{"id":"https://openalex.org/W4283758396","doi":"https://doi.org/10.3390/cancers14133232","title":"Targeting Wnt/\u03b2-Catenin Signaling by TET1/FOXO4 Inhibits Metastatic Spreading and Self-Renewal of Cancer Stem Cells in Gastric Cancer","display_name":"Targeting Wnt/\u03b2-Catenin Signaling by TET1/FOXO4 Inhibits Metastatic Spreading and Self-Renewal of Cancer Stem Cells in Gastric Cancer","publication_year":2022,"publication_date":"2022-06-30","ids":{"openalex":"https://openalex.org/W4283758396","doi":"https://doi.org/10.3390/cancers14133232","pmid":"https://pubmed.ncbi.nlm.nih.gov/35805009","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9264907"},"language":"en","primary_location":{"id":"doi:10.3390/cancers14133232","doi":"https://doi.org/10.3390/cancers14133232","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14133232","pdf_url":"https://www.mdpi.com/2072-6694/14/13/3232/pdf?version=1656638971","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/14/13/3232/pdf?version=1656638971","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jingjing Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121883995","display_name":"Johannes Kepler University of Linz","ror":"https://ror.org/052r2xn60","country_code":"AT","type":"education","lineage":["https://openalex.org/I121883995"]},{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["AT","CN"],"is_corresponding":false,"raw_author_name":"Jingjing Qi","raw_affiliation_strings":["General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital, Hangzhou Medical College), Hangzhou 310014, China","Tumor Epigenetics Laboratory, Johannes Kepler University Linz, Altenbergerstra\u00dfe 69, 4040 Linz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital, Hangzhou Medical College), Hangzhou 310014, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]},{"raw_affiliation_string":"Tumor Epigenetics Laboratory, Johannes Kepler University Linz, Altenbergerstra\u00dfe 69, 4040 Linz, Austria","institution_ids":["https://openalex.org/I121883995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025403350","display_name":"Di Cui","orcid":"https://orcid.org/0000-0003-2874-6480","observed_orcids":["https://orcid.org/0000-0003-2874-6480"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Cui","raw_affiliation_strings":["Cancer Center, Department of Gastroenterology, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital, Hangzhou Medical College), Hangzhou 310014, China","General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital, Hangzhou Medical College), Hangzhou 310014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Department of Gastroenterology, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital, Hangzhou Medical College), Hangzhou 310014, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]},{"raw_affiliation_string":"General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital, Hangzhou Medical College), Hangzhou 310014, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081401106","display_name":"Qi\u2010Nian Wu","orcid":"https://orcid.org/0000-0002-9771-9956","observed_orcids":["https://orcid.org/0000-0002-9771-9956"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi-Nian Wu","raw_affiliation_strings":["State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055435419","display_name":"Qi Zhao","orcid":"https://orcid.org/0000-0002-8683-6145","observed_orcids":["https://orcid.org/0000-0002-8683-6145","https://orcid.org/0009-0009-4149-5912","https://orcid.org/0009-0009-5652-7454"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Zhao","raw_affiliation_strings":["State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China"],"raw_orcid":"https://orcid.org/0000-0002-8683-6145","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101437350","display_name":"Zhanhong Chen","orcid":"https://orcid.org/0000-0003-1802-6375","observed_orcids":["https://orcid.org/0000-0003-1802-6375"]},"institutions":[{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhan-Hong Chen","raw_affiliation_strings":["Department of Oncology, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China","institution_ids":["https://openalex.org/I4210146956"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lianjie Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lianjie Li","raw_affiliation_strings":["General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital, Hangzhou Medical College), Hangzhou 310014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital, Hangzhou Medical College), Hangzhou 310014, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056395986","display_name":"Walter Birchmeier","orcid":"https://orcid.org/0000-0003-1173-0829","observed_orcids":["https://orcid.org/0000-0003-1173-0829"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Walter Birchmeier","raw_affiliation_strings":["Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013313803","display_name":"Yong Yu","orcid":"https://orcid.org/0000-0003-1928-2514","observed_orcids":["https://orcid.org/0000-0003-1928-2514"]},"institutions":[{"id":"https://openalex.org/I121883995","display_name":"Johannes Kepler University of Linz","ror":"https://ror.org/052r2xn60","country_code":"AT","type":"education","lineage":["https://openalex.org/I121883995"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Yong Yu","raw_affiliation_strings":["Tumor Epigenetics Laboratory, Johannes Kepler University Linz, Altenbergerstra\u00dfe 69, 4040 Linz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Epigenetics Laboratory, Johannes Kepler University Linz, Altenbergerstra\u00dfe 69, 4040 Linz, Austria","institution_ids":["https://openalex.org/I121883995"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101448566","display_name":"Ran N. Tao","orcid":"https://orcid.org/0000-0003-0237-4623","observed_orcids":["https://orcid.org/0000-0003-0237-4623"]},"institutions":[{"id":"https://openalex.org/I4210131061","display_name":"Zhejiang Provincial People's Hospital","ror":"https://ror.org/03k14e164","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131061"]},{"id":"https://openalex.org/I4210165441","display_name":"Hangzhou Medical