{"id":"https://openalex.org/W4284896735","doi":"https://doi.org/10.18499/2070-478x-2022-15-1-85-91","title":"Interleukin-2 in the Complex Treatment of Surgical Patients","display_name":"Interleukin-2 in the Complex Treatment of Surgical Patients","publication_year":2022,"publication_date":"2022-03-23","ids":{"openalex":"https://openalex.org/W4284896735","doi":"https://doi.org/10.18499/2070-478x-2022-15-1-85-91"},"language":"en","primary_location":{"id":"doi:10.18499/2070-478x-2022-15-1-85-91","doi":"https://doi.org/10.18499/2070-478x-2022-15-1-85-91","is_oa":true,"landing_page_url":"https://doi.org/10.18499/2070-478x-2022-15-1-85-91","pdf_url":"https://www.vestnik-surgery.com/index.php/journal/article/download/1566/pdf","source":{"id":"https://openalex.org/S2764837912","display_name":"Journal of Experimental and Clinical Surgery","issn_l":"2070-478X","issn":["2070-478X","2409-143X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental and Clinical Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.vestnik-surgery.com/index.php/journal/article/download/1566/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076767599","display_name":"Alexander Alekseevich Andreev","orcid":"https://orcid.org/0000-0001-8215-7519","observed_orcids":["https://orcid.org/0000-0001-8215-7519","https://orcid.org/0000-0002-5242-6105"]},"institutions":[{"id":"https://openalex.org/I2800247874","display_name":"Voronezh State Medical Academy named after N.N. Burdenko","ror":"https://ror.org/05kce7016","country_code":"RU","type":"education","lineage":["https://openalex.org/I2800247874"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander Alekseevich Andreev","raw_affiliation_strings":["N.N. Burdenko Voronezh State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N.N. Burdenko Voronezh State Medical University","institution_ids":["https://openalex.org/I2800247874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092294493","display_name":"Vitalii Donchenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800247874","display_name":"Voronezh State Medical Academy named after N.N. Burdenko","ror":"https://ror.org/05kce7016","country_code":"RU","type":"education","lineage":["https://openalex.org/I2800247874"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vitalii Donchenko","raw_affiliation_strings":["N.N. Burdenko Voronezh State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N.N. Burdenko Voronezh State Medical University","institution_ids":["https://openalex.org/I2800247874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042110113","display_name":"Aleksandr Anatolevich Glukhov","orcid":"https://orcid.org/0000-0001-9675-7611","observed_orcids":["https://orcid.org/0000-0001-9675-7611"]},"institutions":[{"id":"https://openalex.org/I2800247874","display_name":"Voronezh State Medical Academy named after N.N. Burdenko","ror":"https://ror.org/05kce7016","country_code":"RU","type":"education","lineage":["https://openalex.org/I2800247874"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander Anatolievich Gluhov","raw_affiliation_strings":["N.N. Burdenko Voronezh State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N.N. Burdenko Voronezh State Medical University","institution_ids":["https://openalex.org/I2800247874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058003773","display_name":"\u041d\u043e\u0432\u043e\u043c\u043b\u0438\u043d\u0441\u043a\u0438\u0439 \u0412\u043b\u0430\u0434\u0438\u0441\u043b\u0430\u0432 \u0412\u0430\u043b\u0435\u0440\u044c\u0435\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0002-6874-1417","observed_orcids":["https://orcid.org/0000-0002-6874-1417"]},"institutions":[{"id":"https://openalex.org/I2800247874","display_name":"Voronezh State Medical Academy named after N.N. Burdenko","ror":"https://ror.org/05kce7016","country_code":"RU","type":"education","lineage":["https://openalex.org/I2800247874"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vladislav  Valeryevich Novomlinsky","raw_affiliation_strings":["CHUZ Clinical Hospital \"Russian Railways-Medicine\" of Voronezh\nN.N. Burdenko Voronezh State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHUZ Clinical Hospital \"Russian Railways-Medicine\" of Voronezh\nN.N. Burdenko Voronezh State Medical University","institution_ids":["https://openalex.org/I2800247874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003889403","display_name":"Anton