{"id":"https://openalex.org/W4284672001","doi":"https://doi.org/10.3889/oamjms.2022.9768","title":"The Effect of Low Doses of Radon on Ghrelin and Glucose Levels in Rats with Multiple Low-Dose Streptozotoccin-induced Type 2 Diabetes Mellitus","display_name":"The Effect of Low Doses of Radon on Ghrelin and Glucose Levels in Rats with Multiple Low-Dose Streptozotoccin-induced Type 2 Diabetes Mellitus","publication_year":2022,"publication_date":"2022-06-05","ids":{"openalex":"https://openalex.org/W4284672001","doi":"https://doi.org/10.3889/oamjms.2022.9768"},"language":"en","primary_location":{"id":"doi:10.3889/oamjms.2022.9768","doi":"https://doi.org/10.3889/oamjms.2022.9768","is_oa":true,"landing_page_url":"https://doi.org/10.3889/oamjms.2022.9768","pdf_url":"https://oamjms.eu/index.php/mjms/article/download/9768/7556","source":{"id":"https://openalex.org/S2738387300","display_name":"Open Access Macedonian Journal of Medical Sciences","issn_l":"1857-9655","issn":["1857-9655"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310322218","host_organization_name":"ID Design 2012/DOOEL Skopje","host_organization_lineage":["https://openalex.org/P4310322218"],"host_organization_lineage_names":["ID Design 2012/DOOEL Skopje"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Access Macedonian Journal of Medical Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4284672001"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://oamjms.eu/index.php/mjms/article/download/9768/7556","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036628705","display_name":"NATIA CHKHEIDZE","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natia Chkheidze","raw_affiliation_strings":["National Institute of Endocrinology, Tbilisi, Georgia; Ivane Beritashvili Experimental Biomedicine Center, Tbilisi, Georgia","Ivane Beritashvili Experimental Biomedicine Center, Tbilisi, Georgia","National Institute of Endocrinology, Tbilisi, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Endocrinology, Tbilisi, Georgia; Ivane Beritashvili Experimental Biomedicine Center, Tbilisi, Georgia","institution_ids":[]},{"raw_affiliation_string":"Ivane Beritashvili Experimental Biomedicine Center, Tbilisi, Georgia","institution_ids":[]},{"raw_affiliation_string":"National Institute of Endocrinology, Tbilisi, Georgia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057607267","display_name":"Elene Giorgadze","orcid":"https://orcid.org/0000-0002-2404-2382","observed_orcids":["https://orcid.org/0000-0002-2404-2382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elene Giorgadze","raw_affiliation_strings":["National Institute of Endocrinology, Tbilisi, Georgia; Ivane Beritashvili Experimental Biomedicine Center, Tbilisi, Georgia","Ivane Beritashvili Experimental Biomedicine Center, Tbilisi, Georgia","National Institute of Endocrinology, Tbilisi, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Endocrinology, Tbilisi, Georgia; Ivane Beritashvili Experimental Biomedicine Center, Tbilisi, Georgia","institution_ids":[]},{"raw_affiliation_string":"Ivane Beritashvili Experimental Biomedicine Center, Tbilisi, Georgia","institution_ids":[]},{"raw_affiliation_string":"National Institute of Endocrinology, Tbilisi, Georgia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075696757","display_name":"MARINA NIKOLAISHVILI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marina Nikolaishvili","raw_affiliation_strings":["National Institute of Endocrinology, Tbilisi, Georgia; Ivane Beritashvili Experimental Biomedicine Center, Tbilisi, Georgia","Ivane Beritashvili Experimental Biomedicine Center, Tbilisi, Georgia","National Institute of Endocrinology, Tbilisi, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Endocrinology, Tbilisi, Georgia; Ivane Beritashvili Experimental Biomedicine Center, Tbilisi, Georgia","institution_ids":[]},{"raw_affiliation_string":"Ivane Beritashvili Experimental Biomedicine Center, Tbilisi, Georgia","institution_ids":[]},{"raw_affiliation_string":"National Institute of Endocrinology, Tbilisi, Georgia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049569650","display_name":"ANA MALAZONIA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Malazonia","raw_affiliation_strings":["National Institute of Endocrinology, Tbilisi, Georgia; Ivane Beritashvili Experimental Biomedicine Center, Tbilisi, Georgia","Ivane Beritashvili Experimental Biomedicine Center, Tbilisi, Georgia","National Institute of