{"id":"https://openalex.org/W4283759752","doi":"https://doi.org/10.1038/s42003-022-03582-8","title":"Core cysteine residues in the Plasminogen-Apple-Nematode (PAN) domain are critical for HGF/c-MET signaling","display_name":"Core cysteine residues in the Plasminogen-Apple-Nematode (PAN) domain are critical for HGF/c-MET signaling","publication_year":2022,"publication_date":"2022-07-01","ids":{"openalex":"https://openalex.org/W4283759752","doi":"https://doi.org/10.1038/s42003-022-03582-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/35778602","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9249922"},"language":"en","primary_location":{"id":"doi:10.1038/s42003-022-03582-8","doi":"https://doi.org/10.1038/s42003-022-03582-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-022-03582-8","pdf_url":"https://www.nature.com/articles/s42003-022-03582-8.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4283759752"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s42003-022-03582-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079399356","display_name":"Debjani Pal","orcid":"https://orcid.org/0000-0002-5870-0005","observed_orcids":["https://orcid.org/0000-0002-5870-0005"]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debjani Pal","raw_affiliation_strings":["Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA"],"raw_orcid":"https://orcid.org/0000-0002-5870-0005","affiliations":[{"raw_affiliation_string":"Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078887852","display_name":"Kuntal De","orcid":"https://orcid.org/0000-0001-9729-9608","observed_orcids":["https://orcid.org/0000-0001-9729-9608"]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuntal De","raw_affiliation_strings":["Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076550421","display_name":"Carly M. Shanks","orcid":"https://orcid.org/0000-0001-6229-6845","observed_orcids":["https://orcid.org/0000-0001-6229-6845"]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carly M. Shanks","raw_affiliation_strings":["Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100686791","display_name":"Kai Feng","orcid":"https://orcid.org/0000-0002-9903-6497","observed_orcids":["https://orcid.org/0000-0002-9903-6497"]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai Feng","raw_affiliation_strings":["Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088202623","display_name":"Timothy B. Yates","orcid":"https://orcid.org/0009-0004-7943-9493","observed_orcids":["https://orcid.org/0009-0004-7943-9493"]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy B. Yates","raw_affiliation_strings":["Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA","Bredesen Center for Interdisciplinary Research, University of Tennessee, Knoxville, TN, 37996, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA","institution_ids":["https://openalex.org/I1289243028"]},{"raw_affiliation_string":"Bredesen Center for Interdisciplinary Research, University of Tennessee, Knoxville, TN, 37996, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021547930","display_name":"Jennifer L. Morrell\u2010Falvey","orcid":"https://orcid.org/0000-0002-9362-7528","observed_orcids":["https://orcid.org/0000-0002-9362-7528"]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Morrell-Falvey","raw_affiliation_strings":["Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046664249","display_name":"Russell B. Davidson","orcid":"https://orcid.org/0000-0003-2364-4039","observed_orcids":["https://orcid.org/0000-0003-2364-4039"]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell B. Davidson","raw_affiliation_strings":["Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037417242","display_name":"Jerry M. Parks","orcid":"https://orcid.org/0000-0002-3103-9333","observed_orcids":["https://orcid.org/0000-0002-3103-9333"]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry M. Parks","raw_affiliation_strings":["Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA"],"raw_orcid":"https://orcid.org/0000-0002-3103-9333","affiliations":[{"raw_affiliation_string":"Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088920800","display_name":"Wellington Muchero","orcid":"https://orcid.org/0000-0002-0200-9856","observed_orcids":["https://orcid.org/0000-0002-0200-9856"]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wellington Muchero","raw_affiliation_strings":["Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA. mucherow@ornl.gov","Bredesen Center for Interdisciplinary Research, University of Tennessee, Knoxville, TN, 37996, USA. mucherow@ornl.gov","Bredesen Center for Interdisciplinary Research, University of Tennessee, Knoxville, TN, 37996, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience Division, Oak Ridge National Laboratory, 1 Bethel Valley Rd, Oak Ridge, TN, 37831, USA. mucherow@ornl.gov","institution_ids":["https://openalex.org/I1289243028"]},{"raw_affiliation_string":"Bredesen Center for Interdisciplinary Research, University of Tennessee, Knoxville, TN, 37996, USA. mucherow@ornl.gov","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"Bredesen Center for Interdisciplinary Research, University of Tennessee, Knoxville, TN, 37996, USA","institution_ids":["https://openalex.org/I75027704"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088920800"],"corresponding_institution_ids":["https://openalex.org/I1289243028","https://openalex.org/I75027704"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":1.1192,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.73943431,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"5","issue":"1","first_page":"646","last_page":"646"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.045099999755620956,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.734000027179718},{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cysteine-residues","display_name":"cysteine