{"id":"https://openalex.org/W4284893654","doi":"https://doi.org/10.3389/falgy.2022.887672","title":"The External Exposome and Allergies: From the Perspective of the Epithelial Barrier Hypothesis","display_name":"The External Exposome and Allergies: From the Perspective of the Epithelial Barrier Hypothesis","publication_year":2022,"publication_date":"2022-07-08","ids":{"openalex":"https://openalex.org/W4284893654","doi":"https://doi.org/10.3389/falgy.2022.887672","pmid":"https://pubmed.ncbi.nlm.nih.gov/35873598","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9304993"},"language":"en","primary_location":{"id":"doi:10.3389/falgy.2022.887672","doi":"https://doi.org/10.3389/falgy.2022.887672","is_oa":true,"landing_page_url":"https://doi.org/10.3389/falgy.2022.887672","pdf_url":"https://www.frontiersin.org/articles/10.3389/falgy.2022.887672/pdf","source":{"id":"https://openalex.org/S4210191602","display_name":"Frontiers in Allergy","issn_l":"2673-6101","issn":["2673-6101"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Allergy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/falgy.2022.887672/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016973945","display_name":"Zeynep \u00c7elebi S\u00f6zener","orcid":"https://orcid.org/0000-0003-4188-0959","observed_orcids":["https://orcid.org/0000-0003-4188-0959"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zeynep Celebi Sozener","raw_affiliation_strings":["Clinic of Immunology and Allergic Diseases, Ankara City Hospital, Ankara, Turkey","Clinic of Immunology and Allergic Diseases, Ankara City Hospital, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Immunology and Allergic Diseases, Ankara City Hospital, Ankara, Turkey","institution_ids":[]},{"raw_affiliation_string":"Clinic of Immunology and Allergic Diseases, Ankara City Hospital, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059889694","display_name":"\u00dcm\u00fc\u015f \u00d6zbey Y\u00fccel","orcid":"https://orcid.org/0000-0002-1438-0791","observed_orcids":["https://orcid.org/0000-0002-1438-0791"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00dcm\u00fcs \u00d6zbey Y\u00fccel","raw_affiliation_strings":["Department of Nutrition and Diet, Ankara University, Ankara, Turkey","Department of Nutrition and Diet, Ankara University, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Diet, Ankara University, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]},{"raw_affiliation_string":"Department of Nutrition and Diet, Ankara University, Turkey","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050503721","display_name":"Seda Alt\u0131ner","orcid":"https://orcid.org/0000-0001-5648-4284","observed_orcids":["https://orcid.org/0000-0001-5648-4284"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Seda Altiner","raw_affiliation_strings":["Division of Immunology and Allergic Diseases, Department of Internal Medicine, School of Medicine, Ankara University, Ankara, Turkey","Division of Immunology and Allergic Diseases, Department of Internal Medicine, School of Medicine, Ankara University, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Allergic Diseases, Department of Internal Medicine, School of Medicine, Ankara University, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]},{"raw_affiliation_string":"Division of Immunology and Allergic Diseases, Department of Internal Medicine, School of Medicine, Ankara University, Turkey","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013390578","display_name":"Bet\u00fcl \u00d6zdel \u00d6zt\u00fcrk","orcid":"https://orcid.org/0000-0001-8653-3497","observed_orcids":["https://orcid.org/0000-0001-8653-3497"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Bet\u00fcl Ozdel Ozt\u00fcrk","raw_affiliation_strings":["Division of Immunology and Allergic Diseases, Department of Chest Diseases, School of Medicine, Ankara University, Ankara, Turkey","Division of Immunology and Allergic Diseases, Department of Chest Diseases, School of Medicine, Ankara University, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Allergic Diseases, Department of Chest Diseases, School of Medicine, Ankara University, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]},{"raw_affiliation_string":"Division of Immunology and Allergic Diseases, Department of Chest Diseases, School of Medicine, Ankara University, Turkey","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053080627","display_name":"Pamir \u00c7er\u00e7i","orcid":"https://orcid.org/0000-0002-0844-6352","observed_orcids":["https://orcid.org/0000-0002-0844-6352"]},"institutions":[{"id":"https://openalex.org/I4210091745","display_name":"Eski\u015fehir City Hospital","ror":"https://ror.org/00czdkn85","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I1303077703","https://openalex.org/I4210091745"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Pamir Cerci","raw_affiliation_strings":["Clinic of Immunology and Allergic Diseases, Eskisehir City Hospital, Eskisehir, Turkey","Clinic of Immunology and Allergic Diseases, Eskisehir City Hospital, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Immunology and Allergic Diseases, Eskisehir City Hospital, Eskisehir, Turkey","institution_ids":["https://openalex.org/I4210091745"]},{"raw_affiliation_string":"Clinic of Immunology and Allergic Diseases, Eskisehir City Hospital, Turkey","institution_ids":["https://openalex.org/I4210091745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001508354","display_name":"Murat T\u00fcrk","orcid":"https://orcid.org/0000-0002-3290-2661","observed_orcids":["https://orcid.org/0000-0002-3290-2661"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Murat T\u00fcrk","raw_affiliation_strings":["Clinic of Immunology and Allergic Diseases, Kayseri City Hospital, Kayseri, Turkey","Clinic of Immunology and Allergic Diseases, Kayseri City Hospital, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Immunology and Allergic Diseases, Kayseri City Hospital, Kayseri, Turkey","institution_ids":[]},{"raw_affiliation_string":"Clinic of Immunology and Allergic Diseases, Kayseri City Hospital, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062118757","display_name":"Beg\u00fcm Gorg\u00fcl\u00fc Akin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beg\u00fcm Gorg\u00fcl\u00fc Akin","raw_affiliation_strings":["Clinic of Immunology and Allergic Diseases, Ankara City Hospital, Ankara, Turkey","Clinic of Immunology and Allergic Diseases, Ankara City Hospital, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Immunology and Allergic Diseases, Ankara City Hospital, Ankara, Turkey","institution_ids":[]},{"raw_affiliation_string":"Clinic of Immunology and Allergic Diseases, Ankara City Hospital, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019919684","display_name":"M\u00fcbeccel Akdi\u015f","orcid":"https://orcid.org/0000-0003-0554-9943","observed_orcids":["https://orcid.org/0000-0003-0554-9943"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"M\u00fcbeccel Akdis","raw_affiliation_strings":["Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland","Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054648338","display_name":"\u0130nsu Y\u0131lmaz","orcid":"https://orcid.org/0000-0001-6023-6291","observed_orcids":["https://orcid.org/0000-0001-6023-6291"]},"institutions":[{"id":"https://openalex.org/I87673952","display_name":"Erciyes University","ror":"https://ror.org/047g8vk19","country_code":"TR","type":"education","lineage":["https://openalex.org/I87673952"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Insu Yilmaz","raw_affiliation_strings":["Division of Immunology and Allergic Diseases, Department of Chest Diseases, Erciyes University, Kayseri, Turkey","Division of Immunology and Allergic Diseases, Department of Chest Diseases, Erciyes University, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Allergic Diseases, Department of Chest Diseases, Erciyes University, Kayseri, Turkey","institution_ids":["https://openalex.org/I87673952"]},{"raw_affiliation_string":"Division of Immunology and Allergic Diseases, Department of Chest Diseases, Erciyes University, Turkey","institution_ids":["https://openalex.org/I87673952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034899450","display_name":"Cevdet \u00d6zdemir","orcid":"https://orcid.org/0000-0002-9284-4520","observed_orcids":["https://orcid.org/0000-0002-9284-4520"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Cevdet Ozdemir","raw_affiliation_strings":["Department of Pediatric Basic Sciences, Institute of Child Health, Istanbul University, Istanbul, Turkey","Division of Pediatric Allergy and Immunology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey","Department of Pediatric Basic Sciences, Institute of Child Health, Istanbul University, Turkey","Division of Pediatric Allergy and Immunology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Basic