{"id":"https://openalex.org/W4283826467","doi":"https://doi.org/10.1172/jci.insight.159430","title":"Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS/STING/NLRP3 axis in myelodysplastic syndromes","display_name":"Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS/STING/NLRP3 axis in myelodysplastic syndromes","publication_year":2022,"publication_date":"2022-07-05","ids":{"openalex":"https://openalex.org/W4283826467","doi":"https://doi.org/10.1172/jci.insight.159430","pmid":"https://pubmed.ncbi.nlm.nih.gov/35788117","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9462508"},"language":"en","primary_location":{"id":"doi:10.1172/jci.insight.159430","doi":"https://doi.org/10.1172/jci.insight.159430","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.159430","pdf_url":"http://insight.jci.org/articles/view/159430/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://insight.jci.org/articles/view/159430/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055331760","display_name":"Amy F. McLemore","orcid":"https://orcid.org/0000-0002-0155-502X","observed_orcids":["https://orcid.org/0000-0002-0155-502X"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy F. McLemore","raw_affiliation_strings":["Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA"],"raw_orcid":"https://orcid.org/0000-0002-0155-502X","affiliations":[{"raw_affiliation_string":"Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002091044","display_name":"Hsin\u2010An Hou","orcid":"https://orcid.org/0000-0003-2780-4845","observed_orcids":["https://orcid.org/0000-0003-2780-4845"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-An Hou","raw_affiliation_strings":["Department of Internal Medicine, National Taiwan University Hospital (NTUH), Taipei, Taiwan, Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, National Taiwan University Hospital (NTUH), Taipei, Taiwan, Republic of China","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060214103","display_name":"Benjamin S. Meyer","orcid":"https://orcid.org/0000-0002-5164-1639","observed_orcids":["https://orcid.org/0000-0002-5164-1639"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin S. Meyer","raw_affiliation_strings":["Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA"],"raw_orcid":"https://orcid.org/0000-0002-5164-1639","affiliations":[{"raw_affiliation_string":"Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073703366","display_name":"Nghi B. Lam","orcid":"https://orcid.org/0000-0003-3431-4668","observed_orcids":["https://orcid.org/0000-0003-3431-4668"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nghi B. Lam","raw_affiliation_strings":["Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA"],"raw_orcid":"https://orcid.org/0000-0003-3431-4668","affiliations":[{"raw_affiliation_string":"Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082028806","display_name":"Grace Ward","orcid":"https://orcid.org/0000-0003-4404-7727","observed_orcids":["https://orcid.org/0000-0003-4404-7727"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace A. Ward","raw_affiliation_strings":["Cancer Biology PhD Program, University of South Florida, Tampa, Florida, USA","Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA"],"raw_orcid":"https://orcid.org/0000-0003-4404-7727","affiliations":[{"raw_affiliation_string":"Cancer Biology PhD Program, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028445191","display_name":"Amy L. Aldrich","orcid":"https://orcid.org/0009-0004-5108-2410","observed_orcids":["https://orcid.org/0009-0004-5108-2410"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy L. Aldrich","raw_affiliation_strings":["Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069639360","display_name":"Matthew A. Rodrigues","orcid":"https://orcid.org/0000-0003-0989-8403","observed_orcids":["https://orcid.org/0000-0003-0989-8403"]},"institutions":[{"id":"https://openalex.org/I100162341","display_name":"Luminex (United States)","ror":"https://ror.org/03fef0h61","country_code":"US","type":"company","lineage":["https://openalex.org/I100162341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew A. Rodrigues","raw_affiliation_strings":["Luminex Corporation, Seattle, Washington, USA"],"raw_orcid":"https://orcid.org/0000-0003-0989-8403","affiliations":[{"raw_affiliation_string":"Luminex Corporation, Seattle, Washington, USA","institution_ids":["https://openalex.org/I100162341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022143390","display_name":"Alexis Vedder","orcid":"https://orcid.org/0000-0002-1619-874X","observed_orcids":["https://orcid.org/0000-0002-1619-874X"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexis Vedder","raw_affiliation_strings":["Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112805891","display_name":"Ling Zhang","orcid":"https://orcid.org/0000-0003-0076-2470","observed_orcids":["https://orcid.org/0000-0003-0076-2470"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling Zhang","raw_affiliation_strings":["Department of Hematopathology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopathology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041754278","display_name":"Eric Padron","orcid":"https://orcid.org/0000-0002-4707-7916","observed_orcids":["https://orcid.org/0000-0002-4707-7916"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Padron","raw_affiliation_strings":["Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037828741","display_name":"Nicole D. Vincelette","orcid":"https://orcid.org/0000-0001-7627-6781","observed_orcids":["https://orcid.org/0000-0001-7627-6781"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole D. Vincelette","raw_affiliation_strings":["Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029369362","display_name":"David