050"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Yu","raw_affiliation_strings":["Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100417425","display_name":"Tianyu Wang","orcid":"https://orcid.org/0000-0002-6074-7523","observed_orcids":["https://orcid.org/0000-0002-6074-7523"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyu Wang","raw_affiliation_strings":["Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052290693","display_name":"Yalong Zhang","orcid":"https://orcid.org/0000-0002-9995-7659","observed_orcids":["https://orcid.org/0000-0002-9995-7659","https://orcid.org/0009-0001-6430-1051"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yalong Zhang","raw_affiliation_strings":["Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100664846","display_name":"Yiting Liu","orcid":"https://orcid.org/0000-0001-9368-3290","observed_orcids":["https://orcid.org/0000-0001-9368-3290"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiting Liu","raw_affiliation_strings":["Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020886320","display_name":"Jiangqiao Zhou","orcid":"https://orcid.org/0000-0002-6118-0020","observed_orcids":["https://orcid.org/0000-0002-6118-0020"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiangqiao Zhou","raw_affiliation_strings":["Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007388157","display_name":"Tao Qiu","orcid":"https://orcid.org/0000-0002-1410-7795","observed_orcids":["https://orcid.org/0000-0002-1410-7795"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tao Qiu","raw_affiliation_strings":["Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007388157","https://openalex.org/A5020886320"],"corresponding_institution_ids":["https://openalex.org/I4210140357"],"apc_list":null,"apc_paid":null,"fwci":0.119,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.15970288,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"35","issue":"3","first_page":"181","last_page":"187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12369","display_name":"Pneumocystis jirovecii pneumonia detection and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12369","display_name":"Pneumocystis jirovecii pneumonia detection and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/echinocandins","display_name":"echinocandins","score":0.9259999990463257},{"id":"https://openalex.org/keywords/trimethoprim-sulfamethoxazole","display_name":"trimethoprim-sulfamethoxazole","score":0.9700000286102295},{"id":"https://openalex.org/keywords/pneumocystis-jirovecii-pneumonia","display_name":"Pneumocystis carinii pneumonia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7670000195503235},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.9909999966621399},{"id":"https://openalex.org/keywords/treatment-response-rate","display_name":"treatment response rate","score":0.8820000290870667},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.6639999747276306},{"id":"https://openalex.org/keywords/immunocompromised-adults","display_name":"immunocompromised adults","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2910751997","wikidata":"https://www.wikidata.org/wiki/Q3718510","display_name":"Echinocandins","level":5,"score":0.8920226097106934},{"id":"https://openalex.org/C2777160144","wikidata":"https://www.wikidata.org/wiki/Q15401586","display_name":"Pneumocystis pneumonia","level":4,"score":0.6440714001655579},{"id":"https://openalex.org/C2779425571","wikidata":"https://www.wikidata.org/wiki/Q415843","display_name":"Sulfamethoxazole","level":3,"score":0.6092739701271057},{"id":"https://openalex.org/C2780728791","wikidata":"https://www.wikidata.org/wiki/Q422665","display_name":"Trimethoprim","level":3,"score":0.6038334965705872},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5788650512695312},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5234981179237366},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.4898945689201355},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.41119885444641113},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2835444211959839},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2587099075317383},{"id":"https://openalex.org/C2780402444","wikidata":"https://www.wikidata.org/wiki/Q420875","display_name":"Caspofungin","level":4,"score":0.1563696265220642},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14407438039779663},{"id":"https://openalex.org/C2777559004","wikidata":"https://www.wikidata.org/wiki/Q134478","display_name":"Pneumocystis jirovecii","level":3,"score":0.11871623992919922},{"id":"https://openalex.org/C2779629538","wikidata":"https://www.wikidata.org/wiki/Q412223","display_name":"Amphotericin