{"id":"https://openalex.org/W4284713550","doi":"https://doi.org/10.3390/ijms23147508","title":"Integrative Analyses of Transcriptomes to Explore Common Molecular Effects of Antipsychotic Drugs","display_name":"Integrative Analyses of Transcriptomes to Explore Common Molecular Effects of Antipsychotic Drugs","publication_year":2022,"publication_date":"2022-07-06","ids":{"openalex":"https://openalex.org/W4284713550","doi":"https://doi.org/10.3390/ijms23147508","pmid":"https://pubmed.ncbi.nlm.nih.gov/35886854","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9325239"},"language":"en","primary_location":{"id":"doi:10.3390/ijms23147508","doi":"https://doi.org/10.3390/ijms23147508","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23147508","pdf_url":"https://www.mdpi.com/1422-0067/23/14/7508/pdf?version=1657160189","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/23/14/7508/pdf?version=1657160189","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033376716","display_name":"Trang T. T. Truong","orcid":"https://orcid.org/0000-0001-9301-5911","observed_orcids":["https://orcid.org/0000-0001-9301-5911"]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Trang T. T. Truong","raw_affiliation_strings":["The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia"],"raw_orcid":"https://orcid.org/0000-0001-9301-5911","affiliations":[{"raw_affiliation_string":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia","institution_ids":["https://openalex.org/I149704539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023365501","display_name":"Chiara C. Bortolasci","orcid":"https://orcid.org/0000-0002-0794-6363","observed_orcids":["https://orcid.org/0000-0002-0794-6363"]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Chiara C. Bortolasci","raw_affiliation_strings":["The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia","institution_ids":["https://openalex.org/I149704539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034263466","display_name":"Srisaiyini Kidnapillai","orcid":"https://orcid.org/0000-0001-5313-9813","observed_orcids":["https://orcid.org/0000-0001-5313-9813"]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Srisaiyini Kidnapillai","raw_affiliation_strings":["The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia","institution_ids":["https://openalex.org/I149704539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018655678","display_name":"Briana Spolding","orcid":"https://orcid.org/0000-0001-7453-4580","observed_orcids":["https://orcid.org/0000-0001-7453-4580"]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Briana Spolding","raw_affiliation_strings":["The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia","institution_ids":["https://openalex.org/I149704539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055892644","display_name":"Bruna Panizzutti","orcid":"https://orcid.org/0000-0002-8825-734X","observed_orcids":["https://orcid.org/0000-0002-8825-734X"]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Bruna Panizzutti","raw_affiliation_strings":["The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia"],"raw_orcid":"https://orcid.org/0000-0002-8825-734X","affiliations":[{"raw_affiliation_string":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia","institution_ids":["https://openalex.org/I149704539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001140027","display_name":"Zoe Shih-Jung Liu","orcid":"https://orcid.org/0000-0002-0269-0119","observed_orcids":["https://orcid.org/0000-0002-0269-0119"]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Zoe S. J. Liu","raw_affiliation_strings":["The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia","institution_ids":["https://openalex.org/I149704539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100623838","display_name":"Jee Hyun Kim","orcid":"https://orcid.org/0000-0002-1299-4300","observed_orcids":["https://orcid.org/0000-0002-1299-4300"]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jee Hyun Kim","raw_affiliation_strings":["The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville 3010, Australia","The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia"],"raw_orcid":"https://orcid.org/0000-0002-1299-4300","affiliations":[{"raw_affiliation_string":"The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville 3010, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]},{"raw_affiliation_string":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia","institution_ids":["https://openalex.org/I149704539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038776015","display_name":"Olivia May Dean","orcid":"https://orcid.org/0000-0002-2776-3935","observed_orcids":["https://orcid.org/0000-0002-2776-3935"]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Olivia M. Dean","raw_affiliation_strings":["The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville 3010, Australia","The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia"],"raw_orcid":"https://orcid.org/0000-0002-2776-3935","affiliations":[{"raw_affiliation_string":"The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville 3010, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]},{"raw_affiliation_string":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia","institution_ids":["https://openalex.org/I149704539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083686885","display_name":"Mark F. Richardson","orcid":"https://orcid.org/0000-0002-1650-0064","observed_orcids":["https://orcid.org/0000-0002-1650-0064"]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark F. Richardson","raw_affiliation_strings":["Genomics Centre, School of Life and Environmental Sciences, Deakin University, Burwood 3125, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Centre, School of Life and Environmental Sciences, Deakin University, Burwood 