Sciences, Institute of Child Health, Istanbul University, Istanbul, Turkey","institution_ids":["https://openalex.org/I67581229"]},{"raw_affiliation_string":"Division of Pediatric Allergy and Immunology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey","institution_ids":["https://openalex.org/I67581229"]},{"raw_affiliation_string":"Department of Pediatric Basic Sciences, Institute of Child Health, Istanbul University, Turkey","institution_ids":["https://openalex.org/I67581229"]},{"raw_affiliation_string":"Division of Pediatric Allergy and Immunology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Turkey","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056110953","display_name":"Dil\u015fad Mungan","orcid":"https://orcid.org/0000-0001-8806-2764","observed_orcids":["https://orcid.org/0000-0001-8806-2764"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Dilsad Mungan","raw_affiliation_strings":["Division of Immunology and Allergic Diseases, Department of Chest Diseases, School of Medicine, Ankara University, Ankara, Turkey","Division of Immunology and Allergic Diseases, Department of Chest Diseases, School of Medicine, Ankara University, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Allergic Diseases, Department of Chest Diseases, School of Medicine, Ankara University, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]},{"raw_affiliation_string":"Division of Immunology and Allergic Diseases, Department of Chest Diseases, School of Medicine, Ankara University, Turkey","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055404517","display_name":"Cezmi A. Akdi\u015f","orcid":"https://orcid.org/0000-0001-8020-019X","observed_orcids":["https://orcid.org/0000-0001-8020-019X"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210119317","display_name":"CK-CARE","ror":"https://ror.org/02c1jcc15","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210119317"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Cezmi A. Akdis","raw_affiliation_strings":["Christine K\u00fchne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland","Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland","Christine K\u00fchne-Center for Allergy Research and Education (CK-CARE), Switzerland","Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christine K\u00fchne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland","institution_ids":["https://openalex.org/I4210119317"]},{"raw_affiliation_string":"Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Christine K\u00fchne-Center for Allergy Research and Education (CK-CARE), Switzerland","institution_ids":["https://openalex.org/I4210119317"]},{"raw_affiliation_string":"Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5016973945","https://openalex.org/A5055404517"],"corresponding_institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210119317"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":2.7014,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.93859649,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"3","issue":null,"first_page":"887672","last_page":"887672"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.10729999840259552,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.0771000012755394,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergic-diseases","display_name":"allergic diseases","score":0.968999981880188},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.8899999856948853},{"id":"https://openalex.org/keywords/particulate-matter","display_name":"particulate matter","score":0.8209999799728394},{"id":"https://openalex.org/keywords/nitrogen-dioxide","display_name":"nitrogen dioxide","score":0.5730000138282776},{"id":"https://openalex.org/keywords/ozone","display_name":"ozone","score":0.9639999866485596},{"id":"https://openalex.org/keywords/microplastics","display_name":"microplastics","score":0.8330000042915344},{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tobacco-smoke","display_name":"tobacco smoke","score":0.9440000057220459},{"id":"https://openalex.org/keywords/food-emulsifiers","display_name":"food emulsifiers","score":0.890999972820282},{"id":"https://openalex.org/keywords/household-cleaning-products","display_name":"household cleaning products","score":0.6639999747276306},{"id":"https://openalex.org/keywords/climate-change","display_name":"climate change","score":0.9049999713897705},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/bacterial-translocation","display_name":"bacterial