{"id":"https://openalex.org/W4284897591","doi":"https://doi.org/10.1007/s10787-022-01017-8","title":"Pathogenesis and management of traumatic brain injury (TBI): role of neuroinflammation and anti-inflammatory drugs","display_name":"Pathogenesis and management of traumatic brain injury (TBI): role of neuroinflammation and anti-inflammatory drugs","publication_year":2022,"publication_date":"2022-07-08","ids":{"openalex":"https://openalex.org/W4284897591","doi":"https://doi.org/10.1007/s10787-022-01017-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/35802283","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9293826"},"language":"en","primary_location":{"id":"doi:10.1007/s10787-022-01017-8","doi":"https://doi.org/10.1007/s10787-022-01017-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10787-022-01017-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10787-022-01017-8.pdf","source":{"id":"https://openalex.org/S77466329","display_name":"Inflammopharmacology","issn_l":"0925-4692","issn":["0925-4692","1568-5608"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammopharmacology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4284897591"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10787-022-01017-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073125711","display_name":"Sunishtha Kalra","orcid":"https://orcid.org/0000-0001-6730-4648","observed_orcids":["https://orcid.org/0000-0001-6730-4648"]},"institutions":[{"id":"https://openalex.org/I905734797","display_name":"Maharshi Dayanand University","ror":"https://ror.org/03kaab451","country_code":"IN","type":"education","lineage":["https://openalex.org/I905734797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sunishtha Kalra","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India","institution_ids":["https://openalex.org/I905734797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051342485","display_name":"Rohit Malik","orcid":"https://orcid.org/0000-0003-2478-2556","observed_orcids":["https://orcid.org/0000-0003-2478-2556"]},"institutions":[{"id":"https://openalex.org/I905734797","display_name":"Maharshi Dayanand University","ror":"https://ror.org/03kaab451","country_code":"IN","type":"education","lineage":["https://openalex.org/I905734797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rohit Malik","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India","institution_ids":["https://openalex.org/I905734797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010441528","display_name":"Govind Singh","orcid":"https://orcid.org/0000-0001-7906-5744","observed_orcids":["https://orcid.org/0000-0001-7906-5744"]},"institutions":[{"id":"https://openalex.org/I905734797","display_name":"Maharshi Dayanand University","ror":"https://ror.org/03kaab451","country_code":"IN","type":"education","lineage":["https://openalex.org/I905734797"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Govind Singh","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India. drgovind.pharma@mdurohtak.ac.in","Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India. drgovind.pharma@mdurohtak.ac.in","institution_ids":["https://openalex.org/I905734797"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India","institution_ids":["https://openalex.org/I905734797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077443636","display_name":"Saurabh Bhatia","orcid":"https://orcid.org/0000-0002-8266-6927","observed_orcids":["https://orcid.org/0000-0002-8266-6927"]},"institutions":[{"id":"https://openalex.org/I209803261","display_name":"University of Nizwa","ror":"https://ror.org/01pxe3r04","country_code":"OM","type":"education","lineage":["https://openalex.org/I209803261"]},{"id":"https://openalex.org/I5847235","display_name":"University of Petroleum and Energy Studies","ror":"https://ror.org/04q2jes40","country_code":"IN","type":"education","lineage":["https://openalex.org/I5847235"]}],"countries":["IN","OM"],"is_corresponding":true,"raw_author_name":"Saurabh Bhatia","raw_affiliation_strings":["Natural and Medical Sciences Research Centre, University of Nizwa, Birkat Al Mauz, Nizwa, Oman. sbsaurabhbhatia@gmail.com","School of Health Sciences, University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India. sbsaurabhbhatia@gmail.com","School of Health Sciences, University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural and Medical Sciences Research Centre, University of Nizwa, Birkat Al Mauz, Nizwa, Oman. sbsaurabhbhatia@gmail.com","institution_ids":["https://openalex.org/I209803261"]},{"raw_affiliation_string":"School of Health