Petrovich Ostroushko","orcid":"https://orcid.org/0000-0003-3656-5954","observed_orcids":["https://orcid.org/0000-0003-3656-5954"]},"institutions":[{"id":"https://openalex.org/I2800247874","display_name":"Voronezh State Medical Academy named after N.N. Burdenko","ror":"https://ror.org/05kce7016","country_code":"RU","type":"education","lineage":["https://openalex.org/I2800247874"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anton Petrovich Ostroushko","raw_affiliation_strings":["N.N. Burdenko Voronezh State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N.N. Burdenko Voronezh State Medical University","institution_ids":["https://openalex.org/I2800247874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109768950","display_name":"Anastasia Yu. Laptiyova","orcid":"https://orcid.org/0000-0002-3307-1425","observed_orcids":["https://orcid.org/0000-0002-3307-1425"]},"institutions":[{"id":"https://openalex.org/I2800247874","display_name":"Voronezh State Medical Academy named after N.N. Burdenko","ror":"https://ror.org/05kce7016","country_code":"RU","type":"education","lineage":["https://openalex.org/I2800247874"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anastasia  Yurievna Laptiyova","raw_affiliation_strings":["N.N. Burdenko Voronezh State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N.N. Burdenko Voronezh State Medical University","institution_ids":["https://openalex.org/I2800247874"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2800247874"],"apc_list":null,"apc_paid":null,"fwci":0.2807,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.40621339,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"15","issue":"1","first_page":"85","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.17419999837875366,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.17419999837875366,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.16040000319480896,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.08460000157356262,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/recombinant-interleukin-2","display_name":"recombinant interleukin-2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9210000038146973},{"id":"https://openalex.org/keywords/immunodeficiency","display_name":"immunodeficiency","score":0.8059999942779541},{"id":"https://openalex.org/keywords/surgical-patients","display_name":"surgical patients","score":0.8489999771118164},{"id":"https://openalex.org/keywords/purulent-wounds","display_name":"purulent wounds","score":0.8169999718666077},{"id":"https://openalex.org/keywords/pancreatic-necrosis","display_name":"pancreatic necrosis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/osteomyelitis","display_name":"osteomyelitis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.7480000257492065},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.5339999794960022},{"id":"https://openalex.org/keywords/endotoxicosis","display_name":"endotoxicosis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.7390000224113464},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5943096280097961},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5590547323226929},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.46776363253593445},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4421485960483551},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.43522489070892334},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4069802761077881},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29703086614608765},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18499/2070-478x-2022-15-1-85-91","doi":"https://doi.org/10.18499/2070-478x-2022-15-1-85-91","is_oa":true,"landing_page_url":"https://doi.org/10.18499/2070-478x-2022-15-1-85-91","pdf_url":"https://www.vestnik-surgery.com/index.php/journal/article/download/1566/pdf","source":{"id":"https://openalex.org/S2764837912","display_name":"Journal of Experimental and Clinical Surgery","issn_l":"2070-478X","issn":["2070-478X","2409-143X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental and Clinical Surgery","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18499/2070-478x-2022-15-1-85-91","doi":"https://doi.org/10.18499/2070-478x-2022-15-1-85-91","is_oa":true,"landing_page_url":"https://doi.org/10.18499/2070-478x-2022-15-1-85-91","pdf_url":"https://www.vestnik-surgery.com/index.php/journal/article/download/1566/pdf","source":{"id":"https://openalex.org/S2764837912","display_name":"Journal of Experimental and Clinical Surgery","issn_l":"2070-478X","issn":["2070-478X","2409-143X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental and Clinical Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4284896735.pdf","grobid_xml":"https://content.openalex.org/works/W4284896735.