{"id":"https://openalex.org/W4283772680","doi":"https://doi.org/10.3390/vaccines10071057","title":"mRNA Booster Vaccination Enhances Antibody Responses against SARS-CoV2 Omicron Variant in Individuals Primed with mRNA or Inactivated Virus Vaccines","display_name":"mRNA Booster Vaccination Enhances Antibody Responses against SARS-CoV2 Omicron Variant in Individuals Primed with mRNA or Inactivated Virus Vaccines","publication_year":2022,"publication_date":"2022-06-30","ids":{"openalex":"https://openalex.org/W4283772680","doi":"https://doi.org/10.3390/vaccines10071057","pmid":"https://pubmed.ncbi.nlm.nih.gov/35891221"},"language":"en","primary_location":{"id":"doi:10.3390/vaccines10071057","doi":"https://doi.org/10.3390/vaccines10071057","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines10071057","pdf_url":"https://www.mdpi.com/2076-393X/10/7/1057/pdf?version=1657095861","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-393X/10/7/1057/pdf?version=1657095861","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045836594","display_name":"Biyan Zhang","orcid":"https://orcid.org/0000-0003-0329-2451","observed_orcids":["https://orcid.org/0000-0003-0329-2451"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Biyan Zhang","raw_affiliation_strings":["Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, Singapore 138648, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, Singapore 138648, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047677716","display_name":"Jianxin Huo","orcid":"https://orcid.org/0000-0003-2913-6537","observed_orcids":["https://orcid.org/0000-0003-2913-6537"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jianxin Huo","raw_affiliation_strings":["Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, Singapore 138648, Singapore"],"raw_orcid":"https://orcid.org/0000-0003-2913-6537","affiliations":[{"raw_affiliation_string":"Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, Singapore 138648, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101404170","display_name":"Yu\u2010Han Huang","orcid":"https://orcid.org/0000-0002-4276-3060","observed_orcids":["https://orcid.org/0000-0002-4276-3060","https://orcid.org/0009-0001-3370-9273"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yuhan Huang","raw_affiliation_strings":["Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, Singapore 138648, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, Singapore 138648, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079252216","display_name":"Shuan Yong Teo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Shuan Yong Teo","raw_affiliation_strings":["Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, Singapore 138648, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, Singapore 138648, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021178635","display_name":"Kaibo Duan","orcid":"https://orcid.org/0000-0003-0523-8993","observed_orcids":["https://orcid.org/0000-0003-0523-8993"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Kaibo Duan","raw_affiliation_strings":["Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, Singapore 138648, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, Singapore 138648, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yanfeng Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanfeng Li","raw_affiliation_strings":["Genscript, 164 Kallang Way, East Wing, #06-12, Singapore 349248, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genscript, 164 Kallang Way, East Wing, #06-12, Singapore 349248, Singapore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015572535","display_name":"Lim Kai Toh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lim Kai Toh","raw_affiliation_strings":["Doctors for Life Medical, 03 Pickering Street, #01-02, Nankin Row, Singapore 048660, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctors for Life Medical, 03 Pickering Street, #01-02, Nankin Row, Singapore 048660, Singapore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061550899","display_name":"Kong\u2010Peng Lam","orcid":"https://orcid.org/0000-0002-1316-4333","observed_orcids":["https://orcid.org/0000-0002-1316-4333"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Kong Peng Lam","raw_affiliation_strings":["Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117545, Singapore","School of Biological Sciences, College of Science, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore","Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, Singapore 138648, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117545, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"School of Biological Sciences, College of Science, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, Singapore 138648, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2800824516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024592486","display_name":"Shengli Xu","orcid":"https://orcid.org/0000-0002-2541-3608","observed_orcids":["https://orcid.org/0000-0002-2541-3608"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Shengli Xu","raw_affiliation_strings":["Department of Physiology, Yong Loo Lin School of Medicine, 2 Medical Drive, MD9, National University of Singapore, Singapore 1175493, Singapore","Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, Singapore 138648, Singapore"],"raw_orcid":"https://orcid.org/0000-0002-2541-3608","affiliations":[{"raw_affiliation_string":"Department of Physiology, Yong Loo Lin School of Medicine, 2 Medical Drive, MD9, National University of Singapore, Singapore 1175493, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, Singapore 138648, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2800824516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5024592486","https://openalex.org/A5061550899"],"corresponding_institution_ids":["https://openalex.org/I115228651","https://openalex.org/I165932596","https://openalex.org/I172675005","https://openalex.org/I2800824516"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2303},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2303},"fwci":2.0354,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.88369258,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"10","issue":"7","first_page":"1057","last_page":"1057"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10833","display_name":"Vaccine Coverage and Hesitancy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/omicron-variant","display_name":"Omicron variant","score":0.9660000205039978},{"id":"https://openalex.org/keywords/inactivated-vaccine","display_name":"inactivated