{"id":"https://openalex.org/W4284890204","doi":"https://doi.org/10.1007/s11357-022-00618-z","title":"Evidence for preserved insulin responsiveness in the aging rat brain","display_name":"Evidence for preserved insulin responsiveness in the aging rat brain","publication_year":2022,"publication_date":"2022-07-08","ids":{"openalex":"https://openalex.org/W4284890204","doi":"https://doi.org/10.1007/s11357-022-00618-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/35798912","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9768080"},"language":"en","primary_location":{"id":"doi:10.1007/s11357-022-00618-z","doi":"https://doi.org/10.1007/s11357-022-00618-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11357-022-00618-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11357-022-00618-z.pdf","source":{"id":"https://openalex.org/S4210237251","display_name":"GeroScience","issn_l":"2152-4041","issn":["2152-4041","2331-3773","2509-2715","2509-2723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11357-022-00618-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009392810","display_name":"Matthew G. Engel","orcid":"https://orcid.org/0000-0003-3596-1584","observed_orcids":["https://orcid.org/0000-0003-3596-1584"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew G. Engel","raw_affiliation_strings":["Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA","Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Golding Building Room 201, BronxBronx, NY, 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Golding Building Room 201, BronxBronx, NY, 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005337452","display_name":"Jeremy L. Smith","orcid":"https://orcid.org/0000-0003-0841-5297","observed_orcids":["https://orcid.org/0000-0003-0841-5297"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Smith","raw_affiliation_strings":["Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109569406","display_name":"Kai Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai Mao","raw_affiliation_strings":["Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, 10461, USA","Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA","Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Golding Building Room 201, BronxBronx, NY, 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, 10461, USA","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Golding Building Room 201, BronxBronx, NY, 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041078071","display_name":"Gabriela Farias Quipildor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriela Farias Quipildor","raw_affiliation_strings":["Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA","Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Golding Building Room 201, BronxBronx, NY, 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Golding Building Room 201, BronxBronx, NY, 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019710292","display_name":"Min\u2010Hui Cui","orcid":"https://orcid.org/0000-0001-6276-5875","observed_orcids":["https://orcid.org/0000-0001-6276-5875"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min-Hui Cui","raw_affiliation_strings":["Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061451331","display_name":"Maria E. Gulinello","orcid":"https://orcid.org/0000-0002-4647-9622","observed_orcids":["https://orcid.org/0000-0002-4647-9622"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Gulinello","raw_affiliation_strings":["Dominick S. Purpura Department of Neuroscience, Behavioral Core Facility, Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dominick S. Purpura Department of Neuroscience, Behavioral Core Facility, Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014594024","display_name":"Craig A. Branch","orcid":"https://orcid.org/0000-0003-2460-0097","observed_orcids":["https://orcid.org/0000-0003-2460-0097"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig A. Branch","raw_affiliation_strings":["Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103144641","display_name":"Sam Gandy","orcid":"https://orcid.org/0000-0001-6455-4721","observed_orcids":["https://orcid.org/0000-0001-6455-4721"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel E. Gandy","raw_affiliation_strings":["Department of Neurology and the Mount Sinai Center for Cognitive Health, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","Department of Psychiatry and the Mount Sinai Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and the Mount Sinai Center for Cognitive Health, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Psychiatry and the Mount Sinai Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075346656","display_name":"Derek M. Huffman","orcid":"https://orcid.org/0000-0001-9520-3449","observed_orcids":["https://orcid.org/0000-0001-9520-3449"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Derek