B","level":3,"score":0.11716294288635254},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.0},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011020","descriptor_name":"Pneumonia, Pneumocystis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015662","descriptor_name":"Trimethoprim, Sulfamethoxazole Drug Combination","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D054714","descriptor_name":"Echinocandins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/1120009x.2022.2095155","doi":"https://doi.org/10.1080/1120009x.2022.2095155","is_oa":false,"landing_page_url":"https://doi.org/10.1080/1120009x.2022.2095155","pdf_url":null,"source":{"id":"https://openalex.org/S127202688","display_name":"Journal of Chemotherapy","issn_l":"1120-009X","issn":["1120-009X","1973-9478"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemotherapy","raw_type":"journal-article"},{"id":"pmid:35815561","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35815561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemotherapy (Florence, Italy)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1598334296","https://openalex.org/W1606020204","https://openalex.org/W1982099467","https://openalex.org/W2043572962","https://openalex.org/W2071112130","https://openalex.org/W2087074181","https://openalex.org/W2099951777","https://openalex.org/W2116475791","https://openalex.org/W2141405012","https://openalex.org/W2151641156","https://openalex.org/W2157823046","https://openalex.org/W2223238266","https://openalex.org/W2343495206","https://openalex.org/W2548813031","https://openalex.org/W2755688179","https://openalex.org/W2912839354","https://openalex.org/W2969984490","https://openalex.org/W2989970100","https://openalex.org/W3106923286","https://openalex.org/W3155326873","https://openalex.org/W4237637945","https://openalex.org/W4238102905"],"related_works":["https://openalex.org/W4281672077","https://openalex.org/W4415666320","https://openalex.org/W4401406591","https://openalex.org/W2989970100","https://openalex.org/W7127331009","https://openalex.org/W2927968980","https://openalex.org/W4404321561","https://openalex.org/W2043572962","https://openalex.org/W4406013603","https://openalex.org/W2126381453"],"abstract_inverted_index":{"Echinocandins":[0,135],"form":[1],"a":[2,108,141,207,224],"new":[3],"drug":[4,226],"class":[5],"for":[6,39,58,198,227],"the":[7,28,40,87,93,113,158,199],"treatment":[8,41,200,214],"of":[9,22,33,42,46,50,66,70,86,119,146,163,172,201],"Pneumocystis":[10],"pneumonia":[11,148,203],"(PCP),":[12],"but":[13],"their":[14],"efficacies":[15],"have":[16],"not":[17],"been":[18],"confirmed.":[19],"The":[20,84],"objective":[21],"this":[23],"study":[24],"was":[25,62,90,168,189],"to":[26,80,115,140,191,206],"review":[27],"all-cause":[29,144],"mortality":[30,145,210],"and":[31,73,100,127,129,157,211],"efficacy":[32],"echinocandins":[34,51,164,194,221],"combined":[35,52,136,165,195],"with":[36,53,137,166,196],"trimethoprim/sulfamethoxazole":[37],"(TMP/SMZ)":[38],"PCP.":[43,229],"A":[44],"meta-analysis":[45,114,183],"retrospective":[47,186],"case-control":[48,187],"studies":[49,89,131,188],"TMP/SMZ":[54,56,138,167,173,197],"or":[55],"alone":[57],"treating":[59,228],"adult":[60],"PCP":[61],"performed.":[63],"Pubmed,":[64],"Web":[65],"Sciences,":[67],"Cochrane":[68],"Register":[69],"Controlled":[71],"Trials,":[72],"Embase":[74],"databases":[75],"were":[76,105,125,132],"searched":[77],"from":[78],"inception":[79],"October":[81],"20,":[82],"2021.":[83],"quality":[85],"included":[88,133],"assessed":[91],"using":[92,107],"Newcastle-Ottawa":[94],"scale":[95],"(NOS).":[96],"Odds":[97],"ratios":[98],"(OR)":[99],"95%":[101],"confidence":[102],"intervals":[103],"(CI)":[104],"calculated":[106],"fixed":[109],"effects":[110],"model":[111],"in":[112,143,209,213],"derive":[116],"pooled":[117],"estimates":[118],"effect":[120],"size.":[121],"Five-hundred":[122],"forty":[123],"articles":[124],"identified":[126],"screened,":[128],"five":[130],"meta-analysis.":[134],"led":[139],"reduction":[142,208],"pneumocystis":[147,202],"(OR":[149,174],"=":[150,155,175,180],"0.47;":[151],"95%CI":[152,177],"0.32-0.71;":[153],"P":[154,179],"0.0003),":[156],"total":[159],"positive":[160],"response":[161,215],"rate":[162],"higher":[169],"than":[170],"that":[171,193,220],"2.16;":[176],"1.46-3.19;":[178],"0.0001).":[181],"This":[182],"based":[184],"on":[185],"first":[190],"show":[192],"can":[204],"lead":[205],"improvement":[212],"rates.":[216],"It":[217],"is":[218],"suggested":[219],"may":[222],"be":[223],"good":[225]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-10T00:00:00"}