{"id":"https://openalex.org/W4284711739","doi":"https://doi.org/10.1002/cpt.2705","title":"PharmVar GeneFocus : SLCO1B1","display_name":"PharmVar GeneFocus : SLCO1B1","publication_year":2022,"publication_date":"2022-07-07","ids":{"openalex":"https://openalex.org/W4284711739","doi":"https://doi.org/10.1002/cpt.2705","pmid":"https://pubmed.ncbi.nlm.nih.gov/35797228","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10900141"},"language":"en","primary_location":{"id":"doi:10.1002/cpt.2705","doi":"https://doi.org/10.1002/cpt.2705","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpt.2705","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10900141/pdf/nihms-1958803.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049622640","display_name":"Laura B. Ramsey","orcid":"https://orcid.org/0000-0001-6417-3961","observed_orcids":["https://orcid.org/0000-0001-6417-3961"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura B. Ramsey","raw_affiliation_strings":["Divisions of Clinical Pharmacology and Research in Patient Services, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"],"raw_orcid":"https://orcid.org/0000-0001-6417-3961","affiliations":[{"raw_affiliation_string":"Divisions of Clinical Pharmacology and Research in Patient Services, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102966776","display_name":"Li Gong","orcid":"https://orcid.org/0000-0002-1739-8233","observed_orcids":["https://orcid.org/0000-0002-1739-8233"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Gong","raw_affiliation_strings":["Department of Biomedical Data Science, Stanford University, Stanford, California, USA"],"raw_orcid":"https://orcid.org/0000-0002-1739-8233","affiliations":[{"raw_affiliation_string":"Department of Biomedical Data Science, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006813551","display_name":"Seung\u2010been Lee","orcid":"https://orcid.org/0000-0001-9869-1070","observed_orcids":["https://orcid.org/0000-0001-9869-1070"]},"institutions":[{"id":"https://openalex.org/I4210129256","display_name":"Macrogen (South Korea)","ror":"https://ror.org/03qan5r71","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210129256"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung\u2010been Lee","raw_affiliation_strings":["Precision Medicine Institute, Macrogen Inc., Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0001-9869-1070","affiliations":[{"raw_affiliation_string":"Precision Medicine Institute, Macrogen Inc., Seoul, Korea","institution_ids":["https://openalex.org/I4210129256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063675300","display_name":"Jonathan B. Wagner","orcid":"https://orcid.org/0000-0001-7690-6798","observed_orcids":["https://orcid.org/0000-0001-7690-6798"]},"institutions":[{"id":"https://openalex.org/I1328594524","display_name":"Children's Mercy Hospital","ror":"https://ror.org/04zfmcq84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328594524"]},{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan B. Wagner","raw_affiliation_strings":["Division of Clinical Pharmacology, Toxicology &amp; Therapeutic Innovation, Children's Mercy Kansas City Kansas City Missouri USA","School of Medicine, University of Missouri\u2013Kansas City  Kansas City Missouri USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Toxicology &amp; Therapeutic Innovation, Children's Mercy Kansas City Kansas City Missouri USA","institution_ids":["https://openalex.org/I1328594524"]},{"raw_affiliation_string":"School of Medicine, University of Missouri\u2013Kansas City  Kansas City Missouri USA","institution_ids":["https://openalex.org/I75421653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034263698","display_name":"Xujia Zhou","orcid":"https://orcid.org/0000-0003-2491-0933","observed_orcids":["https://orcid.org/0000-0003-2491-0933"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xujia Zhou","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA"],"raw_orcid":"https://orcid.org/0000-0003-2491-0933","affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072681827","display_name":"Katrin Sangkuhl","orcid":"https://orcid.org/0000-0001-7880-5843","observed_orcids":["https://orcid.org/0000-0001-7880-5843"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katrin Sangkuhl","raw_affiliation_strings":["Department of Biomedical Data Science, Stanford University, Stanford, California, USA"],"raw_orcid":"https://orcid.org/0000-0001-7880-5843","affiliations":[{"raw_affiliation_string":"Department of Biomedical Data Science, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035280449","display_name":"Solomon M. Adams","orcid":"https://orcid.org/0000-0002-5583-0322","observed_orcids":["https://orcid.org/0000-0002-5583-0322"]},"institutions":[{"id":"https://openalex.org/I200033832","display_name":"Shenandoah