M. Huffman","raw_affiliation_strings":["Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. derek.huffman@einsteinmed.edu","Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. derek.huffman@einsteinmed.edu","Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Golding Building Room 201, BronxBronx, NY, 10461, USA. derek.huffman@einsteinmed.edu","Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, 10461, USA"],"raw_orcid":"https://orcid.org/0000-0001-9520-3449","affiliations":[{"raw_affiliation_string":"Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. derek.huffman@einsteinmed.edu","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. derek.huffman@einsteinmed.edu","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Golding Building Room 201, BronxBronx, NY, 10461, USA. derek.huffman@einsteinmed.edu","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, 10461, USA","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5075346656"],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":0.9779,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.72621779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"44","issue":"5","first_page":"2491","last_page":"2508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.1468999981880188,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.1468999981880188,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.09939999878406525,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.06669999659061432,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-insulin-resistance","display_name":"brain insulin resistance","score":0.8320000171661377},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.8420000076293945},{"id":"https://openalex.org/keywords/insulin-responsiveness","display_name":"insulin responsiveness","score":0.7459999918937683},{"id":"https://openalex.org/keywords/hyperinsulinemic-euglycemic-clamp","display_name":"hyperinsulinemic-euglycemic clamp","score":0.9240000247955322},{"id":"https://openalex.org/keywords/resting-state-functional-connectivity","display_name":"resting-state functional connectivity","score":0.7419999837875366},{"id":"https://openalex.org/keywords/default-mode-network","display_name":"default mode network","score":0.9959999918937683},{"id":"https://openalex.org/keywords/medial-temporal-lobe","display_name":"medial temporal lobe","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7450000047683716},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.6830000281333923},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-insulin","display_name":"cerebrospinal fluid insulin","score":0.8050000071525574},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9240000247955322},{"id":"https://openalex.org/keywords/septal-nuclei","display_name":"septal nuclei","score":0.6690000295639038},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7693386077880859},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6695920825004578},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6560391783714294},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.5632963180541992},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5330656170845032},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5232242941856384},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.4910433292388916},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47961485385894775},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.47056886553764343},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.45599836111068726},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4235711991786957},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.4226617217063904},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.4125974178314209},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.35699528455734253}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s11357-022-00618-z","doi":"https://doi.org/10.1007/s11357-022-00618-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11357-022-00618-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11357-022-00618-z.pdf","source":{"id":"https://openalex.org/S4210237251","display_name":"GeroScience","issn_l":"2152-4041","issn":["2152-4041","2331-3773","2509-2715","2509-2723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9768080","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9768080","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"Text"},{"id":"pmid:35798912","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35798912","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s11357-022-00618-z","doi":"https://doi.org/10.1007/s11357-022-00618-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11357-022-00618-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11357-022-00618-z.pdf","source":{"id":"https://openalex.org/S4210237251","display_name":"GeroScience","issn_l":"2152-4041","issn":["2152-4041","2331-3773","2509-2715","2509-2723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2203052344","display_name":null,"funder_award_id":"AG068345","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2638674773","display_name":null,"funder_award_id":"CA 