{"id":"https://openalex.org/W4283814002","doi":"https://doi.org/10.1016/s0168-8278(22)01291-0","title":"Addressing the heterogeneity of fibrosis in liver biopsy specimens with qFibrosis \u2013 a new paradigm for an old problem","display_name":"Addressing the heterogeneity of fibrosis in liver biopsy specimens with qFibrosis \u2013 a new paradigm for an old problem","publication_year":2022,"publication_date":"2022-07-01","ids":{"openalex":"https://openalex.org/W4283814002","doi":"https://doi.org/10.1016/s0168-8278(22)01291-0"},"language":"en","primary_location":{"id":"doi:10.1016/s0168-8278(22)01291-0","doi":"https://doi.org/10.1016/s0168-8278(22)01291-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-8278(22)01291-0","pdf_url":null,"source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019378601","display_name":"David Erwin Kleiner","orcid":"https://orcid.org/0000-0003-3442-4453","observed_orcids":["https://orcid.org/0000-0003-3442-4453"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Kleiner","raw_affiliation_strings":["Laboratory of Pathology, Center for Cancer Research, NCI, MD, USA;","PharmaNest, Inc, Princeton, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, Center for Cancer Research, NCI, MD, USA;","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"PharmaNest, Inc, Princeton, United States;","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pik Eu Jason Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2251586001","display_name":"Singapore General Hospital","ror":"https://ror.org/036j6sg82","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2251586001"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Pik Eu Jason Chang","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore;","PharmaNest Inc, Princeton, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore;","institution_ids":["https://openalex.org/I2251586001"]},{"raw_affiliation_string":"PharmaNest Inc, Princeton, United States;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077241004","display_name":"Dean Tai","orcid":"https://orcid.org/0000-0002-6166-5618","observed_orcids":["https://orcid.org/0000-0002-6166-5618"]},"institutions":[{"id":"https://openalex.org/I4210154055","display_name":"Histoindex (Singapore)","ror":"https://ror.org/04hwc4q95","country_code":"SG","type":"company","lineage":["https://openalex.org/I4210154055"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Dean Tai","raw_affiliation_strings":["HistoIndex Pte. Ltd., Singapore;","InSphero AG, Schlieren, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HistoIndex Pte. Ltd., Singapore;","institution_ids":["https://openalex.org/I4210154055"]},{"raw_affiliation_string":"InSphero AG, Schlieren, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027119775","display_name":"Elaine Chng","orcid":"https://orcid.org/0009-0007-8535-2281","observed_orcids":["https://orcid.org/0009-0007-8535-2281"]},"institutions":[{"id":"https://openalex.org/I4210154055","display_name":"Histoindex (Singapore)","ror":"https://ror.org/04hwc4q95","country_code":"SG","type":"company","lineage":["https://openalex.org/I4210154055"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Elaine Chng","raw_affiliation_strings":["HistoIndex Pte. Ltd., Singapore;","InSphero AG, Schlieren, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HistoIndex Pte. Ltd., Singapore;","institution_ids":["https://openalex.org/I4210154055"]},{"raw_affiliation_string":"InSphero AG, Schlieren, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020772043","display_name":"Yayun Ren","orcid":"https://orcid.org/0000-0002-8613-5728","observed_orcids":["https://orcid.org/0000-0002-8613-5728"]},"institutions":[{"id":"https://openalex.org/I4210154055","display_name":"Histoindex (Singapore)","ror":"https://ror.org/04hwc4q95","country_code":"SG","type":"company","lineage":["https://openalex.org/I4210154055"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yayun Ren","raw_affiliation_strings":["HistoIndex Pte. Ltd., Singapore;","InSphero AG, Schlieren, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HistoIndex Pte. Ltd., Singapore;","institution_ids":["https://openalex.org/I4210154055"]},{"raw_affiliation_string":"InSphero AG, Schlieren, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415237","display_name":"Feng Liu","orcid":"https://orcid.org/0000-0002-0316-4938","observed_orcids":["https://orcid.org/0000-0002-0316-4938","https://orcid.org/0000-0002-9566-2909"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Liu","raw_affiliation_strings":["Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing, China;","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053448155","display_name":"Huiying Rao","orcid":"https://orcid.org/0000-0003-2431-3872","observed_orcids":["https://orcid.org/0000-0003-2431-3872"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiying Rao","raw_affiliation_strings":["Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing, China;","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100461552","display_name":"Lai Wei","orcid":"https://orcid.org/0000-0003-2326-1257","observed_orcids":["https://orcid.org/0000-0003-2326-1257"]},"institutions":[{"id":"https://openalex.org/I4210153550","display_name":"Beijing Tsinghua Chang Gung Hospital","ror":"https://ror.org/050nfgr37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153550"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lai Wei","raw_affiliation_strings":["Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, 102218, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, 102218, China;","institution_ids":["https://openalex.org/I4210153550","https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070639714","display_name":"Arun Jayant Sanyal","orcid":"https://orcid.org/0000-0001-8682-5748","observed_orcids":["https://orcid.org/0000-0001-8682-5748"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arun Sanyal","raw_affiliation_strings":["Virginia Commonwealth University, Richmond, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Commonwealth University, Richmond, Virginia, USA","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10026359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":null,"first_page":"S481","last_page":"S481"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.9369999766349792},{"id":"https://openalex.org/keywords/noninvasive-fibrosis-assessment","display_name":"noninvasive fibrosis assessment","score":0.7129999995231628},{"id":"https://openalex.org/keywords/fibrosis-staging","display_name":"fibrosis staging","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.7161591053009033},{"id":"https://openalex.org/C2994217296","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Liver fibrosis","level":3,"score":0.6025723814964294},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5520256161689758},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47941893339157104},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.45783141255378723},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.396641343832016},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.3263666033744812}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0168-8278(22)01291-0","doi":"https://doi.org/10.1016/s0168-8278(22)01291-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-8278(22)01291-0","pdf_url":null,"source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7749000191688538}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1971103797","https://openalex.org/W2037264851","https://openalex.org/W5608413","https://openalex.org/W4245845256","https://openalex.org/W7095733166","https://openalex.org/W2890687862","https://openalex.org/W2510731530","https://openalex.org/W4410173259","https://openalex.org/W2560384658","https://openalex.org/W2031615384"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2022-07-06T00:00:00"}