University","ror":"https://ror.org/05w0p9h92","country_code":"US","type":"education","lineage":["https://openalex.org/I200033832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Solomon M. Adams","raw_affiliation_strings":["School of Pharmacy, Shenandoah University, Fairfax, Virginia, USA"],"raw_orcid":"https://orcid.org/0000-0002-5583-0322","affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shenandoah University, Fairfax, Virginia, USA","institution_ids":["https://openalex.org/I200033832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011472777","display_name":"Robert J. Straka","orcid":"https://orcid.org/0000-0002-9541-7823","observed_orcids":["https://orcid.org/0000-0002-9541-7823"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Straka","raw_affiliation_strings":["Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA"],"raw_orcid":"https://orcid.org/0000-0002-9541-7823","affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074313960","display_name":"Philip E. Empey","orcid":"https://orcid.org/0000-0001-7474-2339","observed_orcids":["https://orcid.org/0000-0001-7474-2339"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip E. Empey","raw_affiliation_strings":["School of Pharmacy and Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0001-7474-2339","affiliations":[{"raw_affiliation_string":"School of Pharmacy and Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044446111","display_name":"Erin C. Boone","orcid":"https://orcid.org/0000-0003-3044-5521","observed_orcids":["https://orcid.org/0000-0003-3044-5521"]},"institutions":[{"id":"https://openalex.org/I1328594524","display_name":"Children's Mercy Hospital","ror":"https://ror.org/04zfmcq84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328594524"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin C. Boone","raw_affiliation_strings":["Division of Clinical Pharmacology, Toxicology &amp; Therapeutic Innovation, Children's Mercy Kansas City Kansas City Missouri USA"],"raw_orcid":"https://orcid.org/0000-0003-3044-5521","affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Toxicology &amp; Therapeutic Innovation, Children's Mercy Kansas City Kansas City Missouri USA","institution_ids":["https://openalex.org/I1328594524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079887236","display_name":"Teri E. Klein","orcid":"https://orcid.org/0000-0001-5527-6475","observed_orcids":["https://orcid.org/0000-0001-5527-6475"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teri E. Klein","raw_affiliation_strings":["Department of Biomedical Data Science, Stanford University, Stanford, California, USA","Department of Medicine (BMIR), Stanford University, Stanford, California, USA"],"raw_orcid":"https://orcid.org/0000-0001-5527-6475","affiliations":[{"raw_affiliation_string":"Department of Biomedical Data Science, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Medicine (BMIR), Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047851431","display_name":"Mikko Niemi","orcid":"https://orcid.org/0000-0003-4550-2189","observed_orcids":["https://orcid.org/0000-0003-4550-2189"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210166427","display_name":"Hospital District of Helsinki and Uusimaa","ror":"https://ror.org/020cpqb94","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mikko Niemi","raw_affiliation_strings":["Department of Clinical Pharmacology University of Helsinki  Helsinki Finland","Department of Clinical Pharmacology, HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland","Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland"],"raw_orcid":"https://orcid.org/0000-0003-4550-2189","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology University of Helsinki  Helsinki Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Department of Clinical Pharmacology, HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"raw_affiliation_string":"Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001681968","display_name":"Andrea Gaedigk","orcid":"https://orcid.org/0000-0001-6968-1893","observed_orcids":["https://orcid.org/0000-0001-6968-1893"]},"institutions":[{"id":"https://openalex.org/I1328594524","display_name":"Children's Mercy Hospital","ror":"https://ror.org/04zfmcq84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328594524"]},{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrea Gaedigk","raw_affiliation_strings":["Division of Clinical Pharmacology, Toxicology &amp; Therapeutic Innovation, Children's Mercy Kansas City Kansas City Missouri USA","School of Medicine, University of Missouri\u2013Kansas City  Kansas City Missouri USA"],"raw_orcid":"https://orcid.org/0000-0001-6968-1893","affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Toxicology &amp; Therapeutic Innovation, Children's Mercy Kansas City Kansas City Missouri USA","institution_ids":["https://openalex.org/I1328594524"]},{"raw_affiliation_string":"School of Medicine, University of Missouri\u2013Kansas City  Kansas City Missouri USA","institution_ids":["https://openalex.org/I75421653"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5001681968"],"corresponding_institution_ids":["https://openalex.org/I1328594524","https://openalex.org/I75421653"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":2.1194,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.8919708,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"113","issue":"4","first_page":"782","last_page":"793"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/slco1b1","display_name":"SLCO1B1","score":1.0},{"id":"https://openalex.org/keywords/oatp1b1","display_name":"OATP1B1","score":0.996999979019165},{"id":"https://openalex.org/keywords/haplotype-variation","display_name":"haplotype variation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/statin-pharmacokinetics","display_name":"statin pharmacokinetics","score":0.7609999775886536},{"id":"https://openalex.org/keywords/drug-transporters","display_name":"drug transporters","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C2776598434","wikidata":"https://www.wikidata.org/wiki/Q18035517","display_name":"SLCO1B1","level":5,"score":0.891047477722168},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.6689936518669128},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5349608063697815},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.5229814052581787},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.45467787981033325},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.42695358395576477},{"id":"https://openalex.org/C97425143","wikidata":"https://www.wikidata.org/wiki/Q164786","display_name":"1000 Genomes Project","level":5,"score":0.41809865832328796},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41199105978012085},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3927229642868042},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3874938488006592},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2772369384765625},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.13543492555618286}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D027381","descriptor_name":"Liver-Specific Organic Anion Transporter 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/cpt.2705","doi":"https://doi.org/10.1002/cpt.2705","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpt.2705","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmid:35797228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35797228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10900141","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10900141","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10900141/pdf/nihms-1958803.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Pharmacol Ther","raw_type":"Text"},{"id":"pmh:oai:helda.helsinki.fi:10138/573160","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/573160","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Review Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10900141","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10900141","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10900141/pdf/nihms-1958803.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Pharmacol Ther","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000863890","display_name":"PharmGKB","funder_award_id":"U24HG010615","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4284711739.pdf","grobid_xml":"https://content.openalex.org/works/W4284711739.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W1585895556","https://openalex.org/W1604547439","https://openalex.org/W1657886501","https://openalex.org/W1783939843","https://openalex.org/W1788032165","https://openalex.org/W1968604782","https://openalex.org/W1978006382","https://openalex.org/W1980514890","https://openalex.org/W1983184704","https://openalex.org/W1988755578","https://openalex.org/W2005615400","https://openalex.org/W2007238584","https://openalex.org/W2014565106","https://openalex.org/W2016918159","https://openalex.org/W2039141364","https://openalex.org/W2039986849","https://openalex.org/W2048593300","https://openalex.org/W2061003736","https://openalex.org/W2083878136","https://openalex.org/W2085448380","https://openalex.org/W2089602495","https://openalex.org/W2096140674","https://openalex.org/W2099236176","https://openalex.org/W2105311148","https://openalex.org/W2106456872","https://openalex.org/W2108182085","https://openalex.org/W2111212838","https://openalex.org/W2113