013330","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G376360547","display_name":"Deciphering the enigmatic role of IGF-1 signaling in cognitive decline and Alzheimer's disease","funder_award_id":"R56AG066431","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5491362581","display_name":"SYSTEMATIC DRUG REPURPOSING TARGETING IMMUNE ACTIVATION NETWORKS IN ALZHEIMER'S DISEASE (AD)","funder_award_id":"RF1AG059319","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6659283985","display_name":"Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging","funder_award_id":"P30AG038072","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7021309351","display_name":"The University of Southern California and Buck Institute Nathan Shock Center","funder_award_id":"P30AG068345","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G87033130","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM007288","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8909779965","display_name":null,"funder_award_id":"AG038072","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000877850","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA013330","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000883697","display_name":"Nathan Shock Centers of Excellence in Basic Biology of Aging (P30 Clinical Trial Not Allowed)","funder_award_id":"P30AG013280","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000899102","display_name":"Mount Sinai Alzheimer's Disease Research Center","funder_award_id":"P30AG066514","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000900974","display_name":"NYR-Diabetes Research Center (NYR-DRC)","funder_award_id":"P30DK020541","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306228","display_name":"American Federation for Aging Research","ror":"https://ror.org/000r61a05"},{"id":"https://openalex.org/F4320314571","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4284890204.pdf","grobid_xml":"https://content.openalex.org/works/W4284890204.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W396231929","https://openalex.org/W1526546205","https://openalex.org/W1723906651","https://openalex.org/W1965600418","https://openalex.org/W1982795519","https://openalex.org/W1986782185","https://openalex.org/W1989164305","https://openalex.org/W1997960386","https://openalex.org/W2012361840","https://openalex.org/W2012848782","https://openalex.org/W2019986565","https://openalex.org/W2034101922","https://openalex.org/W2037226098","https://openalex.org/W2039866424","https://openalex.org/W2040181124","https://openalex.org/W2044832776","https://openalex.org/W2046989794","https://openalex.org/W2047509507","https://openalex.org/W2048740667","https://openalex.org/W2049616256","https://openalex.org/W2050068554","https://openalex.org/W2050597556","https://openalex.org/W2055708395","https://openalex.org/W2056021792","https://openalex.org/W2060174509","https://openalex.org/W2061570884","https://openalex.org/W2061875312","https://openalex.org/W2062858206","https://openalex.org/W2067420381","https://openalex.org/W2067443877","https://openalex.org/W2069306089","https://openalex.org/W2074479414","https://openalex.org/W2076517751","https://openalex.org/W2077337447","https://openalex.org/W2077589894","https://openalex.org/W2080520337","https://openalex.org/W2083909434","https://openalex.org/W2087443596","https://openalex.org/W2089846692","https://openalex.org/W2099589415","https://openalex.org/W2101048381","https://openalex.org/W2102207014","https://openalex.org/W2107328784","https://openalex.org/W2119494733","https://openalex.org/W2124956707","https://openalex.org/W2127513800","https://openalex.org/W2128679037","https://openalex.org/W2135955660","https://openalex.org/W2136493937","https://openalex.org/W2145025818","https://openalex.org/W2148061626","https://openalex.org/W2148105857","https://openalex.org/W2158765009","https://openalex.org/W2160382059","https://openalex.org/W2205233891","https://openalex.org/W2263406196","https://openalex.org/W2313670503","https://openalex.org/W2461377175","https://openalex.org/W2530471346","https://openalex.org/W2550969645","https://openalex.org/W2554885037","https://openalex.org/W2587943027","https://openalex.org/W2601707947","https://openalex.org/W2759489555","https://openalex.org/W2786962139","https://openalex.org/W2806004364","https://openalex.org/W2807914406","https://openalex.org/W2889131922","https://openalex.org