{"id":"https://openalex.org/W4283756987","doi":"https://doi.org/10.1016/j.actbio.2022.06.042","title":"Intra-articular injection of flavopiridol-loaded microparticles for treatment of post-traumatic osteoarthritis","display_name":"Intra-articular injection of flavopiridol-loaded microparticles for treatment of post-traumatic osteoarthritis","publication_year":2022,"publication_date":"2022-06-29","ids":{"openalex":"https://openalex.org/W4283756987","doi":"https://doi.org/10.1016/j.actbio.2022.06.042","pmid":"https://pubmed.ncbi.nlm.nih.gov/35779774","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10281459"},"language":"en","primary_location":{"id":"doi:10.1016/j.actbio.2022.06.042","doi":"https://doi.org/10.1016/j.actbio.2022.06.042","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.actbio.2022.06.042","pdf_url":null,"source":{"id":"https://openalex.org/S173145877","display_name":"Acta Biomaterialia","issn_l":"1742-7061","issn":["1742-7061","1878-7568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Acta Biomaterialia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.actbio.2022.06.042","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004991727","display_name":"Rapeepat Sangsuwan","orcid":"https://orcid.org/0000-0003-0836-4514","observed_orcids":["https://orcid.org/0000-0003-0836-4514"]},"institutions":[{"id":"https://openalex.org/I39737112","display_name":"Chulabhorn Research Institute","ror":"https://ror.org/00nb6mq69","country_code":"TH","type":"facility","lineage":["https://openalex.org/I39737112"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["TH","US"],"is_corresponding":false,"raw_author_name":"Rapeepat Sangsuwan","raw_affiliation_strings":["Department of Biomedical Engineering, University of California, Davis, CA 95616, USA; Laboratory of Natural Products, Chulabhorn Research Institute, Bangkok 10210, Thailand","Department of Biomedical Engineering, University of California, Davis, CA 95616, USA","Laboratory of Natural Products, Chulabhorn Research Institute, Bangkok 10210, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of California, Davis, CA 95616, USA; Laboratory of Natural Products, Chulabhorn Research Institute, Bangkok 10210, Thailand","institution_ids":["https://openalex.org/I39737112","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Laboratory of Natural Products, Chulabhorn Research Institute, Bangkok 10210, Thailand","institution_ids":["https://openalex.org/I39737112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032448354","display_name":"Jasper H. N. Yik","orcid":"https://orcid.org/0000-0001-7532-629X","observed_orcids":["https://orcid.org/0000-0001-7532-629X"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasper H.N. Yik","raw_affiliation_strings":["Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, CA 95618, USA"],"raw_orcid":"https://orcid.org/0000-0001-7532-629X","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, CA 95618, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089406747","display_name":"Matthew J. Owen","orcid":"https://orcid.org/0000-0001-7119-8374","observed_orcids":["https://orcid.org/0000-0001-7119-8374"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Owen","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, CA 95616, USA"],"raw_orcid":"https://orcid.org/0000-0001-7119-8374","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024109314","display_name":"Gang-yu Liu","orcid":"https://orcid.org/0000-0003-3689-0685","observed_orcids":["https://orcid.org/0000-0003-3689-0685"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gang-Yu Liu","raw_affiliation_strings":["Department of Chemistry, University of California, Davis, CA 95616, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073670709","display_name":"Dominik R. Haudenschild","orcid":"https://orcid.org/0000-0001-9947-9864","observed_orcids":["https://orcid.org/0000-0001-9947-9864"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dominik R. Haudenschild","raw_affiliation_strings":["Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, CA 95618, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, CA 95618, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004256774","display_name":"Jamal S. Lewis","orcid":"https://orcid.org/0000-0002-9811-8538","observed_orcids":["https://orcid.org/0000-0002-9811-8538"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jamal S. Lewis","raw_affiliation_strings":["Department of Biomedical Engineering, University of California, Davis, CA 95616, USA. Electronic address: jamlewis@ucdavis.edu","Department of Biomedical Engineering, University of California, Davis, CA 95616, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of California, Davis, CA 95616, USA. Electronic address: jamlewis@ucdavis.edu","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004256774"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":3.235,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.93348394,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"149","issue":null,"first_page":"347","last_page":"358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.029500000178813934,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/post-traumatic-osteoarthritis","display_name":"post-traumatic osteoarthritis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/intra-articular-injection","display_name":"intra-articular injection","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cdk9-inhibition","display_name":"CDK9 inhibition","score":0.753000020980835},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.9419999718666077},{"id":"https://openalex.org/keywords/joint-inflammation","display_name":"joint