{"id":"https://openalex.org/W4284892924","doi":"https://doi.org/10.3389/fimmu.2022.893899","title":"Targeting Multiple End Organs in Lupus and Other Systemic Rheumatic Diseases by Inhibiting Bruton\u2019s Tyrosine Kinase","display_name":"Targeting Multiple End Organs in Lupus and Other Systemic Rheumatic Diseases by Inhibiting Bruton\u2019s Tyrosine Kinase","publication_year":2022,"publication_date":"2022-07-08","ids":{"openalex":"https://openalex.org/W4284892924","doi":"https://doi.org/10.3389/fimmu.2022.893899","pmid":"https://pubmed.ncbi.nlm.nih.gov/35874767","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9304663"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2022.893899","doi":"https://doi.org/10.3389/fimmu.2022.893899","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.893899","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fimmu.2022.893899","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100735339","display_name":"Yong Du","orcid":"https://orcid.org/0000-0003-1687-9024","observed_orcids":["https://orcid.org/0000-0003-1687-9024"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yong Du","raw_affiliation_strings":["The Department of Biomedical Engineering, University of Houston, Houston, TX, United States","The Department of Biomedical Engineering, University of Houston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Biomedical Engineering, University of Houston, Houston, TX, United States","institution_ids":["https://openalex.org/I44461941"]},{"raw_affiliation_string":"The Department of Biomedical Engineering, University of Houston, United States","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026262120","display_name":"Ling Lei","orcid":"https://orcid.org/0000-0002-2221-7740","observed_orcids":["https://orcid.org/0000-0002-2221-7740"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling Lei","raw_affiliation_strings":["The Department of Biomedical Engineering, University of Houston, Houston, TX, United States","The Department of Biomedical Engineering, University of Houston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Biomedical Engineering, University of Houston, Houston, TX, United States","institution_ids":["https://openalex.org/I44461941"]},{"raw_affiliation_string":"The Department of Biomedical Engineering, University of Houston, United States","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063511824","display_name":"Huihua Ding","orcid":"https://orcid.org/0000-0002-7530-8953","observed_orcids":["https://orcid.org/0000-0002-7530-8953"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huihua Ding","raw_affiliation_strings":["The Department of Biomedical Engineering, University of Houston, Houston, TX, United States","The Department of Biomedical Engineering, University of Houston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Biomedical Engineering, University of Houston, Houston, TX, United States","institution_ids":["https://openalex.org/I44461941"]},{"raw_affiliation_string":"The Department of Biomedical Engineering, University of Houston, United States","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100419640","display_name":"Yanping Chen","orcid":"https://orcid.org/0000-0002-8488-6712","observed_orcids":["https://orcid.org/0000-0002-8488-6712"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanping Chen","raw_affiliation_strings":["The Department of Biomedical Engineering, University of Houston, Houston, TX, United States","The Department of Biomedical Engineering, University of Houston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Biomedical Engineering, University of Houston, Houston, TX, United States","institution_ids":["https://openalex.org/I44461941"]},{"raw_affiliation_string":"The Department of Biomedical Engineering, University of Houston, United States","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072483483","display_name":"Simanta Pathak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simanta Pathak","raw_affiliation_strings":["The Department of Biomedical Engineering, University of Houston, Houston, TX, United States","The Department of Biomedical Engineering, University of Houston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Biomedical Engineering, University of Houston, Houston, TX, United States","institution_ids":["https://openalex.org/I44461941"]},{"raw_affiliation_string":"The Department of Biomedical Engineering, University of Houston, United States","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109067868","display_name":"John Hicks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Hicks","raw_affiliation_strings":["Department of Pathology, Texas Children's Hospital, Houston, TX, United States","Department of Pathology, Texas Children's Hospital, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Texas Children's Hospital, Houston, TX, United States","institution_ids":["https://openalex.org/I4210147586"]},{"raw_affiliation_string":"Department of Pathology, Texas Children's Hospital, United States","institution_ids":["https://openalex.org/I4210147586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052253749","display_name":"Phuongthy T. Tran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phuongthy T. Tran","raw_affiliation_strings":["The Department of Biomedical Engineering, University of Houston, Houston, TX, United States","The Department of Biomedical Engineering, University of Houston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Biomedical Engineering, University of