{"id":"https://openalex.org/W4283776089","doi":"https://doi.org/10.1016/j.biopha.2022.113359","title":"In vitro and in vivo pharmacological characterization of dasotraline, a dual dopamine and norepinephrine transporter inhibitor in vivo","display_name":"In vitro and in vivo pharmacological characterization of dasotraline, a dual dopamine and norepinephrine transporter inhibitor in vivo","publication_year":2022,"publication_date":"2022-07-01","ids":{"openalex":"https://openalex.org/W4283776089","doi":"https://doi.org/10.1016/j.biopha.2022.113359","pmid":"https://pubmed.ncbi.nlm.nih.gov/35785702"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2022.113359","doi":"https://doi.org/10.1016/j.biopha.2022.113359","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2022.113359","pdf_url":"https://www.sciencedirect.com/science/article/pii/S075333222200748X/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S075333222200748X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104147869","display_name":"Rudy Schreiber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Rudy Schreiber","raw_affiliation_strings":["Faculty of Psychology and Neuroscience, Section Neuropsychology and Psychopharmacology, Maastricht University, The Netherlands. Electronic address: rudy.schreiber@maastrichtuniversity.nl","Faculty of Psychology and Neuroscience, Section Neuropsychology and Psychopharmacology, Maastricht University, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Psychology and Neuroscience, Section Neuropsychology and Psychopharmacology, Maastricht University, The Netherlands. Electronic address: rudy.schreiber@maastrichtuniversity.nl","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Faculty of Psychology and Neuroscience, Section Neuropsychology and Psychopharmacology, Maastricht University, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019516463","display_name":"Una C. Campbell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122020","display_name":"Sunovion (United States)","ror":"https://ror.org/030zc7t66","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Una Campbell","raw_affiliation_strings":["Sunovion Pharmaceuticals, 84 Waterford Drive, Marlborough, MA 01752, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunovion Pharmaceuticals, 84 Waterford Drive, Marlborough, MA 01752, USA","institution_ids":["https://openalex.org/I4210122020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044919695","display_name":"Maria S. Quinton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria S. Quinton","raw_affiliation_strings":["Neuroscience Translational Medicine, Takeda Pharmaceuticals U.S.A., Inc., 350 Massachusetts Avenue, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Translational Medicine, Takeda Pharmaceuticals U.S.A., Inc., 350 Massachusetts Avenue, Cambridge, MA 02139, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034858279","display_name":"Larry W. Hardy","orcid":"https://orcid.org/0000-0001-9925-0488","observed_orcids":["https://orcid.org/0000-0001-9925-0488"]},"institutions":[{"id":"https://openalex.org/I4210108815","display_name":"Psychogenics (United States)","ror":"https://ror.org/021k6d838","country_code":"US","type":"company","lineage":["https://openalex.org/I4210108815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry W. Hardy","raw_affiliation_strings":["PsychoGenics, 215 College Rd, Paramus, NJ 07652, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PsychoGenics, 215 College Rd, Paramus, NJ 07652, USA","institution_ids":["https://openalex.org/I4210108815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073677677","display_name":"Q. Kevin Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122020","display_name":"Sunovion (United States)","ror":"https://ror.org/030zc7t66","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Q. Kevin Fang","raw_affiliation_strings":["Sunovion Pharmaceuticals, 84 Waterford Drive, Marlborough, MA 01752, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunovion Pharmaceuticals, 84 Waterford Drive, Marlborough, MA 01752, USA","institution_ids":["https://openalex.org/I4210122020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023301201","display_name":"Robert Lew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122020","display_name":"Sunovion (United States)","ror":"https://ror.org/030zc7t66","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Lew","raw_affiliation_strings":["Sunovion Pharmaceuticals, 84 Waterford Drive, Marlborough, MA 01752, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sunovion