College","ror":"https://ror.org/05gpas306","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165441"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ran Tao","raw_affiliation_strings":["Cancer Center, Department of Gastroenterology, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital, Hangzhou Medical College), Hangzhou 310014, China","General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital, Hangzhou Medical College), Hangzhou 310014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Department of Gastroenterology, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital, Hangzhou Medical College), Hangzhou 310014, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]},{"raw_affiliation_string":"General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital, Hangzhou Medical College), Hangzhou 310014, China","institution_ids":["https://openalex.org/I4210131061","https://openalex.org/I4210165441"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5013313803","https://openalex.org/A5101448566"],"corresponding_institution_ids":["https://openalex.org/I121883995","https://openalex.org/I4210131061","https://openalex.org/I4210165441"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2513},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2513},"fwci":2.6922,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.92580607,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"14","issue":"13","first_page":"3232","last_page":"3232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.4235999882221222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.7929999828338623},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tet1","display_name":"TET1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/foxo4","display_name":"FOXO4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.843999981880188},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/epcam","display_name":"EpCAM","score":0.7519999742507935},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.8100000023841858},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9200000166893005},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8632766008377075},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7180117964744568},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6957148909568787},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.6038709282875061},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.5650591850280762},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.5617461800575256},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5425134897232056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45319780707359314},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4442746639251709},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.31512129306793213},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21603399515151978},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/cancers14133232","doi":"https://doi.org/10.3390/cancers14133232","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14133232","pdf_url":"https://www.mdpi.com/2072-6694/14/13/3232/pdf?version=1656638971","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmid:35805009","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35805009","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9264907","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9264907/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmh:oai:edoc.mdc-berlin.de:21780","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mdc-berlin.de/21780/6/21780suppl.zip","pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:e8643f58da6742c6ad38416850e8a0b2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e8643f58da6742c6ad38416850e8a0b2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 14, Iss 3232, p 3232 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cancers14133232","doi":"https://doi.org/10.3390/cancers14133232","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers14133232","pdf_url":"https://www.mdpi.com/2072-6694/14/13/3232/pdf?version=1656638971","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1034572755","display_name":null,"funder_award_id":"2018A0303130282","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G203447990","display_name":null,"funder_award_id":"81001324","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G2230106406","display_name":null,"funder_award_id":"2020KY031","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G2719671887","display_name":null,"funder_award_id":"LR15H100001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3025651520","display_name":null,"funder_award_id":"LY20H160043","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G3443927945","display_name":null,"funder_award_id":"81001324","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G3569551584","display_name":null,"funder_award_id":"LR15H100001","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G405949599","display_name":null,"funder_award_id":"GDACA001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4592867695","display_name":null,"funder_award_id":"81802624","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G4608901065","display_name":null,"funder_award_id":"81001324","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4829689815","display_name":null,"funder_award_id":"2019RC123","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G5027149091","display_name":null,"funder_award_id":"81802624","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5044294470","display_name":null,"funder_award_id":"LY20H160043","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5053303162","display_name":null,"funder_award_id":"GDACA001","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G5400153","display_name":null,"funder_award_id":"8137316 