{"id":"https://openalex.org/W4284892425","doi":"https://doi.org/10.53350/pjmhs22166264","title":"Evaluation of Effects of Remdesivir on the weight of Albino rats and its Testes","display_name":"Evaluation of Effects of Remdesivir on the weight of Albino rats and its Testes","publication_year":2022,"publication_date":"2022-06-29","ids":{"openalex":"https://openalex.org/W4284892425","doi":"https://doi.org/10.53350/pjmhs22166264"},"language":"en","primary_location":{"id":"doi:10.53350/pjmhs22166264","doi":"https://doi.org/10.53350/pjmhs22166264","is_oa":true,"landing_page_url":"https://doi.org/10.53350/pjmhs22166264","pdf_url":null,"source":{"id":"https://openalex.org/S4306521916","display_name":"Pakistan Journal of Medical and Health Sciences","issn_l":"1996-7195","issn":["1996-7195","2957-899X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Medical and Health Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.53350/pjmhs22166264","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Tahir Hussain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tahir Hussain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062473369","display_name":"Rosheena Nabeel Khan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosheena Nabeel Khan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100698698","display_name":"Abdul Rehman","orcid":"https://orcid.org/0000-0002-4789-3462","observed_orcids":["https://orcid.org/0000-0002-4789-3462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdul Rehman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063628286","display_name":"Sadaf Shaheen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sadaf Shaheen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101643695","display_name":"Atif Hussain","orcid":"https://orcid.org/0000-0002-0781-4635","observed_orcids":["https://orcid.org/0000-0002-0781-4635"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atif Hussain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071065610","display_name":"Uzma Najam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uzma Najam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"6","first_page":"264","last_page":"266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.322299987077713,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.322299987077713,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.27489998936653137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.15549999475479126,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/remdesivir","display_name":"remdesivir","score":0.9990000128746033},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.9580000042915344},{"id":"https://openalex.org/keywords/testicular-weight","display_name":"testicular weight","score":0.6959999799728394},{"id":"https://openalex.org/keywords/testicular-toxicity","display_name":"testicular toxicity","score":0.6639999747276306},{"id":"https://openalex.org/keywords/antiviral-drug-effects","display_name":"antiviral drug effects","score":0.625},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.6930000185966492},{"id":"https://openalex.org/keywords/wistar-albino-rats","display_name":"Wistar albino rats","score":0.8349999785423279},{"id":"https://openalex.org/keywords/drug-safety-assessment","display_name":"drug safety assessment","score":0.41600000858306885},{"id":"https://openalex.org/keywords/covid-19-treatment","display_name":"COVID-19 treatment","score":0.8640000224113464}],"concepts":[{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.7807893753051758},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.7125260829925537},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7043383121490479},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.6722085475921631},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.512815535068512},{"id":"https://openalex.org/C2777785397","wikidata":"https://www.wikidata.org/wiki/Q492194","display_name":"Group B","level":2,"score":0.4741066098213196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44595929980278015},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42601001262664795},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.42043808102607727},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3339741826057434}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.53350/pjmhs22166264","doi":"https://doi.org/10.53350/pjmhs22166264","is_oa":true,"landing_page_url":"https://doi.org/10.53350/pjmhs22166264","pdf_url":null,"source":{"id":"https://openalex.org/S4306521916","display_name":"Pakistan Journal of Medical and Health Sciences","issn_l":"1996-7195","issn":["1996-7195","2957-899X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Medical