Andrew Sallman","orcid":"https://orcid.org/0000-0003-0504-8233","observed_orcids":["https://orcid.org/0000-0003-0504-8233"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Sallman","raw_affiliation_strings":["Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025595346","display_name":"Omar Ibrahim Abdel-Wahab","orcid":"https://orcid.org/0000-0002-3907-6171","observed_orcids":["https://orcid.org/0000-0002-3907-6171"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omar Abdel-Wahab","raw_affiliation_strings":["Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA"],"raw_orcid":"https://orcid.org/0000-0002-3907-6171","affiliations":[{"raw_affiliation_string":"Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066001318","display_name":"Alan F. List","orcid":"https://orcid.org/0000-0002-1647-2972","observed_orcids":["https://orcid.org/0000-0002-1647-2972"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I4210108253","display_name":"Precision BioSciences (United States)","ror":"https://ror.org/01pvdcq70","country_code":"US","type":"company","lineage":["https://openalex.org/I4210108253"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan F. List","raw_affiliation_strings":["Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA","Precision Biosciences, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Precision Biosciences, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I4210108253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064032915","display_name":"Kathy L. McGraw","orcid":"https://orcid.org/0000-0001-9184-5399","observed_orcids":["https://orcid.org/0000-0001-9184-5399"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kathy L. McGraw","raw_affiliation_strings":["Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA","Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Malignant Hematology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5064032915"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I3019308854","https://openalex.org/I4210140884"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":{"value":4100,"currency":"USD","value_usd":4100},"fwci":6.3641,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.9751583,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"15","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.38350000977516174,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.38350000977516174,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.28540000319480896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.2531999945640564,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":1.0},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.7990000247955322},{"id":"https://openalex.org/keywords/r-loops","display_name":"R-loops","score":0.8360000252723694},{"id":"https://openalex.org/keywords/rna-polymerase-iii","display_name":"RNA polymerase III","score":0.8560000061988831},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.7760000228881836},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.859000027179718},{"id":"https://openalex.org/keywords/ineffective-hematopoiesis","display_name":"ineffective hematopoiesis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cytosolic-dna-sensing","display_name":"cytosolic DNA sensing","score":0.6790000200271606},{"id":"https://openalex.org/keywords/tet2","display_name":"TET2","score":0.5490000247955322},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.5009999871253967},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6201135516166687},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5471562147140503},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5258403420448303},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.4465929865837097},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4262388050556183},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.41634607315063477},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33330273628234863},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.33237218856811523},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33151865005493164},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30727094411849976},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2842501401901245},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000099197","descriptor_name":"STING Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci.insight.159430","doi":"https://doi.org/10.1172/jci.insight.159430","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.159430","pdf_url":"http://insight.jci.org/articles/view/159430/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9462508","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9462508","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"Text"},{"id":"pmid:35788117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35788117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI insight","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:488f4e3ab6114c1b8723eabf8f2131c9","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/488f4e3ab6114c1b8723eabf8f2131c9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JCI Insight, Vol 7, Iss 15 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1172/jci.insight.159430","doi":"https://doi.org/10.1172/jci.insight.159430","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.159430","pdf_url":"http://insight.jci.org/articles/view/159430/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3620013422","display_name":null,"funder_award_id":"20892","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G362094","display_name":null,"funder_award_id":"P30CA076292","funder_id":"https://openalex.org/F4320311073","funder_display_name":"Moffitt