vaccine","score":0.8920000195503235},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.859000027179718},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.8529999852180481},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.7210000157356262},{"id":"https://openalex.org/keywords/bnt162b2","display_name":"BNT162b2","score":0.906000018119812},{"id":"https://openalex.org/keywords/mrna-1273","display_name":"mRNA-1273","score":0.9990000128746033},{"id":"https://openalex.org/keywords/coronavac","display_name":"CoronaVac","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bbibp-corv","display_name":"BBIBP-CorV","score":0.9599999785423279},{"id":"https://openalex.org/keywords/vaccine-priming","display_name":"vaccine priming","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.7647528648376465},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7314376831054688},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.557427704334259},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.5554959774017334},{"id":"https://openalex.org/C12590561","wikidata":"https://www.wikidata.org/wiki/Q2920497","display_name":"Booster dose","level":4,"score":0.5398035049438477},{"id":"https://openalex.org/C203165030","wikidata":"https://www.wikidata.org/wiki/Q741745","display_name":"Booster (rocketry)","level":2,"score":0.5273386240005493},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5098201632499695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4236440658569336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3896018862724304},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3384780287742615},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.2644475996494293},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/vaccines10071057","doi":"https://doi.org/10.3390/vaccines10071057","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines10071057","pdf_url":"https://www.mdpi.com/2076-393X/10/7/1057/pdf?version=1657095861","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-1577475/v1","doi":"https://doi.org/10.21203/rs.3.rs-1577475/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1577475/v1","pdf_url":"https://www.researchsquare.com/article/rs-1577475/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:35891221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35891221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9315817","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9315817","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vaccines (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7087cf598dbe4cd4bef79e323bea4c18","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7087cf598dbe4cd4bef79e323bea4c18","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vaccines, Vol 10, Iss 7, p 1057 (2022)","raw_type":"article"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/163657","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10356/163657","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/vaccines10071057","doi":"https://doi.org/10.3390/vaccines10071057","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines10071057","pdf_url":"https://www.mdpi.com/2076-393X/10/7/1057/pdf?version=1657095861","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6600000262260437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283772680.pdf","grobid_xml":"https://content.openalex.org/works/W4283772680.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W3044482768","https://openalex.org/W3087924281","https://openalex.org/W3125405808","https://openalex.org/W3134831990","https://openalex.org/W3163785571","https://openalex.org/W3189544042","https://openalex.org/W3198831432","https://openalex.org/W3203602168","https://openalex.org/W3208466650","https://openalex.org/W4206675538","https://openalex.org/W4207047906","https://openalex.org/W4210617949","https://openalex.org/W4220673385","https://openalex.org/W4220987557","https://openalex.org/W4221116249","https://openalex.org/W4225386205","https://openalex.org/W4225982774","https://openalex.org/W4280562953","https://openalex.org/W6801114980","https://openalex.org/W6811292167"],"related_works":["https://openalex.org/W4223961516","https://openalex.org/W2385876451","https://openalex.org/W4200574689","https://openalex.org/W4302774475","https://openalex.org/W3199092625","https://openalex.org/W4311793641","https://openalex.org/W2324037830","https://openalex.org/W4207003944","https://openalex.org/W4283826450","https://openalex.org/W4387965302"],"abstract_inverted_index":{"The":[0],"advent":[1],"of":[2,50,66,87,93,95,100,108,124,143,155,159,180,196,205,236],"the":[3,9,48,160,170,185,190,194,225,255],"Omicron":[4,67,101,171,197,226,256],"variant":[5,172,227],"globally":[6],"has":[7],"hastened":[8],"requirement":[10],"for":[11],"a":[12,152,177],"booster":[13,113,140,153,178,220],"vaccination":[14,52,77],"dose":[15,154,179],"to":[16,38,58,135],"confer":[17],"continuous":[18],"protection":[19,249],"against":[20,98,169,224,250],"symptomatic":[21],"SARS-CoV2":[22],"infection.":[23],"However,":[24],"different":[25,30,51,75],"vaccines":[26,89],"are":[27],"available":[28],"in":[29,54,71,118,121,228],"countries,":[31],"and":[32,64,129],"individuals":[33,72,82,103,136,149,229],"who":[34,73,150,175],"had":[35,74,90,163],"adverse":[36],"reactions":[37],"certain":[39],"vaccine":[40,44,116,145,192,207,216,241],"types":[41],"require":[42],"heterologous":[43],"boosters.":[45],"To":[46],"understand":[47],"efficacy":[49],"regimens":[53],"inducing":[55],"humoral":[56,222],"responses":[57,223],"SARS-CoV2,":[59],"we":[60],"examined":[61],"plasma":[62],"antibodies":[63,164],"frequencies":[65,195],"RBD-specific":[68],"B":[69,199],"cells":[70,200],"priming-booster":[76],"regimens.":[78],"We":[79],"found":[80],"that":[81,213],"with":[83,104,114,165,189,231],"three":[84,105],"homologous":[85,106],"doses":[86,107,235],"mRNA":[88,115,156,191,215,237],"higher":[91,166],"levels":[92,123],"IgG":[94],"all":[96],"subclasses":[97],"RBD":[99],"than":[102,173],"inactivated":[109,138,181,239],"virus":[110,139,182,240],"vaccine.":[111,183],"A":[112],"resulted":[117],"significant":[119],"increases":[120],"median":[122],"RBD-reactive":[125],"IgG1":[126],"(17-19":[127],"fold)":[128,132,203],"IgG3":[130],"(2.3-3.3":[131],"as":[133],"compared":[134],"receiving":[137],"shots":[141],"regardless":[142,204],"priming":[144,161,206],"types.":[146,208],"More":[147],"importantly,":[148],"received":[151,176],"vaccine,":[157,162],"irrespective":[158],"neutralizing":[167],"capability":[168],"those":[174],"Corroborating":[184],"antibody":[186],"results,":[187],"boosting":[188],"increased":[193],"RBD-binding":[198],"by":[201,254],"(1.5-3.3":[202],"Together,":[209],"our":[210],"data":[211],"demonstrate":[212],"an":[214],"(BNT162b2":[217],"or":[218,238,243],"mRNA-1273)":[219],"enhances":[221],"vaccinated":[230],"either":[232],"two":[233],"prior":[234],"(CoronaVac":[242],"BBIBP-CorV),":[244],"potentially":[245],"providing":[246],"more":[247],"effective":[248],"SARS-CoV-2":[251],"infection,":[252],"particularly":[253],"variant.":[257]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}