{"id":"https://openalex.org/W4284881968","doi":"https://doi.org/10.1073/pnas.2206415119","title":"Adenosine A 2A receptor blockade prevents cisplatin-induced impairments in neurogenesis and cognitive function","display_name":"Adenosine A 2A receptor blockade prevents cisplatin-induced impairments in neurogenesis and cognitive function","publication_year":2022,"publication_date":"2022-07-07","ids":{"openalex":"https://openalex.org/W4284881968","doi":"https://doi.org/10.1073/pnas.2206415119","pmid":"https://pubmed.ncbi.nlm.nih.gov/35867768","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9282426"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2206415119","doi":"https://doi.org/10.1073/pnas.2206415119","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2206415119","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2206415119","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047899183","display_name":"Alfredo Oliveros","orcid":"https://orcid.org/0000-0003-0462-3531","observed_orcids":["https://orcid.org/0000-0003-0462-3531"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfredo Oliveros","raw_affiliation_strings":["Neurologic Surgery, Mayo Clinic, Rochester, MN 55905","Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854"],"raw_orcid":"https://orcid.org/0000-0003-0462-3531","affiliations":[{"raw_affiliation_string":"Neurologic Surgery, Mayo Clinic, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037024290","display_name":"Ki Hyun Yoo","orcid":"https://orcid.org/0000-0003-1088-3540","observed_orcids":["https://orcid.org/0000-0003-1088-3540"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ki Hyun Yoo","raw_affiliation_strings":["Neurologic Surgery, Mayo Clinic, Rochester, MN 55905","Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854"],"raw_orcid":"https://orcid.org/0000-0003-1088-3540","affiliations":[{"raw_affiliation_string":"Neurologic Surgery, Mayo Clinic, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054412216","display_name":"Mohammad Abdur Rashid","orcid":"https://orcid.org/0000-0003-0763-8835","observed_orcids":["https://orcid.org/0000-0003-0763-8835"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Abdur Rashid","raw_affiliation_strings":["Neurologic Surgery, Mayo Clinic, Rochester, MN 55905","Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854"],"raw_orcid":"https://orcid.org/0000-0003-0763-8835","affiliations":[{"raw_affiliation_string":"Neurologic Surgery, Mayo Clinic, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079257867","display_name":"Ana Mia Corujo-Ramirez","orcid":"https://orcid.org/0000-0002-5949-3650","observed_orcids":["https://orcid.org/0000-0002-5949-3650"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Corujo-Ramirez","raw_affiliation_strings":["Neurologic Surgery, Mayo Clinic, Rochester, MN 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurologic Surgery, Mayo Clinic, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110414603","display_name":"Benjamin Hur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Hur","raw_affiliation_strings":["Division of Surgery Research, Department of Surgery, Mayo Clinic, Rochester, MN 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgery Research, Department of Surgery, Mayo Clinic, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023975863","display_name":"Jaeyun Sung","orcid":"https://orcid.org/0000-0002-3005-2798","observed_orcids":["https://orcid.org/0000-0002-3005-2798"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaeyun Sung","raw_affiliation_strings":["Division of Surgery Research, Department of Surgery, Mayo Clinic, Rochester, MN 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgery Research, Department of Surgery, Mayo Clinic, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004826155","display_name":"Yuanhang Liu","orcid":"https://orcid.org/0009-0007-5632-5647","observed_orcids":["https://orcid.org/0009-0007-5632-5647","https://orcid.org/0000-0002-0147-8394"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanhang Liu","raw_affiliation_strings":["Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047808879","display_name":"John R. Hawse","orcid":"https://orcid.org/0000-0003-3406-470X","observed_orcids":["https://orcid.org/0000-0003-3406-470X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Hawse","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083436505","display_name":"Doo\u2010Sup Choi","orcid":"https://orcid.org/0000-0002-6796-9938","observed_orcids":["https://orcid.org/0000-0002-6796-9938"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Doo-Sup Choi","raw_affiliation_strings":["Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022672330","display_name":"Detlev Boison","orcid":"https://orcid.org/0000-0002-7740-5781","observed_orcids":["https://orcid.org/0000-0002-7740-5781"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Detlev Boison","raw_affiliation_strings":["Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077230397","display_name":"Mi\u2010Hyeon Jang","orcid":"https://orcid.org/0000-0001-6274-3588","observed_orcids":["https://orcid.org/0000-0001-6274-3588"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mi-Hyeon Jang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905","Neurologic Surgery, Mayo Clinic, Rochester, MN 55905","Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Neurologic Surgery, Mayo Clinic, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077230397"],"corresponding_institution_ids":["https://openalex.org/I102322142","https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":4.1911,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.95677644,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"119","issue":"28","first_page":"e2206415119","last_page":"e2206415119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenosine-a2a-receptor","display_name":"adenosine A2A receptor","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/chemotherapy-induced-cognitive-impairment","display_name":"chemotherapy-induced cognitive impairment","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/adult-neurogenesis","display_name":"adult neurogenesis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9570000171661377},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.7229999899864197},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neural-progenitor-cell-proliferation","display_name":"neural progenitor proliferation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/dendritic-morphogenesis","display_name":"dendrite