3125, Australia","institution_ids":["https://openalex.org/I149704539"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Berk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]},{"id":"https://openalex.org/I4210112801","display_name":"Orygen","ror":"https://ror.org/02apyk545","country_code":"AU","type":"other","lineage":["https://openalex.org/I4210112801"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael Berk","raw_affiliation_strings":["Orygen, The National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health, The Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Parkville 3010, Australia","The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville 3010, Australia","The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orygen, The National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health, The Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, University of Melbourne, Parkville 3010, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682","https://openalex.org/I4210112801"]},{"raw_affiliation_string":"The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville 3010, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I242743682"]},{"raw_affiliation_string":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia","institution_ids":["https://openalex.org/I149704539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070000043","display_name":"Ken R. Walder","orcid":"https://orcid.org/0000-0002-6758-4763","observed_orcids":["https://orcid.org/0000-0002-6758-4763"]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Ken Walder","raw_affiliation_strings":["The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia"],"raw_orcid":"https://orcid.org/0000-0002-6758-4763","affiliations":[{"raw_affiliation_string":"The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong 3220, Australia","institution_ids":["https://openalex.org/I149704539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070000043"],"corresponding_institution_ids":["https://openalex.org/I149704539"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":0.4777,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.59347638,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"23","issue":"14","first_page":"7508","last_page":"7508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.9599999785423279},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.5350000262260437},{"id":"https://openalex.org/keywords/drug-induced-gene-expression","display_name":"drug-induced gene expression","score":0.7770000100135803},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7540000081062317},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.6890000104904175},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"expression quantitative trait loci","score":0.8650000095367432},{"id":"https://openalex.org/keywords/pdcd10","display_name":"PDCD10","score":0.902999997138977},{"id":"https://openalex.org/keywords/ank2","display_name":"ANK2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/akt3","display_name":"AKT3","score":1.0},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.8939999938011169},{"id":"https://openalex.org/keywords/postmortem-brain","display_name":"postmortem brain","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C2778999636","wikidata":"https://www.wikidata.org/wiki/Q418785","display_name":"Amisulpride","level":4,"score":0.793506383895874},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.6901146173477173},{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.6801927089691162},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.6578097939491272},{"id":"https://openalex.org/C2780057945","wikidata":"https://www.wikidata.org/wiki/Q412443","display_name":"Risperidone","level":3,"score":0.5737537145614624},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5195227265357971},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5002648830413818},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.43840503692626953},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.43682873249053955},{"id":"https://openalex.org/C2780211496","wikidata":"https://www.wikidata.org/wiki/Q411188","display_name":"Aripiprazole","level":3,"score":0.4355523884296417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4174697697162628},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3967565894126892},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.39227497577667236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3356115221977234},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3252565860748291},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19245943427085876},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.11833277344703674},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077152","descriptor_name":"Olanzapine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003987","descriptor_name":"Dibenzothiazepines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/ijms23147508","doi":"https://doi.org/10.3390/ijms23147508","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23147508","pdf_url":"https://www.mdpi.com/1422-0067/23/14/7508/pdf?version=1657160189","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9325239","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9325239","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:35886854","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35886854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:44c12c8946514f9bafad2f1307382fce","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/44c12c8946514f9bafad2f1307382fce","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 23, Iss 7508, p 7508 (2022)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/20583348","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Integrative_Analyses_of_Transcriptomes_to_Explore_Common_Molecular_Effects_of_Antipsychotic_Drugs/20583348","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/316719","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/316719","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms23147508","doi":"https://doi.org/10.3390/ijms23147508","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms23147508","pdf_url":"https://www.mdpi.com/1422-0067/23/14/7508/pdf?version=1657160189","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4394325084","display_name":"Gene