Houston, Houston, TX, United States","institution_ids":["https://openalex.org/I44461941"]},{"raw_affiliation_string":"The Department of Biomedical Engineering, University of Houston, United States","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045745011","display_name":"Minghua Wu","orcid":"https://orcid.org/0000-0002-0388-2032","observed_orcids":["https://orcid.org/0000-0002-0388-2032"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minghua Wu","raw_affiliation_strings":["Division of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, TX, United States","Division of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, TX, United States","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Division of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, United States","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062625211","display_name":"Betty Y Chang","orcid":"https://orcid.org/0009-0000-6363-2484","observed_orcids":["https://orcid.org/0009-0000-6363-2484"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Betty Chang","raw_affiliation_strings":["Summit Therapeutics, Menlo Park, CA, United States","Summit Therapeutics, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Summit Therapeutics, Menlo Park, CA, United States","institution_ids":[]},{"raw_affiliation_string":"Summit Therapeutics, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043544975","display_name":"Uwe Wirtz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2948539688","display_name":"AbbVie (United States)","ror":"https://ror.org/02g5p4n58","country_code":"US","type":"company","lineage":["https://openalex.org/I2948539688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uwe Wirtz","raw_affiliation_strings":["AbbVie, Inc., Precision Medicine, San Francisco, CA, United States","AbbVie, Inc., Precision Medicine, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie, Inc., Precision Medicine, San Francisco, CA, United States","institution_ids":["https://openalex.org/I2948539688"]},{"raw_affiliation_string":"AbbVie, Inc., Precision Medicine, United States","institution_ids":["https://openalex.org/I2948539688"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042585597","display_name":"Chandra Mohan","orcid":"https://orcid.org/0000-0001-7896-5740","observed_orcids":["https://orcid.org/0000-0001-7896-5740"]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chandra Mohan","raw_affiliation_strings":["The Department of Biomedical Engineering, University of Houston, Houston, TX, United States","The Department of Biomedical Engineering, University of Houston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Biomedical Engineering, University of Houston, Houston, TX, United States","institution_ids":["https://openalex.org/I44461941"]},{"raw_affiliation_string":"The Department of Biomedical Engineering, University of Houston, United States","institution_ids":["https://openalex.org/I44461941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5042585597","https://openalex.org/A5100735339"],"corresponding_institution_ids":["https://openalex.org/I44461941"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.224,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.76089032,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"893899","last_page":"893899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase","display_name":"Bruton's tyrosine kinase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase-inhibitors","display_name":"BTK inhibitors","score":0.7829999923706055},{"id":"https://openalex.org/keywords/lupus-nephritis","display_name":"lupus nephritis","score":0.953000009059906},{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.722000002861023},{"id":"https://openalex.org/keywords/anti-gbm-nephritis","display_name":"anti-GBM nephritis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/bleomycin-induced-lung-injury","display_name":"bleomycin-induced lung injury","score":0.8889999985694885},{"id":"https://openalex.org/keywords/systemic-rheumatic-diseases","display_name":"systemic rheumatic diseases","score":0.7820000052452087},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.796999990940094},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.6539999842643738},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.6769999861717224},{"id":"https://openalex.org/keywords/skin-fibrosis","display_name":"skin fibrosis","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.8476967215538025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7739765048027039},{"id":"https://openalex.org/C2779912601","wikidata":"https://www.wikidata.org/wiki/Q1621830","display_name":"Lupus nephritis","level":3,"score":0.6862841844558716},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5958768129348755},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5783160924911499},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.5770392417907715},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5463559627532959},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.5242652893066406},{"id":"https://openalex.org/C2777058396","wikidata":"https://www.wikidata.org/wiki/Q401402","display_name":"Nephritis","level":2,"score":0.5000932216644287},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.3972013294696808},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3408849239349365},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28213149309158325},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2564268112182617},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19057655334472656},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077329","descriptor_name":"Agammaglobulinaemia