translocation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/type-2-inflammation","display_name":"type 2 inflammation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/skin-barrier","display_name":"skin barrier","score":0.8190000057220459},{"id":"https://openalex.org/keywords/respiratory-epithelium","display_name":"respiratory epithelium","score":0.8399999737739563},{"id":"https://openalex.org/keywords/gastrointestinal-epithelium","display_name":"gastrointestinal epithelium","score":0.9210000038146973},{"id":"https://openalex.org/keywords/dietary-fatty-acids","display_name":"dietary fatty acids","score":0.7590000033378601},{"id":"https://openalex.org/keywords/western-diet","display_name":"Western diet","score":0.7239999771118164},{"id":"https://openalex.org/keywords/antioxidant-deficiency","display_name":"antioxidant deficiency","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.7535135746002197},{"id":"https://openalex.org/C119709500","wikidata":"https://www.wikidata.org/wiki/Q2142347","display_name":"Exposome","level":2,"score":0.7352204322814941},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.583660900592804},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.5220844149589539},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.5025639533996582},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3873673379421234},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38420432806015015},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.3414958715438843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.337105929851532}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3389/falgy.2022.887672","doi":"https://doi.org/10.3389/falgy.2022.887672","is_oa":true,"landing_page_url":"https://doi.org/10.3389/falgy.2022.887672","pdf_url":"https://www.frontiersin.org/articles/10.3389/falgy.2022.887672/pdf","source":{"id":"https://openalex.org/S4210191602","display_name":"Frontiers in Allergy","issn_l":"2673-6101","issn":["2673-6101"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Allergy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9304993","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9304993","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Allergy","raw_type":"Text"},{"id":"pmid:35873598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35873598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in allergy","raw_type":"Journal Article"},{"id":"pmh:oai:www.zora.uzh.ch:227410","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/227410/1/ZORA_pdf.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/227410/1/ZORA_pdf.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Celebi Sozener, Zeynep; \u00d6zbey Y\u00fccel, \u00dcm\u00fcs; Altiner, Seda; Ozdel Ozt\u00fcrk, Bet\u00fcl; Cerci, Pamir; T\u00fcrk, Murat; Gorg\u00fcl\u00fc Akin, Beg\u00fcm; Akdis, M\u00fcbeccel; Yilmaz, Insu; Ozdemir, Cevdet; Mungan, Dilsad; Akdis, Cezmi A (2022). The External Exposome and Allergies: From the Perspective of the Epithelial Barrier Hypothesis. Frontiers in Allergy, 3:887672.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:0d2bb362d4c5446592345c9e5dd4b97d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0d2bb362d4c5446592345c9e5dd4b97d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Allergy, Vol 3 (2022)","raw_type":"article"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/202968","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/202968","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Celebi Sozener, Z., \u00d6zbey Y\u00fccel, \u00dc., Altiner, S., Ozdel Ozt\u00fcrk, B., Cerci, P., T\u00fcrk, M., Gorg\u00fcl\u00fc Akin, B., Akdis, M., Yilmaz, I., Ozdemir, C., Mungan, D., & Akdis, C. A. (2022). The External Exposome and Allergies: From the Perspective of the Epithelial Barrier Hypothesis. Frontiers in Allergy, 3, 887672. https://doi.org/10.3389/falgy.2022.887672","raw_type":"Journal Article"},{"id":"doi:10.5167/uzh-227410","doi":"https://doi.org/10.5167/uzh-227410","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-227410","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.3389/falgy.2022.887672","doi":"https://doi.org/10.3389/falgy.2022.887672","is_oa":true,"landing_page_url":"https://doi.org/10.3389/falgy.2022.887672","pdf_url":"https://www.frontiersin.org/articles/10.3389/falgy.2022.887672/pdf","source":{"id":"https://openalex.org/S4210191602","display_name":"Frontiers