{"id":"https://openalex.org/W4284894935","doi":"https://doi.org/10.3390/cimb44070216","title":"Antioxidant Activity of New Sulphur- and Selenium-Containing Analogues of Potassium Phenosan against H2O2-Induced Cytotoxicity in Tumour Cells","display_name":"Antioxidant Activity of New Sulphur- and Selenium-Containing Analogues of Potassium Phenosan against H2O2-Induced Cytotoxicity in Tumour Cells","publication_year":2022,"publication_date":"2022-07-07","ids":{"openalex":"https://openalex.org/W4284894935","doi":"https://doi.org/10.3390/cimb44070216","pmid":"https://pubmed.ncbi.nlm.nih.gov/35877440","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9317250"},"language":"en","primary_location":{"id":"doi:10.3390/cimb44070216","doi":"https://doi.org/10.3390/cimb44070216","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb44070216","pdf_url":"https://www.mdpi.com/1467-3045/44/7/216/pdf?version=1657532500","source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1467-3045/44/7/216/pdf?version=1657532500","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035009381","display_name":"Lyubov S. Klyushova","orcid":"https://orcid.org/0000-0003-4820-2536","observed_orcids":["https://orcid.org/0000-0003-4820-2536"]},"institutions":[{"id":"https://openalex.org/I4210134550","display_name":"Federal Research Center of Fundamental and Translational Medicine","ror":"https://ror.org/04545k330","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210134550"]},{"id":"https://openalex.org/I4210150971","display_name":"Institute of Molecular Biology and Biophysics","ror":"https://ror.org/051f11n17","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210150971"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Lyubov S. Klyushova","raw_affiliation_strings":["Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, 2/12 Timakova Str., 630060 Novosibirsk, Russia"],"raw_orcid":"https://orcid.org/0000-0003-4820-2536","affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, 2/12 Timakova Str., 630060 Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210134550","https://openalex.org/I4210150971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008378032","display_name":"\u041d. \u0412. \u041a\u0430\u043d\u0434\u0430\u043b\u0438\u043d\u0446\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0001-6022-934X","observed_orcids":["https://orcid.org/0000-0001-6022-934X"]},"institutions":[{"id":"https://openalex.org/I4210142574","display_name":"Novosibirsk State Pedagogical University","ror":"https://ror.org/03x2fyc79","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210142574"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Natalya V. Kandalintseva","raw_affiliation_strings":["Department of Chemistry, Novosibirsk State Pedagogical University, 28 Vilyuyskaya Str., 630126 Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Novosibirsk State Pedagogical University, 28 Vilyuyskaya Str., 630126 Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210142574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077890349","display_name":"A. Yu. Grishanova","orcid":"https://orcid.org/0000-0002-5894-1159","observed_orcids":["https://orcid.org/0000-0002-5894-1159"]},"institutions":[{"id":"https://openalex.org/I4210134550","display_name":"Federal Research Center of Fundamental and Translational Medicine","ror":"https://ror.org/04545k330","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210134550"]},{"id":"https://openalex.org/I4210150971","display_name":"Institute of Molecular Biology and Biophysics","ror":"https://ror.org/051f11n17","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210150971"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alevtina Y. Grishanova","raw_affiliation_strings":["Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, 2/12 Timakova Str., 630060 Novosibirsk, Russia"],"raw_orcid":"https://orcid.org/0000-0002-5894-1159","affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, 2/12 Timakova Str., 630060 Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210134550","https://openalex.org/I4210150971"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035009381"],"corresponding_institution_ids":["https://openalex.org/I4210134550","https://openalex.org/I4210150971"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1885},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1885},"fwci":0.6468,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.5385178,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"44","issue":"7","first_page":"3131","last_page":"3145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.5,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.5,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11931","display_name":"Organoselenium and organotellurium chemistry","score":0.16990000009536743,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.07760000228881836,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenolic-antioxidants","display_name":"phenolic antioxidants","score":0.7900000214576721},{"id":"https://openalex.org/keywords/water-soluble-antioxidants","display_name":"water-soluble antioxidants","score":0.7940000295639038},{"id":"https://openalex.org/keywords/hydrogen-peroxide-induced-cytotoxicity","display_name":"hydrogen peroxide-induced cytotoxicity","score":0.949999988079071},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.6320000290870667},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hep-2-cells","display_name":"HEp-2 cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/high-content-analysis","display_name":"high-content analysis","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.8986842632293701},{"id":"https://openalex.org/C553756173","wikidata":"https://www.wikidata.org/wiki/Q876","display_name":"Selenium","level":2,"score":0.8725318908691406},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.8520683646202087},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7117761373519897},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.5785219073295593},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5614061951637268},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.5364009141921997},{"id":"https://openalex.org/C518881349","wikidata":"https://www.wikidata.org/wiki/Q682","display_name":"Sulfur","level":2,"score":0.4923919439315796},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47486329078674316},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.46925899386405945},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1842334270477295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12301567196846008},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cimb44070216","doi":"https://doi.org/10.3390/cimb44070216","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb44070216","pdf_url":"https://www.mdpi.com/1467-3045/44/7/216/pdf?version=1657532500","source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},{"id":"pmid:35877440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35877440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current