residues","score":0.9179999828338623},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.46000000834465027},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.7400000095367432},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.9269999861717224},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.31299999356269836}],"concepts":[{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.7819400429725647},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.5897871851921082},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5470713376998901},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5245554447174072},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5228955149650574},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.4495745897293091},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4404067397117615},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3908486068248749},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36722952127456665},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3614065945148468},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24298331141471863},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.13979244232177734},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09404072165489197}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009348","descriptor_name":"Nematoda","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010958","descriptor_name":"Plasminogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027845","descriptor_name":"Malus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057057","descriptor_name":"Serine Proteases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s42003-022-03582-8","doi":"https://doi.org/10.1038/s42003-022-03582-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-022-03582-8","pdf_url":"https://www.nature.com/articles/s42003-022-03582-8.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},{"id":"doi:10.1101/2021.09.20.460979","doi":"https://doi.org/10.1101/2021.09.20.460979","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.09.20.460979","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/09/22/2021.09.20.460979.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:35778602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35778602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9249922","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9249922/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Commun Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:6723ce81c6c14178bfb99e772c5987d5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6723ce81c6c14178bfb99e772c5987d5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)","raw_type":"article"},{"id":"pmh:oai:osti.gov:1875331","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1875331","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1038/s42003-022-03582-8","doi":"https://doi.org/10.1038/s42003-022-03582-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-022-03582-8","pdf_url":"https://www.nature.com/articles/s42003-022-03582-8.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1026679911","display_name":null,"funder_award_id":"DE-AC05","funder_id":"https://openalex.org/F4320316892","funder_display_name":"UT-Battelle"},{"id":"https://openalex.org/G121915436","display_name":null,"funder_award_id":"DEAC05- 00OR22725","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G1528409558","display_name":null,"funder_award_id":"No. DE-AC05-00OR22725","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G1645119126","display_name":null,"funder_award_id":"AC05-00OR22725","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G166562317","display_name":null,"funder_award_id":"DE-AC05- 00OR22725","funder_id":"https://openalex.org/F4320306250","funder_display_name":"Battelle"},{"id":"https://openalex.org/G203625172","display_name":null,"funder_award_id":"DE--AC05--00OR22725","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G2988778103","display_name":null,"funder_award_id":"DE-AC05?","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3049477530","display_name":null,"funder_award_id":"Contract No. DE-AC05-00OR22725","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3121793570","display_name":null,"funder_award_id":"00OR22725","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G313676650","display_name":null,"funder_award_id":"DEAC05-00OR22725","funder_id":"https://openalex.org/F4320316892","funder_display_name":"UT-Battelle"},{"id":"https://openalex.org/G4423657506","display_name":null,"funder_award_id":"AC05-00OR22725","funder_id":"https://openalex.org/F4320338287","funder_display_name":"Oak Ridge National Laboratory"},{"id":"https://openalex.org/G450780475","display_name":null,"funder_award_id":"DE\u2010AC05\u201300OR22725","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G5726405315","display_name":null,"funder_award_id":"DE-AC05","funder_id":"https://openalex.org/F4320306250","funder_display_name":"Battelle"},{"id":"https://openalex.org/G6486853205","display_name":null,"funder_award_id":"Contract No. DE-AC05-00OR22725","funder_id":"https://openalex.org/F4320338287","funder_display_name":"Oak Ridge National Laboratory"},{"id":"https://openalex.org/G675320460","display_name":null,"funder_award_id":"DE-AC05-00OR22725","funder_id":"https://openalex.org/F4320338287","funder_display_name":"Oak Ridge National