{"id":"https://openalex.org/W4284879232","doi":"https://doi.org/10.1159/000525494","title":"Quercetin and Osteoarthritis: A Mechanistic Review on the Present Documents","display_name":"Quercetin and Osteoarthritis: A Mechanistic Review on the Present Documents","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4284879232","doi":"https://doi.org/10.1159/000525494","pmid":"https://pubmed.ncbi.nlm.nih.gov/35793647"},"language":"en","primary_location":{"id":"doi:10.1159/000525494","doi":"https://doi.org/10.1159/000525494","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000525494","pdf_url":"https://www.karger.com/Article/Pdf/525494","source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.karger.com/Article/Pdf/525494","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103059867","display_name":"Faezeh Samadi","orcid":"https://orcid.org/0000-0003-2549-6252","observed_orcids":["https://orcid.org/0000-0003-2549-6252"]},"institutions":[{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Faezeh Samadi","raw_affiliation_strings":["School of Nursing and Midwifery, Tehran University of Medical Science, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing and Midwifery, Tehran University of Medical Science, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072379419","display_name":"Mohammad Saeed Kahrizi","orcid":"https://orcid.org/0000-0002-8076-2413","observed_orcids":["https://orcid.org/0000-0002-8076-2413"]},"institutions":[{"id":"https://openalex.org/I4387153077","display_name":"Alborz University of Medical Sciences","ror":"https://ror.org/03hh69c20","country_code":"IR","type":"education","lineage":["https://openalex.org/I4387153077"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Saeed Kahrizi","raw_affiliation_strings":["Department of Surgery, Alborz University of Medical Sciences, Karaj, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Alborz University of Medical Sciences, Karaj, Iran","institution_ids":["https://openalex.org/I4387153077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102237255","display_name":"Fateme Heydari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fateme Heydari","raw_affiliation_strings":["Student Research Committee, School of Medicine, Shahid Beheshti of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Research Committee, School of Medicine, Shahid Beheshti of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053968558","display_name":"Reza Arefnezhad","orcid":"https://orcid.org/0000-0002-0650-9997","observed_orcids":["https://orcid.org/0000-0002-0650-9997"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Reza Arefnezhad","raw_affiliation_strings":["Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062566704","display_name":"Hossein Roghani\u2010Shahraki","orcid":"https://orcid.org/0000-0001-9530-5744","observed_orcids":["https://orcid.org/0000-0001-9530-5744"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hossein Roghani-Shahraki","raw_affiliation_strings":["Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":"https://orcid.org/0000-0001-9530-5744","affiliations":[{"raw_affiliation_string":"Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000789331","display_name":"Abnoos Mokhtari Ardekani","orcid":"https://orcid.org/0000-0003-4939-2976","observed_orcids":["https://orcid.org/0000-0003-4939-2976"]},"institutions":[{"id":"https://openalex.org/I235686326","display_name":"Kerman University of Medical Sciences","ror":"https://ror.org/02kxbqc24","country_code":"IR","type":"education","lineage":["https://openalex.org/I235686326"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Abnoos Mokhtari Ardekani","raw_affiliation_strings":["Endocrinology and Metabolism Research Center, Physiology Research Center, Institute of Basic and Clinical Physiology Science, Kerman University of Medical Sciences, Kerman, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology and Metabolism Research Center, Physiology Research Center, Institute of Basic and Clinical Physiology Science, Kerman University of Medical Sciences, Kerman, Iran","institution_ids":["https://openalex.org/I235686326"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068777466","display_name":"Fatemeh Rezaei\u2010Tazangi","orcid":"https://orcid.org/0000-0003-1402-6482","observed_orcids":["https://orcid.org/0000-0003-1402-6482"]},"institutions":[{"id":"https://openalex.org/I4210161235","display_name":"Fasa University of Medical Sciences","ror":"https://ror.org/05bh0zx16","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210161235"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fatemeh Rezaei-Tazangi","raw_affiliation_strings":["Department of Anatomy, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran","institution_ids":["https://openalex.org/I4210161235"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8586,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.6574508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"107","issue":"9-10","first_page":"464","last_page":"471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":1.0},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/natural-compounds","display_name":"natural compounds","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cartilage","display_name":"cartilage","score":0.8519999980926514},{"id":"https://openalex.org/keywords/joint-diseases","display_name":"joint diseases","score":0.8119999766349792},{"id":"https://openalex.org/keywords/anti-inflammatory-mechanism","display_name":"anti-inflammatory mechanism","score":0.7940000295639038},{"id":"https://openalex.org/keywords/therapeutic-mechanisms","display_name":"therapeutic