issues in molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9317250","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9317250/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Issues Mol Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b272e6bee3ca4323b77ff48ca6c97899","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b272e6bee3ca4323b77ff48ca6c97899","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Issues in Molecular Biology, Vol 44, Iss 7, Pp 3131-3145 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cimb44070216","doi":"https://doi.org/10.3390/cimb44070216","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb44070216","pdf_url":"https://www.mdpi.com/1467-3045/44/7/216/pdf?version=1657532500","source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1453871403","display_name":null,"funder_award_id":"075-15-2021-691","funder_id":"https://openalex.org/F4320327494","funder_display_name":"Ministry of Science and Higher Education of the Russian Federation"},{"id":"https://openalex.org/G338600197","display_name":null,"funder_award_id":"N1021050601082-2-1.6.4;3.1.6","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"},{"id":"https://openalex.org/G3974991192","display_name":null,"funder_award_id":"19-34-90129","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"},{"id":"https://openalex.org/G4091584216","display_name":null,"funder_award_id":"FGMU-2022-0004","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"},{"id":"https://openalex.org/G5849541225","display_name":null,"funder_award_id":"1.6.4","funder_id":"https://openalex.org/F4320327494","funder_display_name":"Ministry of Science and Higher Education of the Russian Federation"},{"id":"https://openalex.org/G6444257319","display_name":null,"funder_award_id":"075-15-","funder_id":"https://openalex.org/F4320327494","funder_display_name":"Ministry of Science and Higher Education of the Russian Federation"}],"funders":[{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"},{"id":"https://openalex.org/F4320327494","display_name":"Ministry of Science and Higher Education of the Russian Federation","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4284894935.pdf","grobid_xml":"https://content.openalex.org/works/W4284894935.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1964079640","https://openalex.org/W1968193177","https://openalex.org/W1968474561","https://openalex.org/W1973641158","https://openalex.org/W1985183596","https://openalex.org/W1993419555","https://openalex.org/W1998936301","https://openalex.org/W2001645329","https://openalex.org/W2010737385","https://openalex.org/W2011562710","https://openalex.org/W2012945933","https://openalex.org/W2039551947","https://openalex.org/W2043649744","https://openalex.org/W2047966395","https://openalex.org/W2056399724","https://openalex.org/W2059141083","https://openalex.org/W2078265076","https://openalex.org/W2090492836","https://openalex.org/W2098131661","https://openalex.org/W2101405261","https://openalex.org/W2132923788","https://openalex.org/W2139602777","https://openalex.org/W2144542772","https://openalex.org/W2152855697","https://openalex.org/W2154553542","https://openalex.org/W2162898581","https://openalex.org/W2186092918","https://openalex.org/W2275201610","https://openalex.org/W2281055924","https://openalex.org/W2322280362","https://openalex.org/W2488392870","https://openalex.org/W2604104231","https://openalex.org/W2776113064","https://openalex.org/W2799653496","https://openalex.org/W2912396267","https://openalex.org/W2950676432","https://openalex.org/W2969778414","https://openalex.org/W2981310308","https://openalex.org/W3005270555","https://openalex.org/W3041426930","https://openalex.org/W3097716084","https://openalex.org/W3106906779","https://openalex.org/W3108907036","https://openalex.org/W3201171636","https://openalex.org/W4206134263","https://openalex.org/W4224212802","https://openalex.org/W4252360123","https://openalex.org/W6686801248"],"related_works":["https://openalex.org/W4283383104","https://openalex.org/W2528995619","https://openalex.org/W4213030833","https://openalex.org/W2472340761","https://openalex.org/W3044752285","https://openalex.org/W1562983530","https://openalex.org/W7117251803","https://openalex.org/W2955569956","https://openalex.org/W3127541007","https://openalex.org/W2785815089"],"abstract_inverted_index":{"Among":[0],"known":[1,16],"phenolic":[2,26],"antioxidants,":[3],"the":[4,13,32,103,108,134,157],"overwhelming":[5],"majority":[6],"of":[7,15,24,34,39,56,105,136],"compounds":[8,18,41],"have":[9],"lipophilic":[10],"properties":[11],"and":[12,53,65,81,124,156],"number":[14],"water-soluble":[17],"is":[19],"very":[20],"small.":[21],"The":[22,129,144],"list":[23],"hydrophilic":[25],"antioxidants":[27],"can":[28],"be":[29],"expanded":[30],"via":[31],"synthesis":[33],"a":[35,97,112],"structurally":[36],"related":[37],"series":[38],"polyfunctional":[40],"for":[42],"further":[43],"research":[44],"on":[45],"their":[46],"biological":[47,93,149],"activity":[48,71,94,104,150],"in":[49,121,126],"vitro.":[50],"New":[51],"sulphur-":[52],"selenium-containing":[54,89,109,130,158],"analogues":[55],"antioxidant":[57,70,115],"potassium":[58,106,154],"phenosan":[59,155],"were":[60,83],"synthesised.":[61],"In":[62],"vitro":[63],"cytotoxicity":[64,74],"cytostaticity":[66],"as":[67,69,151],"well":[68],"against":[72,117],"H2O2-induced":[73,118],"to":[75,102,153],"human":[76],"cell":[77,113],"lines":[78],"(HepG2,":[79],"Hep-2":[80,127],"MCF-7)":[82],"investigated":[84],"by":[85],"high-content":[86],"analysis.":[87],"A":[88],"analogue":[90,110,131,146],"showed":[91],"higher":[92],"than":[95],"did":[96],"sulphur-containing":[98,145],"one.":[99],"As":[100],"compared":[101,152],"phenosan,":[107],"had":[111],"line-dependent":[114],"effect":[116],"cytotoxicity:":[119],"comparable":[120],"HepG2":[122],"cells":[123,138],"greater":[125],"cells.":[128],"significantly":[132],"increased":[133],"death":[135],"MCF-7":[137],"at":[139],"concentrations":[140],"above":[141],"50":[142],"\u00b5M.":[143],"has":[147],"lower":[148],"analogue.":[159]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-09T00:00:00"}