Pharmaceuticals, 84 Waterford Drive, Marlborough, MA 01752, USA","institution_ids":["https://openalex.org/I4210122020"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5104147869"],"corresponding_institution_ids":["https://openalex.org/I34352273"],"apc_list":{"value":2740,"currency":"USD","value_usd":2740},"apc_paid":{"value":2740,"currency":"USD","value_usd":2740},"fwci":0.863,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.67392702,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"153","issue":null,"first_page":"113359","last_page":"113359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-transporter-inhibitors","display_name":"dopamine transporter inhibitors","score":0.7919999957084656},{"id":"https://openalex.org/keywords/norepinephrine-transporter-inhibitor","display_name":"norepinephrine transporter inhibitor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.796999990940094},{"id":"https://openalex.org/keywords/radioligand-binding","display_name":"radioligand binding","score":0.7250000238418579},{"id":"https://openalex.org/keywords/spect-imaging","display_name":"SPECT imaging","score":0.7250000238418579},{"id":"https://openalex.org/keywords/microdialysis","display_name":"microdialysis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.48500001430511475},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":1.0},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.6800000071525574},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.878000020980835},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.9739999771118164},{"id":"https://openalex.org/keywords/neuropsychiatric-disorders","display_name":"neuropsychiatric disorders","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8565137386322021},{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.6824026107788086},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6661151051521301},{"id":"https://openalex.org/C176233148","wikidata":"https://www.wikidata.org/wiki/Q14874257","display_name":"Norepinephrine transporter","level":4,"score":0.6162921786308289},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.6080353260040283},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5935554504394531},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5818964838981628},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5343308448791504},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5337200164794922},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26095685362815857},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2082137167453766},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.18606066703796387},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13074806332588196},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015057","descriptor_name":"1-Naphthylamine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D050483","descriptor_name":"Dopamine Plasma Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050484","descriptor_name":"Norepinephrine Plasma Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050486","descriptor_name":"Serotonin Plasma Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.biopha.2022.113359","doi":"https://doi.org/10.1016/j.biopha.2022.113359","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2022.113359","pdf_url":"https://www.sciencedirect.com/science/article/pii/S075333222200748X/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:35785702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35785702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/8618a28d-0e35-41c8-bd13-853dab205e89","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/8618a28d-0e35-41c8-bd13-853dab205e89","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schreiber, R, Campbell, U, Quinton, M S, Hardy, L W, Fang, Q K & Lew, R 2022, 'In vitro and in vivo pharmacological characterization of dasotraline, a dual dopamine and norepinephrine transporter inhibitor in vivo', Biomedicine & Pharmacotherapy, vol. 153, 113359. https://doi.org/10.1016/j.biopha.2022.113359","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:afb181bcb2324c0ab10ca6a081e286fb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/afb181bcb2324c0ab10ca6a081e286fb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113359- (2022)","raw_type":"article"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/8618a28d-0e35-41c8-bd13-853dab205e89","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/8618a28d-0e35-41c8-bd13-853dab205e89","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicine & Pharmacotherapy, 153:113359. Elsevier Masson","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2022.113359","doi":"https://doi.org/10.1016/j.biopha.2022.113359","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2022.113359","pdf_url":"https://www.sciencedirect.com/science/article/pii/S075333222200748X/pdf","source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283776089.pdf","grobid_xml":"https://content.openalex.org/works/W4283776089.