inflammation","score":0.6299999952316284},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-activity","display_name":"matrix metalloproteinase activity","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.8099455833435059},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.499300479888916},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4740079343318939},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.44546616077423096},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38871750235557556},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3778172731399536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34815841913223267},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16184085607528687},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.15952417254447937},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15895894169807434},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007270","descriptor_name":"Injections, Intra-Articular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042863","descriptor_name":"Cyclin-Dependent Kinase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.actbio.2022.06.042","doi":"https://doi.org/10.1016/j.actbio.2022.06.042","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.actbio.2022.06.042","pdf_url":null,"source":{"id":"https://openalex.org/S173145877","display_name":"Acta Biomaterialia","issn_l":"1742-7061","issn":["1742-7061","1878-7568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Acta Biomaterialia","raw_type":"journal-article"},{"id":"pmid:35779774","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35779774","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta biomaterialia","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10281459","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10281459","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10281459/pdf/nihms-1902487.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Acta Biomater","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt3cg911k0","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3cg911k0","pdf_url":"https://escholarship.org/content/qt3cg911k0/qt3cg911k0.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Biomaterialia, vol 149","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.actbio.2022.06.042","doi":"https://doi.org/10.1016/j.actbio.2022.06.042","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.actbio.2022.06.042","pdf_url":null,"source":{"id":"https://openalex.org/S173145877","display_name":"Acta Biomaterialia","issn_l":"1742-7061","issn":["1742-7061","1878-7568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Acta Biomaterialia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3032987932","display_name":"Particulate-based in vivo modulation for immunotherapy of Rheumatoid Arthritis","funder_award_id":"R01AI139399","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3737203601","display_name":null,"funder_award_id":"PR171305","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G6209828861","display_name":null,"funder_award_id":"PR171305","funder_id":"https://openalex.org/F4320338273","funder_display_name":"Congressionally Directed Medical Research Programs"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320338273","display_name":"Congressionally Directed Medical Research Programs","ror":"https://ror.org/03g2zjp07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283756987.pdf","grobid_xml":"https://content.openalex.org/works/W4283756987.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W119541310","https://openalex.org/W1487479383","https://openalex.org/W1508578867","https://openalex.org/W1520434148","https://openalex.org/W1539664785","https://openalex.org/W1793532565","https://openalex.org/W1881648922","https://openalex.org/W1886051612","https://openalex.org/W1908291951","https://openalex.org/W1968077631","https://openalex.org/W1976906604","https://openalex.org/W1980246074","https://openalex.org/W1982167517","https://openalex.org/W1984317348","https://openalex.org/W1985569332","https://openalex.org/W1993523958","https://openalex.org/W2017712522","https://openalex.org/W2018647053","https://openalex.org/W2019598869","https://openalex.org/W2020839425","https://openalex.org/W2025505482","https://openalex.org/W2038773696","https://openalex.org/W2050512596","https://openalex.org/W2056282066","https://openalex.org/W2072694036","https://openalex.org/W2076104046","https://openalex.org/W2076178719","https://openalex.org/W2086444341","https://openalex.org/W2087032263","https://openalex.org/W2131042657","https://openalex.org/W2148466312","https://openalex.org/W2155677484","https://openalex.org/W2167037356","https://openalex.org/W2170117497","https://openalex.org/W2346740611","https://openalex.org/W2411356063","https://openalex.org/W2427821467","https://openalex.org/W2472154887","https://openalex.org/W2513313441","https://openalex.org/W2545035916","https://openalex.org/W2776039151","https://openalex.org/W2791239724","https://openalex.org/W2806494694","https://openalex.org/W2944753861","https://openalex.org/W2953933998","https://openalex.org/W2965083651","https://openalex.org/W2969810988","https://openalex.org/W3127196935","https://openalex.org/W3183835688"],"related_works":["https://openalex.org/W7133200645","https://openalex.org/W2283736901","https://openalex.org/W3084961297","https://openalex.org/W2793229599","https://openalex.org/W2085708599","https://openalex.org/W7165446099","https://openalex.org/W3052943937","https://openalex.org/W2781867079","https://openalex.org/W4401582353","https://openalex.org/W7134987053"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-07-02T00:00:00"}