Tyrosine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008181","descriptor_name":"Lupus Nephritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012216","descriptor_name":"Rheumatic Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2022.893899","doi":"https://doi.org/10.3389/fimmu.2022.893899","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.893899","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:35874767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35874767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9304663","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9304663/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:75429d1fb3ec4500afccb2ef34e360e3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/75429d1fb3ec4500afccb2ef34e360e3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2022.893899","doi":"https://doi.org/10.3389/fimmu.2022.893899","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2022.893899","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1813485308","https://openalex.org/W1822225862","https://openalex.org/W1988821153","https://openalex.org/W1993345471","https://openalex.org/W1993384837","https://openalex.org/W2016318369","https://openalex.org/W2019350934","https://openalex.org/W2020674681","https://openalex.org/W2038928791","https://openalex.org/W2054254671","https://openalex.org/W2054526083","https://openalex.org/W2067475334","https://openalex.org/W2089103836","https://openalex.org/W2091347081","https://openalex.org/W2124910352","https://openalex.org/W2130077869","https://openalex.org/W2137760943","https://openalex.org/W2149839143","https://openalex.org/W2154576801","https://openalex.org/W2157486761","https://openalex.org/W2162457090","https://openalex.org/W2163431182","https://openalex.org/W2163690533","https://openalex.org/W2165548657","https://openalex.org/W2166225174","https://openalex.org/W2169537329","https://openalex.org/W2250687747","https://openalex.org/W2405183840","https://openalex.org/W2489827869","https://openalex.org/W2546694530","https://openalex.org/W2875709241","https://openalex.org/W2889804099","https://openalex.org/W2896299871","https://openalex.org/W3119329812","https://openalex.org/W3139157067","https://openalex.org/W4205407880"],"related_works":["https://openalex.org/W2520109107","https://openalex.org/W2909677842","https://openalex.org/W4313385468","https://openalex.org/W2163431182","https://openalex.org/W2896299871","https://openalex.org/W1813485308","https://openalex.org/W2790933581","https://openalex.org/W2556229809","https://openalex.org/W4313384945","https://openalex.org/W2760270300"],"abstract_inverted_index":{"Bruton":[0],"tyrosine":[1],"kinase":[2],"(Btk)":[3],"plays":[4],"a":[5],"vital":[6],"role":[7],"in":[8,16,26,76,80,94,105,135,139,177,191,196,209],"activating":[9],"and":[10,13,59,88,98,132,148,174,224],"differentiating":[11],"B-cells":[12],"regulating":[14],"signaling":[15],"myeloid":[17],"cells.":[18],"Indeed,":[19],"the":[20,67,106,123,178,205],"potential":[21],"use":[22,206],"of":[23,41,82,141,170,207],"Btk":[24],"inhibitors":[25],"preventing":[27],"lupus":[28,46,78,223],"has":[29,129],"been":[30],"reported.":[31],"Here,":[32],"we":[33],"extend":[34],"these":[35,185],"observations":[36],"to":[37,115],"4":[38],"additional":[39],"models":[40],"end-organ":[42],"inflammation:":[43],"(a)":[44],"BWF1":[45],"nephritis":[47,79,108],"mice,":[48],"(b)":[49],"anti-GBM":[50,107],"nephritis,":[51],"(c)":[52],"bleomycin-induced":[53,61,136],"systemic":[54,198,213,225],"sclerosis":[55],"like":[56],"skin":[57,143],"disease,":[58,138],"(d)":[60],"lung":[62,153],"disease.":[63],"In":[64],"agreement":[65],"with":[66,110,118,161,167,212],"previous":[68],"studies,":[69],"BTK":[70,127],"inhibitor":[71],"(BTKB66)":[72],"treatment":[73,160],"was":[74,113,157,165],"effective":[75],"treating":[77],"terms":[81,140],"reducing":[83,142],"renal":[84,103],"damage":[85],"both":[86,130],"functionally":[87],"histologically,":[89],"accompanied":[90],"by":[91],"significant":[92],"decrease":[93],"proteinuria.":[95],"Both":[96],"low-dose":[97],"high-dose":[99],"BTKB66":[100,208],"profoundly":[101],"blocked":[102],"disease":[104],"model,":[109],"efficacy":[111],"that":[112,116,126,184],"comparable":[114],"seen":[117],"dexamethasone.":[119],"This":[120],"study":[121],"provides":[122],"first":[124],"evidence":[125],"inhibition":[128],"therapeutic":[131],"preventative":[133],"effects":[134],"SSc-like":[137],"thickness,":[144],"fibrosis,":[145],"collagen":[146],"deposition,":[147],"inflammation.":[149],"Likewise,":[150],"significantly":[151],"lower":[152,168],"inflammatory":[154],"cell":[155],"infiltration":[156],"observed":[158],"after":[159],"BTKB66.":[162],"Therapeutic":[163],"benefit":[164],"associated":[166],"numbers":[169],"macrophages,":[171],"proliferating":[172],"macrophages":[173],"activated":[175],"T-cells":[176],"respective":[179],"injured":[180],"organs.":[181],"The":[182],"observation":[183],"immune":[186],"cells":[187],"play":[188],"key":[189],"roles":[190],"driving":[192],"end":[193,218],"organ":[194],"inflammation":[195],"multiple":[197,217],"rheumatic":[199,214],"diseases":[200,215],"have":[201],"broad":[202],"implications":[203],"for":[204],"managing":[210],"patients":[211],"where":[216],"organs":[219],"are":[220],"afflicted,":[221],"including":[222],"sclerosis.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-09T00:00:00"}