Sciences, University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India. sbsaurabhbhatia@gmail.com","institution_ids":["https://openalex.org/I5847235"]},{"raw_affiliation_string":"School of Health Sciences, University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India","institution_ids":["https://openalex.org/I5847235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076140757","display_name":"Ahmed Al\u2010Harrasi","orcid":"https://orcid.org/0000-0002-0815-5942","observed_orcids":["https://orcid.org/0000-0002-0815-5942"]},"institutions":[{"id":"https://openalex.org/I209803261","display_name":"University of Nizwa","ror":"https://ror.org/01pxe3r04","country_code":"OM","type":"education","lineage":["https://openalex.org/I209803261"]}],"countries":["OM"],"is_corresponding":false,"raw_author_name":"Ahmed Al-Harrasi","raw_affiliation_strings":["Natural and Medical Sciences Research Centre, University of Nizwa, Birkat Al Mauz, Nizwa, Oman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural and Medical Sciences Research Centre, University of Nizwa, Birkat Al Mauz, Nizwa, Oman","institution_ids":["https://openalex.org/I209803261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080617264","display_name":"Syam Mohan","orcid":"https://orcid.org/0000-0003-2077-1278","observed_orcids":["https://orcid.org/0000-0003-2077-1278"]},"institutions":[{"id":"https://openalex.org/I5847235","display_name":"University of Petroleum and Energy Studies","ror":"https://ror.org/04q2jes40","country_code":"IN","type":"education","lineage":["https://openalex.org/I5847235"]},{"id":"https://openalex.org/I91450128","display_name":"Jazan University","ror":"https://ror.org/02bjnq803","country_code":"SA","type":"education","lineage":["https://openalex.org/I91450128"]}],"countries":["IN","SA"],"is_corresponding":false,"raw_author_name":"Syam Mohan","raw_affiliation_strings":["School of Health Sciences, University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India","Substance Abuse and Toxicology Research Centre, Jazan University, Jazan, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health Sciences, University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India","institution_ids":["https://openalex.org/I5847235"]},{"raw_affiliation_string":"Substance Abuse and Toxicology Research Centre, Jazan University, Jazan, Saudi Arabia","institution_ids":["https://openalex.org/I91450128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050578783","display_name":"Mohammed Albratty","orcid":"https://orcid.org/0000-0001-8687-0573","observed_orcids":["https://orcid.org/0000-0001-8687-0573"]},"institutions":[{"id":"https://openalex.org/I91450128","display_name":"Jazan University","ror":"https://ror.org/02bjnq803","country_code":"SA","type":"education","lineage":["https://openalex.org/I91450128"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mohammed Albratty","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan, Saudi Arabia","institution_ids":["https://openalex.org/I91450128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039271947","display_name":"Ali Albarrati","orcid":"https://orcid.org/0000-0003-0554-8721","observed_orcids":["https://orcid.org/0000-0003-0554-8721"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ali Albarrati","raw_affiliation_strings":["Rehabilitation Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rehabilitation Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079513373","display_name":"Murtaza M. Tambuwala","orcid":"https://orcid.org/0000-0001-8499-9891","observed_orcids":["https://orcid.org/0000-0001-8499-9891"]},"institutions":[{"id":"https://openalex.org/I138801177","display_name":"University of Ulster","ror":"https://ror.org/01yp9g959","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Murtaza M. Tambuwala","raw_affiliation_strings":["School of Pharmacy and Pharmaceutical Sciences, Ulster University, Northern Ireland, UK. m.tambuwala@ulster.ac.uk","School of Pharmacy and Pharmaceutical Sciences, Ulster University, Northern Ireland, UK"],"raw_orcid":"https://orcid.org/0000-0001-8499-9891","affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences, Ulster University, Northern Ireland, UK. m.tambuwala@ulster.ac.uk","institution_ids":["https://openalex.org/I138801177"]},{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences, Ulster University, Northern