{"id":"https://openalex.org/W4283758752","doi":"https://doi.org/10.34014/2227-1848-2022-2-117-127","title":"USE OF KNOTTIN AS A PSMA-TROPIC PEPTIDE CARRIER","display_name":"USE OF KNOTTIN AS A PSMA-TROPIC PEPTIDE CARRIER","publication_year":2022,"publication_date":"2022-06-30","ids":{"openalex":"https://openalex.org/W4283758752","doi":"https://doi.org/10.34014/2227-1848-2022-2-117-127"},"language":"en","primary_location":{"id":"doi:10.34014/2227-1848-2022-2-117-127","doi":"https://doi.org/10.34014/2227-1848-2022-2-117-127","is_oa":true,"landing_page_url":"https://doi.org/10.34014/2227-1848-2022-2-117-127","pdf_url":"http://medbio.ulsu.ru/images/numbers/2022/2-2022/011.pdf","source":{"id":"https://openalex.org/S4210238448","display_name":"Ulyanovsk Medico-biological Journal","issn_l":"2227-1848","issn":["2227-1848","2687-1637"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ulyanovsk Medico-biological Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://medbio.ulsu.ru/images/numbers/2022/2-2022/011.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033832811","display_name":"Evgeniy Alekseevich Beloborodov","orcid":"https://orcid.org/0000-0002-5666-5154","observed_orcids":["https://orcid.org/0000-0002-5666-5154"]},"institutions":[{"id":"https://openalex.org/I194437852","display_name":"Ulyanovsk State University","ror":"https://ror.org/02vn11j58","country_code":"RU","type":"education","lineage":["https://openalex.org/I194437852"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Evgeniy Alekseevich Beloborodov","raw_affiliation_strings":["Ulyanovsk State University"],"raw_orcid":"https://orcid.org/0000-0002-5666-5154","affiliations":[{"raw_affiliation_string":"Ulyanovsk State University","institution_ids":["https://openalex.org/I194437852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114038642","display_name":"Elena Valer'evna Yurova","orcid":"https://orcid.org/0000-0001-7484-2671","observed_orcids":["https://orcid.org/0000-0001-7484-2671"]},"institutions":[{"id":"https://openalex.org/I194437852","display_name":"Ulyanovsk State University","ror":"https://ror.org/02vn11j58","country_code":"RU","type":"education","lineage":["https://openalex.org/I194437852"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elena Valer'evna Yurova","raw_affiliation_strings":["Ulyanovsk State University"],"raw_orcid":"https://orcid.org/0000-0001-7484-2671","affiliations":[{"raw_affiliation_string":"Ulyanovsk State University","institution_ids":["https://openalex.org/I194437852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022879259","display_name":"Evgeniya Vladimirovna Rastorgueva","orcid":"https://orcid.org/0000-0003-1518-4677","observed_orcids":["https://orcid.org/0000-0003-1518-4677"]},"institutions":[{"id":"https://openalex.org/I194437852","display_name":"Ulyanovsk State University","ror":"https://ror.org/02vn11j58","country_code":"RU","type":"education","lineage":["https://openalex.org/I194437852"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Evgeniya Vladimirovna Rastorgueva","raw_affiliation_strings":["Ulyanovsk State University"],"raw_orcid":"https://orcid.org/0000-0003-1518-4677","affiliations":[{"raw_affiliation_string":"Ulyanovsk State University","institution_ids":["https://openalex.org/I194437852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003161568","display_name":"Evgeniya Sergeevna Pogodina","orcid":"https://orcid.org/0000-0001-8183-5103","observed_orcids":["https://orcid.org/0000-0001-8183-5103"]},"institutions":[{"id":"https://openalex.org/I194437852","display_name":"Ulyanovsk State University","ror":"https://ror.org/02vn11j58","country_code":"RU","type":"education","lineage":["https://openalex.org/I194437852"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Evgeniya Sergeevna Pogodina","raw_affiliation_strings":["Ulyanovsk State University"],"raw_orcid":"https://orcid.org/0000-0001-8183-5103","affiliations":[{"raw_affiliation_string":"Ulyanovsk State University","institution_ids":["https://openalex.org/I194437852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002575483","display_name":"Dmitriy Evgen'evich Sugak","orcid":"https://orcid.org/0000-0002-3276-8976","observed_orcids":["https://orcid.org/0000-0002-3276-8976"]},"institutions":[{"id":"https://openalex.org/I194437852","display_name":"Ulyanovsk