719939","https://openalex.org/W2126118473","https://openalex.org/W2138345444","https://openalex.org/W2139121124","https://openalex.org/W2139681313","https://openalex.org/W2152218609","https://openalex.org/W2156173568","https://openalex.org/W2167980243","https://openalex.org/W2169555151","https://openalex.org/W2170052837","https://openalex.org/W2178874084","https://openalex.org/W2260637562","https://openalex.org/W2387341300","https://openalex.org/W2444137400","https://openalex.org/W2444425410","https://openalex.org/W2770460146","https://openalex.org/W2789160819","https://openalex.org/W2790963960","https://openalex.org/W2793349513","https://openalex.org/W2887655204","https://openalex.org/W2902190679","https://openalex.org/W2905106264","https://openalex.org/W2944063617","https://openalex.org/W2950340165","https://openalex.org/W2951716367","https://openalex.org/W2953347947","https://openalex.org/W2962509132","https://openalex.org/W2973113902","https://openalex.org/W2974347378","https://openalex.org/W2976816195","https://openalex.org/W2987709465","https://openalex.org/W3001451314","https://openalex.org/W3010947738","https://openalex.org/W3014072900","https://openalex.org/W3031971218","https://openalex.org/W3083532361","https://openalex.org/W3088068042","https://openalex.org/W3120116794","https://openalex.org/W3133661357","https://openalex.org/W3167268391","https://openalex.org/W3172385553","https://openalex.org/W3175801695","https://openalex.org/W3193170798","https://openalex.org/W3204641903","https://openalex.org/W4205141468","https://openalex.org/W4205170775","https://openalex.org/W4210318794","https://openalex.org/W4210643740","https://openalex.org/W4210644225","https://openalex.org/W4213127162","https://openalex.org/W4214770147","https://openalex.org/W4220698268","https://openalex.org/W4226225611","https://openalex.org/W4249964811","https://openalex.org/W4294012180","https://openalex.org/W6687727594"],"related_works":["https://openalex.org/W2560785130","https://openalex.org/W2113719939","https://openalex.org/W2135590214","https://openalex.org/W4394892276","https://openalex.org/W2079296200","https://openalex.org/W6892206301","https://openalex.org/W4392810634","https://openalex.org/W2949150916","https://openalex.org/W2981395109","https://openalex.org/W7154897555"],"abstract_inverted_index":{"The":[0,177],"Pharmacogene":[1],"Variation":[2],"Consortium":[3,189],"(PharmVar)":[4],"is":[5,54,142],"now":[6,143],"providing":[7],"star":[8,107,111,122,175],"(*)":[9],"allele":[10],"nomenclature":[11,123,134,180],"for":[12,129],"the":[13,20,32,64,78,121,156,185],"highly":[14],"polymorphic":[15],"human":[16],"SLCO1B1":[17,33,106,179],"gene":[18,34,76,96],"encoding":[19],"organic":[21],"anion":[22],"transporting":[23],"polypeptide":[24],"1B1":[25],"(OATP1B1)":[26],"drug":[27,37,74],"transporter.":[28],"Genetic":[29],"variation":[30,89],"within":[31],"locus":[35],"impacts":[36],"transport,":[38],"which":[39],"can":[40],"lead":[41],"to":[42,145,165],"altered":[43],"pharmacokinetic":[44],"profiles":[45],"of":[46,55,61,66,87,95,103],"several":[47],"commonly":[48],"prescribed":[49],"drugs.":[50],"Variable":[51],"OATP1B1":[52],"function":[53],"particular":[56],"importance":[57],"regarding":[58],"hepatic":[59],"uptake":[60],"statins":[62],"and":[63,81,117,141,160],"risk":[65],"statin-associated":[67,194],"musculoskeletal":[68,195],"symptoms.":[69,196],"To":[70],"introduce":[71],"this":[72],"important":[73,147],"transporter":[75],"into":[77],"PharmVar":[79,140],"database":[80],"serve":[82],"as":[83,150],"a":[84],"unified":[85],"reference":[86],"haplotype":[88],"moving":[90],"forward,":[91],"an":[92,100],"international":[93],"group":[94],"experts":[97],"has":[98,136,181],"performed":[99],"extensive":[101],"review":[102],"all":[104],"published":[105,110],"alleles.":[108,176],"Previously":[109],"alleles":[112],"were":[113,163],"self-assigned":[114],"by":[115,139,184],"authors":[116],"only":[118],"loosely":[119],"followed":[120],"system":[124,135],"that":[125],"was":[126],"first":[127],"developed":[128],"cytochrome":[130],"P450":[131],"genes.":[132],"This":[133],"been":[137,182],"standardized":[138],"applied":[144],"other":[146],"pharmacogenes":[148],"such":[149],"SLCO1B1.":[151],"In":[152],"addition,":[153],"data":[154,162],"from":[155],"1000":[157],"Genomes":[158],"Project":[159],"investigator-submitted":[161],"utilized":[164],"confirm":[166],"existing":[167],"haplotypes,":[168],"fill":[169],"knowledge":[170],"gaps,":[171],"and/or":[172],"define":[173],"novel":[174],"PharmVar-developed":[178],"incorporated":[183],"Clinical":[186],"Pharmacogenetics":[187],"Implementation":[188],"(CPIC)":[190],"2022":[191],"guideline":[192],"on":[193]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-08T00:00:00"}