Ireland, UK","institution_ids":["https://openalex.org/I138801177"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5010441528","https://openalex.org/A5077443636","https://openalex.org/A5079513373"],"corresponding_institution_ids":["https://openalex.org/I138801177","https://openalex.org/I209803261","https://openalex.org/I5847235","https://openalex.org/I905734797"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":5.652,"has_fulltext":true,"cited_by_count":212,"citation_normalized_percentile":{"value":0.98236651,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"30","issue":"4","first_page":"1153","last_page":"1166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":1.0},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.9190000295639038},{"id":"https://openalex.org/keywords/secondary-brain-injury","display_name":"secondary brain injury","score":0.7789999842643738},{"id":"https://openalex.org/keywords/blood-brain-barrier-disruption","display_name":"blood-brain barrier disruption","score":0.9950000047683716},{"id":"https://openalex.org/keywords/inflammatory-signaling-pathways","display_name":"inflammatory signaling","score":0.8029999732971191},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.984000027179718},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.906000018119812},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.9480000138282776},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.8859999775886536},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.800000011920929},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.996999979019165},{"id":"https://openalex.org/keywords/herbal-drugs","display_name":"herbal drugs","score":0.6890000104904175},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9020000100135803},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.875}],"concepts":[{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.7787933945655823},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.776943564414978},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7171672582626343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7146998047828674},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.7087048292160034},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5133237242698669},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.44294285774230957},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35686418414115906},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3479706048965454},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3363167941570282},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3324905037879944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12806332111358643},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10402420163154602},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000070642","descriptor_name":"Brain Injuries, Traumatic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1007/s10787-022-01017-8","doi":"https://doi.org/10.1007/s10787-022-01017-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10787-022-01017-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10787-022-01017-8.pdf","source":{"id":"https://openalex.org/S77466329","display_name":"Inflammopharmacology","issn_l":"0925-4692","issn":["0925-4692","1568-5608"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammopharmacology","raw_type":"journal-article"},{"id":"pmid:35802283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35802283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammopharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9293826","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9293826/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammopharmacology","raw_type":"Text"},{"id":"pmh:oai:eprints.lincoln.ac.uk:51718","doi":null,"is_oa":false,"landing_page_url":"https://eprints.lincoln.ac.uk/id/eprint/51718/1/s10787-022-01017-8.pdf","pdf_url":"https://eprints.lincoln.ac.uk/id/eprint/51718/1/s10787-022-01017-8.pdf","source":{"id":"https://openalex.org/S4377196275","display_name":"Lincoln Repository (University of Lincoln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I51532219","host_organization_name":"University of Lincoln","host_organization_lineage":["https://openalex.org/I51532219"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eprints.lincoln.ac.uk:51738","doi":null,"is_oa":false,"landing_page_url":"https://eprints.lincoln.ac.uk/id/eprint/51738/1/s10787-022-01017-8.pdf","pdf_url":"https://eprints.lincoln.ac.uk/id/eprint/51738/1/s10787-022-01017-8.pdf","source":{"id":"https://openalex.org/S4377196275","display_name":"Lincoln Repository (University of Lincoln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I51532219","host_organization_name":"University of Lincoln","host_organization_lineage":["https://openalex.org/I51532219"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eprints.lincoln.ac.uk:51958","doi":null,"is_oa":false,"landing_page_url":"https://eprints.lincoln.ac.uk/id/eprint/51958/1/s10787-022-01017-8.pdf","pdf_url":"https://eprints.lincoln.ac.uk/id/eprint/51958/1/s10787-022-01017-8.pdf","source":{"id":"https://openalex.org/S4377196275","display_name":"Lincoln