Laboratory"},{"id":"https://openalex.org/G6911681599","display_name":null,"funder_award_id":"No. DE-AC05-00OR22725","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G7769062580","display_name":null,"funder_award_id":"No. DE-AC05-00OR22725","funder_id":"https://openalex.org/F4320316892","funder_display_name":"UT-Battelle"},{"id":"https://openalex.org/G8269158468","display_name":null,"funder_award_id":"AC05-00OR22725","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G8906985441","display_name":null,"funder_award_id":"00OR22725","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G8943143067","display_name":null,"funder_award_id":"AC05-00OR22725","funder_id":"https://openalex.org/F4320316892","funder_display_name":"UT-Battelle"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306250","display_name":"Battelle","ror":"https://ror.org/01h5tnr73"},{"id":"https://openalex.org/F4320316892","display_name":"UT-Battelle","ror":"https://ror.org/04nza6677"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337509","display_name":"Biological and Environmental Research","ror":"https://ror.org/0114b2m14"},{"id":"https://openalex.org/F4320338287","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283759752.pdf","grobid_xml":"https://content.openalex.org/works/W4283759752.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1505887721","https://openalex.org/W1579494178","https://openalex.org/W1722029454","https://openalex.org/W1750535841","https://openalex.org/W1899730350","https://openalex.org/W1965879808","https://openalex.org/W1970047032","https://openalex.org/W1976495032","https://openalex.org/W1976499671","https://openalex.org/W1976695989","https://openalex.org/W1977298054","https://openalex.org/W1985828707","https://openalex.org/W1986137370","https://openalex.org/W1986752758","https://openalex.org/W1989297142","https://openalex.org/W1991710519","https://openalex.org/W1992011946","https://openalex.org/W1992124193","https://openalex.org/W1993490928","https://openalex.org/W1993528234","https://openalex.org/W1996262838","https://openalex.org/W1998024235","https://openalex.org/W1999574084","https://openalex.org/W2004296886","https://openalex.org/W2005782838","https://openalex.org/W2011717936","https://openalex.org/W2021452013","https://openalex.org/W2032839326","https://openalex.org/W2036253239","https://openalex.org/W2047642514","https://openalex.org/W2052498797","https://openalex.org/W2057234572","https://openalex.org/W2057550065","https://openalex.org/W2058479011","https://openalex.org/W2062591332","https://openalex.org/W2100991907","https://openalex.org/W2107399866","https://openalex.org/W2111054613","https://openalex.org/W2111842868","https://openalex.org/W2126604693","https://openalex.org/W2139344290","https://openalex.org/W2143241095","https://openalex.org/W2147624501","https://openalex.org/W2157485801","https://openalex.org/W2160378127","https://openalex.org/W2162449964","https://openalex.org/W2165135596","https://openalex.org/W2170551349","https://openalex.org/W2170711116","https://openalex.org/W2179438025","https://openalex.org/W2311078281","https://openalex.org/W2404280981","https://openalex.org/W2412211046","https://openalex.org/W2510475640","https://openalex.org/W2522144728","https://openalex.org/W2566600825","https://openalex.org/W2578187984","https://openalex.org/W2739028852","https://openalex.org/W2766505963","https://openalex.org/W2900359059","https://openalex.org/W2949223833","https://openalex.org/W2968982291","https://openalex.org/W2972030764","https://openalex.org/W2989052455","https://openalex.org/W3008215385","https://openalex.org/W3033743293","https://openalex.org/W3102740077","https://openalex.org/W3109741298","https://openalex.org/W3136899227","https://openalex.org/W3174413142","https://openalex.org/W3177828909","https://openalex.org/W4281790889","https://openalex.org/W6950304745"],"related_works":["https://openalex.org/W4393089163","https://openalex.org/W2283698778","https://openalex.org/W1429908884","https://openalex.org/W1962464218","https://openalex.org/W1575527265","https://openalex.org/W2228172152","https://openalex.org/W1991710519","https://openalex.org/W2369744008","https://openalex.org/W1984466161"],"abstract_inverted_index":{"Abstract":[0],"The":[1,33,53],"Plasminogen-Apple-Nematode":[2],"(PAN)":[3],"domain,":[4],"with":[5],"a":[6,133],"core":[7,73],"of":[8,45,55,89,97,109,129,142],"four":[9,72],"to":[10,57],"six":[11],"cysteine":[12,74],"residues,":[13],"is":[14,29],"found":[15],"in":[16,26,39,49,76,114],">":[17],"28,000":[18],"proteins":[19],"across":[20],"959":[21],"genera.":[22],"Still,":[23],"its":[24,58,90,100],"role":[25],"protein":[27],"function":[28],"not":[30],"fully":[31],"understood.":[32],"PAN":[34,79,127],"domain":[35,80,128],"was":[36],"initially":[37],"characterized":[38],"numerous":[40],"proteins,":[41],"including":[42],"HGF.":[43],"Dysregulation":[44],"HGF-mediated":[46],"signaling":[47],"results":[48],"multiple":[50],"deadly":[51],"cancers.":[52],"binding":[54,139],"HGF":[56,78,130],"cell":[59,120],"surface":[60],"receptor,":[61,101],"c-MET,":[62,102],"triggers":[63],"all":[64],"biological":[65],"impacts.":[66],"Here,":[67],"we":[68],"show":[69],"that":[70],"mutating":[71],"residues":[75],"the":[77,126,138,143],"reduces":[81],"c-MET":[82,85,104,144],"interaction,":[83],"subsequent":[84],"autophosphorylation,":[86],"and":[87,99,103,119,140],"phosphorylation":[88],"downstream":[91],"targets,":[92],"perinuclear":[93],"localization,":[94],"cellular":[95],"internalization":[96],"HGF,":[98],"ubiquitination.":[105],"Furthermore,":[106],"transcriptional":[107],"activation":[108,141],"HGF/c-MET":[110],"signaling-related":[111],"genes":[112],"involved":[113],"cancer":[115],"progression,":[116],"invasion,":[117],"metastasis,":[118],"survival":[121],"were":[122],"impaired.":[123],"Thus,":[124],"targeting":[125],"may":[131],"represent":[132],"mechanism":[134],"for":[135],"selectively":[136],"regulating":[137],"pathway.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2022-07-02T00:00:00"}