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1598676150","https://openalex.org/W1767927283","https://openalex.org/W1967249950","https://openalex.org/W1973824257","https://openalex.org/W1975760311","https://openalex.org/W1976172596","https://openalex.org/W1981363848","https://openalex.org/W1985352992","https://openalex.org/W1990613322","https://openalex.org/W2021223587","https://openalex.org/W2021999429","https://openalex.org/W2022293843","https://openalex.org/W2032746281","https://openalex.org/W2044907318","https://openalex.org/W2087877032","https://openalex.org/W2095253451","https://openalex.org/W2101650598","https://openalex.org/W2107186809","https://openalex.org/W2108190605","https://openalex.org/W2122694895","https://openalex.org/W2129633806","https://openalex.org/W2132854576","https://openalex.org/W2163815564","https://openalex.org/W2167051392","https://openalex.org/W2167977201","https://openalex.org/W2169994301","https://openalex.org/W2172658446","https://openalex.org/W2177106729","https://openalex.org/W2191492937","https://openalex.org/W2402489441","https://openalex.org/W2405138604","https://openalex.org/W2489026659","https://openalex.org/W2533986239","https://openalex.org/W2560523658","https://openalex.org/W2581985549","https://openalex.org/W3056135028","https://openalex.org/W6685767983","https://openalex.org/W6712907035"],"related_works":["https://openalex.org/W3174621684","https://openalex.org/W2198434096","https://openalex.org/W2043228701","https://openalex.org/W1976172596","https://openalex.org/W2214928936","https://openalex.org/W1964668056","https://openalex.org/W2018664808","https://openalex.org/W1493305388","https://openalex.org/W2061807374","https://openalex.org/W2041836514"],"abstract_inverted_index":{"Inhibitors":[0],"of":[1,56,89,187,196],"dopamine":[2,143,155,204],"transporters":[3,6,10],"(DAT),":[4],"norepinephrine":[5,145,160,206],"(NET)":[7],"and":[8,36,41,61,86,98,124,134,144,159,176,184,205],"serotonin":[9,166],"(SERT)":[11],"are":[12],"effective":[13],"treatments":[14],"for":[15,29,193],"neuropsychiatric":[16],"diseases.":[17],"Dasotraline":[18,136,147],"[(1R,4":[19],"S)\u2212":[20],"4-(3,4-dichlorophenyl)\u2212":[21],"1,2,3,4-tetrahydro-1-naphthalenamine,":[22],"also":[23,149],"known":[24],"as":[25],"SEP-225289)":[26],"was":[27,148],"evaluated":[28],"its":[30],"inhibitory":[31],"potency":[32],"at":[33,83,122,152],"DAT,":[34,84],"NET":[35,85,123,177],"SERT":[37],"using":[38],"in":[39,42,106,131,142,156,161,167],"vitro":[40,46],"vivo":[43,74],"assays.":[44],"In":[45,71,102,170],"radiometric":[47],"functional":[48],"uptake":[49],"studies":[50,105,128],"showed":[51],"preferential":[52],"inhibition":[53],"by":[54,117],"dasotraline":[55,77,108,172,188],"hDAT":[57],"(IC50":[58,63],"=3":[59],"nM)":[60],"hNET":[62],"=4":[64],"nM":[65],"relative":[66,178],"to":[67,115,179],"hSERT(IC50":[68],"=15":[69],"nM).":[70],"mouse":[72],"ex":[73],"occupancy":[75,82,183],"studies,":[76],"demonstrated":[78],"total":[79],"plasma":[80],"concentration-dependent":[81],"SERT.":[87,125,180],"Determination":[88],"the":[90,157,162,182,194],"TO50":[91],"(50%":[92],"transporter":[93],"occupancy)":[94],"were":[95,129],"32,":[96],"109":[97],"276":[99],"ng/ml,":[100],"respectively.":[101],"SPECT":[103],"imaging":[104],"baboons,":[107],"(0.2":[109],"mg/kg":[110],"iv)":[111],"displaced":[112],"radiotracer":[113],"binding":[114],"DAT":[116,175],"87%":[118],"but":[119],"only":[120],"20%":[121],"Rat":[126],"microdialysis":[127],"performed":[130],"prefrontal":[132,163],"cortex":[133,164],"striatum.":[135],"produced":[137],"sustained":[138],"(>4":[139],"h)":[140],"increases":[141],"concentrations.":[146],"more":[150],"potent":[151],"increasing":[153],"synaptic":[154],"striatum,":[158],"than":[165],"these":[168],"regions.":[169],"summary,":[171],"preferentially":[173],"inhibits":[174],"Together,":[181],"neurochemical":[185],"profile":[186],"provide":[189],"a":[190],"mechanistic":[191],"basis":[192],"treatment":[195],"diseases":[197],"that":[198],"have":[199],"an":[200],"underlying":[201],"causality":[202],"involving":[203],"dysfunction.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-03T00:00:00"}