morphogenesis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/memory","display_name":"memory","score":0.6320000290870667},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.8451151847839355},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.8228021860122681},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.6566709280014038},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6036196947097778},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5232883095741272},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.4985957145690918},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44748741388320923},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.44532129168510437},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3960862159729004},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39173948764801025},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3374176025390625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3247576355934143},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30761027336120605},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1698119044303894},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.15303117036819458},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.09824368357658386},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0630747377872467},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000084202","descriptor_name":"Chemotherapy-Related Cognitive Impairment","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D043705","descriptor_name":"Receptor, Adenosine A2A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D058917","descriptor_name":"Adenosine A2 Receptor Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.2206415119","doi":"https://doi.org/10.1073/pnas.2206415119","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2206415119","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9282426","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9282426","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:35867768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35867768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:alma.01RUT_INST:11742450180004646","doi":null,"is_oa":false,"landing_page_url":"https://scholarship.libraries.rutgers.edu/esploro/outputs/journalArticle/Adenosine-A2A-receptor-blockade-prevents-cisplatin-induced/991031925497104646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401388","display_name":"Rutgers University Community Repository (Rutgers University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102322142","host_organization_name":"Rutgers, The State University of New Jersey","host_organization_lineage":["https://openalex.org/I102322142"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"doi:10.1073/pnas.2206415119","doi":"https://doi.org/10.1073/pnas.2206415119","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2206415119","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6899999976158142,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2069264790","display_name":"PQ#12; Targeting Nampt-mediated NAD+ metabolism in chemobrain","funder_award_id":"R01CA242158","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6978482895","display_name":"[Jang R01AG058560 transfer] Role of BubR1 as a juvenile protective factor in hippocampal aging","funder_award_id":"R01AG058560","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7112030560","display_name":null,"funder_award_id":"19-40-60-OLIV","funder_id":"https://openalex.org/F4320306091","funder_display_name":"American Association for Cancer Research"},{"id":"https://openalex.org/G8968442424","display_name":"Ketogenic Diet and Adenosine: Epigenetics and Antiepileptogenesis","funder_award_id":"R01NS065957","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000863409","display_name":"Therapies for Epilepsy Prevention - Focus on Adenosine","funder_award_id":"R01NS127846","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306091","display_name":"American Association for Cancer Research","ror":"https://ror.org/02fnpv153"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W47610224","https://openalex.org/W1588286407","https://openalex.org/W1986745837","https://openalex.org/W2050513958","https://openalex.org/W2077933134","https://openalex.org/W2153969912","https://openalex.org/W2168711831","https://openalex.org/W2472172082","https://openalex.org/W2742143229","https://openalex.org/W2811459126","https://openalex.org/W2978821781","https://openalex.org/W2982637342","https://openalex.org/W3136103971","https://openalex.org/W3215973836","https://openalex.org/W4251259027"],"related_works":["https://openalex.org/W3083645254","https://openalex.org/W3177513020","https://openalex.org/W7160998931","https://openalex.org/W4210405243","https://openalex.org/W4362593475","https://openalex.org/W3212117714","https://openalex.org/W3136103971","https://openalex.org/W2482638973","https://openalex.org/W2767693017","https://openalex.org/W2588760645"],"abstract_inverted_index":{"Chemotherapy-induced":[0],"cognitive":[1,120],"impairment":[2],"(CICI)":[3],"has":[4],"emerged":[5],"as":[6,108],"a":[7,49,109],"significant":[8],"medical":[9],"problem":[10],"without":[11,92],"therapeutic":[12],"options.":[13],"Using":[14],"the":[15,27,45,63],"platinum-based":[16],"chemotherapy":[17],"cisplatin":[18,43],"to":[19,117],"model":[20],"CICI,":[21],"we":[22],"revealed":[23],"robust":[24],"elevations":[25],"in":[26,44,76],"adenosine":[28],"A":[29,58,68,104],"2A":[30,33,59,69,105],"receptor":[31],"(A":[32],"R)":[34],"and":[35,40,55,65,80,89],"its":[36],"downstream":[37],"effectors,":[38],"cAMP":[39],"CREB,":[41],"by":[42,62],"adult":[46],"mouse":[47],"hippocampus,":[48],"critical":[50],"brain":[51],"structure":[52],"for":[53],"learning":[54],"memory.":[56],"Notably,":[57],"R":[60,70,106],"inhibition":[61],"Food":[64],"Drug":[66],"Administration\u2013approved":[67],"antagonist":[71],"KW-6002":[72],"prevented":[73],"cisplatin-induced":[74,119],"impairments":[75],"neural":[77],"progenitor":[78],"proliferation":[79],"dendrite":[81],"morphogenesis":[82],"of":[83],"adult-born":[84],"neurons,":[85],"while":[86],"improving":[87],"memory":[88],"anxiety-like":[90],"behavior,":[91],"affecting":[93],"tumor":[94],"growth":[95],"or":[96],"cisplatin\u2019s":[97],"antitumor":[98],"activity.":[99],"Collectively,":[100],"our":[101],"study":[102],"identifies":[103],"signaling":[107],"key":[110],"pathway":[111],"that":[112],"can":[113],"be":[114],"therapeutically":[115],"targeted":[116],"prevent":[118],"impairments.":[121]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":12}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2022-07-09T00:00:00"}