Endocrinology, Tbilisi, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Endocrinology, Tbilisi, Georgia; Ivane Beritashvili Experimental Biomedicine Center, Tbilisi, Georgia","institution_ids":[]},{"raw_affiliation_string":"Ivane Beritashvili Experimental Biomedicine Center, Tbilisi, Georgia","institution_ids":[]},{"raw_affiliation_string":"National Institute of Endocrinology, Tbilisi, Georgia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2388,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.40510762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"10","issue":"B","first_page":"1468","last_page":"1472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.3578999936580658,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.3578999936580658,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10946","display_name":"Radioactivity and Radon Measurements","score":0.27390000224113464,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13108","display_name":"Therapeutic Uses of Natural Elements","score":0.11330000311136246,"subfield":{"id":"https://openalex.org/subfields/3603","display_name":"Complementary and Manual Therapy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radon","display_name":"radon","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hormesis","display_name":"hormesis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/balneotherapy","display_name":"balneotherapy","score":0.8169999718666077},{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":0.8270000219345093},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9649999737739563},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9850000143051147},{"id":"https://openalex.org/keywords/glycemia","display_name":"glycemia","score":0.6899999976158142},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.8690000176429749},{"id":"https://openalex.org/keywords/radon-inhalation","display_name":"radon inhalation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8535599708557129},{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.8039081692695618},{"id":"https://openalex.org/C2779051738","wikidata":"https://www.wikidata.org/wiki/Q2016490","display_name":"Balneotherapy","level":3,"score":0.6947047114372253},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.5901438593864441},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.51255202293396},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49298831820487976},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.4359048008918762},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.43543821573257446},{"id":"https://openalex.org/C186256576","wikidata":"https://www.wikidata.org/wiki/Q1058294","display_name":"Hormesis","level":3,"score":0.4197729229927063},{"id":"https://openalex.org/C545943180","wikidata":"https://www.wikidata.org/wiki/Q1133","display_name":"Radon","level":2,"score":0.4167507588863373},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2038772702217102},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.18635854125022888},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10788595676422119},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3889/oamjms.2022.9768","doi":"https://doi.org/10.3889/oamjms.2022.9768","is_oa":true,"landing_page_url":"https://doi.org/10.3889/oamjms.2022.9768","pdf_url":"https://oamjms.eu/index.php/mjms/article/download/9768/7556","source":{"id":"https://openalex.org/S2738387300","display_name":"Open Access Macedonian Journal of Medical Sciences","issn_l":"1857-9655","issn":["1857-9655"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310322218","host_organization_name":"ID Design 2012/DOOEL Skopje","host_organization_lineage":["https://openalex.org/P4310322218"],"host_organization_lineage_names":["ID Design 2012/DOOEL Skopje"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Access Macedonian Journal of Medical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:oamjms.eu:article/9768","doi":null,"is_oa":true,"landing_page_url":"https://oamjms.eu/index.php/mjms/article/view/9768","pdf_url":null,"source":{"id":"https://openalex.org/S2738387300","display_name":"Open Access Macedonian Journal of Medical Sciences","issn_l":"1857-9655","issn":["1857-9655"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310322218","host_organization_name":"ID Design 2012/DOOEL Skopje","host_organization_lineage":["https://openalex.org/P4310322218"],"host_organization_lineage_names":["ID Design 2012/DOOEL