and Health Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.53350/pjmhs22166264","doi":"https://doi.org/10.53350/pjmhs22166264","is_oa":true,"landing_page_url":"https://doi.org/10.53350/pjmhs22166264","pdf_url":null,"source":{"id":"https://openalex.org/S4306521916","display_name":"Pakistan Journal of Medical and Health Sciences","issn_l":"1996-7195","issn":["1996-7195","2957-899X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Medical and Health Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3190572795","https://openalex.org/W3093544526","https://openalex.org/W7131370440","https://openalex.org/W4313910053","https://openalex.org/W7218600982","https://openalex.org/W4323771460","https://openalex.org/W7217352366","https://openalex.org/W2324761771","https://openalex.org/W1582421707","https://openalex.org/W7091464621"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"find":[2],"out":[3],"the":[4,9,28,50,71,153,189,195,198,244,246,265,268,310,330,344,354,377],"effects":[5],"of":[6,12,25,31,73,121,144,155,161,172,250,279,281,315,334,343,357],"remdesivir":[7,235,338],"on":[8],"body":[10,51,138,156,170,204,248,332],"weight":[11,52,157,160,171,205,249,278,313,333,342,356],"treated":[13,60,111,336],"albino":[14,76,206],"rats":[15,59,77,207],"and":[16,53,118,141,158,239,260,264,297],"its":[17,54],"testes":[18,55,162,316,345,358],"Study":[19],"Design:":[20],"Experimental":[21],"Place":[22],"&":[23,42,87,108,182,194,224,254],"Duration":[24],"study:":[26],"At":[27],"Anatomy":[29],"Department":[30],"Baqai":[32],"Medical":[33],"University":[34],"Karachi,":[35],"from":[36,326],"August":[37],"2021-":[38],"February":[39],"2022":[40],"Material":[41],"Method:":[43],"The":[44,75,146,168,202,275],"research":[45],"was":[46,99,132,149,179,191,200,215,221,228,256,271,303],"undertaken":[47],"to":[48,134,151,212,243],"record":[49],"in":[56,137,218,225,283,309,351,376],"Albino":[57,94],"Wistar":[58,95],"by":[61,112],"antiviral":[62],"agent":[63],"remdesivir.":[64],"This":[65],"drug":[66,190,364],"is":[67],"also":[68],"recommended":[69],"for":[70,124],"treatment":[72,178,211,232],"Covid-19.":[74],"were":[78,110],"divided":[79],"into":[80],"4":[81],"groups":[82,319],"as":[83,369],"A,":[84],"B,":[85,106,252],"C":[86,107,220,253],"D.":[88],"In":[89,360],"each":[90],"group":[91,103,105,173,213,219,226,251,284],"having":[92],"6":[93],"rats.":[96],"Group":[97],"A":[98,128,174],"untreated":[100],"i.e.":[101],"control":[102],"while":[104,341],"D":[109,227,255],"intraperitoneal":[113,234],"injection":[114,186],"with":[115,233,236,337],"low,":[116,237],"Intermediate":[117],"high":[119,240,352,361],"doses":[120,241],"Remdesivir":[122],"respectively":[123,263],"10":[125],"consecutive":[126],"days.":[127],"paired":[129],"sample":[130],"t-test":[131],"performed":[133],"determine":[135],"changes":[136,314],"weights":[139],"before":[140,175,208],"after":[142,183],"provision":[143],"drugs.":[145],"one-way":[147],"ANOVA":[148],"conducted":[150],"compare":[152],"difference":[154,196,266,307],"relative":[159,277,312,355],"amongst":[163,317],"all":[164],"four":[165,318],"groups.":[166],"Results:":[167],"mean":[169,203,247,276,331],"giving":[176,209],"any":[177,210],"173.10\u00b13.42":[180],"g":[181,193,223,259,262,296],"sterile":[184],"saline":[185],"intraperitoneally":[187],"without":[188],"173.48\u00b13.46":[192],"between":[197,267],"two":[199,269],"insignificant.":[201],"B":[214],"178.24\u00b11.78":[216],"g,":[217,288,292],"174.33\u00b12.49":[222],"173.76\u00b13.22":[229],"g.":[230,301],"After":[231],"intermediate":[238],"given":[242],"rats,":[245],"179.88\u00b11.87":[257],"g,177.17\u00b12.41":[258],"176.44\u00b13.15":[261],"means":[270],"highly":[272],"significant":[273,306],"(p=0.0001).":[274],"tetes":[280],"rat":[282],"A=0.713":[285],"\u00b1":[286,290,294,299],"8.56":[287],"B=0.717":[289],"15.83":[291],"C=0.716":[293],"14.18":[295],"D=0.705":[298],"4.15":[300],"There":[302],"no":[304],"statistically":[305],"found":[308],"overall":[311],"(p=0.876).":[320],"Conclusion:":[321],"It":[322],"has":[323],"been":[324],"concluded":[325],"this":[327,363],"study":[328],"that":[329],"animal":[335],"increased":[339],"significantly":[340,349],"did":[346],"not":[347],"affect":[348,372],"but":[350],"dose":[353,362],"decreases.":[359],"should":[365],"be":[366],"used":[367],"cautiously":[368],"it":[370],"can":[371],"germ":[373],"cells":[374],"present":[375],"testes.":[378],"Keywords:":[379],"Germ":[380],"cells,":[381],"Reproductive,":[382],"Remdesivir,":[383],"Saline,":[384],"Intraperitoneal.":[385]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2022-07-09T00:00:00"}