Expression Signature Technology to Repurpose Drugs for Bipolar Disorder","funder_award_id":"1078928","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G8415457339","display_name":null,"funder_award_id":"COVID-19","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G955010633","display_name":"CREDIT: The CRE for the Development of Innovative Therapies for Psychiatric Disorders","funder_award_id":"1153607","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320273","display_name":"University of Cambridge","ror":"https://ror.org/013meh722"},{"id":"https://openalex.org/F4320320290","display_name":"University of Oxford","ror":"https://ror.org/052gg0110"},{"id":"https://openalex.org/F4320322858","display_name":"State Government of Victoria","ror":"https://ror.org/02xvc5r05"},{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"},{"id":"https://openalex.org/F4320327918","display_name":"H. Lundbeck A/S","ror":"https://ror.org/0564cd633"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4906014721","display_name":"Medical Research Future Fund","ror":"https://ror.org/0513v5k17"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4284713550.pdf","grobid_xml":"https://content.openalex.org/works/W4284713550.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1527927437","https://openalex.org/W1645493186","https://openalex.org/W1776914999","https://openalex.org/W1968901518","https://openalex.org/W1970751001","https://openalex.org/W1977732091","https://openalex.org/W1986607765","https://openalex.org/W1999029326","https://openalex.org/W2013482405","https://openalex.org/W2030811160","https://openalex.org/W2032503223","https://openalex.org/W2035618305","https://openalex.org/W2039663696","https://openalex.org/W2055127006","https://openalex.org/W2060936083","https://openalex.org/W2084345288","https://openalex.org/W2087200610","https://openalex.org/W2089352389","https://openalex.org/W2093098541","https://openalex.org/W2101357408","https://openalex.org/W2110065044","https://openalex.org/W2114104545","https://openalex.org/W2115807273","https://openalex.org/W2118822739","https://openalex.org/W2121247237","https://openalex.org/W2131271579","https://openalex.org/W2131426434","https://openalex.org/W2137801561","https://openalex.org/W2144035284","https://openalex.org/W2164425582","https://openalex.org/W2169456326","https://openalex.org/W2278070452","https://openalex.org/W2526546796","https://openalex.org/W2604861430","https://openalex.org/W2611814985","https://openalex.org/W2734505834","https://openalex.org/W2763836527","https://openalex.org/W2790195606","https://openalex.org/W2790951755","https://openalex.org/W2797098486","https://openalex.org/W2800330668","https://openalex.org/W2875515511","https://openalex.org/W2886100207","https://openalex.org/W2943327443","https://openalex.org/W2951370624","https://openalex.org/W2969957655","https://openalex.org/W2972617523","https://openalex.org/W2995245946","https://openalex.org/W3092045521","https://openalex.org/W3107527779","https://openalex.org/W3145257564","https://openalex.org/W3175589947"],"related_works":["https://openalex.org/W2093098541","https://openalex.org/W7132975288","https://openalex.org/W6927257139","https://openalex.org/W2738242273","https://openalex.org/W2088454704","https://openalex.org/W2089683746","https://openalex.org/W2794373093","https://openalex.org/W6993183248","https://openalex.org/W2796405652","https://openalex.org/W4220951246"],"abstract_inverted_index":{"There":[0],"is":[1],"little":[2],"understanding":[3],"of":[4,14,50,80,98],"the":[5,11,51,85],"underlying":[6],"molecular":[7],"mechanism(s)":[8],"involved":[9],"in":[10,72,84,117],"clinical":[12],"efficacy":[13],"antipsychotics":[15],"for":[16,45],"schizophrenia.":[17],"This":[18],"study":[19],"integrated":[20],"schizophrenia-associated":[21,69],"transcriptional":[22,70],"perturbations":[23],"with":[24,48],"antipsychotic-induced":[25],"gene":[26,63],"expression":[27,64,152],"profiles":[28],"to":[29,68,88],"detect":[30],"potentially":[31],"relevant":[32],"therapeutic":[33],"targets":[34],"shared":[35],"by":[36,78,124],"multiple":[37],"antipsychotics.":[38],"Human":[39],"neuronal-like":[40],"cells":[41],"(NT2-N)":[42],"were":[43,66,90,101,121],"treated":[44],"24":[46],"h":[47],"one":[49,107],"following":[52],"antipsychotic":[53,82,127],"drugs:":[54],"amisulpride,":[55],"aripiprazole,":[56],"clozapine,":[57],"risperidone,":[58],"or":[59],"vehicle":[60],"controls.":[61],"Drug-induced":[62],"patterns":[65],"compared":[67],"data":[71],"post-mortem":[73],"brain":[74],"tissues.":[75],"Genes":[76],"regulated":[77,123],"each":[79],"four":[81,126],"drugs":[83],"reverse":[86],"direction":[87],"schizophrenia":[89,113,151],"identified":[91],"as":[92,159,170],"potential":[93,139,171],"therapeutic-relevant":[94],"genes.":[95],"A":[96],"total":[97],"886":[99],"genes":[100,120,157,169],"reversely":[102],"expressed":[103],"between":[104],"at":[105],"least":[106],"drug":[108],"treatment":[109,173],"(versus":[110,114],"vehicle)":[111],"and":[112,137,162],"healthy":[115],"control),":[116],"which":[118],"218":[119],"commonly":[122],"all":[125],"drugs.":[128],"The":[129,141],"most":[130],"enriched":[131],"biological":[132],"pathways":[133],"include":[134],"Wnt":[135],"signaling":[136],"action":[138],"regulation.":[140],"protein-protein":[142],"interaction":[143],"(PPI)":[144],"networks":[145],"found":[146],"two":[147],"main":[148],"clusters":[149],"having":[150],"quantitative":[153],"trait":[154],"loci":[155],"(eQTL)":[156],"such":[158],"PDCD10,":[160],"ANK2,":[161],"AKT3,":[163],"suggesting":[164],"further":[165],"investigation":[166],"on":[167],"these":[168],"novel":[172],"targets.":[174]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-08T00:00:00"}