Repository (University of Lincoln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I51532219","host_organization_name":"University of Lincoln","host_organization_lineage":["https://openalex.org/I51532219"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pure.atira.dk:openaire/d4205a79-147e-41ae-a07f-9f6c3591301a","doi":null,"is_oa":true,"landing_page_url":"https://pure.ulster.ac.uk/en/publications/d4205a79-147e-41ae-a07f-9f6c3591301a","pdf_url":"https://pure.ulster.ac.uk/ws/files/102393686/s10787_022_01017_8.pdf","source":{"id":"https://openalex.org/S4306402454","display_name":"Ulster University Research Portal (Ulster University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138801177","host_organization_name":"University of Ulster","host_organization_lineage":["https://openalex.org/I138801177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kalra, S, Malik, R, Singh, G, Bhatia, S, Al-Harrasi, A, Mohan, S, Albratty, M, Albarrati, A & Tambuwala, M M 2022, 'Pathogenesis and management of traumatic brain injury (TBI): role of neuroinflammation and anti-inflammatory drugs', Inflammopharmacology, vol. 30, no. 4, pp. 1153-1166. https://doi.org/10.1007/s10787-022-01017-8","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:figshare.com:article/24398926","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Pathogenesis_and_management_of_traumatic_brain_injury_TBI_role_of_neuroinflammation_and_anti-inflammatory_drugs_/24398926","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/24398968","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Pathogenesis_and_management_of_traumatic_brain_injury_TBI_role_of_neuroinflammation_and_anti-inflammatory_drugs_/24398968","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/24399340","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Pathogenesis_and_management_of_traumatic_brain_injury_TBI_role_of_neuroinflammation_and_anti-inflammatory_drugs_/24399340","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s10787-022-01017-8","doi":"https://doi.org/10.1007/s10787-022-01017-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10787-022-01017-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10787-022-01017-8.pdf","source":{"id":"https://openalex.org/S77466329","display_name":"Inflammopharmacology","issn_l":"0925-4692","issn":["0925-4692","1568-5608"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammopharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4284897591.pdf","grobid_xml":"https://content.openalex.org/works/W4284897591.grobid-xml"},"referenced_works_count":113,"referenced_works":["https://openalex.org/W106706123","https://openalex.org/W1480468820","https://openalex.org/W1503384439","https://openalex.org/W1514824226","https://openalex.org/W1597257240","https://openalex.org/W1633340712","https://openalex.org/W1804602290","https://openalex.org/W1880007786","https://openalex.org/W1964780858","https://openalex.org/W1966483255","https://openalex.org/W1966558330","https://openalex.org/W1967664485","https://openalex.org/W1969074927","https://openalex.org/W1972696005","https://openalex.org/W1975908033","https://openalex.org/W1976422798","https://openalex.org/W1978585388","https://openalex.org/W1980162719","https://openalex.org/W1984879214","https://openalex.org/W1991010754","https://openalex.org/W1991743392","https://openalex.org/W1997176513","https://openalex.org/W1999377197","https://openalex.org/W2000254200","https://openalex.org/W2005700669","https://openalex.org/W2006901798","https://openalex.org/W2008898645","https://openalex.org/W2014847742","https://openalex.org/W2015348924","https://openalex.org/W2016087991","https://openalex.org/W2016316143","https://openalex.org/W2017589879","https://openalex.org/W2018067227","https://openalex.org/W2019610319","https://openalex.org/W2026876347","https://openalex.org/W2028976687","https://openalex.org/W2030033188","https://openalex.org/W2030688762","https://openalex.org/W2032514423","https://openalex.org/W2038720901","https://openalex.org/W2048826724","https://openalex.org/W2049593742","https://openalex.org/W2052249006","https://openalex.org/W2053657643","https://openalex.org/W2059640335","https://openalex.org/W2066844939","https://openalex.org/W2066886841","https://openalex.org/W2067097932","https://openalex.org/W2067889266","https://openalex.org/W2068870527","https://openalex.org/W2069318388","https://openalex.org/W2069544582","https://openalex.org/W2070093243","https://openalex.org/W2070614971","https://openalex.org/W2070759879","https://openalex.org/W2074127106","https://openalex.org/W2074883812","https://openalex.org/W2075089959","https://openalex.org/W2078442598","https://openalex.org/W2088404163","https://openalex.org/W2090188507","https://openalex.org/W2093215756","https://openalex.org/W2100391645","https://openalex.org/W2101577668","https://openalex.org/W2104236238","https://openalex.org/W2112462557","https://openalex.org/W2115785921","https://openalex.org/W2120307371","https://openalex.org/W2121860798","https://openalex.org/W2122828560","https://openalex.org/W2130139152","https://openalex.org/W2131686384","https://openalex.org/W2135339492","https://openalex.org/W2136052079","https://openalex.org/W2141102146","https://openalex.org/W2142413341","https://openalex.org/W2144091853","https://openalex.org/W2145283772","https://openalex.org/W2146373526","https://openalex.org/W2149168766","https://openalex.org/W2149868462","https://openalex.org/W2151283331","https://openalex.org/W2159744238","https://openalex.org/W2165467410","https://openalex.org/W2166851454","https://openalex.org/W2171571060","https://openalex.org/W2171761571","https://openalex.org/W2221099823","https://openalex.org/W2277097362","https://openalex.org/W2402460712","https://openalex.org/W2491393351","https://openalex.org/W2556724687","https://openalex.org/W2560809990","https://openalex.org/W2599820799","https://openalex.org/W2601018027","https://openalex.org/W2735527928","https://openalex.org/W2745631067","https://openalex.org/W2750054522","https://openalex.org/W2754554955","https://openalex.org/W2781409010","https://openalex.org/W2782190022","https://openalex.org/W2789715680","https://openalex.org/W2795085477","https://openalex.org/W2809319525","https://openalex.org/W2811029810","https://openalex.org/W2886737554","https://openalex.org/W2944718957","https://openalex.org/W2947436212","https://openalex.org/W2951992845","https://openalex.org/W2999339913","https://openalex.org/W3005184394","https://openalex.org/W3090452093","https://openalex.org/W4407602523"],"related_works":["https://openalex.org/W4411537228","https://openalex.org/W4400781390","https://openalex.org/W4281678741","https://openalex.org/W2095916445","https://openalex.org/W2009178440","https://openalex.org/W3122780703","https://openalex.org/W3158138032","https://openalex.org/W4285283196","https://openalex.org/W1978708614","https://openalex.org/W2140729052"],"abstract_inverted_index":{"Traumatic":[0],"brain":[1],"injury":[2,88],"(TBI)":[3],"is":[4],"an":[5,44],"important":[6],"global":[7],"health":[8],"concern":[9],"that":[10,59],"represents":[11],"a":[12],"leading":[13],"cause":[14],"of":[15,46,52,72,81,93,106,126,133],"death":[16],"and":[17,38,63,77,84,104,120,137,143,163],"disability.":[18],"It":[19,68],"occurs":[20],"due":[21],"to":[22,61],"direct":[23],"impact":[24],"or":[25],"hit":[26],"on":[27],"the":[28,41,50,55,73,79,87,102,124,131],"head":[29],"caused":[30],"by":[31],"factors":[32],"such":[33],"as":[34],"motor":[35],"vehicles,":[36],"crushes,":[37],"assaults.":[39],"During":[40],"past":[42],"decade,":[43],"abundance":[45],"new":[47],"evidence":[48],"highlighted":[49],"importance":[51],"inflammation":[53],"in":[54,70,123,130],"secondary":[56],"damage":[57],"response":[58],"contributes":[60],"neurodegenerative":[62],"neurological":[64],"deficits":[65],"after":[66],"TBI.":[67,134],"results":[69],"disruption":[71],"blood-brain":[74],"barrier":[75],"(BBB)":[76],"initiates":[78],"release":[80],"macrophages,":[82],"neutrophils,":[83],"lymphocytes":[85],"at":[86],"site.":[89],"A":[90],"growing":[91],"number":[92],"researchers":[94],"have":[95],"discovered":[96],"various":[97],"signalling":[98,110,153],"pathways":[99,111],"associated":[100,155],"with":[101,140,165],"initiation":[103],"progression":[105],"inflammation.":[107],"Targeting":[108],"different":[109,152],"(NF-\u03baB,":[112],"JAK/STAT,":[113],"MAPKs,":[114],"PI3K/Akt/mTOR,":[115],"GSK-3,":[116],"Nrf2,":[117],"RhoGTPase,":[118],"TGF-\u03b21,":[119],"NLRP3)":[121],"helps":[122],"development":[125],"novel":[127],"anti-inflammatory":[128,142,166],"drugs":[129,139],"management":[132],"Several":[135],"synthetic":[136],"herbal":[138],"both":[141],"neuroprotective":[144],"potential":[145],"showed":[146],"effective":[147],"results.":[148],"This":[149],"review":[150],"summarizes":[151],"pathways,":[154],"pathologies,":[156],"inflammatory":[157],"mediators,":[158],"pharmacological":[159],"potential,":[160],"current":[161],"status,":[162],"challenges":[164],"drugs.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":61},{"year":2025,"cited_by_count":71},{"year":2024,"cited_by_count":48},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-07-09T00:00:00"}