Cancer Center"},{"id":"https://openalex.org/G4551976579","display_name":null,"funder_award_id":"CA076292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G569689914","display_name":null,"funder_award_id":"7018-19","funder_id":"https://openalex.org/F4320308295","funder_display_name":"Leukemia and Lymphoma Society"},{"id":"https://openalex.org/G8135003176","display_name":null,"funder_award_id":"CA076292","funder_id":"https://openalex.org/F4320311073","funder_display_name":"Moffitt Cancer Center"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000876523","display_name":"Moffitt Cancer Center Support Grant","funder_award_id":"P30CA076292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320311073","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524"},{"id":"https://openalex.org/F4320312570","display_name":"Jazz Pharmaceuticals","ror":"https://ror.org/055mhsv54"},{"id":"https://openalex.org/F4320317479","display_name":"CTI Biopharma","ror":"https://ror.org/017bk0e71"},{"id":"https://openalex.org/F4320317544","display_name":"Incyte","ror":"https://ror.org/00cvzzg84"},{"id":"https://openalex.org/F4320317987","display_name":"Syndax Pharmaceuticals","ror":"https://ror.org/02w9kv048"},{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283826467.pdf","grobid_xml":"https://content.openalex.org/works/W4283826467.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1506037097","https://openalex.org/W1547637047","https://openalex.org/W1575193685","https://openalex.org/W1974261530","https://openalex.org/W1984337734","https://openalex.org/W1994987603","https://openalex.org/W1997998180","https://openalex.org/W2047645952","https://openalex.org/W2099610218","https://openalex.org/W2108141473","https://openalex.org/W2111063688","https://openalex.org/W2113601375","https://openalex.org/W2116205277","https://openalex.org/W2128741337","https://openalex.org/W2132327973","https://openalex.org/W2149858388","https://openalex.org/W2161887614","https://openalex.org/W2166961107","https://openalex.org/W2327514570","https://openalex.org/W2402577698","https://openalex.org/W2469317767","https://openalex.org/W2497595434","https://openalex.org/W2530814271","https://openalex.org/W2578808037","https://openalex.org/W2605406102","https://openalex.org/W2738136165","https://openalex.org/W2759921274","https://openalex.org/W2761784274","https://openalex.org/W2763462755","https://openalex.org/W2786842416","https://openalex.org/W2801544762","https://openalex.org/W2807928142","https://openalex.org/W2852959587","https://openalex.org/W2854081253","https://openalex.org/W2886760226","https://openalex.org/W2887994251","https://openalex.org/W2921928966","https://openalex.org/W2929105074","https://openalex.org/W2943579502","https://openalex.org/W2948176163","https://openalex.org/W2948421512","https://openalex.org/W3010750792","https://openalex.org/W3014242925","https://openalex.org/W3017327186","https://openalex.org/W3134981746","https://openalex.org/W3158935424","https://openalex.org/W4205403816"],"related_works":["https://openalex.org/W2901130255","https://openalex.org/W2530814271","https://openalex.org/W2752308322","https://openalex.org/W2423491126","https://openalex.org/W2607093691","https://openalex.org/W2913296480","https://openalex.org/W2921928966","https://openalex.org/W4405047928","https://openalex.org/W2971896481","https://openalex.org/W3114000578"],"abstract_inverted_index":{"NLRP3":[0,88],"inflammasome":[1,30,89,113],"and":[2,14,25,32,46,54,65,91,112,129,141,146,172],"IFN-stimulated":[3],"gene":[4,52],"(ISG)":[5],"induction":[6],"are":[7],"key":[8],"biological":[9],"drivers":[10],"of":[11,62,70,80,93,99],"ineffective":[12],"hematopoiesis":[13],"inflammation":[15],"in":[16,36,139,142,166],"myelodysplastic":[17],"syndromes":[18],"(MDSs).":[19],"Gene":[20],"mutations":[21,53,160],"involving":[22],"mRNA":[23],"splicing":[24],"epigenetic":[26],"regulatory":[27],"pathways":[28],"induce":[29],"activation":[31,69],"myeloid":[33,130,173],"lineage":[34,131,174],"skewing":[35],"MDSs":[37],"through":[38],"undefined":[39],"mechanisms.":[40],"Using":[41],"immortalized":[42],"murine":[43],"hematopoietic":[44,144],"stem":[45,145],"progenitor":[47,147],"cells":[48],"harboring":[49],"these":[50,151],"somatic":[51],"primary":[55],"MDS":[56],"BM":[57],"specimens,":[58],"we":[59],"showed":[60],"accumulation":[61],"unresolved":[63],"R-loops":[64],"micronuclei":[66],"with":[67],"concurrent":[68],"the":[71,94,118,163],"cytosolic":[72,104],"sensor":[73],"cyclic":[74],"GMP-AMP":[75,78],"synthase.":[76],"Cyclic":[77],"synthase/stimulator":[79],"IFN":[81],"genes":[82],"(cGAS/STING)":[83],"signaling":[84],"caused":[85],"ISG":[86,111,169],"induction,":[87,170],"activation,":[90],"maturation":[92],"effector":[95],"protease":[96],"caspase-1.":[97],"Deregulation":[98],"RNA":[100],"polymerase":[101],"III":[102],"drove":[103],"R-loop":[105],"generation,":[106],"which":[107,157],"upon":[108,162],"inhibition,":[109],"extinguished":[110],"response.":[114],"Mechanistically,":[115],"caspase-1":[116],"degraded":[117],"master":[119],"erythroid":[120],"transcription":[121],"factor,":[122],"GATA":[123],"binding":[124],"protein":[125],"1,":[126],"provoking":[127],"anemia":[128],"bias":[132],"that":[133],"was":[134],"reversed":[135],"by":[136,156],"cGAS":[137],"inhibition":[138],"vitro":[140],"Tet2-/-":[143],"cell-transplanted":[148],"mice.":[149],"Together,":[150],"data":[152],"identified":[153],"a":[154],"mechanism":[155],"functionally":[158],"distinct":[159],"converged":[161],"cGAS/STING/NLRP3":[164],"axis":[165],"MDS,":[167],"directing":[168],"pyroptosis,":[171],"skewing.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-07-07T00:00:00"}