3","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5602619152","display_name":null,"funder_award_id":"81373163","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G5840915601","display_name":null,"funder_award_id":"2018M643340","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G5857489616","display_name":null,"funder_award_id":"LY20H160043","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G588515834","display_name":null,"funder_award_id":"81802624","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G6133963478","display_name":null,"funder_award_id":"2020KY031","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6403144191","display_name":null,"funder_award_id":"2018A0303130282","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6418283942","display_name":null,"funder_award_id":"2020KY031","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G6544950946","display_name":null,"funder_award_id":"2019RC123","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6651880047","display_name":null,"funder_award_id":"2018A0303130282","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G6654813557","display_name":null,"funder_award_id":"81373163","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G6688491423","display_name":null,"funder_award_id":"2018M643340","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7042572277","display_name":null,"funder_award_id":"LR15H100001","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G7125109957","display_name":null,"funder_award_id":"2018M643340","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G7972507253","display_name":null,"funder_award_id":"GDACA001","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G8983723759","display_name":null,"funder_award_id":"2019RC123","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283758396.pdf","grobid_xml":"https://content.openalex.org/works/W4283758396.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W808646684","https://openalex.org/W1492600479","https://openalex.org/W1765981352","https://openalex.org/W1897095351","https://openalex.org/W1964081206","https://openalex.org/W1965603112","https://openalex.org/W1970145665","https://openalex.org/W1974006411","https://openalex.org/W1975267683","https://openalex.org/W1977846137","https://openalex.org/W1981463058","https://openalex.org/W1985515480","https://openalex.org/W1986342614","https://openalex.org/W1988503641","https://openalex.org/W1992127683","https://openalex.org/W1994711799","https://openalex.org/W1997453048","https://openalex.org/W2009102003","https://openalex.org/W2011843149","https://openalex.org/W2012701284","https://openalex.org/W2029746613","https://openalex.org/W2030406772","https://openalex.org/W2036465329","https://openalex.org/W2040942754","https://openalex.org/W2040977469","https://openalex.org/W2058138221","https://openalex.org/W2072177644","https://openalex.org/W2072899029","https://openalex.org/W2073952925","https://openalex.org/W2087500600","https://openalex.org/W2092780583","https://openalex.org/W2108664872","https://openalex.org/W2112763851","https://openalex.org/W2116205277","https://openalex.org/W2117277612","https://openalex.org/W2126547130","https://openalex.org/W2126817554","https://openalex.org/W2134061682","https://openalex.org/W2138472595","https://openalex.org/W2154589460","https://openalex.org/W2168894872","https://openalex.org/W2179438025","https://openalex.org/W2225733508","https://openalex.org/W2261100060","https://openalex.org/W2336262453","https://openalex.org/W2525047674","https://openalex.org/W2586020508","https://openalex.org/W2606001457","https://openalex.org/W2609637792","https://openalex.org/W2753132569","https://openalex.org/W2790004746","https://openalex.org/W2911646969","https://openalex.org/W3116974981","https://openalex.org/W3128646645","https://openalex.org/W3147736188"],"related_works":["https://openalex.org/W3194327487","https://openalex.org/W3047054085","https://openalex.org/W7214508159","https://openalex.org/W4413834711","https://openalex.org/W1988503641","https://openalex.org/W2489384179","https://openalex.org/W2604965774","https://openalex.org/W2763237291","https://openalex.org/W2170566094","https://openalex.org/W2119540244"],"abstract_inverted_index":{"Metastasis":[0],"is":[1,172],"the":[2,40,69,112,134,151,188],"main":[3],"cause":[4],"of":[5,23,26,42,101,120,130,136,143,153,160,167,192],"death":[6],"for":[7,174],"patients":[8],"suffering":[9],"gastric":[10,52,60,193],"cancer.":[11],"Epithelial-mesenchymal":[12],"transition":[13],"(EMT)":[14],"and":[15,34,50,56,64,83,108,141,178,190],"cancer":[16,53,61,194],"stem":[17],"cells":[18,62],"(CSC)":[19],"are":[20,28],"critical":[21],"attributes":[22],"metastasis,":[24],"both":[25],"which":[27,85],"regulated":[29],"tightly":[30],"by":[31,88,170],"DNA":[32,43],"methylation":[33],"Wnt/\u03b2-catenin":[35,91],"signaling.":[36,92],"Here,":[37],"we":[38],"studied":[39],"functions":[41],"dioxygenase":[44],"TET1":[45,58,75,137],"in":[46,51,59,71,111,187],"regulating":[47],"Wnt":[48,121,168],"signaling":[49,169],"metastasis.":[54,195],"Knocking-down":[55],"overexpressing":[57],"promoted":[63],"inhibited":[65],"metastatic":[66],"spreading":[67],"to":[68,116],"liver":[70],"immune-deficient":[72],"mice,":[73],"respectively.":[74],"showed":[76],"inhibitory":[77],"effects":[78,135],"on":[79,139],"metastasis-related":[80],"features":[81],"-EMT":[82],"CSC,":[84],"were":[86],"reversed":[87],"interfering":[89],"with":[90,106,147],"RNA-sequencing":[93],"identified":[94],"FOXO4":[95,103,131,154],"as":[96,115,155,184],"a":[97],"direct":[98],"transactivating":[99],"target":[100,122],"TET1.":[102],"directly":[104],"interacted":[105],"\u03b2-catenin":[107],"recruited":[109],"it":[110],"cytoplasm,":[113],"so":[114],"inhibit":[117],"\u03b2-catenin-mediated":[118],"transcription":[119],"genes,":[123],"including":[124],"CSC":[125],"marker":[126],"EpCAM.":[127],"Moreover,":[128],"modulation":[129],"could":[132],"reverse":[133],"manipulation":[138],"EMT":[140],"self-renewal":[142],"CSCs.":[144],"The":[145],"analysis":[146],"clinical":[148],"samples":[149],"confirmed":[150],"value":[152],"an":[156],"independent":[157],"prognostic":[158],"predictor":[159],"patients'":[161],"overall":[162],"survival.":[163],"Taken":[164],"together,":[165],"regulation":[166],"TET1/FOXO4":[171],"essential":[173],"metastasis-associated":[175],"cellular":[176],"properties,":[177],"targeting":[179],"TET1/FOXO4/\u03b2-catenin":[180],"pathway":[181],"may":[182],"serve":[183],"promising":[185],"therapeutics":[186],"prevention":[189],"treatment":[191]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-07-02T00:00:00"}