State University","ror":"https://ror.org/02vn11j58","country_code":"RU","type":"education","lineage":["https://openalex.org/I194437852"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitriy Evgen'evich Sugak","raw_affiliation_strings":["Ulyanovsk State University"],"raw_orcid":"https://orcid.org/0000-0002-3276-8976","affiliations":[{"raw_affiliation_string":"Ulyanovsk State University","institution_ids":["https://openalex.org/I194437852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007591839","display_name":"Aleksandr Nikolaevich Fomin","orcid":"https://orcid.org/0000-0003-0826-1857","observed_orcids":["https://orcid.org/0000-0003-0826-1857"]},"institutions":[{"id":"https://openalex.org/I194437852","display_name":"Ulyanovsk State University","ror":"https://ror.org/02vn11j58","country_code":"RU","type":"education","lineage":["https://openalex.org/I194437852"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Aleksandr Nikolaevich Fomin","raw_affiliation_strings":["Ulyanovsk State University"],"raw_orcid":"https://orcid.org/0000-0003-0826-1857","affiliations":[{"raw_affiliation_string":"Ulyanovsk State University","institution_ids":["https://openalex.org/I194437852"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040399254","display_name":"Yury Saenko","orcid":"https://orcid.org/0000-0002-4402-1482","observed_orcids":["https://orcid.org/0000-0002-4402-1482"]},"institutions":[{"id":"https://openalex.org/I194437852","display_name":"Ulyanovsk State University","ror":"https://ror.org/02vn11j58","country_code":"RU","type":"education","lineage":["https://openalex.org/I194437852"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yuriy Vladimirovich Saenko","raw_affiliation_strings":["Ulyanovsk State University"],"raw_orcid":"https://orcid.org/0000-0002-4402-1482","affiliations":[{"raw_affiliation_string":"Ulyanovsk State University","institution_ids":["https://openalex.org/I194437852"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I194437852"],"apc_list":null,"apc_paid":null,"fwci":0.1194,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.31809559,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":"2","first_page":"117","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/knottins","display_name":"knottins","score":0.9319999814033508},{"id":"https://openalex.org/keywords/peptide-receptor-radionuclide-therapy","display_name":"peptide receptor radionuclide therapy","score":0.7590000033378601},{"id":"https://openalex.org/keywords/lutetium-177","display_name":"lutetium-177","score":0.8690000176429749},{"id":"https://openalex.org/keywords/peptide-stability","display_name":"peptide stability","score":0.6010000109672546},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.6800000071525574},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8840000033378601},{"id":"https://openalex.org/keywords/peptide-binding","display_name":"peptide binding","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.878851056098938},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.7321409583091736},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7261567711830139},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7223472595214844},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5811475515365601},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4728049635887146},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4666925072669983},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43703025579452515},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36344391107559204},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33791646361351013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.290449321269989},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25108832120895386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2392052710056305},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.34014/2227-1848-2022-2-117-127","doi":"https://doi.org/10.34014/2227-1848-2022-2-117-127","is_oa":true,"landing_page_url":"https://doi.org/10.34014/2227-1848-2022-2-117-127","pdf_url":"http://medbio.ulsu.ru/images/numbers/2022/2-2022/011.pdf","source":{"id":"https://openalex.org/S4210238448","display_name":"Ulyanovsk Medico-biological