{"id":"https://openalex.org/W4284896475","doi":"https://doi.org/10.3389/fimmu.2022.929837","title":"Photobiomodulation Improves Serum Cytokine Response in Mild to Moderate COVID-19: The First Randomized, Double-Blind, Placebo Controlled, Pilot Study","display_name":"Photobiomodulation Improves Serum Cytokine Response in Mild to Moderate COVID-19: The First Randomized, Double-Blind, Placebo Controlled, Pilot Study","publication_year":2022,"publication_date":"2022-07-08","ids":{"openalex":"https://openalex.org/W4284896475","doi":"https://doi.org/10.3389/fimmu.2022.929837","pmid":"https://pubmed.ncbi.nlm.nih.gov/35874678","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9304695"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2022.929837","doi":"https://doi.org/10.3389/fimmu.2022.929837","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.929837","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.929837/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.929837/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079891794","display_name":"Seyed Mehran Marashian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019658157","display_name":"Masih Daneshvari Hospital","ror":"https://ror.org/039mjhc39","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I3019658157"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Seyed Mehran Marashian","raw_affiliation_strings":["Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I3019658157","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043986552","display_name":"Mohammadreza Hashemian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019658157","display_name":"Masih Daneshvari Hospital","ror":"https://ror.org/039mjhc39","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I3019658157"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammadreza Hashemian","raw_affiliation_strings":["Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I3019658157","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108606465","display_name":"Mihan Pourabdollah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019658157","display_name":"Masih Daneshvari Hospital","ror":"https://ror.org/039mjhc39","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I3019658157"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mihan Pourabdollah","raw_affiliation_strings":["Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I3019658157","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055488184","display_name":"Mansour Nasseri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mansour Nasseri","raw_affiliation_strings":["Department of Immunology, School of Public Health, University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Public Health, University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013571912","display_name":"Saeed Mahmoudian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019658157","display_name":"Masih Daneshvari Hospital","ror":"https://ror.org/039mjhc39","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I3019658157"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Saeed Mahmoudian","raw_affiliation_strings":["National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I3019658157","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059060775","display_name":"Florian Reinhart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Florian Reinhart","raw_affiliation_strings":["Medical Research & Innovation Department, Medical and Biomedical Consultancy Office \"Innolys\", Illkirch-Graffenstaden, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research & Innovation Department, Medical and Biomedical Consultancy Office \"Innolys\", Illkirch-Graffenstaden, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008315785","display_name":"Alireza Eslaminejad","orcid":"https://orcid.org/0000-0002-8788-4544","observed_orcids":["https://orcid.org/0000-0002-8788-4544"]},"institutions":[{"id":"https://openalex.org/I3019658157","display_name":"Masih Daneshvari Hospital","ror":"https://ror.org/039mjhc39","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I3019658157"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Alireza Eslaminejad","raw_affiliation_strings":["Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I3019658157","https://openalex.org/I58048189"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059060775"],"corresponding_institution_ids":[],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.1742,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.86937675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"929837","last_page":"929837"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-level-laser-therapy","display_name":"low-level laser therapy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.8629999756813049},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8759999871253967},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9959999918937683},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/il-6-il-10-ratio","display_name":"IL-6/IL-10 ratio","score":0.9079999923706055},{"id":"https://openalex.org/keywords/serum-cytokines","display_name":"serum cytokines","score":0.6700000166893005},{"id":"https://openalex.org/keywords/hospitalized-patients","display_name":"hospitalized patients","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.761267364025116},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.7355676293373108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7213649749755859},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6466567516326904},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5796253681182861},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.5528780221939087},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5186187624931335},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4597499668598175},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.4499078392982483},{"id":"https://openalex.org/C2994577977","wikidata":"https://www.wikidata.org/wiki/Q1203526","display_name":"Pilot