in Allergy","issn_l":"2673-6101","issn":["2673-6101"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Allergy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4284893654.pdf","grobid_xml":"https://content.openalex.org/works/W4284893654.grobid-xml"},"referenced_works_count":132,"referenced_works":["https://openalex.org/W862199011","https://openalex.org/W1508974651","https://openalex.org/W1634069075","https://openalex.org/W1965811013","https://openalex.org/W1970338638","https://openalex.org/W1971385130","https://openalex.org/W1975288335","https://openalex.org/W1978482118","https://openalex.org/W1992152055","https://openalex.org/W1996866247","https://openalex.org/W1996955331","https://openalex.org/W1998332577","https://openalex.org/W2007662173","https://openalex.org/W2012899431","https://openalex.org/W2018186263","https://openalex.org/W2034280065","https://openalex.org/W2036396112","https://openalex.org/W2043001164","https://openalex.org/W2060130170","https://openalex.org/W2064414039","https://openalex.org/W2065178330","https://openalex.org/W2071412938","https://openalex.org/W2072383922","https://openalex.org/W2075661134","https://openalex.org/W2077211361","https://openalex.org/W2079282933","https://openalex.org/W2083684149","https://openalex.org/W2091662896","https://openalex.org/W2092762767","https://openalex.org/W2094076600","https://openalex.org/W2095499340","https://openalex.org/W2096337121","https://openalex.org/W2101274375","https://openalex.org/W2102410401","https://openalex.org/W2105517096","https://openalex.org/W2105559411","https://openalex.org/W2126723541","https://openalex.org/W2130402304","https://openalex.org/W2138640786","https://openalex.org/W2150757807","https://openalex.org/W2153232658","https://openalex.org/W2177510005","https://openalex.org/W2199956965","https://openalex.org/W2208625245","https://openalex.org/W2270709635","https://openalex.org/W2320466466","https://openalex.org/W2324817717","https://openalex.org/W2338240784","https://openalex.org/W2368044794","https://openalex.org/W2512723153","https://openalex.org/W2581083256","https://openalex.org/W2587345414","https://openalex.org/W2603407221","https://openalex.org/W2604513881","https://openalex.org/W2614381061","https://openalex.org/W2663817648","https://openalex.org/W2732858253","https://openalex.org/W2734679447","https://openalex.org/W2737177212","https://openalex.org/W2740995085","https://openalex.org/W2750811111","https://openalex.org/W2759338004","https://openalex.org/W2782401531","https://openalex.org/W2783050126","https://openalex.org/W2783448862","https://openalex.org/W2783780088","https://openalex.org/W2785550642","https://openalex.org/W2786298164","https://openalex.org/W2792132015","https://openalex.org/W2792596323","https://openalex.org/W2800757159","https://openalex.org/W2803131266","https://openalex.org/W2829956686","https://openalex.org/W2884818389","https://openalex.org/W2889479406","https://openalex.org/W2890213671","https://openalex.org/W2890544519","https://openalex.org/W2893411731","https://openalex.org/W2894357633","https://openalex.org/W2896164386","https://openalex.org/W2899379076","https://openalex.org/W2901011713","https://openalex.org/W2902828293","https://openalex.org/W2905759281","https://openalex.org/W2915910708","https://openalex.org/W2921034435","https://openalex.org/W2921505662","https://openalex.org/W2924540856","https://openalex.org/W2927175340","https://openalex.org/W2936803887","https://openalex.org/W2937545859","https://openalex.org/W2945049333","https://openalex.org/W2949123518","https://openalex.org/W2952069795","https://openalex.org/W2965403771","https://openalex.org/W2965413929","https://openalex.org/W2965859137","https://openalex.org/W2970433500","https://openalex.org/W2971739096","https://openalex.org/W2973497117","https://openalex.org/W2975001191","https://openalex.org/W2986996779","https://openalex.org/W2999105223","https://openalex.org/W3012792875","https://openalex.org/W3016897056","https://openalex.org/W3028350032","https://openalex.org/W3030890563","https://openalex.org/W3030972254","https://openalex.org/W3033954215","https://openalex.org/W3037642106","https://openalex.org/W3037678227","https://openalex.org/W3045109507","https://openalex.org/W3046469301","https://openalex.org/W3046723137","https://openalex.org/W3048397887","https://openalex.org/W3080499610","https://openalex.org/W3098914336","https://openalex.org/W3104831