Skopje"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Macedonian Journal of Medical Sciences; Vol. 10 No. B (2022): B - Clinical Sciences; 1468-1472","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3889/oamjms.2022.9768","doi":"https://doi.org/10.3889/oamjms.2022.9768","is_oa":true,"landing_page_url":"https://doi.org/10.3889/oamjms.2022.9768","pdf_url":"https://oamjms.eu/index.php/mjms/article/download/9768/7556","source":{"id":"https://openalex.org/S2738387300","display_name":"Open Access Macedonian Journal of Medical Sciences","issn_l":"1857-9655","issn":["1857-9655"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310322218","host_organization_name":"ID Design 2012/DOOEL Skopje","host_organization_lineage":["https://openalex.org/P4310322218"],"host_organization_lineage_names":["ID Design 2012/DOOEL Skopje"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Access Macedonian Journal of Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4284672001.pdf","grobid_xml":"https://content.openalex.org/works/W4284672001.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1878946427","https://openalex.org/W1964081706","https://openalex.org/W1972505815","https://openalex.org/W2013076312","https://openalex.org/W2050315451","https://openalex.org/W2083832174","https://openalex.org/W2105573142","https://openalex.org/W2112202133","https://openalex.org/W2113628166","https://openalex.org/W2127927802","https://openalex.org/W2331648288","https://openalex.org/W2485344877"],"related_works":["https://openalex.org/W4281632041","https://openalex.org/W2183822110","https://openalex.org/W2392886694","https://openalex.org/W2347036027","https://openalex.org/W3175056059","https://openalex.org/W2356297774","https://openalex.org/W2375847610","https://openalex.org/W2410745635","https://openalex.org/W4408157187","https://openalex.org/W18160384"],"abstract_inverted_index":{"AIM:":[0],"The":[1,100,220],"aim":[2],"of":[3,26,34,52,57,73,75,90,123,139,165,222],"our":[4,223],"research":[5,183,232],"was":[6,97,126,143,176,207],"to":[7,22,111,113,163,229,233],"identify":[8],"the":[9,24,50,71,78,91,104,114,121,124,140,146,151,155,159,166,170,205],"ghrelin":[10,41,141,173,196],"concentration":[11],"in":[12,54,145,198,240],"experimental":[13,58,101,117,147,171],"animals":[14,59,89],"with":[15,95,133,200],"type":[16],"2":[17],"diabetes":[18],"mellitus":[19],"(T2DM)":[20],"and":[21,42,103,149,161,202,204,244,250],"study":[23,49],"effect":[25,39,51],"radon":[27,53,76,96,130,189,241],"hormesis":[28,242],"balneotherapy":[29],"using":[30],"natural":[31],"thermal":[32],"waters":[33],"Tskaltubo":[35,79,110,134,186],"spring,":[36],"practically,":[37],"its":[38],"on":[40,217,247],"glucose":[43,218,248],"metabolism.":[44],"MATERIALS":[45],"AND":[46],"METHODS:":[47],"To":[48],"balneotherapy,":[55],"group":[56,102,106,148],"(multiple":[60],"low":[61],"doses":[62],"streptozotocin-induced":[63],"T2DM":[64,201,251],"Wistar":[65],"rats":[66,125],"were":[67,107,157],"used)":[68],"went":[69],"through":[70],"procedure":[72],"inhalation":[74,94,131,190],"by":[77,178],"mineral":[80,135,187],"water":[81,188],"pool,":[82],"once":[83],"daily,":[84],"during":[85,209],"10":[86],"days.":[87],"In":[88,169],"control":[92,105,167],"groups,":[93],"not":[98],"used.":[99],"brought":[108],"from":[109],"Tbilisi":[112],"Ivane":[115],"Beritashvili":[116],"biomedicine":[118],"center,":[119],"where":[120],"blood":[122],"analyzed.":[127],"RESULTS:":[128],"After":[129],"therapy":[132],"water,":[136],"a":[137,227],"normalization":[138,175],"levels":[142,156,197,249],"observed":[144],"despite":[150],"different":[152],"body":[153],"weight,":[154],"approximately":[158],"same":[160],"close":[162],"those":[164],"group.":[168],"group,":[172],"level":[174,213],"accompanied":[177],"glycemia":[179],"normalization.":[180],"CONCLUSION:":[181],"This":[182],"showed":[184],"that":[185],"caused":[191],"hormesis,":[192],"which":[193],"consequently":[194],"decreased":[195],"rodents":[199],"obesity":[203],"result":[206,221],"stable":[208],"3":[210],"months.":[211],"Ghrelin":[212],"stabilization":[214],"positively":[215,245],"influenced":[216],"levels.":[219],"experiment":[224],"gives":[225],"us":[226],"stimulus":[228],"continue":[230],"future":[231],"find":[234],"more":[235],"specific":[236],"neurochemical":[237],"mechanisms":[238],"participating":[239],"processes":[243],"influencing":[246],"outcome.":[252]},"counts_by_year":[{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2022-07-08T00:00:00"}