mechanisms","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7719175815582275},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7713683843612671},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.590194821357727},{"id":"https://openalex.org/C2778484676","wikidata":"https://www.wikidata.org/wiki/Q20707196","display_name":"Nonsteroidal","level":2,"score":0.5316897630691528},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.485400527715683},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45408371090888977},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42763620615005493},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3547748625278473},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31569457054138184},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11329483985900879},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09830901026725769},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.08830755949020386},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1159/000525494","doi":"https://doi.org/10.1159/000525494","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000525494","pdf_url":"https://www.karger.com/Article/Pdf/525494","source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},{"id":"pmid:35793647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35793647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:figshare.com:article/22494310","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Quercetin_and_Osteoarthritis_A_Mechanistic_Review_on_the_Present_Documents/22494310","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1159/000525494","doi":"https://doi.org/10.1159/000525494","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000525494","pdf_url":"https://www.karger.com/Article/Pdf/525494","source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4284879232.pdf","grobid_xml":"https://content.openalex.org/works/W4284879232.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W1935296231","https://openalex.org/W1969655362","https://openalex.org/W1991838559","https://openalex.org/W2017720269","https://openalex.org/W2019639349","https://openalex.org/W2020211926","https://openalex.org/W2027831505","https://openalex.org/W2029404853","https://openalex.org/W2038773696","https://openalex.org/W2041517292","https://openalex.org/W2046434994","https://openalex.org/W2053935131","https://openalex.org/W2054673633","https://openalex.org/W2094115539","https://openalex.org/W2115523644","https://openalex.org/W2127003157","https://openalex.org/W2139292125","https://openalex.org/W2143626453","https://openalex.org/W2164993228","https://openalex.org/W2166415953","https://openalex.org/W2168516343","https://openalex.org/W2179754368","https://openalex.org/W2288508021","https://openalex.org/W2342796331","https://openalex.org/W2529645095","https://openalex.org/W2534339546","https://openalex.org/W2553659869","https://openalex.org/W2555428666","https://openalex.org/W2565383127","https://openalex.org/W2567777408","https://openalex.org/W2582214777","https://openalex.org/W2606097289","https://openalex.org/W2765689799","https://openalex.org/W2766313058","https://openalex.org/W2811106727","https://openalex.org/W2811212358","https://openalex.org/W2856490399","https://openalex.org/W2907733667","https://openalex.org/W2911458519","https://openalex.org/W2912918280","https://openalex.org/W2924930352","https://openalex.org/W2943478912","https://openalex.org/W2951905322","https://openalex.org/W2955294901","https://openalex.org/W2963487203","https://openalex.org/W2974242780","https://openalex.org/W2974643180","https://openalex.org/W2982607390","https://openalex.org/W2983142717","https://openalex.org/W2983363499","https://openalex.org/W2988310131","https://openalex.org/W2990114946","https://openalex.org/W2995046159","https://openalex.org/W2997032704","https://openalex.org/W2999540436","https://openalex.org/W3000425699","https://openalex.org/W3005879110","https://openalex.org/W3015333601","https://openalex.org/W3020154434","https://openalex.org/W3025683076","https://openalex.org/W3037040360","https://openalex.org/W3044515532","https://openalex.org/W3045969513","https://openalex.org/W3087628011","https://openalex.org/W3091854037","https://openalex.org/W3097763475","https://openalex.org/W3101423962","https://openalex.org/W3106192529","https://openalex.org/W3125190770","https://openalex.org/W3131497052","https://openalex.org/W3139450778","https://openalex.org/W3141007726","https://openalex.org/W3165269514","https://openalex.org/W3179518327","https://openalex.org/W3184823685","https://openalex.org/W3198445546","https://openalex.org/W3198878469"],"related_works":["https://openalex.org/W4383956731","https://openalex.org/W4387566458","https://openalex.org/W4318754640","https://openalex.org/W3138871015","https://openalex.org/W4311585308","https://openalex.org/W2974242780","https://openalex.org/W4414079284","https://openalex.org/W1504515282","https://openalex.org/W4400410130","https://openalex.org/W4405575240"],"abstract_inverted_index":{"BACKGROUND:":[0],"Osteoarthritis":[1],"(OA),":[2],"as":[3,22],"one":[4],"of":[5,12,92],"the":[6,88,93,97],"chronic":[7],"debilitating":[8],"conditions,":[9],"affects":[10],"15%":[11],"people":[13],"globally":[14],"and":[15,27,48,64,102,111,118],"is":[16,74,100],"linked":[17],"with":[18,136],"serious":[19],"problems,":[20],"such":[21],"cardiovascular":[23],"diseases,":[24],"metabolic":[25],"syndrome,":[26],"autoimmune":[28],"inflammatory":[29],"disorders.":[30],"The":[31],"current":[32,89],"therapeutic":[33,104],"options":[34],"for":[35,67],"this":[36,125],"disease":[37],"include":[38],"nonsteroidal":[39],"anti-inflammatory":[40],"drugs,":[41],"surgery,":[42],"gene":[43],"therapy,":[44],"intrasynovial":[45],"gel":[46],"injection,":[47],"warm":[49],"needle":[50],"penetration.":[51],"However,":[52],"these":[53],"approaches":[54],"may":[55],"be":[56],"accompanied":[57],"by":[58],"considerable":[59],"side":[60],"effects,":[61],"high":[62],"costs,":[63],"some":[65],"limitations":[66],"patients.":[68],"Thus,":[69],"using":[70],"an":[71],"alternative":[72],"way":[73],"needed.":[75],"SUMMARY:":[76],"Presently,":[77],"natural":[78],"compounds":[79,94],"based-therapies,":[80],"like":[81],"flavonoids,":[82],"have":[83,113],"acquired":[84],"much":[85],"attention":[86],"in":[87,116,119],"era.":[90],"One":[91],"belonging":[95],"to":[96,109],"flavonoid":[98],"family":[99],"quercetin,":[101],"its":[103,131],"effects":[105],"on":[106],"disorders":[107],"related":[108],"joints":[110],"cartilage":[112],"been":[114],"addressed":[115],"vivo":[117],"vitro":[120],"studies.":[121],"KEY":[122],"MESSAGES:":[123],"In":[124],"review,":[126],"we":[127],"summarized":[128],"evidence":[129],"indicating":[130],"curative":[132],"capacity":[133],"against":[134],"OA":[135],"a":[137],"mechanistic":[138],"insight.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-09T00:00:00"}
