{"id":"https://openalex.org/W4283811896","doi":"https://doi.org/10.1016/s0168-8278(22)00474-3","title":"Machine learned histological fibrosis score empowers characterization of baseline gene signatures associated with fibrosis progression or regression in a NASH F3/F4 clinical trial","display_name":"Machine learned histological fibrosis score empowers characterization of baseline gene signatures associated with fibrosis progression or regression in a NASH F3/F4 clinical trial","publication_year":2022,"publication_date":"2022-07-01","ids":{"openalex":"https://openalex.org/W4283811896","doi":"https://doi.org/10.1016/s0168-8278(22)00474-3"},"language":"en","primary_location":{"id":"doi:10.1016/s0168-8278(22)00474-3","doi":"https://doi.org/10.1016/s0168-8278(22)00474-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-8278(22)00474-3","pdf_url":null,"source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022990159","display_name":"Michael D. Bereket","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael D. Bereket","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020741102","display_name":"Francesco Paolo Casale","orcid":"https://orcid.org/0000-0002-5450-1981","observed_orcids":["https://orcid.org/0000-0002-5450-1981"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Paolo Casale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074592765","display_name":"Lorn Kategaya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lorn Kategaya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062907444","display_name":"Anna Shcherbina","orcid":"https://orcid.org/0000-0002-5080-5494","observed_orcids":["https://orcid.org/0000-0002-5080-5494"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Shcherbina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081511925","display_name":"Navpreet Ranu","orcid":"https://orcid.org/0000-0001-5412-8200","observed_orcids":["https://orcid.org/0000-0001-5412-8200"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Navpreet Ranu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006747369","display_name":"Alicia Lee","orcid":"https://orcid.org/0009-0006-2045-2479","observed_orcids":["https://orcid.org/0009-0006-2045-2479","https://orcid.org/0000-0003-1378-7511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alicia Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006213411","display_name":"Kelly M. Haston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelly Haston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052059601","display_name":"Rohit Seth Loomba","orcid":"https://orcid.org/0000-0002-4845-9991","observed_orcids":["https://orcid.org/0000-0002-4845-9991"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rohit Loomba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070639714","display_name":"Arun Jayant Sanyal","orcid":"https://orcid.org/0000-0001-8682-5748","observed_orcids":["https://orcid.org/0000-0001-8682-5748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arun Sanyal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091625375","display_name":"Stephen A. Harrison","orcid":"https://orcid.org/0000-0001-8285-2204","observed_orcids":["https://orcid.org/0000-0001-8285-2204","https://orcid.org/0000-0001-6399-5744"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Harrison","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080386622","display_name":"Zobair M. Younossi","orcid":"https://orcid.org/0000-0001-9313-577X","observed_orcids":["https://orcid.org/0000-0001-9313-577X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zobair Younossi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112244533","display_name":"Catherine Jia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine Jia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"David Lopez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Lopez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112887955","display_name":"Li Li","orcid":"https://orcid.org/0000-0003-1802-9517","observed_orcids":["https://orcid.org/0000-0003-1802-9517"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108739802","display_name":"Robert P. Myers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Myers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030589761","display_name":"David Breckinridge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Breckinridge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035626395","display_name":"Andrew N. Billin","orcid":"https://orcid.org/0000-0001-7752-0934","observed_orcids":["https://orcid.org/0000-0001-7752-0934"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Billin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002930131","display_name":"Ellen Lakey Berg","orcid":"https://orcid.org/0000-0001-5149-6665","observed_orcids":["https://orcid.org/0000-0001-5149-6665"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ellen Berg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011474179","display_name":"Santhosh Satapati","orcid":"https://orcid.org/0000-0002-9087-809X","observed_orcids":["https://orcid.org/0000-0002-9087-809X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Santhosh Satapati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060599199","display_name":"Eilon Sharon","orcid":"https://orcid.org/0000-0002-1262-350X","observed_orcids":["https://orcid.org/0000-0002-1262-350X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eilon Sharon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064498575","display_name":"Theofanis Karaletsos","orcid":"https://orcid.org/0000-0002-0296-3092","observed_orcids":["https://orcid.org/0000-0002-0296-3092"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theofanis Karaletsos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051658526","display_name":"Daphne Koller","orcid":"https://orcid.org/0000-0002-2361-6479","observed_orcids":["https://orcid.org/0000-0002-2361-6479","https://orcid.org/0009-0007-1645-951X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daphne Koller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078075662","display_name":"Matthew L. Albert","orcid":"https://orcid.org/0000-0001-7285-6973","observed_orcids":["https://orcid.org/0000-0001-7285-6973","https://orcid.org/0000-0002-6910-3708"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew Albert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10034882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":null,"first_page":"S31","last_page":"S31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.9390000104904175},{"id":"https://openalex.org/keywords/fibrosis-regression","display_name":"fibrosis regression","score":0.8109999895095825},{"id":"https://openalex.org/keywords/fibrosis-progression","display_name":"fibrosis progression","score":0.949999988079071},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.712645411491394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6312962174415588},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5720512270927429},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.5075985193252563},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.4479128122329712},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.446077823638916},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43083593249320984},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3421899676322937},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33813390135765076},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28462299704551697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15013766288757324},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11383667588233948},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08990287780761719},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07301557064056396},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.05560654401779175},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0168-8278(22)00474-3","doi":"https://doi.org/10.1016/s0168-8278(22)00474-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-8278(22)00474-3","pdf_url":null,"source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4283818868","https://openalex.org/W4243157674","https://openalex.org/W2799570530","https://openalex.org/W4229876662","https://openalex.org/W4235889955","https://openalex.org/W7162579568","https://openalex.org/W4244586672","https://openalex.org/W2613043759","https://openalex.org/W2800527541","https://openalex.org/W4283809934"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-07-06T00:00:00"}