Journal","issn_l":"2227-1848","issn":["2227-1848","2687-1637"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ulyanovsk Medico-biological Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.34014/2227-1848-2022-2-117-127","doi":"https://doi.org/10.34014/2227-1848-2022-2-117-127","is_oa":true,"landing_page_url":"https://doi.org/10.34014/2227-1848-2022-2-117-127","pdf_url":"http://medbio.ulsu.ru/images/numbers/2022/2-2022/011.pdf","source":{"id":"https://openalex.org/S4210238448","display_name":"Ulyanovsk Medico-biological Journal","issn_l":"2227-1848","issn":["2227-1848","2687-1637"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ulyanovsk Medico-biological Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283758752.pdf","grobid_xml":"https://content.openalex.org/works/W4283758752.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W626649172","https://openalex.org/W2031731044","https://openalex.org/W2037535235","https://openalex.org/W2076335256","https://openalex.org/W2081200036","https://openalex.org/W2133892833","https://openalex.org/W2138798296","https://openalex.org/W2332361930","https://openalex.org/W2625293218","https://openalex.org/W2727380696","https://openalex.org/W2791746735","https://openalex.org/W2804723564","https://openalex.org/W2905295080","https://openalex.org/W3080771684","https://openalex.org/W3117491625","https://openalex.org/W3118921680","https://openalex.org/W4205360868"],"related_works":["https://openalex.org/W3139125677","https://openalex.org/W4393937923","https://openalex.org/W3011367086","https://openalex.org/W2596023559","https://openalex.org/W4311968047","https://openalex.org/W4212766972","https://openalex.org/W4413027067","https://openalex.org/W1973043502","https://openalex.org/W3165650231","https://openalex.org/W3152567653"],"abstract_inverted_index":{"Prostate":[0],"cancer":[1,8,17,42,98],"is":[2,32,50,70],"the":[3,23,51,68,131,184,200],"most":[4],"common":[5],"type":[6],"of":[7,15,30,40,48,56,67,75,133,171,183,202],"in":[9,82,85,90,159,175,209,212],"males.":[10],"Approximately":[11],"1.3":[12],"million":[13],"cases":[14],"prostate":[16,41,97],"and":[18,87,93,102,128,140,162,211,223],"over":[19],"400,000":[20],"deaths":[21,31],"from":[22],"disease":[24],"are":[25,156],"diagnosed":[26],"annually.":[27],"The":[28,54,65,108,146],"number":[29],"expected":[33],"to":[34,61,71,125,189,220],"double":[35],"by":[36],"2040.":[37],"Common":[38],"methods":[39,139],"treatment":[43],"have":[44,59,167],"many":[45],"disadvantages;":[46],"one":[47],"them":[49],"relapse":[52],"risk.":[53],"shortcomings":[55],"traditional":[57],"therapy":[58],"led":[60],"peptide-receptor":[62],"radionuclide":[63],"therapy.":[64],"aim":[66],"study":[69],"examine":[72],"binding":[73,124,181,219],"efficiency":[74],"Lu177":[76],"labeled":[77],"knottins":[78],"containing":[79],"PSMA-tropic":[80,196],"peptide":[81,114,120,186,197],"different":[83],"domains":[84],"vitro":[86],"their":[88,122],"biodistribution":[89,129],"vivo.":[91],"Materials":[92],"Methods.":[94],"We":[95,118],"used":[96],"cell":[99,105,126,221],"(LNCaP,":[100],"PC3)":[101],"ovarian":[103],"fibroblast":[104],"(CHO-K1)":[106],"cultures.":[107],"peptides":[109,148,193],"were":[110,143],"synthesized":[111,147,185],"using":[112],"a":[113,168,179,195],"synthesizer":[115],"(ResPepSL,":[116],"Intavis).":[117],"studied":[119],"stability,":[121],"toxicity,":[123],"cultures,":[127],"on":[130],"example":[132],"breast":[134],"adenocarcinoma-bearing":[135],"BALB/c":[136,176],"mice.":[137],"Chromatographic":[138],"radiometric":[141],"techniques":[142],"used.":[144],"Results.":[145],"with":[149,194],"GTIQPYPFSWGY":[150],"sequence":[151],"inserted":[152,198],"into":[153,199],"U5-cytotoxin-Sth1a":[154],"node":[155],"more":[157],"stable":[158],"blood":[160,213],"plasma":[161],"saline":[163,210],"than":[164],"177Lu-PSMA-617a,":[165],"but":[166],"similar":[169],"degree":[170],"binding.":[172],"Biodistribution":[173],"studies":[174],"mice":[177],"show":[178],"higher":[180],"index":[182],"if":[187],"compared":[188],"177Lu-PSMA-617.":[190],"Conclusion.":[191],"Modified":[192],"structure":[201],"U5-Sth1a":[203],"toxin":[204],"demonstrate":[205],"high":[206],"stability":[207],"both":[208],"plasma,":[214],"as":[215,217],"well":[216],"good":[218],"cultures":[222],"tumors.":[224]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-07-02T00:00:00"}