469","https://openalex.org/W3120891438","https://openalex.org/W3129119892","https://openalex.org/W3129687012","https://openalex.org/W3146067563","https://openalex.org/W3151619855","https://openalex.org/W3153993009","https://openalex.org/W3164542342","https://openalex.org/W3168161382","https://openalex.org/W3196570448","https://openalex.org/W3204217766","https://openalex.org/W4210766401","https://openalex.org/W4213048147","https://openalex.org/W6687553080","https://openalex.org/W6757074932"],"related_works":["https://openalex.org/W4210744779","https://openalex.org/W4388551609","https://openalex.org/W2792596323","https://openalex.org/W3033954215","https://openalex.org/W4306914640","https://openalex.org/W2989894512","https://openalex.org/W3088895462","https://openalex.org/W4404232176","https://openalex.org/W4306666597","https://openalex.org/W4415029637"],"abstract_inverted_index":{"Introduction:":[0],"In":[1,73],"the":[2,12,69,80,83,93,100,106,111,114,129,137,177,183,189,192,196,203,207,231,256,264,278,288,295,300,303,306],"last":[3],"decades,":[4],"we":[5,76],"have":[6],"seen":[7],"a":[8,235],"rapid":[9],"increase":[10],"in":[11,39,102,110,172,176,191,243],"prevalence":[13],"of":[14,56,62,82,95,105,113,179,185,195,206,248,259,282,297,302,308],"allergic":[15,20,96],"diseases":[16,97],"such":[17,42,152],"as":[18,43,153],"asthma,":[19],"rhinitis,":[21],"atopic":[22],"dermatitis,":[23],"and":[24,34,60,68,89,125,143,163,166,170,188,210,220,227,234,255,267,269,285,299,305],"food":[25,160],"allergies.":[26],"The":[27],"environmental":[28,150,283],"changes":[29,101,284],"caused":[30],"by":[31,98],"industrialization,":[32],"urbanization":[33],"modernization,":[35],"including":[36],"dramatic":[37],"increases":[38,242],"air":[40,244],"pollutants":[41],"particulate":[44],"matter":[45],"(PM),":[46],"diesel":[47],"exhaust,":[48],"nitrogen":[49],"dioxide":[50],"(NO2),":[51],"ozone":[52],"(O3),":[53],"alarming":[54],"effects":[55,81,247,281],"global":[57,249],"warming,":[58,250],"change":[59,171],"loss":[61,169],"biodiversity,":[63,174],"affect":[64,263],"both":[65],"human":[66],"health":[67,280],"entire":[70],"ecosystem.":[71],"Objective:":[72],"this":[74],"review,":[75],"aimed":[77],"to":[78,148,217,274,277,286,290],"discuss":[79],"external":[84],"exposome":[85,108],"on":[86,128],"epithelial":[87,117,204,265],"barriers":[88,205,266],"its":[90],"relationship":[91],"with":[92,141],"development":[94],"considering":[99],"all":[103,260],"stakeholders":[104],"outer":[107],"together,":[109],"light":[112],"recently":[115],"proposed":[116],"barrier":[118],"hypothesis.":[119],"Method:":[120],"To":[121],"reach":[122],"current,":[123],"prominent,":[124],"comprehensive":[126],"studies":[127],"subject,":[130],"PubMed":[131],"databases":[132],"were":[133],"searched.":[134],"We":[135,272],"included":[136],"more":[138,215],"resounding":[139],"articles":[140],"reliable":[142],"strong":[144],"results.":[145],"Results:":[146],"Exposure":[147],"altered":[149],"factors":[151,262],"increased":[154],"pollution,":[155,245],"microplastics,":[156],"nanoparticles,":[157],"tobacco":[158],"smoke,":[159],"emulsifiers,":[161,186],"detergents,":[162],"household":[164],"cleaners,":[165],"climate":[167],"change,":[168],"microbial":[173,225],"modifications":[175],"consumption":[178],"dietary":[180,253],"fatty":[181],"acids,":[182],"use":[184],"preservatives":[187],"decrease":[190],"antioxidant":[193],"content":[194],"widely":[197],"consumed":[198],"western":[199],"diet":[200],"may":[201],"disrupt":[202,230],"skin,":[208],"respiratory":[209],"gastrointestinal":[211],"tracts,":[212],"making":[213],"us":[214],"vulnerable":[216],"exogeneous":[218],"allergens":[219],"microbes.":[221],"Epithelial":[222],"cell":[223],"activation,":[224],"dysbiosis":[226],"bacterial":[228],"translocation":[229],"immune":[232],"balance":[233],"chronic":[236],"Th2":[237],"inflammation":[238],"ensues.":[239],"Conclusion:":[240],"Dramatic":[241],"worrisome":[246],"dysbiosis,":[251],"changing":[252],"habits":[254],"complex":[257],"interactions":[258],"these":[261],"local":[268],"systemic":[270],"inflammation.":[271],"want":[273],"draw":[275],"attention":[276],"emerging":[279],"motivate":[287],"public":[289],"influence":[291],"government":[292],"policies":[293],"for":[294],"well-being":[296,307],"humans":[298],"nature":[301],"earth":[304],"future":[309],"generations.":[310]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-07-09T00:00:00"}