/W2902940972","https://openalex.org/W2904733759","https://openalex.org/W2912841818","https://openalex.org/W2913193891","https://openalex.org/W2913776456","https://openalex.org/W2914026129","https://openalex.org/W2919546012","https://openalex.org/W2920728968","https://openalex.org/W2922829546","https://openalex.org/W2944277235","https://openalex.org/W2948402413","https://openalex.org/W2961954273","https://openalex.org/W2965961249","https://openalex.org/W3015175593","https://openalex.org/W3026345469","https://openalex.org/W3035782677","https://openalex.org/W3045828365","https://openalex.org/W3097894196","https://openalex.org/W3183589699"],"related_works":["https://openalex.org/W1852289178","https://openalex.org/W396231929","https://openalex.org/W4292466838","https://openalex.org/W2728993663","https://openalex.org/W2023501181","https://openalex.org/W4414145156","https://openalex.org/W2119494733","https://openalex.org/W4365443217","https://openalex.org/W4286312226","https://openalex.org/W4248694092"],"abstract_inverted_index":{"Insulin":[0],"appears":[1],"to":[2,19,34,45,67,71,108,145,199,204,302],"exert":[3],"salutary":[4],"effects":[5,74],"in":[6,23,39,50,75,86,93,117,151,181,190,208,221,227,237,257],"the":[7,69,76,155,164,205,216,230,288],"central":[8],"nervous":[9],"system":[10],"(CNS).":[11],"Thus,":[12,42,284],"brain":[13,24,47,292,300,324],"insulin":[14,48,73,92,98,135,197,252,271,293,303,325],"resistance":[15],"has":[16],"been":[17],"proposed":[18],"play":[20],"a":[21,62,212,320],"role":[22],"aging":[25,118],"and":[26,32,54,106,136,148,169,233,235,239,272,295],"dementia":[27],"but":[28,262],"is":[29],"conceptually":[30],"complex":[31],"unlikely":[33],"fit":[35],"classic":[36],"definitions":[37],"established":[38],"peripheral":[40,97],"tissues.":[41],"we":[43],"sought":[44],"characterize":[46],"responsiveness":[49],"young":[51,109,209,258],"(4-5":[52],"months)":[53,57],"old":[55,94,104,182,264],"(24":[56],"FBN":[58],"male":[59],"rats":[60],"using":[61],"diverse":[63],"set":[64],"of":[65,91,113,215,229,247,270,277,290,315,322],"assays":[66],"determine":[68],"extent":[70],"which":[72,184],"CNS":[77,313,331],"are":[78],"impaired":[79,312],"with":[80,186,249,282,304],"age.":[81,283],"When":[82],"performing":[83],"hyperinsulinemic-euglycemic":[84],"clamps":[85],"rats,":[87,110,183,210],"intracerebroventricular":[88],"(ICV)":[89],"infusion":[90],"animals":[95],"improved":[96],"sensitivity":[99],"by":[100,130,225],"nearly":[101],"two-fold":[102],"over":[103],"controls":[105],"comparable":[107],"suggesting":[111,311],"preservation":[112],"this":[114],"insulin-triggered":[115],"response":[116],"per":[119],"se":[120],"(p":[121,259],"<":[122,260],"0.05).":[123],"We":[124],"next":[125],"used":[126],"an":[127],"imaging-based":[128],"approach":[129],"comparing":[131],"ICV":[132,196],"vehicle":[133],"versus":[134],"performed":[137],"resting":[138],"state":[139],"functional":[140],"magnetic":[141],"resonance":[142],"imaging":[143],"(rs-fMRI)":[144],"evaluate":[146],"age-":[147],"insulin-related":[149],"changes":[150],"network":[152],"connectivity":[153,162],"within":[154],"default":[156],"mode":[157],"network.":[158],"In":[159,242],"aging,":[160],"lower":[161],"between":[163],"mesial":[165],"temporal":[166],"(MT)":[167],"region":[168],"other":[170],"areas,":[171],"as":[172,174],"well":[173],"reduced":[175,281,323],"MT":[176],"signal":[177,207,218],"complexity,":[178],"was":[179,219],"observed":[180,220],"correlated":[185],"greater":[187],"cognitive":[188],"deficits":[189],"old.":[191],"Despite":[192,266],"these":[193,278,285,316],"stark":[194],"differences,":[195],"failed":[198],"elicit":[200],"any":[201],"significant":[202,213],"alteration":[203],"BOLD":[206,217],"while":[211],"deviation":[214],"older":[222],"animals,":[223],"characterized":[224],"augmentation":[226],"regions":[228],"septal":[231],"nucleus":[232,240],"hypothalamus,":[234],"reduction":[236],"thalamus":[238],"accumbens.":[241],"contrast,":[243],"ex":[244],"vivo":[245],"stimulation":[246],"hippocampus":[248],"10":[250],"nM":[251],"revealed":[253],"increased":[254],"Akt":[255],"activation":[256],"0.05),":[261],"not":[263],"rats.":[265],"similar":[267],"circulating":[268],"levels":[269],"IGF-1,":[273],"cerebrospinal":[274],"fluid":[275],"concentrations":[276],"ligands":[279,317],"were":[280],"data":[286],"highlight":[287],"complexity":[289],"capturing":[291],"action":[294],"demonstrate":[296],"preserved":[297],"or":[298],"heightened":[299],"responses":[301],"age,":[305],"despite":[306],"dampened":[307],"canonical":[308],"signaling,":[309],"thereby":[310],"input":[314],"may":[318],"be":[319],"feature":[321],"action,":[326],"providing":[327],"further":[328],"rationale":[329],"for":[330],"replacement":[332],"strategies.":[333]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-09T00:00:00"}