trial","level":3,"score":0.42252999544143677},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4039008915424347},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3491649031639099},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.29476046562194824},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.27284741401672363},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17202317714691162},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.09733247756958008},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.08388000726699829},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2022.929837","doi":"https://doi.org/10.3389/fimmu.2022.929837","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.929837","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.929837/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:35874678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35874678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9304695","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9304695/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:88c9fb5457c848f2b3d59d47dfe8ce4d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/88c9fb5457c848f2b3d59d47dfe8ce4d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2022.929837","doi":"https://doi.org/10.3389/fimmu.2022.929837","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.929837","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2022.929837/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4284896475.pdf","grobid_xml":"https://content.openalex.org/works/W4284896475.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1842842423","https://openalex.org/W1946919574","https://openalex.org/W1966553076","https://openalex.org/W1984662660","https://openalex.org/W2002078449","https://openalex.org/W2007653638","https://openalex.org/W2024174668","https://openalex.org/W2030294879","https://openalex.org/W2036433737","https://openalex.org/W2063194492","https://openalex.org/W2084990572","https://openalex.org/W2087068236","https://openalex.org/W2087967163","https://openalex.org/W2089035904","https://openalex.org/W2091852726","https://openalex.org/W2108692814","https://openalex.org/W2118112316","https://openalex.org/W2137784781","https://openalex.org/W2161074777","https://openalex.org/W2173672722","https://openalex.org/W2228033993","https://openalex.org/W2247054841","https://openalex.org/W2276108106","https://openalex.org/W2318337867","https://openalex.org/W2333884451","https://openalex.org/W2396171833","https://openalex.org/W2529601819","https://openalex.org/W2557169050","https://openalex.org/W2560419663","https://openalex.org/W2736200882","https://openalex.org/W2756025095","https://openalex.org/W2765592620","https://openalex.org/W2789400878","https://openalex.org/W2891533504","https://openalex.org/W2900819958","https://openalex.org/W2902337962","https://openalex.org/W2910657316","https://openalex.org/W2927678279","https://openalex.org/W2981100201","https://openalex.org/W2982181868","https://openalex.org/W2994512357","https://openalex.org/W3008090866","https://openalex.org/W3009992310","https://openalex.org/W3012515447","https://openalex.org/W3012862568","https://openalex.org/W3033588777","https://openalex.org/W3047681788","https://openalex.org/W3080654873","https://openalex.org/W3081502886","https://openalex.org/W3107992103","https://openalex.org/W3127392579","https://openalex.org/W3127797936","https://openalex.org/W3129397954","https://openalex.org/W3145300561","https://openalex.org/W3170113405","https://openalex.org/W3206188296","https://openalex.org/W4254062836","https://openalex.org/W4281786114"],"related_works":["https://openalex.org/W6957767978","https://openalex.org/W4324123480","https://openalex.org/W4200154906","https://openalex.org/W4386401075","https://openalex.org/W3107992103","https://openalex.org/W3175564952","https://openalex.org/W3092423953","https://openalex.org/W3119788001","https://openalex.org/W4386951961","https://openalex.org/W3205884880"],"abstract_inverted_index":{"Background":[0],"Because":[1],"the":[2,8,53,59,73,170,212,247],"major":[3,251],"event":[4],"in":[5,49,72,91,138,143,155,173,181,209,219,232,253],"COVID-19":[6,254],"is":[7,37],"release":[9],"of":[10,38,61,76,115,122,184],"pre-":[11],"and":[12,29,52,97,118,141,158,163,195,259,266,273],"inflammatory":[13],"cytokines,":[14],"finding":[15],"a":[16,94,98,119,178,206,268,275],"reliable":[17],"therapeutic":[18],"strategy":[19],"to":[20,57,243,263],"inhibit":[21],"this":[22,50],"release,":[23],"help":[24,48],"patients":[25,136],"manage":[26],"organ":[27],"damage":[28],"avoid":[30],"ICU":[31],"admission":[32],"or":[33,228,240],"severe":[34],"disease":[35],"progression":[36],"paramount":[39],"importance.":[40],"Photobiomodulation":[41],"(PBM),":[42],"based":[43],"on":[44,64],"numerous":[45],"studies,":[46],"may":[47],"regard,":[51],"present":[54],"study":[55,69,80,171],"sought":[56],"evaluate":[58],"effects":[60],"said":[62],"technology":[63],"cytokine":[65,276],"reduction.":[66],"Methods":[67],"This":[68],"was":[70,177],"conducted":[71],"2nd":[74],"half":[75],"2021.":[77],"The":[78,214,222,250],"current":[79],"included":[81],"52":[82],"mild-to-moderately":[83],"ill":[84],"COVID-19,":[85],"hospitalized":[86],"patients.":[87],"They":[88],"were":[89,137,151,166,236],"divided":[90],"two":[92],"groups:":[93],"Placebo":[95,139,223],"group":[96,140,224],"PBM":[99,103,144,174,220,244,264],"group,":[100,175],"treated":[101],"with":[102,131],"(620-635":[104],"nm":[105],"light":[106],"via":[107],"8":[108],"LEDs":[109],"that":[110],"provide":[111],"an":[112,230],"energy":[113],"density":[114,121],"45.40":[116],"J/cm2":[117],"power":[120],"0.12":[123],"W/cm2),":[124],"twice":[125],"daily":[126],"for":[127,271],"three":[128,156],"days,":[129],"along":[130],"classical":[132],"approved":[133],"treatment.":[134],"28":[135],"24":[142],"group.":[145,221],"In":[146],"both":[147],"groups,":[148],"blood":[149],"samples":[150],"taken":[152],"four":[153],"times":[154],"days":[157],"serum":[159,182],"IL-6,":[160,257],"IL-8,":[161,258],"IL-10,":[162],"TNF-\u03b1":[164,196],"levels":[165,183],"determined.":[167],"Results":[168],"During":[169],"period,":[172],"there":[176],"significant":[179,207],"decrease":[180,227],"IL-6":[185],"(-82.5%":[186],"+/-":[187],"4,":[188],"P<0.001),":[189,194,200],"IL-8":[190],"(-54.4%":[191],"\u00b1":[192,198],"8,":[193,199],"(-82.4%":[197],"although":[201],"we":[202],"did":[203],"not":[204],"detect":[205],"change":[208],"IL-10":[210],"during":[211],"study.":[213,248],"IL-6/IL-10":[215],"Ratio":[216],"also":[217],"improved":[218],"showed":[225],"no":[226,237],"even":[229],"increase":[231],"these":[233],"parameters.":[234],"There":[235],"reported":[238],"complications":[239],"sequelae":[241],"due":[242],"therapy":[245,265],"throughout":[246],"Conclusion":[249],"cytokines":[252],"pathophysiology,":[255],"including":[256],"TNF-\u03b1,":[260],"responded":[261],"positively":[262],"opened":[267],"new":[269],"window":[270],"inhibiting":[272],"managing":[274],"storm":[277],"within":[278],"only":[279],"3-10":[280],"days.":[281]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-09T00:00:00"}