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W101574256","https://openalex.org/W2514165839","https://openalex.org/W2593771451","https://openalex.org/W3097463343","https://openalex.org/W4212805490"],"related_works":["https://openalex.org/W1995585950","https://openalex.org/W2045908268","https://openalex.org/W1981912238","https://openalex.org/W2461230125","https://openalex.org/W2026073203","https://openalex.org/W1990078051","https://openalex.org/W2151754709","https://openalex.org/W3213222550","https://openalex.org/W2372269909","https://openalex.org/W3191533798"],"abstract_inverted_index":{"Immunotherapy":[0],"for":[1,40,254],"surgical":[2,228,258],"diseases":[3,153],"remains":[4],"one":[5],"of":[6,43,48,59,68,81,88,91,101,112,131,140,148,179,193,200,203,214,233,238,248],"the":[7,41,65,110,129,141,146,185,249],"urgent":[8],"scientific":[9],"and":[10,29,61,73,84,97,114,122,134,167,184,206,242,245],"clinical":[11,138,231],"issues.":[12],"Immunodeficiency":[13],"is":[14,105,171,217],"manifested":[15,225],"in":[16,145,154,177,226,257],"patients":[17,155],"with":[18,156],"purulent":[19],"wounds,":[20],"pancreatic":[21],"necrosis,":[22],"osteomyelitis,":[23],"oncological":[24],"diseases,":[25],"echinococcosis,":[26],"gastroduodenal":[27],"ulcers":[28],"other":[30],"pathology.":[31],"Drugs":[32],"inducing":[33],"interleukin-2":[34,176],"synthesis":[35,87],"have":[36],"shown":[37],"high":[38,137,219],"efficacy":[39,232],"correction":[42],"immunodeficiency":[44],"status.":[45],"Clinical":[46],"effects":[47],"rIL-2":[49],"are":[50,224],"due":[51],"to":[52,55,63,98,127,173],"its":[53,215,218],"ability":[54],"activate":[56],"clonal":[57],"proliferation":[58],"T-":[60],"B-lymphocytes,":[62],"enhance":[64],"effector":[66],"potential":[67],"cytotoxic":[69],"T-lymphocytes":[70],"(CTL":[71],"cells)":[72],"natural":[74],"killer":[75],"cells":[76,96],"(NK":[77],"cells),":[78],"functional":[79],"activity":[80,139],"mononuclear":[82],"phagocytes":[83],"antigen-presenting":[85],"cells,":[86],"specific":[89],"immunoglobulins":[90],"most":[92],"isotypes":[93],"by":[94],"plasma":[95],"reduce":[99],"apoptosis":[100],"mononuclears.":[102],"This":[103],"cytokine":[104],"a":[106,191],"key":[107],"link":[108],"determining":[109],"development":[111],"cellular":[113],"humoral":[115],"immunity.":[116],"Interleukin-2":[117],"provides":[118],"antitumor,":[119],"antiviral,":[120],"antibacterial":[121],"antifungal":[123],"protection,":[124],"being":[125],"able":[126],"stimulate":[128],"processes":[130],"tissue":[132],"regeneration":[133],"repair.":[135],"The":[136,188,211],"drug":[142,189,250],"was":[143],"revealed":[144],"treatment":[147,183],"endotoxicosis,":[149],"immunological":[150],"insufficiency,":[151],"inflammatory":[152],"surgical,":[157],"oncological,":[158],"traumatological,":[159],"combustiological,":[160],"resuscitation":[161],"profiles,":[162],"involving":[163],"abdominal":[164],"organs,":[165],"pelvis":[166],"retroperitoneal":[168],"space.":[169],"It":[170],"rational":[172],"use":[174,256],"recombinant":[175,234],"case":[178],"previous":[180],"inefficient":[181],"conventional":[182],"process":[186],"chronization.":[187],"has":[190],"number":[192],"positive":[194],"aspects:":[195],"rapid":[196],"effect;":[197],"reduced":[198,208],"terms":[199],"treatment,":[201],"frequency":[202],"infectious":[204],"complications":[205],"sepsis;":[207],"mortality":[209],"rate.":[210],"negative":[212],"side":[213],"administration":[216],"cost.":[220],"Thus,":[221],"immunosuppressive":[222],"conditions":[223],"multiple":[227],"diseases.":[229],"High":[230],"interleukin":[235],"2,":[236],"absence":[237],"complications,":[239],"adverse":[240],"reactions":[241],"undesirable":[243],"effects,":[244],"favourable":[246],"tolerability":[247],"allow":[251],"recommending":[252],"it":[253],"wider":[255],"practice.":[259]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-07-09T00:00:00"}
